LOCUS       NM_015717               1866 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens CD207 molecule (CD207), mRNA.
ACCESSION   NM_015717
VERSION     NM_015717.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1866)
  AUTHORS   Solhaug,M.B., Schreurs,O., Schenck,K., Blix,I.J. and
            Baekkevold,E.S.
  TITLE     Origin of langerin (CD207)-expressing antigen presenting cells in
            the normal oral mucosa and in oral lichen planus lesions
  JOURNAL   Eur J Oral Sci 130 (1), e12835 (2022)
   PUBMED   34935212
  REMARK    GeneRIF: Origin of langerin (CD207)-expressing antigen presenting
            cells in the normal oral mucosa and in oral lichen planus lesions.
REFERENCE   2  (bases 1 to 1866)
  AUTHORS   Joswig,J.O., Anders,J., Zhang,H., Rademacher,C. and Keller,B.G.
  TITLE     The molecular basis for the pH-dependent calcium affinity of the
            pattern recognition receptor langerin
  JOURNAL   J Biol Chem 296, 100718 (2021)
   PUBMED   33989634
  REMARK    GeneRIF: The molecular basis for the pH-dependent calcium affinity
            of the pattern recognition receptor langerin.
REFERENCE   3  (bases 1 to 1866)
  AUTHORS   Maarifi,G., Czubala,M.A., Lagisquet,J., Ivory,M.O., Fuchs,K.,
            Papin,L., Birchall,J.C., Nisole,S., Piguet,V. and Blanchet,F.P.
  TITLE     Langerin (CD207) represents a novel interferon-stimulated gene in
            Langerhans cells
  JOURNAL   Cell Mol Immunol 17 (5), 547-549 (2020)
   PUBMED   31607745
  REMARK    GeneRIF: Langerin (CD207) represents a novel interferon-stimulated
            gene in Langerhans cells.
REFERENCE   4  (bases 1 to 1866)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1866)
  AUTHORS   Ward,E.M., Stambach,N.S., Drickamer,K. and Taylor,M.E.
  TITLE     Polymorphisms in human langerin affect stability and sugar binding
            activity
  JOURNAL   J Biol Chem 281 (22), 15450-15456 (2006)
   PUBMED   16567809
  REMARK    GeneRIF: The effects of the amino acid changes on the activity of
            langerin were examined by expressing each of the polymorphic forms.
REFERENCE   6  (bases 1 to 1866)
  AUTHORS   Hunger,R.E., Sieling,P.A., Ochoa,M.T., Sugaya,M., Burdick,A.E.,
            Rea,T.H., Brennan,P.J., Belisle,J.T., Blauvelt,A., Porcelli,S.A.
            and Modlin,R.L.
  TITLE     Langerhans cells utilize CD1a and langerin to efficiently present
            nonpeptide antigens to T cells
  JOURNAL   J Clin Invest 113 (5), 701-708 (2004)
   PUBMED   14991068
  REMARK    GeneRIF: CD1a and langerin have roles in antigen presentation to T
            cells
REFERENCE   7  (bases 1 to 1866)
  AUTHORS   Plzakova,Z., Chovanec,M., Smetana,K. Jr., Plzak,J., Stork,J. and
            Saeland,S.
  TITLE     Comparison of the expression of Langerin and 175 kD mannose
            receptor in antigen-presenting cells in normal human skin and basal
            cell carcinoma
  JOURNAL   Folia Biol (Praha) 50 (2), 71-73 (2004)
   PUBMED   15222130
  REMARK    GeneRIF: The Langerin-positive cells strictly colonized the
            epidermis and no cells were found in the dermis.
REFERENCE   8  (bases 1 to 1866)
  AUTHORS   Valladeau,J., Dezutter-Dambuyant,C. and Saeland,S.
  TITLE     Langerin/CD207 sheds light on formation of birbeck granules and
            their possible function in Langerhans cells
  JOURNAL   Immunol Res 28 (2), 93-107 (2003)
   PUBMED   14610287
  REMARK    GeneRIF: Langerin is a potent langerhans cells -specific regulator
            of membrane superimposition and zippering, representing a key
            molecule to trace Langerhans cells [Review].
