LOCUS       NM_001371762            3492 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens CD1d molecule (CD1D), transcript variant 4, mRNA.
ACCESSION   NM_001371762
VERSION     NM_001371762.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3492)
  AUTHORS   Traves,R., Opadchy,T., Slobedman,B. and Abendroth,A.
  TITLE     Varicella Zoster Virus Downregulates Expression of the Nonclassical
            Antigen Presentation Molecule CD1d
  JOURNAL   J Infect Dis 230 (2), e416-e426 (2024)
   PUBMED   37972257
  REMARK    GeneRIF: Varicella Zoster Virus Downregulates Expression of the
            Nonclassical Antigen Presentation Molecule CD1d.
REFERENCE   2  (bases 1 to 3492)
  AUTHORS   Pei,S., Sjolund,J., Pan,Y., Pietras,K. and Karlsson,M.C.I.
  TITLE     Cancer-associated fibroblasts express CD1d and activate invariant
            natural killer T cells under cellular stress
  JOURNAL   Cell Mol Immunol 21 (1), 91-94 (2024)
   PUBMED   37735500
  REMARK    GeneRIF: Cancer-associated fibroblasts express CD1d and activate
            invariant natural killer T cells under cellular stress.
REFERENCE   3  (bases 1 to 3492)
  AUTHORS   Wang,M.M., Koskela,S.A., Mehmood,A., Langguth,M., Maranou,E. and
            Figueiredo,C.R.
  TITLE     Epigenetic control of CD1D expression as a mechanism of resistance
            to immune checkpoint therapy in poorly immunogenic melanomas
  JOURNAL   Front Immunol 14, 1152228 (2023)
   PUBMED   37077920
  REMARK    GeneRIF: Epigenetic control of CD1D expression as a mechanism of
            resistance to immune checkpoint therapy in poorly immunogenic
            melanomas.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3492)
  AUTHORS   Hara,A., Koyama-Nasu,R., Takami,M., Toyoda,T., Aoki,T., Ihara,F.,
            Kobayashi,M., Hirono,S., Matsutani,T., Nakayama,T., Iwadate,Y. and
            Motohashi,S.
  TITLE     CD1d expression in glioblastoma is a promising target for NKT
            cell-based cancer immunotherapy
  JOURNAL   Cancer Immunol Immunother 70 (5), 1239-1254 (2021)
   PUBMED   33128583
  REMARK    GeneRIF: CD1d expression in glioblastoma is a promising target for
            NKT cell-based cancer immunotherapy.
REFERENCE   5  (bases 1 to 3492)
  AUTHORS   Sofer,T., Li,R., Joehanes,R., Lin,H., Gower,A.C., Wang,H.,
            Kurniansyah,N., Cade,B.E., Lee,J., Williams,S., Mehra,R.,
            Patel,S.R., Quan,S.F., Liu,Y., Rotter,J.I., Rich,S.S., Spira,A.,
            Levy,D., Gharib,S.A., Redline,S. and Gottlieb,D.J.
  TITLE     Low oxygen saturation during sleep reduces CD1D and RAB20
            expressions that are reversed by CPAP therapy
  JOURNAL   EBioMedicine 56, 102803 (2020)
   PUBMED   32512511
  REMARK    GeneRIF: Low oxygen saturation during sleep reduces CD1D and RAB20
            expressions that are reversed by CPAP therapy.
REFERENCE   6  (bases 1 to 3492)
  AUTHORS   Blumberg,R.S., Terhorst,C., Bleicher,P., McDermott,F.V.,
            Allan,C.H., Landau,S.B., Trier,J.S. and Balk,S.P.
  TITLE     Expression of a nonpolymorphic MHC class I-like molecule, CD1D, by
            human intestinal epithelial cells
  JOURNAL   J Immunol 147 (8), 2518-2524 (1991)
   PUBMED   1717564
REFERENCE   7  (bases 1 to 3492)
  AUTHORS   Yu,C.Y. and Milstein,C.
  TITLE     A physical map linking the five CD1 human thymocyte differentiation
            antigen genes
  JOURNAL   EMBO J 8 (12), 3727-3732 (1989)
   PUBMED   2583117
REFERENCE   8  (bases 1 to 3492)
  AUTHORS   Calabi,F., Jarvis,J.M., Martin,L. and Milstein,C.
  TITLE     Two classes of CD1 genes
  JOURNAL   Eur J Immunol 19 (2), 285-292 (1989)
   PUBMED   2467814
REFERENCE   9  (bases 1 to 3492)
  AUTHORS   Balk,S.P., Bleicher,P.A. and Terhorst,C.
  TITLE     Isolation and characterization of a cDNA and gene coding for a
            fourth CD1 molecule
  JOURNAL   Proc Natl Acad Sci U S A 86 (1), 252-256 (1989)
   PUBMED   2463622
REFERENCE   10 (bases 1 to 3492)
  AUTHORS   Martin,L.H., Calabi,F. and Milstein,C.
