LOCUS       NM_138940                969 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens CD200 receptor 1 (CD200R1), transcript variant 3,
            mRNA.
ACCESSION   NM_138940
VERSION     NM_138940.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 969)
  AUTHORS   Lin,S., Shu,Y., Shen,R., Zhou,Y., Pan,H., He,L., Fang,F., Zhu,X.,
            Wang,X., Wang,Y., Xu,W. and Ding,J.
  TITLE     The regulation of NFKB1 on CD200R1 expression and their potential
            roles in Parkinson's disease
  JOURNAL   J Neuroinflammation 21 (1), 229 (2024)
   PUBMED   39294682
  REMARK    GeneRIF: The regulation of NFKB1 on CD200R1 expression and their
            potential roles in Parkinson's disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 969)
  AUTHORS   Hu,Y., Wei,T., Gao,S., Gao,N., Chen,L. and Cheng,Q.
  TITLE     CD200R promotes high glucose-induced oxidative stress and damage in
            human retinal pigment epithelial cells by activating the mTOR
            signaling pathway
  JOURNAL   Tissue Cell 88, 102381 (2024)
   PUBMED   38692160
  REMARK    GeneRIF: CD200R promotes high glucose-induced oxidative stress and
            damage in human retinal pigment epithelial cells by activating the
            mTOR signaling pathway.
REFERENCE   3  (bases 1 to 969)
  AUTHORS   Ahmed,M., Tezera,L.B., Herbert,N., Chambers,M., Reichmann,M.T.,
            Nargan,K., Kloverpris,H., Karim,F., Hlatshwayo,M., Madensein,R.,
            Habesh,M., Hoque,M., Steyn,A.J.C., Elkington,P.T. and Leslie,A.J.
  TITLE     Myeloid cell expression of CD200R is modulated in active TB disease
            and regulates Mycobacterium tuberculosis infection in a biomimetic
            model
  JOURNAL   Front Immunol 15, 1360412 (2024)
   PUBMED   38745652
  REMARK    GeneRIF: Myeloid cell expression of CD200R is modulated in active
            TB disease and regulates Mycobacterium tuberculosis infection in a
            biomimetic model.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 969)
  AUTHORS   Lin,M., Chen,D., Shao,Z., Liu,Q., Hao,Z., Xin,Z., Chen,Y., Wu,W.,
            Chen,X., He,T., Wu,D. and Wu,P.
  TITLE     Inflammatory dendritic cells restrain CD11b+CD4+ CTLs via CD200R in
            human NSCLC
  JOURNAL   Cell Rep 43 (2), 113767 (2024)
   PUBMED   38354085
  REMARK    GeneRIF: Inflammatory dendritic cells restrain CD11b[+]CD4[+] CTLs
            via CD200R in human NSCLC.
REFERENCE   5  (bases 1 to 969)
  AUTHORS   Tang,Y., Liu,W., Kadu,S., Johnson,O., Hasanali,Z.S., Kelly,A.,
            Shestov,A., Pajarillo,R., Greenblatt,E., Holmes,M., Wang,L.P.,
            Shih,N., O'Connor,R.S., Ruella,M., Garfall,A.L., Allman,D.,
            Vogl,D.T., Cohen,A., June,C.H. and Sheppard,N.C.
  TITLE     Exploiting the CD200-CD200R immune checkpoint axis in multiple
            myeloma to enhance CAR T-cell therapy
  JOURNAL   Blood 143 (2), 139-151 (2024)
   PUBMED   37616575
  REMARK    GeneRIF: Exploiting the CD200-CD200R immune checkpoint axis in
            multiple myeloma to enhance CAR T-cell therapy.
REFERENCE   6  (bases 1 to 969)
  AUTHORS   Vieites,J.M., de la Torre,R., Ortega,M.A., Montero,T., Peco,J.M.,
            Sanchez-Pozo,A., Gil,A. and Suarez,A.
  TITLE     Characterization of human cd200 glycoprotein receptor gene located
            on chromosome 3q12-13
  JOURNAL   Gene 311, 99-104 (2003)
   PUBMED   12853143
REFERENCE   7  (bases 1 to 969)
  AUTHORS   Barclay,A.N., Wright,G.J., Brooke,G. and Brown,M.H.
  TITLE     CD200 and membrane protein interactions in the control of myeloid
            cells
  JOURNAL   Trends Immunol 23 (6), 285-290 (2002)
   PUBMED   12072366
  REMARK    Review article
REFERENCE   8  (bases 1 to 969)
  AUTHORS   Wright,G.J., Jones,M., Puklavec,M.J., Brown,M.H. and Barclay,A.N.
  TITLE     The unusual distribution of the neuronal/lymphoid cell surface
            CD200 (OX2) glycoprotein is conserved in humans
  JOURNAL   Immunology 102 (2), 173-179 (2001)
   PUBMED   11260322
REFERENCE   9  (bases 1 to 969)
  AUTHORS   Dick,A.D., Broderick,C., Forrester,J.V. and Wright,G.J.
