LOCUS       NM_005944               2129 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens CD200 molecule (CD200), transcript variant 1, mRNA.
ACCESSION   NM_005944
VERSION     NM_005944.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2129)
  AUTHORS   Wedig,J., Jasani,S., Mukherjee,D., Lathrop,H., Matreja,P., Pfau,T.,
            D'Alesio,L., Guenther,A., Fenn,L., Kaiser,M., Torok,M.A., McGue,J.,
            Sizemore,G.M., Noonan,A.M., Dillhoff,M.E., Blaser,B.W.,
            Frankel,T.L., Culp,S., Hart,P.A., Cruz-Monserrate,Z. and Mace,T.A.
  TITLE     CD200 is overexpressed in the pancreatic tumor microenvironment and
            predictive of overall survival
  JOURNAL   Cancer Immunol Immunother 73 (6), 96 (2024)
   PUBMED   38619621
  REMARK    GeneRIF: CD200 is overexpressed in the pancreatic tumor
            microenvironment and predictive of overall survival.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2129)
  AUTHORS   Gonzalez-Montes,Y., Osca-Gelis,G., Rodriguez-Romanos,R.,
            Villavicencio,A., Gonzalez-Bartulos,M., Llopis,F., Clapes,V.,
            Oriol,A., Sureda,A., Escoda,L., Sarra,J., Garzo,A., Lloveras,N.,
            Gomez,B., Granada,I. and Gallardo,D.
  TITLE     CD200 genotype is associated with clinical outcome of patients with
            multiple myeloma
  JOURNAL   Front Immunol 15, 1252445 (2024)
   PUBMED   38455039
  REMARK    GeneRIF: CD200 genotype is associated with clinical outcome of
            patients with multiple myeloma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2129)
  AUTHORS   Tang,Y., Liu,W., Kadu,S., Johnson,O., Hasanali,Z.S., Kelly,A.,
            Shestov,A., Pajarillo,R., Greenblatt,E., Holmes,M., Wang,L.P.,
            Shih,N., O'Connor,R.S., Ruella,M., Garfall,A.L., Allman,D.,
            Vogl,D.T., Cohen,A., June,C.H. and Sheppard,N.C.
  TITLE     Exploiting the CD200-CD200R immune checkpoint axis in multiple
            myeloma to enhance CAR T-cell therapy
  JOURNAL   Blood 143 (2), 139-151 (2024)
   PUBMED   37616575
  REMARK    GeneRIF: Exploiting the CD200-CD200R immune checkpoint axis in
            multiple myeloma to enhance CAR T-cell therapy.
REFERENCE   4  (bases 1 to 2129)
  AUTHORS   Zhang,M., Qian,X.H., Hu,J., Zhang,Y., Lin,X., Hai,W., Shi,K.,
            Jiang,X., Li,Y., Tang,H.D. and Li,B.
  TITLE     Integrating TSPO PET imaging and transcriptomics to unveil the role
            of neuroinflammation and amyloid-beta deposition in Alzheimer's
            disease
  JOURNAL   Eur J Nucl Med Mol Imaging 51 (2), 455-467 (2024)
   PUBMED   37801139
  REMARK    GeneRIF: Integrating TSPO PET imaging and transcriptomics to unveil
            the role of neuroinflammation and amyloid-beta deposition in
            Alzheimer's disease.
REFERENCE   5  (bases 1 to 2129)
  AUTHORS   Moon,S.Y., Han,M., Ryu,G., Shin,S.A., Lee,J.H. and Lee,C.S.
  TITLE     Emerging Immune Checkpoint Molecules on Cancer Cells: CD24 and
            CD200
  JOURNAL   Int J Mol Sci 24 (20), 15072 (2023)
   PUBMED   37894750
  REMARK    GeneRIF: Emerging Immune Checkpoint Molecules on Cancer Cells: CD24
            and CD200.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2129)
  AUTHORS   Chen,Z., Marsden,P.A. and Gorczynski,R.M.
  TITLE     Cloning and characterization of the human CD200 promoter region
  JOURNAL   Mol Immunol 43 (6), 579-587 (2006)
   PUBMED   15955564
  REMARK    GeneRIF: revealed a 169 bp region responsible for constitutive
            expression of CD200; positive regulatory domains were identified in
            the core promoter; and documented evidence for C/EBPbeta as being
            important in transcriptional regulation of CD200
REFERENCE   7  (bases 1 to 2129)
  AUTHORS   Preston,S., Wright,G.J., Starr,K., Barclay,A.N. and Brown,M.H.