  TITLE     Isolation of CD1 genes: a family of major histocompatibility
            complex-related differentiation antigens
  JOURNAL   Proc Natl Acad Sci U S A 83 (23), 9154-9158 (1986)
   PUBMED   3097645
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL138899.23.
            
            On Aug 1, 2019 this sequence version replaced NM_001371762.1.
            
            Summary: This gene encodes a divergent member of the CD1 family of
            transmembrane glycoproteins, which are structurally related to the
            major histocompatibility complex (MHC) proteins and form
            heterodimers with beta-2-microglobulin. The CD1 proteins mediate
            the presentation of primarily lipid and glycolipid antigens of self
            or microbial origin to T cells. The human genome contains five CD1
            family genes organized in a cluster on chromosome 1. The CD1 family
            members are thought to differ in their cellular localization and
            specificity for particular lipid ligands. The protein encoded by
            this gene localizes to late endosomes and lysosomes via a
            tyrosine-based motif in the cytoplasmic tail. Two transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jan 2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J04142.1, SRR1803612.123497.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000674085.2/ ENSP00000501100.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-268               AL138899.23        59447-59714
            269-535             AL138899.23        60007-60273
            536-814             AL138899.23        60584-60862
            815-1093            AL138899.23        61430-61708
            1094-1193           AL138899.23        62488-62587
            1194-3492           AL138899.23        62681-64979
FEATURES             Location/Qualifiers
     source          1..3492
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.1"
     gene            1..3492
                     /gene="CD1D"
                     /gene_synonym="CD1A; R3; R3G1"
                     /note="CD1d molecule"
                     /db_xref="GeneID:912"
                     /db_xref="HGNC:HGNC:1637"
                     /db_xref="IMGT/GENE-DB:CD1D"
                     /db_xref="MIM:188410"
     exon            1..268
                     /gene="CD1D"
                     /gene_synonym="CD1A; R3; R3G1"
                     /inference="alignment:Splign:2.1.0"
     exon            269..535
                     /gene="CD1D"
                     /gene_synonym="CD1A; R3; R3G1"
                     /inference="alignment:Splign:2.1.0"
     exon            536..814
                     /gene="CD1D"
                     /gene_synonym="CD1A; R3; R3G1"
                     /inference="alignment:Splign:2.1.0"
     exon            815..1093
                     /gene="CD1D"
                     /gene_synonym="CD1A; R3; R3G1"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1193
                     /gene="CD1D"
                     /gene_synonym="CD1A; R3; R3G1"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..3492
                     /gene="CD1D"
                     /gene_synonym="CD1A; R3; R3G1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1941..1946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD1D"
                     /gene_synonym="CD1A; R3; R3G1"
                     /note="hexamer: AATAAA"
     polyA_site      1961
                     /gene="CD1D"
                     /gene_synonym="CD1A; R3; R3G1"
                     /note="major polyA site"
ORIGIN      
        1 gcagctcgca cagctaaggg cgagggcgcc cttcggcaga agcagcaaac cgccggcaag
       61 cccagcgagg agggctgccg gggtctgggc ttgggaattg gctggcaccc agcggaaagg
      121 gacgtgagct gagcggcggg ggagaagagt gcgcaggtca gagggcggcg cgcagcggcg
      181 ctccgcgagg tccccacgcc gggcgatatg gggtgcctgc tgtttctgct gctctgggcg
      241 ctcctccagg cttggggaag cgctgaagtc ccgcaaaggc ttttccccct ccgctgcctc
