LOCUS       NM_001767               1565 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens CD2 molecule (CD2), transcript variant 2, mRNA.
ACCESSION   NM_001767 XM_001720795 XM_001723014 XM_001723737
VERSION     NM_001767.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1565)
  AUTHORS   Wu,M., Chen,Y., Hua,G. and Chunhui,L.
  TITLE     The CD2-CD58 axis: A novel marker predicting poor prognosis in
            patients with low-grade gliomas and potential therapeutic
            approaches
  JOURNAL   Immun Inflamm Dis 11 (10), e1022 (2023)
   PUBMED   37904707
  REMARK    GeneRIF: The CD2-CD58 axis: A novel marker predicting poor
            prognosis in patients with low-grade gliomas and potential
            therapeutic approaches.
REFERENCE   2  (bases 1 to 1565)
  AUTHORS   Romain,G., Strati,P., Rezvan,A., Fathi,M., Bandey,I.N.,
            Adolacion,J.R.T., Heeke,D., Liadi,I., Marques-Piubelli,M.L.,
            Solis,L.M., Mahendra,A., Vega,F., Cooper,L.J., Singh,H., Mattie,M.,
            Bot,A., Neelapu,S.S. and Varadarajan,N.
  TITLE     Multidimensional single-cell analysis identifies a role for
            CD2-CD58 interactions in clinical antitumor T cell responses
  JOURNAL   J Clin Invest 132 (17) (2022)
   PUBMED   35881486
  REMARK    GeneRIF: Multidimensional single-cell analysis identifies a role
            for CD2-CD58 interactions in clinical antitumor T cell responses.
REFERENCE   3  (bases 1 to 1565)
  AUTHORS   Fernandez Lahore,G., Forster,M., Johannesson,M., Sabatier,P.,
            Lonnblom,E., Aoun,M., He,Y., Nandakumar,K.S., Zubarev,R.A. and
            Holmdahl,R.
  TITLE     Polymorphic estrogen receptor binding site causes Cd2-dependent sex
            bias in the susceptibility to autoimmune diseases
  JOURNAL   Nat Commun 12 (1), 5565 (2021)
   PUBMED   34552089
  REMARK    GeneRIF: Polymorphic estrogen receptor binding site causes
            Cd2-dependent sex bias in the susceptibility to autoimmune
            diseases.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1565)
  AUTHORS   Rozenova,K.A., Jevremovic,D., Reichard,K.K., Nguyen,P.,
            Otteson,G.E., Timm,M.M., Horna,P., Olteanu,H. and Shi,M.
  TITLE     CD2 and CD7 are sensitive flow cytometry screening markers for
            T-lineage acute leukemia(s): a study of 465 acute leukemia cases
  JOURNAL   Hum Pathol 114, 66-73 (2021)
   PUBMED   34019867
  REMARK    GeneRIF: CD2 and CD7 are sensitive flow cytometry screening markers
            for T-lineage acute leukemia(s): a study of 465 acute leukemia
            cases.
REFERENCE   5  (bases 1 to 1565)
  AUTHORS   Zurli,V., Montecchi,T., Heilig,R., Poschke,I., Volkmar,M.,
            Wimmer,G., Boncompagni,G., Turacchio,G., D'Elios,M.M.,
            Campoccia,G., Resta,N., Offringa,R., Fischer,R., Acuto,O.,
            Baldari,C.T. and Kabanova,A.
  TITLE     Phosphoproteomics of CD2 signaling reveals AMPK-dependent
            regulation of lytic granule polarization in cytotoxic T cells
  JOURNAL   Sci Signal 13 (631) (2020)
   PUBMED   32398348
  REMARK    GeneRIF: Phosphoproteomics of CD2 signaling reveals AMPK-dependent
            regulation of lytic granule polarization in cytotoxic T cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1565)
  AUTHORS   Luzzati,A.L., Giacomini,E., Giordani,L., Pugliese,O., Viora,M. and
            Chersi,A.