  TITLE     The leukocyte/neuron cell surface antigen OX2 binds to a ligand on
            macrophages
  JOURNAL   Eur J Immunol 27 (8), 1911-1918 (1997)
   PUBMED   9295026
REFERENCE   8  (bases 1 to 2129)
  AUTHORS   Douglas,J., Albertson,D.G., Barclay,A.N., Davis,M. and
            Rabbitts,P.H.
  TITLE     RFLP and mapping of human MOX-1 gene on chromosome 3
  JOURNAL   Nucleic Acids Res 16 (18), 9067 (1988)
   PUBMED   2902568
REFERENCE   9  (bases 1 to 2129)
  AUTHORS   McCaughan,G.W., Clark,M.J., Hurst,J., Grosveld,F. and Barclay,A.N.
  TITLE     The gene for MRC OX-2 membrane glycoprotein is localized on human
            chromosome 3
  JOURNAL   Immunogenetics 25 (2), 133-135 (1987)
   PUBMED   3817906
REFERENCE   10 (bases 1 to 2129)
  AUTHORS   McCaughan,G.W., Clark,M.J. and Barclay,A.N.
  TITLE     Characterization of the human homolog of the rat MRC OX-2 membrane
            glycoprotein
  JOURNAL   Immunogenetics 25 (5), 329-335 (1987)
   PUBMED   3032785
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA544134.1, BC022522.1 and
            AL832529.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005944.6.
            
            Summary: This gene encodes a type I membrane glycoprotein
            containing two extracellular immunoglobulin domains, a
            transmembrane and a cytoplasmic domain. This gene is expressed by
            various cell types, including B cells, a subset of T cells,
            thymocytes, endothelial cells, and neurons. The encoded protein
            plays an important role in immunosuppression and regulation of
            anti-tumor activity. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.139571.1,
                                           SRR3476690.781140.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000315711.12/ ENSP00000312766.8
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-187               DA544134.1         88-274
            188-2044            BC022522.1         190-2046
            2045-2129           AL832529.1         2041-2125
FEATURES             Location/Qualifiers
     source          1..2129
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.2"
     gene            1..2129
                     /gene="CD200"
                     /gene_synonym="MOX1; MOX2; MRC; OX-2"
                     /note="CD200 molecule"
                     /db_xref="GeneID:4345"
                     /db_xref="HGNC:HGNC:7203"
                     /db_xref="MIM:155970"
     exon            1..69
                     /gene="CD200"
                     /gene_synonym="MOX1; MOX2; MRC; OX-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..867
                     /gene="CD200"
                     /gene_synonym="MOX1; MOX2; MRC; OX-2"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; CD200 antigen; antigen identified by monoclonal
                     antibody MRC OX-2; OX-2 membrane glycoprotein"
                     /codon_start=1
                     /product="OX-2 membrane glycoprotein isoform a precursor"
                     /protein_id="NP_005935.4"
                     /db_xref="CCDS:CCDS2965.1"
                     /db_xref="GeneID:4345"
                     /db_xref="HGNC:HGNC:7203"
                     /db_xref="MIM:155970"
                     /translation="MERLVIRMPFSHLSTYSLVWVMAAVVLCTAQVQVVTQDEREQLY
                     TPASLKCSLQNAQEALIVTWQKKKAVSPENMVTFSENHGVVIQPAYKDKINITQLGLQ
                     NSTITFWNITLEDEGCYMCLFNTFGFGKISGTACLTVYVQPIVSLHYKFSEDHLNITC
                     SATARPAPMVFWKVPRSGIENSTVTLSHPNGTTSVTSILHIKDPKNQVGKEVICQVLH
                     LGTVTDFKQTVNKGYWFSVPLLLSIVSLVILLVLISILLYWKRHRNQDREP"
     exon            70..151
                     /gene="CD200"
