LOCUS       NM_021155               4284 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens CD209 molecule (CD209), transcript variant 1, mRNA.
ACCESSION   NM_021155
VERSION     NM_021155.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4284)
  AUTHORS   Stewart,E.L., Counoupas,C., Steain,M., Ashley,C., Alca,S.,
            Hartley-Tassell,L., von Itzstein,M., Britton,W.J., Petrovsky,N. and
            Triccas,J.A.
  TITLE     Dendritic cell-specific intercellular adhesion molecule-3-grabbing
            nonintegrin (DC-SIGN) is a cellular receptor for delta inulin
            adjuvant
  JOURNAL   Immunol Cell Biol 102 (7), 593-604 (2024)
   PUBMED   38757764
  REMARK    GeneRIF: Dendritic cell-specific intercellular adhesion
            molecule-3-grabbing nonintegrin (DC-SIGN) is a cellular receptor
            for delta inulin adjuvant.
REFERENCE   2  (bases 1 to 4284)
  AUTHORS   van der Donk,L.E.H., Bermejo-Jambrina,M., van Hamme,J.L.,
            Volkers,M.M.W., van Nuenen,A.C., Kootstra,N.A. and
            Geijtenbeek,T.B.H.
  TITLE     SARS-CoV-2 suppresses TLR4-induced immunity by dendritic cells via
            C-type lectin receptor DC-SIGN
  JOURNAL   PLoS Pathog 19 (10), e1011735 (2023)
   PUBMED   37844099
  REMARK    GeneRIF: SARS-CoV-2 suppresses TLR4-induced immunity by dendritic
            cells via C-type lectin receptor DC-SIGN.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4284)
  AUTHORS   Amraei,R., Yin,W., Napoleon,M.A., Suder,E.L., Berrigan,J., Zhao,Q.,
            Olejnik,J., Chandler,K.B., Xia,C., Feldman,J., Hauser,B.M.,
            Caradonna,T.M., Schmidt,A.G., Gummuluru,S., Muhlberger,E.,
            Chitalia,V., Costello,C.E. and Rahimi,N.
  TITLE     CD209L/L-SIGN and CD209/DC-SIGN act as receptors for SARS-CoV-2
  JOURNAL   bioRxiv (2021)
   PUBMED   32607506
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4284)
  AUTHORS   Amraei,R. and Rahimi,N.
  TITLE     COVID-19, Renin-Angiotensin System and Endothelial Dysfunction
  JOURNAL   Cells 9 (7), 1652 (2020)
   PUBMED   32660065
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4284)
  AUTHORS   Zhang,F., Ren,S. and Zuo,Y.
  TITLE     DC-SIGN, DC-SIGNR and LSECtin: C-type lectins for infection
  JOURNAL   Int Rev Immunol 33 (1), 54-66 (2014)
   PUBMED   24156700
  REMARK    Review article
REFERENCE   6  (bases 1 to 4284)
  AUTHORS   Chan,K.Y., Xu,M.S., Ching,J.C., So,T.M., Lai,S.T., Chu,C.M.,
            Yam,L.Y., Wong,A.T., Chung,P.H., Chan,V.S., Lin,C.L., Sham,P.C.,
            Leung,G.M., Peiris,J.S. and Khoo,U.S.
  TITLE     CD209 (DC-SIGN) -336A>G promoter polymorphism and severe acute
            respiratory syndrome in Hong Kong Chinese
  JOURNAL   Hum Immunol 71 (7), 702-707 (2010)
   PUBMED   20359516
  REMARK    GeneRIF: The CD209 -336A>G single nucleotide polymorphism affects
            its promoter activity and was associated with higher standardized
            LDH levels in Hong Kong Chinese on admission, which is an
            independent prognostic indicator for severe acute respiratory
            syndrome.
REFERENCE   7  (bases 1 to 4284)
  AUTHORS   Soilleux,E.J., Barten,R. and Trowsdale,J.
  TITLE     DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13
  JOURNAL   J Immunol 165 (6), 2937-2942 (2000)
   PUBMED   10975799
REFERENCE   8  (bases 1 to 4284)
  AUTHORS   Geijtenbeek,T.B., Kwon,D.S., Torensma,R., van Vliet,S.J., van
            Duijnhoven,G.C., Middel,J., Cornelissen,I.L., Nottet,H.S.,
            KewalRamani,V.N., Littman,D.R., Figdor,C.G. and van Kooyk,Y.
