LOCUS       NM_138806               3765 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens CD200 receptor 1 (CD200R1), transcript variant 1,
            mRNA.
ACCESSION   NM_138806
VERSION     NM_138806.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3765)
  AUTHORS   Lin,S., Shu,Y., Shen,R., Zhou,Y., Pan,H., He,L., Fang,F., Zhu,X.,
            Wang,X., Wang,Y., Xu,W. and Ding,J.
  TITLE     The regulation of NFKB1 on CD200R1 expression and their potential
            roles in Parkinson's disease
  JOURNAL   J Neuroinflammation 21 (1), 229 (2024)
   PUBMED   39294682
  REMARK    GeneRIF: The regulation of NFKB1 on CD200R1 expression and their
            potential roles in Parkinson's disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3765)
  AUTHORS   Hu,Y., Wei,T., Gao,S., Gao,N., Chen,L. and Cheng,Q.
  TITLE     CD200R promotes high glucose-induced oxidative stress and damage in
            human retinal pigment epithelial cells by activating the mTOR
            signaling pathway
  JOURNAL   Tissue Cell 88, 102381 (2024)
   PUBMED   38692160
  REMARK    GeneRIF: CD200R promotes high glucose-induced oxidative stress and
            damage in human retinal pigment epithelial cells by activating the
            mTOR signaling pathway.
REFERENCE   3  (bases 1 to 3765)
  AUTHORS   Ahmed,M., Tezera,L.B., Herbert,N., Chambers,M., Reichmann,M.T.,
            Nargan,K., Kloverpris,H., Karim,F., Hlatshwayo,M., Madensein,R.,
            Habesh,M., Hoque,M., Steyn,A.J.C., Elkington,P.T. and Leslie,A.J.
  TITLE     Myeloid cell expression of CD200R is modulated in active TB disease
            and regulates Mycobacterium tuberculosis infection in a biomimetic
            model
  JOURNAL   Front Immunol 15, 1360412 (2024)
   PUBMED   38745652
  REMARK    GeneRIF: Myeloid cell expression of CD200R is modulated in active
            TB disease and regulates Mycobacterium tuberculosis infection in a
            biomimetic model.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3765)
  AUTHORS   Lin,M., Chen,D., Shao,Z., Liu,Q., Hao,Z., Xin,Z., Chen,Y., Wu,W.,
            Chen,X., He,T., Wu,D. and Wu,P.
  TITLE     Inflammatory dendritic cells restrain CD11b+CD4+ CTLs via CD200R in
            human NSCLC
  JOURNAL   Cell Rep 43 (2), 113767 (2024)
   PUBMED   38354085
  REMARK    GeneRIF: Inflammatory dendritic cells restrain CD11b[+]CD4[+] CTLs
            via CD200R in human NSCLC.
REFERENCE   5  (bases 1 to 3765)
  AUTHORS   Tang,Y., Liu,W., Kadu,S., Johnson,O., Hasanali,Z.S., Kelly,A.,
            Shestov,A., Pajarillo,R., Greenblatt,E., Holmes,M., Wang,L.P.,
            Shih,N., O'Connor,R.S., Ruella,M., Garfall,A.L., Allman,D.,
            Vogl,D.T., Cohen,A., June,C.H. and Sheppard,N.C.
  TITLE     Exploiting the CD200-CD200R immune checkpoint axis in multiple
            myeloma to enhance CAR T-cell therapy
  JOURNAL   Blood 143 (2), 139-151 (2024)
   PUBMED   37616575
  REMARK    GeneRIF: Exploiting the CD200-CD200R immune checkpoint axis in
            multiple myeloma to enhance CAR T-cell therapy.
REFERENCE   6  (bases 1 to 3765)
  AUTHORS   Vieites,J.M., de la Torre,R., Ortega,M.A., Montero,T., Peco,J.M.,
            Sanchez-Pozo,A., Gil,A. and Suarez,A.
  TITLE     Characterization of human cd200 glycoprotein receptor gene located
            on chromosome 3q12-13
  JOURNAL   Gene 311, 99-104 (2003)
   PUBMED   12853143
REFERENCE   7  (bases 1 to 3765)
  AUTHORS   Barclay,A.N., Wright,G.J., Brooke,G. and Brown,M.H.
