LOCUS       NM_001764               1391 bp    mRNA    linear   PRI 06-DEC-2024
DEFINITION  Homo sapiens CD1b molecule (CD1B), mRNA.
ACCESSION   NM_001764
VERSION     NM_001764.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1391)
  AUTHORS   Evans,L. and Barral,P.
  TITLE     CD1 molecules: Beyond antigen presentation
  JOURNAL   Mol Immunol 170, 1-8 (2024)
   PUBMED   38579449
  REMARK    GeneRIF: CD1 molecules: Beyond antigen presentation.
            Review article
REFERENCE   2  (bases 1 to 1391)
  AUTHORS   James,C.A., Xu,Y., Aguilar,M.S., Jing,L., Layton,E.D., Gilleron,M.,
            Minnaard,A.J., Scriba,T.J., Day,C.L., Warren,E.H., Koelle,D.M. and
            Seshadri,C.
  TITLE     CD4 and CD8 co-receptors modulate functional avidity of
            CD1b-restricted T cells
  JOURNAL   Nat Commun 13 (1), 78 (2022)
   PUBMED   35013257
  REMARK    GeneRIF: CD4 and CD8 co-receptors modulate functional avidity of
            CD1b-restricted T cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1391)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1391)
  AUTHORS   Eckhardt,E. and Bastian,M.
  TITLE     Animal models for human group 1 CD1 protein function
  JOURNAL   Mol Immunol 130, 159-163 (2021)
   PUBMED   33384157
  REMARK    GeneRIF: Animal models for human group 1 CD1 protein function.
            Review article
REFERENCE   5  (bases 1 to 1391)
  AUTHORS   Reijneveld,J.F., Holzheimer,M., Young,D.C., Lopez,K., Suliman,S.,
            Jimenez,J., Calderon,R., Lecca,L., Murray,M.B., Ishikawa,E.,
            Yamasaki,S., Minnaard,A.J., Moody,D.B. and Van Rhijn,I.
  TITLE     Synthetic mycobacterial diacyl trehaloses reveal differential
            recognition by human T cell receptors and the C-type lectin Mincle
  JOURNAL   Sci Rep 11 (1), 2010 (2021)
   PUBMED   33479373
  REMARK    GeneRIF: Synthetic mycobacterial diacyl trehaloses reveal
            differential recognition by human T cell receptors and the C-type
            lectin Mincle.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1391)
  AUTHORS   Beckman,E.M., Porcelli,S.A., Morita,C.T., Behar,S.M., Furlong,S.T.
            and Brenner,M.B.
  TITLE     Recognition of a lipid antigen by CD1-restricted alpha beta+ T
            cells
  JOURNAL   Nature 372 (6507), 691-694 (1994)
   PUBMED   7527500
REFERENCE   7  (bases 1 to 1391)
  AUTHORS   Yu,C.Y. and Milstein,C.
  TITLE     A physical map linking the five CD1 human thymocyte differentiation
            antigen genes
  JOURNAL   EMBO J 8 (12), 3727-3732 (1989)
   PUBMED   2583117
REFERENCE   8  (bases 1 to 1391)
  AUTHORS   Aruffo,A. and Seed,B.
  TITLE     Expression of cDNA clones encoding the thymocyte antigens CD1a, b,
            c demonstrates a hierarchy of exclusion in fibroblasts
  JOURNAL   J Immunol 143 (5), 1723-1730 (1989)
   PUBMED   2701945
REFERENCE   9  (bases 1 to 1391)
  AUTHORS   Martin,L.H., Calabi,F., Lefebvre,F.A., Bilsland,C.A. and
            Milstein,C.
  TITLE     Structure and expression of the human thymocyte antigens CD1a,
            CD1b, and CD1c
  JOURNAL   Proc Natl Acad Sci U S A 84 (24), 9189-9193 (1987)
   PUBMED   2447586
REFERENCE   10 (bases 1 to 1391)
  AUTHORS   Martin,L.H., Calabi,F. and Milstein,C.
  TITLE     Isolation of CD1 genes: a family of major histocompatibility
            complex-related differentiation antigens
  JOURNAL   Proc Natl Acad Sci U S A 83 (23), 9154-9158 (1986)
   PUBMED   3097645
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD687240.1, BC104217.1 and
            AI336342.1.
            
            On May 17, 2019 this sequence version replaced NM_001764.2.
