LOCUS       NM_001763               1809 bp    mRNA    linear   PRI 06-DEC-2024
DEFINITION  Homo sapiens CD1a molecule (CD1A), transcript variant 1, mRNA.
ACCESSION   NM_001763
VERSION     NM_001763.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1809)
  AUTHORS   Evans,L. and Barral,P.
  TITLE     CD1 molecules: Beyond antigen presentation
  JOURNAL   Mol Immunol 170, 1-8 (2024)
   PUBMED   38579449
  REMARK    GeneRIF: CD1 molecules: Beyond antigen presentation.
            Review article
REFERENCE   2  (bases 1 to 1809)
  AUTHORS   Marques,E.R.M.D.C., Hsieh,R., Lourenco,S.V. and Nico,M.M.S.
  TITLE     Oral lupus erythematosus: Immunohistochemical evaluation of CD1a,
            CD21, CD123, and langerin expression in dendritic cells
  JOURNAL   J Cutan Pathol 51 (5), 368-378 (2024)
   PUBMED   38287771
  REMARK    GeneRIF: Oral lupus erythematosus: Immunohistochemical evaluation
            of CD1a, CD21, CD123, and langerin expression in dendritic cells.
REFERENCE   3  (bases 1 to 1809)
  AUTHORS   Ye,J.H., Chen,Y.L. and Ogg,G.
  TITLE     CD1a and skin T cells: a pathway for therapeutic intervention
  JOURNAL   Clin Exp Dermatol 49 (5), 450-458 (2024)
   PUBMED   38173286
  REMARK    GeneRIF: CD1a and skin T cells: a pathway for therapeutic
            intervention.
            Review article
REFERENCE   4  (bases 1 to 1809)
  AUTHORS   Bryan,E., Teague,J.E., Eligul,S., Arkins,W.C., Moody,D.B.,
            Clark,R.A. and Van Rhijn,I.
  TITLE     Human Skin T Cells Express Conserved T-Cell Receptors that
            Cross-React with Staphylococcal Superantigens and CD1a
  JOURNAL   J Invest Dermatol 144 (4), 833-843 (2024)
   PUBMED   37951348
  REMARK    GeneRIF: Human Skin T Cells Express Conserved T-Cell Receptors that
            Cross-React with Staphylococcal Superantigens and CD1a.
REFERENCE   5  (bases 1 to 1809)
  AUTHORS   Kobiela,A., Hewelt-Belka,W., Frackowiak,J.E., Kordulewska,N.,
            Hovhannisyan,L., Bogucka,A., Etherington,R., Pirog,A., Dapic,I.,
            Gabrielsson,S., Brown,S.J., Ogg,G.S. and Gutowska-Owsiak,D.
  TITLE     Keratinocyte-derived small extracellular vesicles supply antigens
            for CD1a-resticted T cells and promote their type 2 bias in the
            context of filaggrin insufficiency
  JOURNAL   Front Immunol 15, 1369238 (2024)
   PUBMED   38585273
  REMARK    GeneRIF: Keratinocyte-derived small extracellular vesicles supply
            antigens for CD1a-resticted T cells and promote their type 2 bias
            in the context of filaggrin insufficiency.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1809)
  AUTHORS   Oakey,R.J., Watson,M.L. and Seldin,M.F.
  TITLE     Construction of a physical map on mouse and human chromosome 1:
            comparison of 13 Mb of mouse and 11 Mb of human DNA
  JOURNAL   Hum Mol Genet 1 (8), 613-620 (1992)
   PUBMED   1301170
REFERENCE   7  (bases 1 to 1809)
  AUTHORS   Yu,C.Y. and Milstein,C.
  TITLE     A physical map linking the five CD1 human thymocyte differentiation
            antigen genes
  JOURNAL   EMBO J 8 (12), 3727-3732 (1989)
   PUBMED   2583117
REFERENCE   8  (bases 1 to 1809)
  AUTHORS   Aruffo,A. and Seed,B.
  TITLE     Expression of cDNA clones encoding the thymocyte antigens CD1a, b,
            c demonstrates a hierarchy of exclusion in fibroblasts
  JOURNAL   J Immunol 143 (5), 1723-1730 (1989)
   PUBMED   2701945
REFERENCE   9  (bases 1 to 1809)
  AUTHORS   Moseley,W.S., Watson,M.L., Kingsmore,S.F. and Seldin,M.F.