  TITLE     CD200 and membrane protein interactions in the control of myeloid
            cells
  JOURNAL   Trends Immunol 23 (6), 285-290 (2002)
   PUBMED   12072366
  REMARK    Review article
REFERENCE   8  (bases 1 to 3765)
  AUTHORS   Wright,G.J., Jones,M., Puklavec,M.J., Brown,M.H. and Barclay,A.N.
  TITLE     The unusual distribution of the neuronal/lymphoid cell surface
            CD200 (OX2) glycoprotein is conserved in humans
  JOURNAL   Immunology 102 (2), 173-179 (2001)
   PUBMED   11260322
REFERENCE   9  (bases 1 to 3765)
  AUTHORS   Dick,A.D., Broderick,C., Forrester,J.V. and Wright,G.J.
  TITLE     Distribution of OX2 antigen and OX2 receptor within retina
  JOURNAL   Invest Ophthalmol Vis Sci 42 (1), 170-176 (2001)
   PUBMED   11133863
REFERENCE   10 (bases 1 to 3765)
  AUTHORS   Wright,G.J., Puklavec,M.J., Willis,A.C., Hoek,R.M., Sedgwick,J.D.,
            Brown,M.H. and Barclay,A.N.
  TITLE     Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel
            receptor on macrophages implicated in the control of their function
  JOURNAL   Immunity 13 (2), 233-242 (2000)
   PUBMED   10981966
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC074044.8, AY358910.1,
            AF495380.1 and AK126349.1.
            
            On Nov 22, 2018 this sequence version replaced NM_138806.3.
            
            Summary: This gene encodes a receptor for the OX-2 membrane
            glycoprotein. Both the receptor and substrate are cell surface
            glycoproteins containing two immunoglobulin-like domains. This
            receptor is restricted to the surfaces of myeloid lineage cells and
            the receptor-substrate interaction may function as a myeloid
            downregulatory signal. Mouse studies of a related gene suggest that
            this interaction may control myeloid function in a tissue-specific
            manner. Alternative splicing of this gene results in multiple
            transcript variants. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript variant and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358910.1, SRR1163658.245221.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308611.8/ ENSP00000311035.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC074044.8         148095-148107       c
            14-191              AY358910.1         26-203
            192-1540            AF495380.1         1-1349
            1541-2285           AK126349.1         1459-2203
            2286-3765           AC074044.8         94209-95688         c
FEATURES             Location/Qualifiers
     source          1..3765
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.2"
     gene            1..3765
                     /gene="CD200R1"
                     /gene_synonym="CD200R; HCRTR2; MOX2R; OX2R"
                     /note="CD200 receptor 1"
                     /db_xref="GeneID:131450"
                     /db_xref="HGNC:HGNC:24235"
                     /db_xref="MIM:607546"
     exon            1..313
                     /gene="CD200R1"
                     /gene_synonym="CD200R; HCRTR2; MOX2R; OX2R"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..1293
                     /gene="CD200R1"
                     /gene_synonym="CD200R; HCRTR2; MOX2R; OX2R"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; MOX2 receptor; cell surface glycoprotein
                     receptor CD200; cell surface glycoprotein CD200 receptor
                     1; CD200 cell surface glycoprotein receptor; cell surface
                     glycoprotein OX2 receptor 1"
                     /codon_start=1
