LOCUS       NM_001770               1918 bp    mRNA    linear   PRI 13-MAY-2024
DEFINITION  Homo sapiens CD19 molecule (CD19), transcript variant 2, mRNA.
ACCESSION   NM_001770
VERSION     NM_001770.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1918)
  AUTHORS   Aminov,S., Giricz,O., Melnekoff,D.T., Sica,R.A., Polishchuk,V.,
            Papazoglu,C., Yates,B., Wang,H.W., Sahu,S., Wang,Y.,
            Gordon-Mitchell,S., Leshchenko,V.V., Schinke,C., Pradhan,K.,
            Aluri,S., Sohn,M., Barta,S.K., Agarwal,B., Goldfinger,M.,
            Mantzaris,I., Shastri,A., Matsui,W., Steidl,U., Brody,J.D.,
            Shah,N.N., Parekh,S. and Verma,A.
  TITLE     Immunotherapy-resistant acute lymphoblastic leukemia cells exhibit
            reduced CD19 and CD22 expression and BTK pathway dependency
  JOURNAL   J Clin Invest 134 (8), e175199 (2024)
   PUBMED   38376944
  REMARK    GeneRIF: Immunotherapy-resistant acute lymphoblastic leukemia cells
            exhibit reduced CD19 and CD22 expression and BTK pathway
            dependency.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1918)
  AUTHORS   Kuccukturk,S., Karaselek,M.A., Duran,T. and Reisli,I.
  TITLE     Evaluation of transcription factors and cytokine expressions of
            T-cell subsets in CD19 deficiency and their possible relationship
            with autoimmune disease
  JOURNAL   APMIS 132 (2), 122-129 (2024)
   PUBMED   38095318
  REMARK    GeneRIF: Evaluation of transcription factors and cytokine
            expressions of T-cell subsets in CD19 deficiency and their possible
            relationship with autoimmune disease.
REFERENCE   3  (bases 1 to 1918)
  AUTHORS   Hao,Y., Chen,P., Guo,S., Li,M., Jin,X., Zhang,M., Deng,W., Li,P.,
            Lei,W., Liang,A. and Qian,W.
  TITLE     Tumor-derived exosomes induce initial activation by exosomal CD19
            antigen but impair the function of CD19-specific CAR T-cells via
            TGF-beta signaling
  JOURNAL   Front Med 18 (1), 128-146 (2024)
   PUBMED   37870681
  REMARK    GeneRIF: Tumor-derived exosomes induce initial activation by
            exosomal CD19 antigen but impair the function of CD19-specific CAR
            T-cells via TGF-beta signaling.
REFERENCE   4  (bases 1 to 1918)
  AUTHORS   Acharya,L., Garg,A., Rai,M., Kshetri,R., Grewal,U.S. and Dhakal,P.
  TITLE     Novel chimeric antigen receptor targets and constructs for acute
            lymphoblastic leukemia: Moving beyond CD19
  JOURNAL   J Investig Med 72 (1), 32-46 (2024)
   PUBMED   37497999
  REMARK    GeneRIF: Novel chimeric antigen receptor targets and constructs for
            acute lymphoblastic leukemia: Moving beyond CD19.
            Review article
REFERENCE   5  (bases 1 to 1918)
  AUTHORS   Anderson,N.D., Birch,J., Accogli,T., Criado,I., Khabirova,E.,
            Parks,C., Wood,Y., Young,M.D., Porter,T., Richardson,R.,
            Albon,S.J., Popova,B., Lopes,A., Wynn,R., Hough,R., Gohil,S.H.,
            Pule,M., Amrolia,P.J., Behjati,S. and Ghorashian,S.
  TITLE     Transcriptional signatures associated with persisting CD19 CAR-T
            cells in children with leukemia
  JOURNAL   Nat Med 29 (7), 1700-1709 (2023)
   PUBMED   37407840
  REMARK    GeneRIF: Transcriptional signatures associated with persisting CD19
            CAR-T cells in children with leukemia.
REFERENCE   6  (bases 1 to 1918)
  AUTHORS   Bradbury,L.E., Kansas,G.S., Levy,S., Evans,R.L. and Tedder,T.F.
  TITLE     The CD19/CD21 signal transducing complex of human B lymphocytes
            includes the target of antiproliferative antibody-1 and Leu-13
            molecules
  JOURNAL   J Immunol 149 (9), 2841-2850 (1992)
   PUBMED   1383329
REFERENCE   7  (bases 1 to 1918)
  AUTHORS   Kozmik,Z., Wang,S., Dorfler,P., Adams,B. and Busslinger,M.
