LOCUS       NM_001199215            1603 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens CD200 receptor 1 like (CD200R1L), transcript variant
            2, coding, mRNA.
ACCESSION   NM_001199215 XM_011512763
VERSION     NM_001199215.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1603)
  AUTHORS   Pascoal Ramos,M.I., Kesmir,C., Stok,J.E., Geerdink,R.,
            Satravelas,N., Westerlaken,G.H.A., Meyaard,L. and van der Vlist,M.
  TITLE     CD200R1L is a functional evolutionary conserved activating receptor
            in human neutrophils
  JOURNAL   J Leukoc Biol 111 (2), 367-377 (2022)
   PUBMED   33884657
REFERENCE   2  (bases 1 to 1603)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1603)
  AUTHORS   Tao,S., Wang,Z., Feng,J., Hsu,F.C., Jin,G., Kim,S.T., Zhang,Z.,
            Gronberg,H., Zheng,L.S., Isaacs,W.B., Xu,J. and Sun,J.
  TITLE     A genome-wide search for loci interacting with known prostate
            cancer risk-associated genetic variants
  JOURNAL   Carcinogenesis 33 (3), 598-603 (2012)
   PUBMED   22219177
REFERENCE   4  (bases 1 to 1603)
  AUTHORS   Minas,K. and Liversidge,J.
  TITLE     Is the CD200/CD200 receptor interaction more than just a myeloid
            cell inhibitory signal?
  JOURNAL   Crit Rev Immunol 26 (3), 213-230 (2006)
   PUBMED   16928187
  REMARK    Review article
REFERENCE   5  (bases 1 to 1603)
  AUTHORS   Voehringer,D., Rosen,D.B., Lanier,L.L. and Locksley,R.M.
  TITLE     CD200 receptor family members represent novel DAP12-associated
            activating receptors on basophils and mast cells
  JOURNAL   J Biol Chem 279 (52), 54117-54123 (2004)
   PUBMED   15471863
REFERENCE   6  (bases 1 to 1603)
  AUTHORS   Wright,G.J., Cherwinski,H., Foster-Cuevas,M., Brooke,G.,
            Puklavec,M.J., Bigler,M., Song,Y., Jenmalm,M., Gorman,D.,
            McClanahan,T., Liu,M.R., Brown,M.H., Sedgwick,J.D., Phillips,J.H.
            and Barclay,A.N.
  TITLE     Characterization of the CD200 receptor family in mice and humans
            and their interactions with CD200
  JOURNAL   J Immunol 171 (6), 3034-3046 (2003)
   PUBMED   12960329
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC074044.8 and AC092892.5.
            
            On Apr 30, 2021 this sequence version replaced NM_001199215.2.
            
            Transcript Variant: This variant (2, coding) represents the allele
            encoded by the GRCh38 reference genome and encodes isoform (2).
            