  TITLE     The antigen-specific induction of normal human lymphocytes in vitro
            is down-regulated by a conserved HIV p24 epitope
  JOURNAL   Immunol Lett 33 (3), 307-314 (1992)
   PUBMED   1385321
  REMARK    Erratum:[Immunol Lett 1993 Jan;35(1):82]
REFERENCE   7  (bases 1 to 1565)
  AUTHORS   Hahn,W.C., Menu,E., Bothwell,A.L., Sims,P.J. and Bierer,B.E.
  TITLE     Overlapping but nonidentical binding sites on CD2 for CD58 and a
            second ligand CD59
  JOURNAL   Science 256 (5065), 1805-1807 (1992)
   PUBMED   1377404
REFERENCE   8  (bases 1 to 1565)
  AUTHORS   Marie-Cardine,A., Maridonneau-Parini,I., Ferrer,M., Danielian,S.,
            Rothhut,B., Fagard,R., Dautry-Varsat,A. and Fischer,S.
  TITLE     The lymphocyte-specific tyrosine protein kinase p56lck is
            endocytosed in Jurkat cells stimulated via CD2
  JOURNAL   J Immunol 148 (12), 3879-3884 (1992)
   PUBMED   1351089
REFERENCE   9  (bases 1 to 1565)
  AUTHORS   Bell,G.M., Seaman,W.E., Niemi,E.C. and Imboden,J.B.
  TITLE     The OX-44 molecule couples to signaling pathways and is associated
            with CD2 on rat T lymphocytes and a natural killer cell line
  JOURNAL   J Exp Med 175 (2), 527-536 (1992)
   PUBMED   1346273
REFERENCE   10 (bases 1 to 1565)
  AUTHORS   Schraven,B., Samstag,Y., Altevogt,P. and Meuer,S.C.
  TITLE     Association of CD2 and CD45 on human T lymphocytes
  JOURNAL   Nature 345 (6270), 71-74 (1990)
   PUBMED   1970422
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD691699.1, AK313614.1 and
            BC033583.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001767.4.
            
            Summary: The protein encoded by this gene is a surface antigen
            found on all peripheral blood T-cells. The encoded protein
            interacts with LFA3 (CD58) on antigen presenting cells to optimize
            immune recognition. A locus control region (LCR) has been found in
            the 3' flanking sequence of this gene. [provided by RefSeq, Jun
            2016].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction compared to variant 1. The resulting isoform (2)
            has the same N- and C-termini but is shorter compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK223393.1, M16336.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369478.4/ ENSP00000358490.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 CD691699.1         21-25
            6-1119              AK313614.1         1-1114
            1120-1565           BC033583.1         1070-1515
FEATURES             Location/Qualifiers
     source          1..1565
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.1"
     gene            1..1565
                     /gene="CD2"
                     /gene_synonym="LFA-2; SRBC; T11"
                     /note="CD2 molecule"
                     /db_xref="GeneID:914"
                     /db_xref="HGNC:HGNC:1639"
                     /db_xref="MIM:186990"
     exon            1..124
                     /gene="CD2"
                     /gene_synonym="LFA-2; SRBC; T11"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1119
                     /gene="CD2"
                     /gene_synonym="LFA-2; SRBC; T11"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; lymphocyte-function antigen-2; CD2 antigen
                     (p50), sheep red blood cell receptor; T-cell surface
                     antigen CD2; LFA-3 receptor; rosette receptor; erythrocyte
                     receptor; T-cell surface antigen T11/Leu-5"
                     /codon_start=1
                     /product="T-cell surface antigen CD2 isoform 2 precursor"
                     /protein_id="NP_001758.2"