  TITLE     The promoter of the CD19 gene is a target for the B-cell-specific
            transcription factor BSAP
  JOURNAL   Mol Cell Biol 12 (6), 2662-2672 (1992)
   PUBMED   1375324
REFERENCE   8  (bases 1 to 1918)
  AUTHORS   Carter,R.H. and Fearon,D.T.
  TITLE     CD19: lowering the threshold for antigen receptor stimulation of B
            lymphocytes
  JOURNAL   Science 256 (5053), 105-107 (1992)
   PUBMED   1373518
REFERENCE   9  (bases 1 to 1918)
  AUTHORS   Zhou,L.J., Ord,D.C., Omori,S.A. and Tedder,T.F.
  TITLE     Structure of the genes encoding the CD19 antigen of human and mouse
            B lymphocytes
  JOURNAL   Immunogenetics 35 (2), 102-111 (1992)
   PUBMED   1370948
REFERENCE   10 (bases 1 to 1918)
  AUTHORS   Matsumoto,A.K., Kopicky-Burd,J., Carter,R.H., Tuveson,D.A.,
            Tedder,T.F. and Fearon,D.T.
  TITLE     Intersection of the complement and immune systems: a signal
            transduction complex of the B lymphocyte-containing complement
            receptor type 2 and CD19
  JOURNAL   J Exp Med 173 (1), 55-64 (1991)
   PUBMED   1702139
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC006338.2.
            
            On Aug 31, 2019 this sequence version replaced NM_001770.5.
            
            Summary: This gene encodes a member of the immunoglobulin gene
            superfamily. Expression of this cell surface protein is restricted
            to B cell lymphocytes. This protein is a reliable marker for pre-B
            cells but its expression diminishes during terminal B cell
            differentiation in antibody secreting plasma cells. The protein has
            two N-terminal extracellular Ig-like domains separated by a
            non-Ig-like domain, a hydrophobic transmembrane domain, and a large
            C-terminal cytoplasmic domain. This protein forms a complex with
            several membrane proteins including complement receptor type 2
            (CD21) and tetraspanin (CD81) and this complex reduces the
            threshold for antigen-initiated B cell activation. Activation of
            this B-cell antigen receptor complex activates the
            phosphatidylinositol 3-kinase signalling pathway and the subsequent
            release of intracellular stores of calcium ions. This protein is a
            target of chimeric antigen receptor (CAR) T-cells used in the
            treatment of lymphoblastic leukemia. Mutations in this gene are
            associated with the disease common variable immunodeficiency 3
            (CVID3) which results in a failure of B-cell differentiation and
            impaired secretion of immunoglobulins. CVID3 is characterized by
            hypogammaglobulinemia, an inability to mount an antibody response
            to antigen, and recurrent bacterial infections. Alternative
            splicing results in multiple transcript variants encoding distinct
            isoforms. [provided by RefSeq, Jul 2020].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. This
            results in a shorter protein (isoform 2), compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006338.2, M21097.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000538922.8/ ENSP00000437940.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1918              BC006338.2         15-1932
FEATURES             Location/Qualifiers
     source          1..1918
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..1918
                     /gene="CD19"
                     /gene_synonym="B4; CVID3"
                     /note="CD19 molecule"
                     /db_xref="GeneID:930"
                     /db_xref="HGNC:HGNC:1633"
                     /db_xref="MIM:107265"
     exon            1..118
                     /gene="CD19"
                     /gene_synonym="B4; CVID3"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1701
                     /gene="CD19"
                     /gene_synonym="B4; CVID3"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; differentiation antigen CD19; T-cell surface
                     antigen Leu-12; B-lymphocyte surface antigen B4"
                     /codon_start=1
                     /product="B-lymphocyte antigen CD19 isoform 2 precursor"
                     /protein_id="NP_001761.3"
                     /db_xref="CCDS:CCDS10644.1"
                     /db_xref="GeneID:930"