                     /product="cell surface glycoprotein CD200 receptor 1
                     isoform a precursor"
                     /protein_id="NP_620161.1"
                     /db_xref="CCDS:CCDS2969.1"
                     /db_xref="GeneID:131450"
                     /db_xref="HGNC:HGNC:24235"
                     /db_xref="MIM:607546"
                     /translation="MLCPWRTANLGLLLILTIFLVAEAEGAAQPNNSLMLQTSKENHA
                     LASSSLCMDEKQITQNYSKVLAEVNTSWPVKMATNAVLCCPPIALRNLIIITWEIILR
                     GQPSCTKAYKKETNETKETNCTDERITWVSRPDQNSDLQIRTVAITHDGYYRCIMVTP
                     DGNFHRGYHLQVLVTPEVTLFQNRNRTAVCKAVAGKPAAHISWIPEGDCATKQEYWSN
                     GTVTVKSTCHWEVHNVSTVTCHVSHLTGNKSLYIELLPVPGAKKSAKLYIPYIILTII
                     ILTIVGFIWLLKVNGCRKYKLNKTESTPVVEEDEMQPYASYTEKNNPLYDTTNKVKAS
                     EALQSEVDTDLHTL"
     exon            314..382
                     /gene="CD200R1"
                     /gene_synonym="CD200R; HCRTR2; MOX2R; OX2R"
                     /inference="alignment:Splign:2.1.0"
     exon            383..448
                     /gene="CD200R1"
                     /gene_synonym="CD200R; HCRTR2; MOX2R; OX2R"
                     /inference="alignment:Splign:2.1.0"
     exon            449..766
                     /gene="CD200R1"
                     /gene_synonym="CD200R; HCRTR2; MOX2R; OX2R"
                     /inference="alignment:Splign:2.1.0"
     exon            767..1015
                     /gene="CD200R1"
                     /gene_synonym="CD200R; HCRTR2; MOX2R; OX2R"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1124
                     /gene="CD200R1"
                     /gene_synonym="CD200R; HCRTR2; MOX2R; OX2R"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1170
                     /gene="CD200R1"
                     /gene_synonym="CD200R; HCRTR2; MOX2R; OX2R"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..3765
                     /gene="CD200R1"
                     /gene_synonym="CD200R; HCRTR2; MOX2R; OX2R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3739..3744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD200R1"
                     /gene_synonym="CD200R; HCRTR2; MOX2R; OX2R"
                     /note="hexamer: AATAAA"
     polyA_site      3765
                     /gene="CD200R1"
                     /gene_synonym="CD200R; HCRTR2; MOX2R; OX2R"
                     /note="major polyA site"
ORIGIN      
        1 atacaggaaa tctattgctg tgtcaagttc cagagaaaag cttctgttcg tccaagttac
       61 taaccaggct aaaccacata gacgtgaagg aaggggctag aaggaaggga gtgccccact
      121 gttgatgggg taagaggatc ctgtactgag aagttgacca gagagggtct caccatgcgc
      181 acagttcctt ctgtacctgt gtggaggaaa agtactgagt gaagggcaga aaaagagaaa
      241 acagaaatgc tctgcccttg gagaactgct aacctagggc tactgttgat tttgactatc
      301 ttcttagtgg ccgaagcgga gggtgctgct caaccaaaca actcattaat gctgcaaact
      361 agcaaggaga atcatgcttt agcttcaagc agtttatgta tggatgaaaa acagattaca
      421 cagaactact cgaaagtact cgcagaagtt aacacttcat ggcctgtaaa gatggctaca
      481 aatgctgtgc tttgttgccc tcctatcgca ttaagaaatt tgatcataat aacatgggaa
      541 ataatcctga gaggccagcc ttcctgcaca aaagcctaca agaaagaaac aaatgagacc
      601 aaggaaacca actgtactga tgagagaata acctgggtct ccagacctga tcagaattcg
      661 gaccttcaga ttcgtaccgt ggccatcact catgacgggt attacagatg cataatggta
      721 acacctgatg ggaatttcca tcgtggatat cacctccaag tgttagttac acctgaagtg
      781 accctgtttc aaaacaggaa tagaactgca gtatgcaagg cagttgcagg gaagccagct
      841 gcgcatatct cctggatccc agagggcgat tgtgccacta agcaagaata ctggagcaat