            Review article
REFERENCE   9  (bases 1 to 1866)
  AUTHORS   Turville,S.G., Cameron,P.U., Handley,A., Lin,G., Pohlmann,S.,
            Doms,R.W. and Cunningham,A.L.
  TITLE     Diversity of receptors binding HIV on dendritic cell subsets
  JOURNAL   Nat Immunol 3 (10), 975-983 (2002)
   PUBMED   12352970
  REMARK    GeneRIF: langerin was expressed by Langerhans cells
REFERENCE   10 (bases 1 to 1866)
  AUTHORS   Valladeau,J., Ravel,O., Dezutter-Dambuyant,C., Moore,K.,
            Kleijmeer,M., Liu,Y., Duvert-Frances,V., Vincent,C., Schmitt,D.,
            Davoust,J., Caux,C., Lebecque,S. and Saeland,S.
  TITLE     Langerin, a novel C-type lectin specific to Langerhans cells, is an
            endocytic receptor that induces the formation of Birbeck granules
  JOURNAL   Immunity 12 (1), 71-81 (2000)
   PUBMED   10661407
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AJ242859.1, AC007395.4 and
            BX104865.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_015717.4.
            
            Summary: The protein encoded by this gene is expressed only in
            Langerhans cells which are immature dendritic cells of the
            epidermis and mucosa. It is localized in the Birbeck granules,
            organelles present in the cytoplasm of Langerhans cells and
            consisting of superimposed and zippered membranes. It is a C-type
            lectin with mannose binding specificity, and it has been proposed
            that mannose binding by this protein leads to internalization of
            antigen into Birbeck granules and providing access to a
            nonclassical antigen-processing pathway. Mutations in this gene
            result in Birbeck granules deficiency or loss of sugar binding
            activity. [provided by RefSeq, Aug 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022278.1, AJ242859.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000410009.5/ ENSP00000386378.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-872               AJ242859.1         8-879
            873-873             AC007395.4         156184-156184       c
            874-1315            AJ242859.1         881-1322
            1316-1316           AC007395.4         155241-155241       c
            1317-1861           AJ242859.1         1324-1868
            1862-1865           BX104865.1         306-309
            1866-1866           AC007395.4         154691-154691       c
FEATURES             Location/Qualifiers
     source          1..1866
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.3"
     gene            1..1866
                     /gene="CD207"
                     /gene_synonym="CLEC4K"
                     /note="CD207 molecule"
                     /db_xref="GeneID:50489"
                     /db_xref="HGNC:HGNC:17935"
                     /db_xref="MIM:604862"
     exon            1..113
                     /gene="CD207"
                     /gene_synonym="CLEC4K"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1027
                     /gene="CD207"
                     /gene_synonym="CLEC4K"
                     /note="Langerhans cell specific c-type lectin; CD207
                     molecule, langerin; CD207 antigen, langerin; C-type lectin
                     domain family 4, member K"
                     /codon_start=1
                     /product="C-type lectin domain family 4 member K"
                     /protein_id="NP_056532.4"
                     /db_xref="CCDS:CCDS74520.1"
                     /db_xref="GeneID:50489"
                     /db_xref="HGNC:HGNC:17935"
                     /db_xref="MIM:604862"
                     /translation="MTVEKEAPDAHFTVDKQNISLWPREPPPKSGPSLVPGKTPTVRA
                     ALICLTLVLVASVLLQAVLYPRFMGTISDVKTNVQLLKGRVDNISTLDSEIKKNSDGM