  TITLE     CD1 defines conserved linkage group border between human
            chromosomes 1 and mouse chromosomes 1 and 3
  JOURNAL   Immunogenetics 30 (5), 378-382 (1989)
   PUBMED   2478463
REFERENCE   10 (bases 1 to 1809)
  AUTHORS   Martin,L.H., Calabi,F., Lefebvre,F.A., Bilsland,C.A. and
            Milstein,C.
  TITLE     Structure and expression of the human thymocyte antigens CD1a,
            CD1b, and CD1c
  JOURNAL   Proc Natl Acad Sci U S A 84 (24), 9189-9193 (1987)
   PUBMED   2447586
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB108750.1, M28825.1 and
            CA432941.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001763.2.
            
            Summary: This gene encodes a member of the CD1 family of
            transmembrane glycoproteins, which are structurally related to the
            major histocompatibility complex (MHC) proteins and form
            heterodimers with beta-2-microglobulin. The CD1 proteins mediate
            the presentation of primarily lipid and glycolipid antigens of self
            or microbial origin to T cells. The human genome contains five CD1
            family genes organized in a cluster on chromosome 1. The CD1 family
            members are thought to differ in their cellular localization and
            specificity for particular lipid ligands. The protein encoded by
            this gene localizes to the plasma membrane and to recycling
            vesicles of the early endocytic system. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Mar
            2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M28825.1, AK312945.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000289429.6/ ENSP00000289429.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-450               DB108750.1         27-476
            451-1508            M28825.1           738-1795
            1509-1809           CA432941.1         16-316              c
FEATURES             Location/Qualifiers
     source          1..1809
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.1"
     gene            1..1809
                     /gene="CD1A"
                     /gene_synonym="CD1; FCB6; HTA1; R4; T6"
                     /note="CD1a molecule"
                     /db_xref="GeneID:909"
                     /db_xref="HGNC:HGNC:1634"
                     /db_xref="MIM:188370"
     exon            1..304
                     /gene="CD1A"
                     /gene_synonym="CD1; FCB6; HTA1; R4; T6"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..1230
                     /gene="CD1A"
                     /gene_synonym="CD1; FCB6; HTA1; R4; T6"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CD1A antigen, a polypeptide; T-cell surface
                     glycoprotein CD1a; cortical thymocyte antigen CD1A;
                     epidermal dendritic cell marker CD1a; differentiation
                     antigen CD1-alpha-3; cluster of differentiation 1 A;
                     T-cell surface antigen T6/Leu-6; hTa1 thymocyte antigen"
                     /codon_start=1
                     /product="T-cell surface glycoprotein CD1a isoform 1
                     precursor"
                     /protein_id="NP_001754.2"
                     /db_xref="CCDS:CCDS1174.1"
                     /db_xref="GeneID:909"
                     /db_xref="HGNC:HGNC:1634"
                     /db_xref="MIM:188370"
                     /translation="MLFLLLPLLAVLPGDGNADGLKEPLSFHVTWIASFYNHSWKQNL
                     VSGWLSDLQTHTWDSNSSTIVFLCPWSRGNFSNEEWKELETLFRIRTIRSFEGIRRYA
                     HELQFEYPFEIQVTGGCELHSGKVSGSFLQLAYQGSDFVSFQNNSWLPYPVAGNMAKH