      301 cagatctcgt ccttcgccaa tagcagctgg acgcgcaccg acggcttggc gtggctgggg
      361 gagctgcaga cgcacagctg gagcaacgac tcggacaccg tccgctctct gaagccttgg
      421 tcccagggca cgttcagcga ccagcagtgg gagacgctgc agcatatatt tcgggtttat
      481 cgaagcagct tcaccaggga cgtgaaggaa ttcgccaaaa tgctacgctt atcctatccc
      541 ttggagctcc aggtgtccgc tggctgtgag gtgcaccctg ggaacgcctc aaataacttc
      601 ttccatgtag catttcaagg aaaagatatc ctgagtttcc aaggaacttc ttgggagcca
      661 acccaagagg ccccactttg ggtaaacttg gccattcaag tgctcaacca ggacaagtgg
      721 acgagggaaa cagtgcagtg gctccttaat ggcacctgcc cccaatttgt cagtggcctc
      781 cttgagtcag ggaagtcgga actgaagaag caagtgaagc ccaaggcctg gctgtcccgt
      841 ggccccagtc ctggccctgg ccgtctgctg ctggtgtgcc atgtctcagg attctaccca
      901 aagcctgtat gggtgaagtg gatgcggggt gagcaggagc agcagggcac tcagccaggg
      961 gacatcctgc ccaatgctga cgagacatgg tatctccgag caaccctgga tgtggtggct
     1021 ggggaggcag ctggcctgtc ctgtcgggtg aagcacagca gtctagaggg ccaggacatc
     1081 gtcctctact ggggtgggag ctacacctcc atgggcttga ttgccttggc agtcctggcg
     1141 tgcttgctgt tcctcctcat tgtgggcttt acctcccggt ttaagaggca aacttcctat
     1201 cagggcgtcc tgtgactcgc cttgccacat ctgtgtctct ggaacccagg acctctggac
     1261 ctcaggttcc taagacttca gtcctggtct gctcaggaat tgaagatgta aggaattgaa
     1321 gataggagag ataccttgaa aaagtagaga acagtcatga ggcagctttc atcacaccct
     1381 tttaacattt atctaaaaga atttaaattc tttttcaaaa attacactac aagtttataa
     1441 gcccaaatgg ctctgtgaaa tcagaagtgc aaaggtgtgc aaacttgtat ctgaagacct
     1501 accagggaca agcaggtaag agctgatgtg agtgtgtgtg atgggatctg taaggaactg
     1561 gaacacacat gtcctatcca aaggaatcag ctgcagctgc ttgttgtcaa gtataaagtc
     1621 aggacctggc ttggctttaa ccgtttttca agaaaactgg aaatctggat tttcagcgaa
     1681 catgcctgat tttaaaaggt tgactcaagt ttttacaaaa tactatgtgg gacacctcaa
     1741 atacatacct actgactgat gacaaaccca ggagtttgtg tgtcttttat aaaaagtttg
     1801 ccctggatgt catattggca gttggaggac acagtttcta ttgtaaattt ggatttacga
     1861 ctgaagaagg acattttctc tttaaaagaa agttaggtta taagaaacag aggcgtctca
     1921 catttttact tggtgtaatt aataaacgaa gataaatcat agtgtatgtg tattatgttg
     1981 aaaaaaacta ctctgagtaa ggatatttct ctcaaatggt catcactttt tttccttgga
     2041 ggaagattgt catgaaggca tcccttcctt cccaaaacga caacggcaac aacaacagtc
     2101 tcctttactt acagctatta aaagagacaa tgtagggaaa gggccaacac cacttgggca
     2161 agcatgagct gcagcgatga tggtgatggt agcccagcca tgctgtgttc ttatcttaga
     2221 gaggacagag caggaaactt acaggggtag cagacctttc tgatgccaaa gaaataagga
     2281 ggccaaaatc atgtttgcct agctgggagg taaatctctt ggcagtcagg gtccctgaac
     2341 acccagaaaa aataagtgag acttaacggt tggagagtgt ttgcttgaga aaagtaacat
     2401 ttcacactct ctatactaga cttgcacata tgaatttagg atgtgcgtga agattctgct
     2461 agcttcaaca tatcccaaag cacttggata tgcctataat ccaagtgctt tgggaggctg
     2521 agataggagg attgtttaag gccaggcatt tgaaatcagc ctgggcaaca tagtgagacc
     2581 ctgtctctac aaaaaattaa aaaactagcc acccatggtg gtgagcgcct gtagtcctag
     2641 ctactctgga ggctgaggtg ggaggatccc ttgagcccat gaattccagg ttagtgtgag
     2701 ctgtgattgt gtcactacag tgtaaggatg acagagggag accctgtctt aaaaaaaaat
     2761 tatgctagct tttaaatcaa tggttcccaa attgtagtaa cctgaccaac agcctcagca
     2821 ggacctggga acttgttata aatgcaaatt gttttgggcc tcatcctata cccgctgaat
     2881 gagaaactct gagtctggaa gcaggctcaa tagtcaagcc ccctggtgat tctgatgctt
     2941 agctaaagtt agagaaccac tgttcttaga cattgtgcaa tgttatacaa caacttcctc
     3001 aaagtgctaa gtgaaaagga cattggcctg gcgttagtca gggaaggcgt cctggaggga
     3061 ggggaatttg aagcagagct ttgaaaaaca aaggcagtga ggtgaaccag caagtgcact
     3121 ggctgagggg actggagttc tagcctctga accagtttcc tcctgtgcca aaggaggata
     3181 ataattatct attattgatt atctcctaga cttgtggagt tcaagtgtgt aatgccttaa
     3241 aagatgtgga ggctgttgct gtgtttggta ccacattgcc caccctcacg tggcgctctt
     3301 cagcttaggt tcctctagca gtgtcaagtt tgtgaaccaa ccccactggc cttctgcatt
     3361 ctgagggcac gtgtgttaaa gtctctactg atgtcctttt ggaaatgcct ctgcatgaat
     3421 ttatggtagc tctgactcat ctttaaacaa ttttaattta tttagaaaat aaaggcttat
     3481 ctctccagga aa
//