                     EAAGVQIQMVNESLGYVRSQFLKLKTSVEKANAQIQILTRSWEEVSTLNAQIPELKSD
                     LEKASALNTKIRALQGSLENMSKLLKRQNDILQVVSQGWKYFKGNFYYFSLIPKTWYS
                     AEQFCVSRNSHLTSVTSESEQEFLYKTAGGLIYWIGLTKAGMEGDWSWVDDTPFNKVQ
                     SVRFWIPGEPNNAGNNEHCGNIKAPSLQAWNDAPCDKTFLFICKRPYVPSEP"
     exon            114..230
                     /gene="CD207"
                     /gene_synonym="CLEC4K"
                     /inference="alignment:Splign:2.1.0"
     exon            231..605
                     /gene="CD207"
                     /gene_synonym="CLEC4K"
                     /inference="alignment:Splign:2.1.0"
     exon            606..757
                     /gene="CD207"
                     /gene_synonym="CLEC4K"
                     /inference="alignment:Splign:2.1.0"
     exon            758..876
                     /gene="CD207"
                     /gene_synonym="CLEC4K"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1866
                     /gene="CD207"
                     /gene_synonym="CLEC4K"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1837..1842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD207"
                     /gene_synonym="CLEC4K"
                     /note="hexamer: AATAAA"
     polyA_site      1866
                     /gene="CD207"
                     /gene_synonym="CLEC4K"
                     /note="major polyA site"
ORIGIN      
        1 agaagcacct gtgctcccag gataagggtg agcactcagg atgactgtgg agaaggaggc
       61 ccctgatgcg cacttcactg tggacaaaca gaacatctcc ctctggcccc gagagcctcc
      121 tcccaagtcc ggtccatctc tggtcccggg gaaaacaccc acagtccgtg ctgcattaat
      181 ctgcctgacg ctggtcctgg tcgcctccgt cctgctgcag gccgtccttt atccccggtt
      241 tatgggcacc atatcagatg taaagaccaa tgtccagttg ctgaaaggtc gtgtggacaa
      301 catcagcacc ctggattctg aaattaaaaa gaatagtgac ggcatggagg cagctggcgt
      361 tcagatccag atggtgaatg agagcctggg ttatgtgcgt tctcagttcc tgaagttaaa
      421 aaccagtgtg gagaaggcca acgcacagat ccagatctta acaagaagtt gggaagaagt
      481 cagtacctta aatgcccaaa tcccagagtt aaaaagtgat ttggagaaag ccagtgcttt
      541 aaatacaaag atccgggcac tccagggcag cttggagaat atgagcaagt tgctcaaacg
      601 acaaaatgat attctacagg tggtttctca aggctggaag tacttcaagg ggaacttcta
      661 ttacttttct ctcattccaa agacctggta tagtgccgag cagttctgtg tgtccaggaa
      721 ttcacacctg acctcggtga cctcagagag tgagcaggag tttctgtata aaacagcggg
      781 gggactcatc tactggattg gcctgactaa agcagggatg gaaggggact ggtcctgggt
      841 ggatgacacg ccattcaaca aggtccaaag tgtgaggttc tggattccag gtgagcccaa
      901 caatgctggg aacaatgaac actgtggcaa tataaaggct ccctcacttc aggcctggaa
      961 tgatgcccca tgtgacaaaa cgtttctttt catttgtaag cgaccctatg tcccatcaga
     1021 accgtgacag gacaggctcc caagctcact ctttgagctc caacgcttgt taaacatgag
     1081 gaaatgcctc tttcttcccc agactccagg atgactttgc acgttaattt ttcttgcttc
     1141 aaaattgtcc cacagtggca ttctggagtc cgtctgtctt ggctggaaat tctctgacgt
     1201 cttggaggca gctggaatgg aaaggagaat tcaggttaaa gtgggagggg tgggtagaga
     1261 ggatttagaa gttccaattg ccctgctaag gaggatcaag acccgtaatc cggcataaca
     1321 ccctggggtt ttccactctt tcagagaaac ctcagcttca tcacatcaaa gttactccag
     1381 agcaaccaag caattctcct gatattgtca tccagggctt ttcttggcca aaccccctag
     1441 aatttccatg tctctgctta gctgtgctgg cagctagcag ctggctgtgt ttgcagtgca
     1501 aatagctctg ttcttggaaa tcctgctcat ggtatgtccc cagtggtttc ttcatccaca
     1561 tcatctaaag cctgaacccg ttcttctctg gttcaagtca gtggctgaca cggacttgta
     1621 tctccttcag agctcggctg gcacccagcc tcccttctcc ttccactccc ttagtacact
     1681 ggagtgccga gccctgcctt ccacccagcg tccatccagc ccctgtcctc acctctccgg
     1741 cacctcctcc tccttctgca tttcctatct tcctgtgtct tgtgcatggg aagcagcctt
     1801 cagtgccttc atgaattcac cttccagctt cctcagaata aaatgctgcc tgggtcaagg
     1861 actcac
//
