LOCUS       NM_001765               2442 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens CD1c molecule (CD1C), mRNA.
ACCESSION   NM_001765
VERSION     NM_001765.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2442)
  AUTHORS   Xiang,X., Gao,L.M., Zhang,Y., Zhu,Q., Zhao,S., Liu,W., Ye,Y.,
            Tang,Y. and Zhang,W.
  TITLE     Identifying CD1c as a potential biomarker by the comprehensive
            exploration of tumor mutational burden and immune infiltration in
            diffuse large B cell lymphoma
  JOURNAL   PeerJ 11, e16618 (2023)
   PUBMED   38099311
  REMARK    GeneRIF: Identifying CD1c as a potential biomarker by the
            comprehensive exploration of tumor mutational burden and immune
            infiltration in diffuse large B cell lymphoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2442)
  AUTHORS   Chen,X., Zhang,J., Lei,X., Yang,L., Li,W., Zheng,L., Zhang,S.,
            Ding,Y., Shi,J., Zhang,L., Li,J., Tang,T. and Jia,W.
  TITLE     CD1C is associated with breast cancer prognosis and immune
            infiltrates
  JOURNAL   BMC Cancer 23 (1), 129 (2023)
   PUBMED   36755259
  REMARK    GeneRIF: CD1C is associated with breast cancer prognosis and immune
            infiltrates.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2442)
  AUTHORS   Reijneveld,J.F., Marino,L., Cao,T.P., Cheng,T.Y., Dam,D.,
            Shahine,A., Witte,M.D., Filippov,D.V., Suliman,S., van der
            Marel,G.A., Moody,D.B., Minnaard,A.J., Rossjohn,J., Codee,J.D.C.
            and Van Rhijn,I.
  TITLE     Rational design of a hydrolysis-resistant mycobacterial
            phosphoglycolipid antigen presented by CD1c to T cells
  JOURNAL   J Biol Chem 297 (4), 101197 (2021)
   PUBMED   34536421
  REMARK    GeneRIF: Rational design of a hydrolysis-resistant mycobacterial
            phosphoglycolipid antigen presented by CD1c to T cells.
REFERENCE   4  (bases 1 to 2442)
  AUTHORS   Eckhardt,E. and Bastian,M.
  TITLE     Animal models for human group 1 CD1 protein function
  JOURNAL   Mol Immunol 130, 159-163 (2021)
   PUBMED   33384157
  REMARK    GeneRIF: Animal models for human group 1 CD1 protein function.
            Review article
REFERENCE   5  (bases 1 to 2442)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 2442)
  AUTHORS   Woolfson,A. and Milstein,C.
  TITLE     Alternative splicing generates secretory isoforms of human CD1
  JOURNAL   Proc Natl Acad Sci U S A 91 (14), 6683-6687 (1994)
   PUBMED   7517559
REFERENCE   7  (bases 1 to 2442)
  AUTHORS   Yu,C.Y. and Milstein,C.
  TITLE     A physical map linking the five CD1 human thymocyte differentiation
            antigen genes
  JOURNAL   EMBO J 8 (12), 3727-3732 (1989)
   PUBMED   2583117
REFERENCE   8  (bases 1 to 2442)
  AUTHORS   Aruffo,A. and Seed,B.
  TITLE     Expression of cDNA clones encoding the thymocyte antigens CD1a, b,
            c demonstrates a hierarchy of exclusion in fibroblasts
  JOURNAL   J Immunol 143 (5), 1723-1730 (1989)
   PUBMED   2701945
REFERENCE   9  (bases 1 to 2442)
  AUTHORS   Martin,L.H., Calabi,F., Lefebvre,F.A., Bilsland,C.A. and
            Milstein,C.
  TITLE     Structure and expression of the human thymocyte antigens CD1a,
            CD1b, and CD1c
  JOURNAL   Proc Natl Acad Sci U S A 84 (24), 9189-9193 (1987)
   PUBMED   2447586
REFERENCE   10 (bases 1 to 2442)
  AUTHORS   Martin,L.H., Calabi,F. and Milstein,C.
  TITLE     Isolation of CD1 genes: a family of major histocompatibility
            complex-related differentiation antigens
  JOURNAL   Proc Natl Acad Sci U S A 83 (23), 9154-9158 (1986)
   PUBMED   3097645
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121986.12, M28827.1 and
            AA824381.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001765.2.