                     /gene_synonym="MOX1; MOX2; MRC; OX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            152..478
                     /gene="CD200"
                     /gene_synonym="MOX1; MOX2; MRC; OX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            479..751
                     /gene="CD200"
                     /gene_synonym="MOX1; MOX2; MRC; OX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            752..859
                     /gene="CD200"
                     /gene_synonym="MOX1; MOX2; MRC; OX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            860..2129
                     /gene="CD200"
                     /gene_synonym="MOX1; MOX2; MRC; OX-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2109..2114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD200"
                     /gene_synonym="MOX1; MOX2; MRC; OX-2"
                     /note="hexamer: ATTAAA"
     polyA_site      2129
                     /gene="CD200"
                     /gene_synonym="MOX1; MOX2; MRC; OX-2"
                     /note="major polyA site"
ORIGIN      
        1 agagctccag gcgcacatcc gcagtcagcc acctcgcgcg cgcctccagg agcaaggatg
       61 gagaggctgg tgatcaggat gcccttctct catctgtcta cctacagcct ggtttgggtc
      121 atggcagcag tggtgctgtg cacagcacaa gtgcaagtgg tgacccagga tgaaagagag
      181 cagctgtaca cacctgcttc cttaaaatgc tctctgcaaa atgcccagga agccctcatt
      241 gtgacatggc agaaaaagaa agctgtaagc ccagaaaaca tggtcacctt cagcgagaac
      301 catggggtgg tgatccagcc tgcctataag gacaagataa acattaccca gctgggactc
      361 caaaactcaa ccatcacctt ctggaatatc accctggagg atgaagggtg ttacatgtgt
      421 ctcttcaata cctttggttt tgggaagatc tcaggaacgg cctgcctcac cgtctatgta
      481 cagcccatag tatcccttca ctacaaattc tctgaagacc acctaaatat cacttgctct
      541 gccactgccc gcccagcccc catggtcttc tggaaggtcc ctcggtcagg gattgaaaat
      601 agtacagtga ctctgtctca cccaaatggg accacgtctg ttaccagcat cctccatatc
      661 aaagacccta agaatcaggt ggggaaggag gtgatctgcc aggtgctgca cctggggact
      721 gtgaccgact ttaagcaaac cgtcaacaaa ggctattggt tttcagttcc gctattgcta
      781 agcattgttt ccctggtaat tcttctcgtc ctaatctcaa tcttactgta ctggaaacgt
      841 caccggaatc aggaccgaga gccctaaata agtcacacag caccctgaaa gtgattccct
      901 ggtctacttg aatttgacac aagagaaaag caggaggaaa aggggccatt ctccaaagga
      961 cctgaaagag caaaagaggt gggagcgaaa gccttaagga tcccacgact ttttactgcc
     1021 atctgagcta ctcagtgttt gaatcccaag aggaagtcag tttacctctc aggtctgttg
     1081 taggacttga ttttgtaaag caatgccatg ttatgtggtt gaaagggcac tggacttagt
     1141 tagtatcagg agcactgagc tcacagactg acttgggctc ctactggtgg ggacctctgt
     1201 tagtcacttt acctcatcca aagtataaag gaattggacc aaataattta ccacatagct
     1261 ctaaaactta atttaaaatg taattccaga aaaaaaaagg gaataagcaa agggggaaga
     1321 attgaaagag agagagaaga aagaatacag agagcttacc ttttgccttt ctgttgatgt
     1381 tacatctctt cttcctatgt tcttaggtct atgagtctgt ttccccatca tttggtatct
     1441 agtccagttc ctgcttactg ctttgctaat agctggcctt gctagaatcc ttggtttcac
     1501 tgctgttctt catgtgcttc tatgagattt actccaacac aaataggact gaatttattg
     1561 tgaagtaaca ttggcaatct taacttattc atttaactta tttttatagc tagataaata
     1621 ttgttagtct tagacaatag ctcacatttt ttgagaagca tgccctccct gtccatttgt
     1681 cttataacat gacccagccc tattttacgt cattctaaat tcagcctcat ataatgaaaa
     1741 tacattatga aaacagatgt ttaggagatt tcctgtatag cagtcagcca attcatatgc
     1801 tttgtctctg ctggcttctt tttccatgcg ttaacttttc ccaatagcag aggaggcaaa
     1861 tatgagcata caatcccttt gttctaaaga tattgttcca gctagtggaa tgatgttgaa
     1921 tctttaataa ccataattag ttgctttttc agtatcttct gctttgtctg tgtctatcca
     1981 gtggcctagg aattaaagtg taagttgttt tcgctgttaa attggatatt tatatatata
     2041 tatagcaaga ttttcatgtg ttatttaatt ctgtattgtt tcttatattt gtagtaaaat
     2101 attgaacaat taaaagtgtt gactccaaa
//