                     /db_xref="CCDS:CCDS889.1"
                     /db_xref="GeneID:914"
                     /db_xref="HGNC:HGNC:1639"
                     /db_xref="MIM:186990"
                     /translation="MSFPCKFVASFLLIFNVSSKGAVSKEITNALETWGALGQDINLD
                     IPSFQMSDDIDDIKWEKTSDKKKIAQFRKEKETFKEKDTYKLFKNGTLKIKHLKTDDQ
                     DIYKVSIYDTKGKNVLEKIFDLKIQERVSKPKISWTCINTTLTCEVMNGTDPELNLYQ
                     DGKHLKLSQRVITHKWTTSLSAKFKCTAGNKVSKESSVEPVSCPEKGLDIYLIIGICG
                     GGSLLMVFVALLVFYITKRKKQRSRRNDEELETRAHRVATEERGRKPHQIPASTPQNP
                     ATSQHPPPPPGHRSQAPSHRPPPPGHRVQHQPQKRPPAPSGTQVHQQKGPPLPRPRVQ
                     PKPPHGAAENSLSPSSN"
     exon            125..445
                     /gene="CD2"
                     /gene_synonym="LFA-2; SRBC; T11"
                     /inference="alignment:Splign:2.1.0"
     exon            446..676
                     /gene="CD2"
                     /gene_synonym="LFA-2; SRBC; T11"
                     /inference="alignment:Splign:2.1.0"
     exon            677..799
                     /gene="CD2"
                     /gene_synonym="LFA-2; SRBC; T11"
                     /inference="alignment:Splign:2.1.0"
     exon            800..1565
                     /gene="CD2"
                     /gene_synonym="LFA-2; SRBC; T11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1547..1552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD2"
                     /gene_synonym="LFA-2; SRBC; T11"
                     /note="hexamer: AATAAA"
     polyA_site      1565
                     /gene="CD2"
                     /gene_synonym="LFA-2; SRBC; T11"
                     /note="major polyA site"
ORIGIN      
        1 agtctcactt cagttccttt tgcatgaaga gctcagaatc aaaagaggaa accaacccct
       61 aagatgagct ttccatgtaa atttgtagcc agcttccttc tgattttcaa tgtttcttcc
      121 aaaggtgcag tctccaaaga gattacgaat gccttggaaa cctggggtgc cttgggtcag
      181 gacatcaact tggacattcc tagttttcaa atgagtgatg atattgacga tataaaatgg
      241 gaaaaaactt cagacaagaa aaagattgca caattcagaa aagagaaaga gactttcaag
      301 gaaaaagata catataagct atttaaaaat ggaactctga aaattaagca tctgaagacc
      361 gatgatcagg atatctacaa ggtatcaata tatgatacaa aaggaaaaaa tgtgttggaa
      421 aaaatatttg atttgaagat tcaagagagg gtctcaaaac caaagatctc ctggacttgt
      481 atcaacacaa ccctgacctg tgaggtaatg aatggaactg accccgaatt aaacctgtat
      541 caagatggga aacatctaaa actttctcag agggtcatca cacacaagtg gaccaccagc
      601 ctgagtgcaa aattcaagtg cacagcaggg aacaaagtca gcaaggaatc cagtgtcgag
      661 cctgtcagct gtccagagaa aggtctggac atctatctca tcattggcat atgtggagga
      721 ggcagcctct tgatggtctt tgtggcactg ctcgttttct atatcaccaa aaggaaaaaa
      781 cagaggagtc ggagaaatga tgaggagctg gagacaagag cccacagagt agctactgaa
      841 gaaaggggcc ggaagcccca ccaaattcca gcttcaaccc ctcagaatcc agcaacttcc
      901 caacatcctc ctccaccacc tggtcatcgt tcccaggcac ctagtcatcg tcccccgcct
      961 cctggacacc gtgttcagca ccagcctcag aagaggcctc ctgctccgtc gggcacacaa
     1021 gttcaccagc agaaaggccc gcccctcccc agacctcgag ttcagccaaa acctccccat
     1081 ggggcagcag aaaactcatt gtccccttcc tctaattaaa aaagatagaa actgtctttt
     1141 tcaataaaaa gcactgtgga tttctgccct cctgatgtgc atatccgtac ttccatgagg
     1201 tgttttctgt gtgcagaaca ttgtcacctc ctgaggctgt gggccacagc cacctctgca
     1261 tcttcgaact cagccatgtg gtcaacatct ggagtttttg gtctcctcag agagctccat
     1321 cacaccagta aggagaagca atataagtgt gattgcaaga atggtagagg accgagcaca
     1381 gaaatcttag agatttcttg tcccctctca ggtcatgtgt agatgcgata aatcaagtga
     1441 ttggtgtgcc tgggtctcac tacaagcagc ctatctgctt aagagactct ggagtttctt
     1501 atgtgccctg gtggacactt gcccaccatc ctgtgagtaa aagtgaaata aaagctttga
     1561 ctaga
//