  TITLE     DC-SIGN, a dendritic cell-specific HIV-1-binding protein that
            enhances trans-infection of T cells
  JOURNAL   Cell 100 (5), 587-597 (2000)
   PUBMED   10721995
REFERENCE   9  (bases 1 to 4284)
  AUTHORS   Geijtenbeek,T.B., Torensma,R., van Vliet,S.J., van Duijnhoven,G.C.,
            Adema,G.J., van Kooyk,Y. and Figdor,C.G.
  TITLE     Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3
            receptor that supports primary immune responses
  JOURNAL   Cell 100 (5), 575-585 (2000)
   PUBMED   10721994
REFERENCE   10 (bases 1 to 4284)
  AUTHORS   Curtis,B.M., Scharnowske,S. and Watson,A.J.
  TITLE     Sequence and expression of a membrane-associated C-type lectin that
            exhibits CD4-independent binding of human immunodeficiency virus
            envelope glycoprotein gp120
  JOURNAL   Proc Natl Acad Sci U S A 89 (17), 8356-8360 (1992)
   PUBMED   1518869
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313585.1, AY042221.1 and
            AC008763.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_021155.3.
            
            Summary: This gene encodes a C-type lectin that functions in cell
            adhesion and pathogen recognition. This receptor recognizes a wide
            range of evolutionarily divergent pathogens with a large impact on
            public health, including leprosy and tuberculosis mycobacteria, the
            Ebola, hepatitis C, HIV-1 and Dengue viruses, and the SARS-CoV
            acute respiratory syndrome coronavirus. The protein is organized
            into four distinct domains: a C-terminal carbohydrate recognition
            domain, a flexible tandem-repeat neck domain, a transmembrane
            region and an N-terminal cytoplasmic domain involved in
            internalization. This gene is closely related in terms of both
            sequence and function to a neighboring gene, CLEC4M (Gene ID:
            10332), also known as L-SIGN. The two genes differ in viral
            recognition and expression patterns, with this gene showing high
            expression on the surface of dendritic cells. Polymorphisms in the
            neck region are associated with protection from HIV-1 infection,
            while single nucleotide polymorphisms in the promoter of this gene
            are associated with differing resistance and susceptibility to and
            severity of infectious disease, including rs4804803, which is
            associated with SARS severity. [provided by RefSeq, May 2020].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This record was created from transcript and genomic
            sequence data to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK293089.1, AF290886.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in SARS-CoV-2 infection
            MANE Ensembl match     :: ENST00000315599.12/ ENSP00000315477.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AK313585.1         46-68
            24-1238             AY042221.1         1-1215
            1239-4284           AC008763.9         170805-173850       c
FEATURES             Location/Qualifiers
     source          1..4284
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..4284
                     /gene="CD209"
                     /gene_synonym="CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1;
                     hDC-SIGN"
                     /note="CD209 molecule"
                     /db_xref="GeneID:30835"
                     /db_xref="HGNC:HGNC:1641"
                     /db_xref="MIM:604672"
     exon            1..69
                     /gene="CD209"
                     /gene_synonym="CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1;