      901 ggcacagtga ctgttaagag tacatgccac tgggaggtcc acaatgtgtc taccgtgacc
      961 tgccacgtct cccatttgac tggcaacaag agtctgtaca tagagctact tcctgttcca
     1021 ggtgccaaaa aatcagcaaa attatatatt ccatatatca tccttactat tattattttg
     1081 accatcgtgg gattcatttg gttgttgaaa gtcaatggct gcagaaaata taaattgaat
     1141 aaaacagaat ctactccagt tgttgaggag gatgaaatgc agccctatgc cagctacaca
     1201 gagaagaaca atcctctcta tgatactaca aacaaggtga aggcatctga ggcattacaa
     1261 agtgaagttg acacagacct ccatacttta taagttgttg gactctagta ccaagaaaca
     1321 acaacaaacg agatacatta taattactgt ctgattttct tacagttcta gaatgaagac
     1381 ttatattgaa attaggtttt ccaaggttct tagaagacat tttaatggat tctcattcat
     1441 acccttgtat aattggaatt tttgattctt agctgctacc agctagttct ctgaagaact
     1501 gatgttatta caaagaaaat acatgcccat gaccaaatat tcaaattgtg caggacagta
     1561 aataatgaaa accaaatttc ctcaagaaat aactgaagaa ggagcaagtg tgaacagttt
     1621 cttgtgtatc ctttcagaat attttaatgt acatatgaca tgtgtatatg cctatggtat
     1681 atgtgtcaat ttatgtgtcc ccttacatat acatgcacat atctttgtca aggcaccagt
     1741 gggaacaata cactgcatta ctgttctata catatgaaaa cctaataata taagtcttag
     1801 agatcatttt atatcatgac aagtagagct acctcattct ttttaatggt tatataaaat
     1861 tccattgtat agttatatca ttatttaatt aaaaacaacc ctaatgatgg atatttagat
     1921 tcttttaagt tttgtttatt tcttttaagt tttgtttgtg gtataaacaa taccacatag
     1981 aatgtttctt gtgcatatat ctctttgttt ttgagtatat ctgtaggata actttcttga
     2041 gtggaattgt caggtcaaag ggtttgtgca ttttactatt gatatatatg ttaaattgtg
     2101 tcaaatatat atgtcaaatt ccctccaaca ttgtttaaat gtgcctttcc ctaaatttct
     2161 attttaataa ctgtactatt cctgcttcta cagttgccac tttctctttt taatcaacca
     2221 gattaaatat gatgtgagat tataataaga attatactat ttaataaaaa tggatttata
     2281 tttttggtca tgtttgtaag agagtgaatg cacgtgtgag aacattagct tcttctgaac
     2341 tcattatatc tccacagagg tgttgatact tgatgcctaa cagttttgca gatgtgctac
     2401 attggaattg tgtattttta tggtgtacat tctattgtga tatatttatt gaataattaa
     2461 tgtctattga ccatataagt ggcgaaaaat gcaccataga ggacatgggg tatttattta
     2521 caaactatga gctacataat aagcaagtgg ccatgggatg gcatgaccct cccctccata
     2581 tttttgtgga gcaaaatatt ggcaatgttt atgtaaatca ttgttaatat catgaaatta
     2641 tttttaatta aaaacataag tctatttgct ccatagcaga aaaaacatga gaagtttttt
     2701 catcatgata gaaattgaaa caaaatatat tcattcttca atcataccat ctgagatttt
     2761 taagacagct attttgtctt ataagtatat ttttctccct ctagacattt cagttactat
     2821 ggattttgtc ctcaaaggga cttttagtct attttggatg taaagctaat ctaatgacac
     2881 ttggcacatg atattttgat caagccattt tgacttgacc aaaaagcagt gtccattagg
     2941 tttctgcata taaatattac caagcaatgt tcacaataga catcattaca ctgtccttga
     3001 aatttattaa ttcttcatcc aaccctggtt gagctgaggc tcatagttag gttcaagact
     3061 atctgtttaa atattactga aaaacaaagt aagacagtac tatgcttacc tcttaacttg
     3121 ataatgtcaa aacaggcatg ttaaatgaca tcatagaaaa gacttcaaga taatttatag
     3181 aagttaaatt atattgtaca gaaaataatt gtatgaaaat ctctactatg gggctggaac
     3241 atggttgaac attagaatga tataaaaaat tatatatatt ctccaaatcc acgctagacc
     3301 tgtcaaatta gagaatctag agattagacc tggcgtgtca gcaaggtcat ccaggaagca
     3361 gaggctgaga cggagttagg tgtgattact tacatagtcg attacatttt acaaataaca
     3421 ttttatatgt ctcatttact gtgctttctc cccatcccat tttgtatctt ttcctttgct
     3481 ttgctagatt tgtcaatttt ctctctcttt ctctgtctct ctctctttca atatctctaa
     3541 taatttgaaa gtaattcatc ataactaaat atctattggg gttatgcttc acttacaaac
     3601 ttctgaaaac ggctttactg agatataatt gatatattta agtgtacagt ttgttaaatt
     3661 ttgcacatat ttaaaatgtg gactttggta aatgttgaca tagttttaca tctgtgaaac
     3721 catcagcata atcaagataa taaacttgtc catcaccccc caaaa
//