            ##Evidence-Data-START##
            CDS exon combination :: AY284976.1, BC144504.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1968968, SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000488794.6/ ENSP00000418413.1
            polymorphic pseudogene :: based on alignments, homology
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-240               AC074044.8         19629-19868         c
            241-512             AC074044.8         18683-18954         c
            513-581             AC074044.8         10946-11014         c
            582-647             AC074044.8         2323-2388           c
            648-965             AC092892.5         46839-47156         c
            966-1214            AC092892.5         46465-46713         c
            1215-1338           AC092892.5         39244-39367         c
            1339-1603           AC092892.5         35183-35447         c
FEATURES             Location/Qualifiers
     source          1..1603
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.2"
     gene            1..1603
                     /gene="CD200R1L"
                     /gene_synonym="CD200R2; CD200RLa"
                     /note="CD200 receptor 1 like"
                     /db_xref="GeneID:344807"
                     /db_xref="HGNC:HGNC:24665"
     exon            1..240
                     /gene="CD200R1L"
                     /gene_synonym="CD200R2; CD200RLa"
                     /inference="alignment:Splign:2.1.0"
     exon            241..512
                     /gene="CD200R1L"
                     /gene_synonym="CD200R2; CD200RLa"
                     /inference="alignment:Splign:2.1.0"
     exon            513..581
                     /gene="CD200R1L"
                     /gene_synonym="CD200R2; CD200RLa"
                     /inference="alignment:Splign:2.1.0"
     exon            582..647
                     /gene="CD200R1L"
                     /gene_synonym="CD200R2; CD200RLa"
                     /inference="alignment:Splign:2.1.0"
     CDS             599..1351
                     /gene="CD200R1L"
                     /gene_synonym="CD200R2; CD200RLa"
                     /note="isoform 2 is encoded by transcript variant 2,
                     coding; CD200 receptor 2; cell surface glycoprotein CD200
                     receptor 2; CD200 cell surface glycoprotein receptor 2;
                     CD200 receptor-like 2; cell surface glycoprotein OX2
                     receptor 2; CD200 cell surface glycoprotein receptor-like
                     2; CD200 cell surface glycoprotein receptor-like a; cell
                     surface glycoprotein CD200 receptor 1-like"
                     /codon_start=1
                     /product="cell surface glycoprotein CD200 receptor 2
                     isoform 2"
                     /protein_id="NP_001186144.1"
                     /db_xref="CCDS:CCDS56267.1"
                     /db_xref="GeneID:344807"
                     /db_xref="HGNC:HGNC:24665"
                     /translation="MGGKQMTQNYSTIFAEGNISQPVLMDINAVLCCPPIALRNLIII
                     TWEIILRGQPSCTKAYKKETNETKETNCTVERITWVSRPDQNSDLQIRPVDTTHDGYY
                     RGIVVTPDGNFHRGYHLQVLVTPEVNLFQSRNITAVCKAVTGKPAAQISWIPEGSILA
                     TKQEYWGNGTVTVKSTCPWEGHKSTVTCHVSHLTGNKSLSVKLNSGLRTSGSPALSLL
                     IILYVKLSLFVVILVTTGFVFFQRINHVRKVL"
     exon            648..965
                     /gene="CD200R1L"
                     /gene_synonym="CD200R2; CD200RLa"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1214
                     /gene="CD200R1L"
                     /gene_synonym="CD200R2; CD200RLa"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1338
                     /gene="CD200R1L"
                     /gene_synonym="CD200R2; CD200RLa"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1603
                     /gene="CD200R1L"
                     /gene_synonym="CD200R2; CD200RLa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1583..1588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD200R1L"
                     /gene_synonym="CD200R2; CD200RLa"
                     /note="hexamer: AATAAA"
     polyA_site      1603
                     /gene="CD200R1L"
                     /gene_synonym="CD200R2; CD200RLa"
                     /note="major polyA site"
ORIGIN      
        1 gtagaagaaa catcactcag atctctgcct tttatcttca catggtgttc ctgtgtatgc
       61 gcccagtttt cctcttttta taaggacacc ataaaaagct aagaagtgca aaagaagaaa
      121 aaaagaataa accaaagacg ccagtcatat tggattaggg accaatctat ttcagcatgg
      181 ccacatctta actaattata tctccaatga ccctatttcc aaataaggtc atcttctgag
      241 caaaactcac tgacatttcc catcagtggt taatcagtca aaaacatata gaatgacagc
      301 aaaaattaaa gataagcaag ataatgaaga aatatgtttt gcaatcctgt tgaagacaga
      361 ataagcaaaa gtgaccaaga gaaacagatt caccaagtct gttgattgat ttaaagtgga
      421 tttatgttta agtagaaaac cactccaaaa gcatacttta gggaagatgt cagctccaag
      481 attactgatt tccatcatta tcatggtgtc tgcctcagat aataattcct gtctgatgac
      541 acaactggaa atacaaagtt agagaatacg tcttaatgaa gcttcaagta gttcatgcat
      601 gggtggaaag cagatgacac agaactattc aacaattttt gcagaaggta acatttcaca
      661 gcctgtactg atggatataa atgctgtgct ttgttgccct cctatcgcat taagaaattt
      721 gatcataata acatgggaaa taatcctgag aggccagcct tcctgcacaa aagcctacaa
      781 gaaagaaaca aatgagacca aggaaaccaa ctgtactgtt gagagaataa cctgggtctc
      841 tagacctgat cagaattcgg accttcagat tcgtccggtg gacaccactc atgacgggta
      901 ttacagaggc atagtggtaa cacctgatgg gaatttccat cgtggatatc acctccaagt
      961 gttagttaca cccgaagtga acctatttca aagcaggaat ataactgcag tatgcaaggc
     1021 agttacaggg aagccagctg cccagatctc ctggatccca gagggatcta ttcttgccac
     1081 taagcaagaa tactggggca atggcacagt gacggttaag agtacatgcc cctgggaggg
     1141 ccacaagtct actgtgacct gccatgtctc ccatttgact ggcaacaaga gtctgtccgt
     1201 aaagttgaat tcaggtctca gaacctcagg atctccagcg ttgtccttac tgatcattct
     1261 ttatgtgaaa ctctctcttt ttgtggtcat tctggtcacc acaggatttg ttttcttcca
     1321 gaggataaat catgtcagaa aagttcttta aagaagaagg aagggtcttc ttttgcttct
     1381 cctccttgtc tctggactgc aacattggtg agatgagtga tggtccagca gtgaacttgg
     1441 gccatggatg atgttaagga tagaagccac tcagtaggat agaagaaaag aaagatggaa
     1501 gaaggatcct gggcttgatg accatgaagt ttccctataa accctcaacc acctattcat
     1561 tgacttcttt tgtgttagag tgaataaaat tttgttcatg cca
//