                     hDC-SIGN"
                     /inference="alignment:Splign:2.1.0"
     exon            70..129
                     /gene="CD209"
                     /gene_synonym="CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1;
                     hDC-SIGN"
                     /inference="alignment:Splign:2.1.0"
     exon            130..201
                     /gene="CD209"
                     /gene_synonym="CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1;
                     hDC-SIGN"
                     /inference="alignment:Splign:2.1.0"
     exon            202..771
                     /gene="CD209"
                     /gene_synonym="CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1;
                     hDC-SIGN"
                     /inference="alignment:Splign:2.1.0"
     exon            772..923
                     /gene="CD209"
                     /gene_synonym="CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1;
                     hDC-SIGN"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1036
                     /gene="CD209"
                     /gene_synonym="CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1;
                     hDC-SIGN"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..4284
                     /gene="CD209"
                     /gene_synonym="CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1;
                     hDC-SIGN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4262..4267
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD209"
                     /gene_synonym="CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1;
                     hDC-SIGN"
                     /note="hexamer: AATAAA"
     polyA_site      4284
                     /gene="CD209"
                     /gene_synonym="CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1;
                     hDC-SIGN"
                     /note="major polyA site"
ORIGIN      
        1 acactggggg agagtggggt gacatgagtg actccaagga accaagactg cagcagctgg
       61 gcctcctgga ggaggaacag ctgagaggcc ttggattccg acagactcga ggatacaaga
      121 gcttagcagg gtgtcttggc catggtcccc tggtgctgca actcctctcc ttcacgctct
      181 tggctgggct ccttgtccaa gtgtccaagg tccccagctc cataagtcag gaacaatcca
      241 ggcaagacgc gatctaccag aacctgaccc agcttaaagc tgcagtgggt gagctctcag
      301 agaaatccaa gctgcaggag atctaccagg agctgaccca gctgaaggct gcagtgggtg
      361 agcttccaga gaaatctaag ctgcaggaga tctaccagga gctgacccgg ctgaaggctg
      421 cagtgggtga gcttccagag aaatctaagc tgcaggagat ctaccaggag ctgacctggc
      481 tgaaggctgc agtgggtgag cttccagaga aatctaagat gcaggagatc taccaggagc
      541 tgactcggct gaaggctgca gtgggtgagc ttccagagaa atctaagcag caggagatct
      601 accaggagct gacccggctg aaggctgcag tgggtgagct tccagagaaa tctaagcagc
      661 aggagatcta ccaggagctg acccggctga aggctgcagt gggtgagctt ccagagaaat
      721 ctaagcagca ggagatctac caggagctga cccagctgaa ggctgcagtg gaacgcctgt
      781 gccacccctg tccctgggaa tggacattct tccaaggaaa ctgttacttc atgtctaact
      841 cccagcggaa ctggcacgac tccatcaccg cctgcaaaga agtgggggcc cagctcgtcg
      901 taatcaaaag tgctgaggag cagaacttcc tacagctgca gtcttccaga agtaaccgct
      961 tcacctggat gggactttca gatctaaatc aggaaggcac gtggcaatgg gtggacggct
     1021 cacctctgtt gcccagcttc aagcagtatt ggaacagagg agagcccaac aacgttgggg
     1081 aggaagactg cgcggaattt agtggcaatg gctggaacga cgacaaatgt aatcttgcca
     1141 aattctggat ctgcaaaaag tccgcagcct cctgctccag ggatgaagaa cagtttcttt
     1201 ctccagcccc tgccacccca aacccccctc ctgcgtagca gaacttcacc cccttttaag
     1261 ctacagttcc ttctctccat ccttcgacct tcacaaaatc tctgggactg ttctttgtca
     1321 gattcttcct cctttagaag gctgggtccc attctgtcct tcttgtcatg cctccaattt