  TITLE     Distribution of OX2 antigen and OX2 receptor within retina
  JOURNAL   Invest Ophthalmol Vis Sci 42 (1), 170-176 (2001)
   PUBMED   11133863
REFERENCE   10 (bases 1 to 969)
  AUTHORS   Wright,G.J., Puklavec,M.J., Willis,A.C., Hoek,R.M., Sedgwick,J.D.,
            Brown,M.H. and Barclay,A.N.
  TITLE     Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel
            receptor on macrophages implicated in the control of their function
  JOURNAL   Immunity 13 (2), 233-242 (2000)
   PUBMED   10981966
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC074044.8, AK126349.1 and
            AF497550.1.
            
            On May 31, 2019 this sequence version replaced NM_138940.2.
            
            Summary: This gene encodes a receptor for the OX-2 membrane
            glycoprotein. Both the receptor and substrate are cell surface
            glycoproteins containing two immunoglobulin-like domains. This
            receptor is restricted to the surfaces of myeloid lineage cells and
            the receptor-substrate interaction may function as a myeloid
            downregulatory signal. Mouse studies of a related gene suggest that
            this interaction may control myeloid function in a tissue-specific
            manner. Alternative splicing of this gene results in multiple
            transcript variants. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) contains multiple differences
            in the coding region, compared to variant 1. This results in a
            frameshift and early stop codon, as well as loss of an
            immunoglobulin and transmembrane domain in the protein (isoform c),
            compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF497550.1, DB239072.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC074044.8         148095-148107       c
            14-191              AK126349.1         1-178
            192-969             AF497550.1         1-778
FEATURES             Location/Qualifiers
     source          1..969
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.2"
     gene            1..969
                     /gene="CD200R1"
                     /gene_synonym="CD200R; HCRTR2; MOX2R; OX2R"
                     /note="CD200 receptor 1"
                     /db_xref="GeneID:131450"
                     /db_xref="HGNC:HGNC:24235"
                     /db_xref="MIM:607546"
     exon            1..313
                     /gene="CD200R1"
                     /gene_synonym="CD200R; HCRTR2; MOX2R; OX2R"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..744
                     /gene="CD200R1"
                     /gene_synonym="CD200R; HCRTR2; MOX2R; OX2R"
                     /note="isoform c precursor is encoded by transcript
                     variant 3; MOX2 receptor; cell surface glycoprotein
                     receptor CD200; cell surface glycoprotein CD200 receptor
                     1; CD200 cell surface glycoprotein receptor; cell surface
                     glycoprotein OX2 receptor 1"
                     /codon_start=1
                     /product="cell surface glycoprotein CD200 receptor 1
                     isoform c precursor"
                     /protein_id="NP_620386.1"
                     /db_xref="CCDS:CCDS54623.1"
                     /db_xref="GeneID:131450"
                     /db_xref="HGNC:HGNC:24235"
                     /db_xref="MIM:607546"
                     /translation="MLCPWRTANLGLLLILTIFLVAASSSLCMDEKQITQNYSKVLAE
                     VNTSWPVKMATNAVLCCPPIALRNLIIITWEIILRGQPSCTKAYKKETNETKETNCTD
                     ERITWVSRPDQNSDLQIRTVAITHDGYYRCIMVTPDGNFHRGYHLQVLGKEHHILRYF
                     TSPDL"
     exon            314..379
                     /gene="CD200R1"
                     /gene_synonym="CD200R; HCRTR2; MOX2R; OX2R"
                     /inference="alignment:Splign:2.1.0"
     exon            380..969
                     /gene="CD200R1"
                     /gene_synonym="CD200R; HCRTR2; MOX2R; OX2R"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atacaggaaa tctattgctg tgtcaagttc cagagaaaag cttctgttcg tccaagttac
       61 taaccaggct aaaccacata gacgtgaagg aaggggctag aaggaaggga gtgccccact
      121 gttgatgggg taagaggatc ctgtactgag aagttgacca gagagggtct caccatgcgc
      181 acagttcctt ctgtacctgt gtggaggaaa agtactgagt gaagggcaga aaaagagaaa
      241 acagaaatgc tctgcccttg gagaactgct aacctagggc tactgttgat tttgactatc
      301 ttcttagtgg ccgcttcaag cagtttatgt atggatgaaa aacagattac acagaactac
      361 tcgaaagtac tcgcagaagt taacacttca tggcctgtaa agatggctac aaatgctgtg
      421 ctttgttgcc ctcctatcgc attaagaaat ttgatcataa taacatggga aataatcctg
      481 agaggccagc cttcctgcac aaaagcctac aagaaagaaa caaatgagac caaggaaacc
      541 aactgtactg atgagagaat aacctgggtc tccagacctg atcagaattc ggaccttcag
      601 attcgtaccg tggccatcac tcatgacggg tattacagat gcataatggt aacacctgat
      661 gggaatttcc atcgtggata tcacctccaa gtgttaggta aggagcatca tatattgagg
      721 tatttcacat caccagattt gtgacggaaa caaatgtctc tctgaattcc atatgcttta
      781 tgtgaaaacc gaagcatttt tttccctctt tcctctctgc agttacacct gaagtgaccc
      841 tgtttcaaaa caggaataga actgcagtat gcaaggcagt tgcagggaag ccagctgcgc
      901 atatctcctg gatcccagag ggcgattgtg ccactaagca agaatactgg agcaatggca
      961 cagtgactg
//