            
            Summary: This gene encodes a member of the CD1 family of
            transmembrane glycoproteins, which are structurally related to the
            major histocompatibility complex (MHC) proteins and form
            heterodimers with beta-2-microglobulin. The CD1 proteins mediate
            the presentation of primarily lipid and glycolipid antigens of self
            or microbial origin to T cells. The human genome contains five CD1
            family genes organized in a cluster on chromosome 1. The CD1 family
            members are thought to differ in their cellular localization and
            specificity for particular lipid ligands. The protein encoded by
            this gene localizes to late endosomes and lysosomes via a
            tyrosine-based motif in the cytoplasmic tail, and requires
            vesicular acidification to bind lipid antigens. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC104217.1, M28826.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368168.4/ ENSP00000357150.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                CD687240.1         31-93
            64-1339             BC104217.1         1-1276
            1340-1391           AI336342.1         8-59                c
FEATURES             Location/Qualifiers
     source          1..1391
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.1"
     gene            1..1391
                     /gene="CD1B"
                     /gene_synonym="CD1; CD1A; R1"
                     /note="CD1b molecule"
                     /db_xref="GeneID:910"
                     /db_xref="HGNC:HGNC:1635"
                     /db_xref="MIM:188360"
     exon            1..169
                     /gene="CD1B"
                     /gene_synonym="CD1; CD1A; R1"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1110
                     /gene="CD1B"
                     /gene_synonym="CD1; CD1A; R1"
                     /note="CD1B antigen, b polypeptide; T-cell surface
                     glycoprotein CD1b; differentiation antigen CD1-alpha-3;
                     cortical thymocyte antigen CD1B"
                     /codon_start=1
                     /product="T-cell surface glycoprotein CD1b precursor"
                     /protein_id="NP_001755.1"
                     /db_xref="CCDS:CCDS1176.1"
                     /db_xref="GeneID:910"
                     /db_xref="HGNC:HGNC:1635"
                     /db_xref="MIM:188360"
                     /translation="MLLLPFQLLAVLFPGGNSEHAFQGPTSFHVIQTSSFTNSTWAQT
                     QGSGWLDDLQIHGWDSDSGTAIFLKPWSKGNFSDKEVAELEEIFRVYIFGFAREVQDF
                     AGDFQMKYPFEIQGIAGCELHSGGAIVSFLRGALGGLDFLSVKNASCVPSPEGGSRAQ
                     KFCALIIQYQGIMETVRILLYETCPRYLLGVLNAGKADLQRQVKPEAWLSSGPSPGPG
                     RLQLVCHVSGFYPKPVWVMWMRGEQEQQGTQLGDILPNANWTWYLRATLDVADGEAAG
                     LSCRVKHSSLEGQDIILYWRNPTSIGSIVLAIIVPSLLLLLCLALWYMRRRSYQNIP"
     exon            170..436
                     /gene="CD1B"
                     /gene_synonym="CD1; CD1A; R1"
                     /inference="alignment:Splign:2.1.0"
     exon            437..715
                     /gene="CD1B"
                     /gene_synonym="CD1; CD1A; R1"
                     /inference="alignment:Splign:2.1.0"
     exon            716..994
                     /gene="CD1B"
                     /gene_synonym="CD1; CD1A; R1"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1088
                     /gene="CD1B"
                     /gene_synonym="CD1; CD1A; R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1391
                     /gene="CD1B"
                     /gene_synonym="CD1; CD1A; R1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1241..1246
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD1B"
                     /gene_synonym="CD1; CD1A; R1"
                     /note="hexamer: AATAAA"
     polyA_site      1271
                     /gene="CD1B"
                     /gene_synonym="CD1; CD1A; R1"
                     /note="major polyA site"
ORIGIN      
        1 ggcagttgga agagagaaga agtcactaca gggtactgag gaaaagcttt gctgaaattg
       61 gagatcaaat accagctctg ccagtaagaa gttgcatctc ccagtgaaat gctgctgctg
      121 ccatttcaac tgttagctgt tctctttcct ggtggtaaca gtgaacatgc cttccagggg
      181 ccgacctcct ttcatgttat ccagacctcg tcctttacca atagtacctg ggcacaaact
      241 caaggctcag gctggttgga tgatttgcag attcatggct gggatagcga ctcaggcact
      301 gccatattcc tgaagccttg gtctaaaggt aactttagtg ataaggaggt tgctgagtta
      361 gaggagatat tccgagtcta catctttgga ttcgctcgag aagtacaaga ctttgccggt
      421 gatttccaga tgaaataccc ctttgagatc cagggcatag caggctgtga gctacattct
      481 ggaggtgcca tagtaagctt cctgagggga gctctaggag gattggattt cctgagtgtc
      541 aagaatgctt catgtgtgcc ttccccagaa ggtggcagca gggcacagaa attctgtgca
      601 ctaatcatac aatatcaagg tatcatggaa actgtgagaa ttctcctcta tgaaacctgc
      661 ccccgatatc tcttgggcgt cctcaatgca ggaaaagcag atctgcaaag acaagtgaag
      721 cctgaggcct ggctgtccag tggccccagt cctggacctg gccgtctgca gcttgtgtgc
      781 catgtctcag gattctaccc aaagcccgtg tgggtgatgt ggatgcgggg tgagcaggag
      841 cagcagggca ctcagctagg ggacatcctg cccaatgcta actggacatg gtatctccga
      901 gcaaccctgg atgtggcaga tggggaggcg gctggcctgt cctgtcgggt gaagcacagc
      961 agtttagagg gccaggacat catcctctac tggagaaacc ccacctccat tggctcaatt
     1021 gttttggcaa taatagtgcc ttccttgctc cttttgctat gccttgcatt atggtatatg
     1081 aggcgccggt catatcagaa tatcccatga gccatcatca tgtctcctct cccattcgca
     1141 ataagtacca agaagcccaa gatatcagcc caaaagtcaa tcttatcata tttcaaatga
     1201 ttttcaaatt tgatgaaatc agagttttca tgtattttaa aataaattat tatttaaaca
     1261 tcagcaaaaa agtacttaaa actgtaaatt tattatgaga ctgtactaac agtgtgattc
     1321 accctgattt tacacacatt aaaatgttag aaaaaatgtg tctcaaaata aatgaaatat
     1381 aatacatatg a
//