                     FCKVLNQNQHENDITHNLLSDTCPRFILGLLDAGKAHLQRQVKPEAWLSHGPSPGPGH
                     LQLVCHVSGFYPKPVWVMWMRGEQEQQGTQRGDILPSADGTWYLRATLEVAAGEAADL
                     SCRVKHSSLEGQDIVLYWEHHSSVGFIILAVIVPLLLLIGLALWFRKRCFC"
     exon            305..571
                     /gene="CD1A"
                     /gene_synonym="CD1; FCB6; HTA1; R4; T6"
                     /inference="alignment:Splign:2.1.0"
     exon            572..850
                     /gene="CD1A"
                     /gene_synonym="CD1; FCB6; HTA1; R4; T6"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1129
                     /gene="CD1A"
                     /gene_synonym="CD1; FCB6; HTA1; R4; T6"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1220
                     /gene="CD1A"
                     /gene_synonym="CD1; FCB6; HTA1; R4; T6"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1809
                     /gene="CD1A"
                     /gene_synonym="CD1; FCB6; HTA1; R4; T6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1780..1785
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD1A"
                     /gene_synonym="CD1; FCB6; HTA1; R4; T6"
                     /note="hexamer: AATAAA"
     polyA_site      1809
                     /gene="CD1A"
                     /gene_synonym="CD1; FCB6; HTA1; R4; T6"
                     /note="major polyA site"
ORIGIN      
        1 aagttggagg ttggtgacaa ggagagaagc tggaacagag aggagagtca gaaccagagg
       61 gaaatgagag actgagtagg catctcaggg tttttgaagg agtggatttt ctttgttgca
      121 gtcaggggag gtttgtctgt tggctgcaga aagaagtcag aatagagata tcgtggggta
      181 ggtttgtttg gaacagaaat caaagaccaa tttttctgag agaaggaaat aacatctgca
      241 aatgatatgc tgtttttgct acttccattg ttagctgttc tcccaggtga tggcaatgca
      301 gacgggctca aggagcctct ctccttccat gtcacctgga tcgcatcctt ttacaaccat
      361 tcctggaaac aaaatctggt ctcaggttgg ctgagtgatt tgcagactca tacctgggac
      421 agcaattcca gcaccatcgt tttcctgtgc ccctggtcca ggggaaactt cagcaatgag
      481 gagtggaagg aactggaaac attattccgt atacgcacca ttcggtcatt tgagggaatt
      541 cgtagatacg cccatgaatt gcagtttgaa tatccttttg agatacaggt gacaggaggc
      601 tgtgagctgc actctggaaa ggtctcagga agcttcttgc agttagctta tcaaggatca
      661 gactttgtga gcttccagaa caattcatgg ttgccatatc cagtggctgg gaatatggcc
      721 aagcatttct gcaaagtgct caatcagaat cagcatgaaa atgacataac acacaatctt
      781 ctcagtgaca cctgcccacg tttcatcttg ggtcttcttg atgcaggaaa ggcacatctc
      841 cagcggcaag tgaagcccga ggcctggctg tcccatggcc ccagtcctgg ccctggccat
      901 ctgcagcttg tgtgccatgt ctcaggattc tacccaaagc ccgtgtgggt gatgtggatg
      961 cggggtgagc aggagcagca gggcactcag cgaggggaca tcttgcccag tgctgatggg
     1021 acatggtatc tccgcgcaac cctggaggtg gccgctgggg aggcagctga cctgtcctgt
     1081 cgggtgaagc acagcagtct agagggccag gacatcgtcc tctactggga gcatcacagt
     1141 tccgtgggct tcatcatctt ggcggtgata gtgcctttac ttcttctgat aggtcttgcg
     1201 ctttggttca ggaaacgctg tttctgttaa gacacaccat gagcctcctc gtcacccttc
     1261 tccttttggg gtgagagacc agcagcccaa gggctccaga cacacctgaa cacatcgtga
     1321 tgatgacgtc ctctcaactc tctttgtaaa aattttgtta tttttgcttg tttctgatta
     1381 atgattgttt gtcaatataa gctcaattta attttgcagg atttgttgtt ctgacctggg
     1441 ttctgggact tttaaattca aattttatct ccagatggaa tggggtccta gcaacctcca
     1501 catgttcaac tattaatgga tcatcaggcc tgttttagat atcccttact ccagagggcc
     1561 ttccctgact tacaagtggg aagcagtctc ttcctggtct gaactcccgc cacattttag
     1621 ccgtactttg ctaactgtgc tcctcacttc ctcttcttca ttgcagttat ttagatcccc
     1681 cctttccttc taatttttca gctccttcaa tgcaaagtac atgtattttt aatatatgca
     1741 tccctggtga aggatcttgc ctgcatgaaa catgttctca ataaaactct gtgttgaatt
     1801 tatgccaaa
//