     1381 cccctggtgt agagcttgtt tttctggccc atccttggag ctttatgagt gagctggtgt
     1441 gggatgcctt tgggggtgga cttgtgttcc aagaatccac tctctcttcc ttttggagat
     1501 taggatattt gggttgccat gtgtagctgc tatgtcccct ggggcgttat cttatacatg
     1561 caaacctacc atctgttcaa cttccaccta ccacctcctg cacccctttg atcggggact
     1621 tactggttgc aagagctcat tttgcaggct ggaagcacca gggaattaat tcccccagtc
     1681 aaccaatggc acccagagag ggcatggagg ctccacgcaa ccccttccac ccccacatct
     1741 tcctttgtct tatacatggc ttccatttgg ctgtttctaa gttgtattct ttattttatt
     1801 attattatta ctatttttcg agatggagtt tcactcttgt cgctcaggct ggagtgccat
     1861 ggcgcgatct tggctcactg caacctctgc ctcccgggtt caagtgattc tcctgcctca
     1921 gcctcacgag tagctggaat tacaggcagg cgccaccaga cccggctaat tttttgtatt
     1981 tttagtacag atggggtttc tccgtgttgg tcaggctggt cttgaactcc cgacctcaga
     2041 tgatctgccc gcctcggcct cccaaaattg ctgggattac aggtgtgagc caccgcgcct
     2101 ggcctattat tttttgtaag aataaaacag gtttattggg atttgggact ctgaacagtt
     2161 ctgtctctac tacctgatct cctcctacca cgactttggg atctagagga gctttggctc
     2221 cggctgtgac ggctccggcc gttctcactg cggctgcacc ggcccccgct gcggtcacta
     2281 tttcttcctc tgctaggtga attgtgcctc tcctggctct ttgacatgtg ctagtgagat
     2341 ttcttccttt tcctttcgga ttccccattt cttttgtagg aatggtctgg actagggttc
     2401 tccttccccg cagcctgtag tattcatcgt ggtggcccac cctctctctc cccttggagc
     2461 tcttgccaaa ggaggagaca agcagaggtc tctattggat ttctcaacac ctgaagaaag
     2521 ttgcagtgtt ttcctcttgg acattgttgt atttcaaata aaccacaaat catcattttc
     2581 caccgagcca ctgggcagaa ttcacactga agctgtcgtc ctgcgtacat accatcgtcc
     2641 gttaaacaga gaaagagctg cttggcattc ttcttccgac tggtactgaa catatatact
     2701 tgcccctcag gtgaggttcc aagttgcaac tgaccttgaa ctgaatcact ctccccacgt
     2761 tattttttaa ttactatttt tttttaaaga tggggtcttg ctctgtcgcc aggctggagt
     2821 gcagtggcgc gatctaggct cactgcaact tccgcctccc gggttcaagc gattctcctg
     2881 cctcagcctc ccgagtagct gggactccac taaaagtaca aaaattagct gggcgtgcac
     2941 cactgcgccc agctaattct tgtatttttg gtagagacgg ggtttcaaca tgttgaccag
     3001 gatggtctcg atctcttgac ctcgtgattc gcccgccgcg tcctcccaaa gtgctgggat
     3061 tacaggcctg agccaccgcg cccagtctct ccccacgttc ttgaactcgg gcagcacatc
     3121 ctcacagaaa tctaggaact gttggtaggt ttcttcctcg ctgtactcca ggcttgcttc
     3181 ggagtcatag tcatccctcc tgcactgctc ctttccaaac actgtaaaca tgcttttaat
     3241 aagaagggta ggactggatg ttgggaaatc atgtgaacat ctatctccaa atctgcaagc
     3301 tcctgtttta ctgtagaagg gacaattaac tccatccttc tccatgactc tgaaatccaa
     3361 gggggggttc cgggttttgc catgtggcgc cattttccaa ctcattttca gcctgatcca
     3421 gcatcttctg gacagcttcc ggtttttgtt tcttctgtcg tttctgttcc tcctcctctc
     3481 tctctttcct ctgctgttct tcccattgtt cctttaactt tcgctcttgt tcttgccgtt
     3541 ttctagccac ctcttccttt tccttcttta ttctgaattc ttcttgtgcc ttctgctctc
     3601 tcagcaacca ctcctcatgt aatctttgcc tctctcttcc ccatagcttt tctagttgtt
     3661 gtttttcaat aaaagtgtcc tcctctttct gtgagagtcc tgagtccctc agtggagcaa
     3721 gttcctgctg gcgtttcttt cgtttctcct tcttcagggc ggccctgtac tttttgtggc
     3781 ttggtttctc tggaaatgtc accttttcgg gcgcagccat cttgccggca ccgccccgcc
     3841 cctctagttg tatcctttat aataaactgg taaacattgt aaccgcagat tcagcccaat
     3901 ctggttcaac tttgtgtaat aaaatggcga gttgtttttc agttgtcgtg gacccccagg
     3961 ttgcaagtta cataccctgg gcatgtccag atgaacgaag cgtgcaaatc cacgtggaac
     4021 ctaagtgctc agaccgagga acagggactg agttaagaag tggacaccac gtggcatgat
     4081 ccttgatcca atcagattga gccctggcgt gatccagtca gatcaagcct cctgaatccc
     4141 ctcattacaa gatccaatca tatcatgcct cactaccctc tgtatataaa atctgcccca
     4201 gcctccaact tggagagaca gatttgggcc agactcctgt gtccttgctt ggctgccttg
     4261 caataaattt ttctctctac aaaa
//