            
            Summary: This gene encodes a member of the CD1 family of
            transmembrane glycoproteins, which are structurally related to the
            major histocompatibility complex (MHC) proteins and form
            heterodimers with beta-2-microglobulin. The CD1 proteins mediate
            the presentation of primarily lipid and glycolipid antigens of self
            or microbial origin to T cells. The human genome contains five CD1
            family genes organized in a cluster on chromosome 1. The CD1 family
            members are thought to differ in their cellular localization and
            specificity for particular lipid ligands. The protein encoded by
            this gene is broadly distributed throughout the endocytic system
            via a tyrosine-based motif in the cytoplasmic tail. Alternatively
            spliced transcript variants of this gene have been observed, but
            their full-length nature is not known. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.131085.1,
                                           SRR1163657.175873.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368170.8/ ENSP00000357152.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AL121986.12        36338-36428
            92-1040             M28827.1           1-949
            1041-1041           AL121986.12        39636-39636
            1042-1285           M28827.1           951-1194
            1286-1991           AL121986.12        40033-40738
            1992-2442           AA824381.1         4-454               c
FEATURES             Location/Qualifiers
     source          1..2442
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.1"
     gene            1..2442
                     /gene="CD1C"
                     /gene_synonym="BDCA1; CD1; CD1A; R7"
                     /note="CD1c molecule"
                     /db_xref="GeneID:911"
                     /db_xref="HGNC:HGNC:1636"
                     /db_xref="MIM:188340"
     exon            1..203
                     /gene="CD1C"
                     /gene_synonym="BDCA1; CD1; CD1A; R7"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1144
                     /gene="CD1C"
                     /gene_synonym="BDCA1; CD1; CD1A; R7"
                     /note="CD1C antigen, c polypeptide; T-cell surface
                     glycoprotein CD1c; differentiation antigen CD1-alpha-3;
                     cortical thymocyte antigen CD1C"
                     /codon_start=1
                     /product="T-cell surface glycoprotein CD1c precursor"
                     /protein_id="NP_001756.2"
                     /db_xref="CCDS:CCDS1175.1"
                     /db_xref="GeneID:911"
                     /db_xref="HGNC:HGNC:1636"
                     /db_xref="MIM:188340"
                     /translation="MLFLQFLLLALLLPGGDNADASQEHVSFHVIQIFSFVNQSWARG
                     QGSGWLDELQTHGWDSESGTIIFLHNWSKGNFSNEELSDLELLFRFYLFGLTREIQDH
                     ASQDYSKYPFEVQVKAGCELHSGKSPEGFFQVAFNGLDLLSFQNTTWVPSPGCGSLAQ
                     SVCHLLNHQYEGVTETVYNLIRSTCPRFLLGLLDAGKMYVHRQVRPEAWLSSRPSLGS
                     GQLLLVCHASGFYPKPVWVTWMRNEQEQLGTKHGDILPNADGTWYLQVILEVASEEPA
                     GLSCRVRHSSLGGQDIILYWGHHFSMNWIALVVIVPLVILIVLVLWFKKHCSYQDIL"
     exon            204..470
                     /gene="CD1C"
                     /gene_synonym="BDCA1; CD1; CD1A; R7"
                     /inference="alignment:Splign:2.1.0"
     exon            471..752
                     /gene="CD1C"
                     /gene_synonym="BDCA1; CD1; CD1A; R7"
                     /inference="alignment:Splign:2.1.0"
     exon            753..1031
                     /gene="CD1C"
                     /gene_synonym="BDCA1; CD1; CD1A; R7"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1122
                     /gene="CD1C"
                     /gene_synonym="BDCA1; CD1; CD1A; R7"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..2442
                     /gene="CD1C"
                     /gene_synonym="BDCA1; CD1; CD1A; R7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1259..1264
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD1C"
                     /gene_synonym="BDCA1; CD1; CD1A; R7"
                     /note="hexamer: AATAAA"
     regulatory      1273..1278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD1C"
                     /gene_synonym="BDCA1; CD1; CD1A; R7"
                     /note="hexamer: AATAAA"
     polyA_site      1285
                     /gene="CD1C"
                     /gene_synonym="BDCA1; CD1; CD1A; R7"
                     /note="major polyA site"
     polyA_site      1298
                     /gene="CD1C"
                     /gene_synonym="BDCA1; CD1; CD1A; R7"
     regulatory      2422..2427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD1C"
                     /gene_synonym="BDCA1; CD1; CD1A; R7"
                     /note="hexamer: AATAAA"
     polyA_site      2442
                     /gene="CD1C"
                     /gene_synonym="BDCA1; CD1; CD1A; R7"
ORIGIN      
        1 agatcttctt agttgctgtc agcggctgat ggggaagatt gttggtagaa ggaagtcaga
       61 atataggtac agagggataa gtttgctaag aacagagatc agcaaacagc ttttctgaga
      121 gaaagaaaca tctgcaaatg acatgctgtt tctgcagttt ctgctgctag ctcttcttct
      181 cccaggtggt gacaatgcag acgcatccca ggaacacgtc tccttccatg tcatccagat
      241 cttctcattt gtcaaccaat cctgggcacg aggtcagggc tcaggatggc tggacgagtt
      301 gcagactcat ggctgggaca gtgaatcagg cacaataatt ttcctgcata actggtccaa
      361 gggcaacttc agcaatgaag agttgtcaga cctagagttg ttatttcgtt tctacctctt
      421 tggattaact cgggagattc aagaccatgc aagtcaagat tactcgaaat atccctttga
      481 agtacaggtg aaagcgggct gtgagctgca ttctggaaag agcccagaag gcttctttca
      541 ggtagctttc aacggattag atttactgag tttccagaat acaacatggg tgccatctcc
      601 aggctgtgga agtttggccc aaagtgtctg tcatctactc aatcatcagt atgaaggcgt
      661 cacagaaaca gtgtataatc tcataagaag cacttgcccc cgatttctct tgggtctcct
      721 ggatgcaggg aagatgtatg tacacaggca agtgaggcca gaagcctggc tgtccagtcg
      781 ccccagcctt gggtctggcc agctgttgct ggtttgtcat gcctccggct tctacccaaa
      841 gcctgtttgg gtgacatgga tgcggaatga acaggagcaa ctgggcacta aacatggtga
      901 tattcttcct aatgctgatg ggacatggta tcttcaggtg atcctggagg tggcatctga
      961 ggagcctgct ggcctgtctt gtcgagtgag acacagcagt ctaggaggcc aggacatcat
     1021 cctctactgg ggacaccact tttccatgaa ttggattgcc ttggtagtga tagtgccctt
     1081 ggtgattcta atagtccttg tgttatggtt taagaagcac tgctcatatc aggacatcct
     1141 gtgagactct tccccctgac tcccccattg tgttaagaac ccagcaaccc aggagcctag
     1201 tacaatatag tgatgccatc ccgtcgactc tccatttaaa ttgtttctct ttctgcataa
     1261 taaacatttg ttaataaaaa ccaaattcta atttggaatg tttttcttgg aatctccact
     1321 ttttatatag cactcaacct tcaaagccca tttctgatgt catttcctcc aacgatcttc
     1381 cttgacccat actgaaccca gagagcccct caactgttat gtgcatgcaa cacttcctac
     1441 cctgtgttgc agctacttga gtctttcatt tcacattttt aagcttttag gaggcaagga
     1501 tcatgataaa tgtgcctttc ctgcatatga taggctcagt gaaacacaaa acaaaacatc
     1561 atatctaagt tggattaact gtcatgttga caatttttct cattatattc cttcccaatg
     1621 ttgttgtagc attggaaata ttcatgcttc tctttttgtt taaatgcttc atacctagca
     1681 gataaattcc actctccttt agctccctca ttttctcctt aaacatttaa ggaaaagtgc
     1741 agccttgtgc cttgatacac ttattttcta aacacagaga attacaaatg caaatagaca
     1801 gagagtgtgc aagttacatg tgatgatcag tggtgcagat atgtcacaga atacttaaga
     1861 aaaggaacaa gagatttggt cctcagggtt ggagtgggat caaggcaacc gttgtgctgt
     1921 atatggaaga caaatttcct aaaggactgt gttatctgag atagccttgg ctaaacttta
     1981 gtccctttag gtttcattca ctaattcaac taatattttt tgggtactga gttgagacag
     2041 gcacatacag cttctaaact ggtggtggat aaaacaaatg agattgtgtc cactctcctg
     2101 aagttgcaat gtttgcttcc tcaatctgtc catgtttctt ttctattgtt ttcatgtttt
     2161 tatttatttc aaaaaatttt aaatagattt tattgatgta taatttatag taaaatttga
     2221 atctttaagt gtacagttct atttattttg ataattatat aagcccatgt aaacaaaatc
     2281 acaatcaaga tattaaatgt cataacccct catacctgtt tgtagtcaag cacaccaaca
     2341 acctggcatt cttgcaacta ctgatatact ttatgtcact taagcttaaa cttgtatttt
     2401 ctatgatttt attaagatgg aaataaacat atctacttgg ta
//