                     /db_xref="HGNC:HGNC:1633"
                     /db_xref="MIM:107265"
                     /translation="MPPPRLLFFLLFLTPMEVRPEEPLVVKVEEGDNAVLQCLKGTSD
                     GPTQQLTWSRESPLKPFLKLSLGLPGLGIHMRPLAIWLFIFNVSQQMGGFYLCQPGPP
                     SEKAWQPGWTVNVEGSGELFRWNVSDLGGLGCGLKNRSSEGPSSPSGKLMSPKLYVWA
                     KDRPEIWEGEPPCLPPRDSLNQSLSQDLTMAPGSTLWLSCGVPPDSVSRGPLSWTHVH
                     PKGPKSLLSLELKDDRPARDMWVMETGLLLPRATAQDAGKYYCHRGNLTMSFHLEITA
                     RPVLWHWLLRTGGWKVSAVTLAYLIFCLCSLVGILHLQRALVLRRKRKRMTDPTRRFF
                     KVTPPPGSGPQNQYGNVLSLPTPTSGLGRAQRWAAGLGGTAPSYGNPSSDVQADGALG
                     SRSPPGVGPEEEEGEGYEEPDSEEDSEFYENDSNLGQDQLSQDGSGYENPEDEPLGPE
                     DEDSFSNAESYENEDEELTQPVARTMDFLSPHGSAWDPSREATSLGSQSYEDMRGILY
                     AAPQLRSIRGQPGPNHEEDADSYENMDNPDGPDPAWGGGGRMGTWSTR"
     exon            119..385
                     /gene="CD19"
                     /gene_synonym="B4; CVID3"
                     /inference="alignment:Splign:2.1.0"
     exon            386..589
                     /gene="CD19"
                     /gene_synonym="B4; CVID3"
                     /inference="alignment:Splign:2.1.0"
     exon            590..865
                     /gene="CD19"
                     /gene_synonym="B4; CVID3"
                     /inference="alignment:Splign:2.1.0"
     exon            866..976
                     /gene="CD19"
                     /gene_synonym="B4; CVID3"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1025
                     /gene="CD19"
                     /gene_synonym="B4; CVID3"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1114
                     /gene="CD19"
                     /gene_synonym="B4; CVID3"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1228
                     /gene="CD19"
                     /gene_synonym="B4; CVID3"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1333
                     /gene="CD19"
                     /gene_synonym="B4; CVID3"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1402
                     /gene="CD19"
                     /gene_synonym="B4; CVID3"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1459
                     /gene="CD19"
                     /gene_synonym="B4; CVID3"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1516
                     /gene="CD19"
                     /gene_synonym="B4; CVID3"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1609
                     /gene="CD19"
                     /gene_synonym="B4; CVID3"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1716
                     /gene="CD19"
                     /gene_synonym="B4; CVID3"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1918
                     /gene="CD19"
                     /gene_synonym="B4; CVID3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1895..1900
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD19"
                     /gene_synonym="B4; CVID3"
                     /note="hexamer: AATAAA"
     polyA_site      1918
                     /gene="CD19"
                     /gene_synonym="B4; CVID3"
                     /note="major polyA site"
ORIGIN      
        1 aagctgggtg ccccggagag tctgaccacc atgccacctc ctcgcctcct cttcttcctc
       61 ctcttcctca cccccatgga agtcaggccc gaggaacctc tagtggtgaa ggtggaagag
      121 ggagataacg ctgtgctgca gtgcctcaag gggacctcag atggccccac tcagcagctg
      181 acctggtctc gggagtcccc gcttaaaccc ttcttaaaac tcagcctggg gctgccaggc
      241 ctgggaatcc acatgaggcc cctggccatc tggcttttca tcttcaacgt ctctcaacag
      301 atggggggct tctacctgtg ccagccgggg cccccctctg agaaggcctg gcagcctggc
      361 tggacagtca atgtggaggg cagcggggag ctgttccggt ggaatgtttc ggacctaggt
      421 ggcctgggct gtggcctgaa gaacaggtcc tcagagggcc ccagctcccc ttccgggaag
      481 ctcatgagcc ccaagctgta tgtgtgggcc aaagaccgcc ctgagatctg ggagggagag
      541 cctccgtgtc tcccaccgag ggacagcctg aaccagagcc tcagccagga cctcaccatg
      601 gcccctggct ccacactctg gctgtcctgt ggggtacccc ctgactctgt gtccaggggc
      661 cccctctcct ggacccatgt gcaccccaag gggcctaagt cattgctgag cctagagctg
      721 aaggacgatc gcccggccag agatatgtgg gtaatggaga cgggtctgtt gttgccccgg
      781 gccacagctc aagacgctgg aaagtattat tgtcaccgtg gcaacctgac catgtcattc
      841 cacctggaga tcactgctcg gccagtacta tggcactggc tgctgaggac tggtggctgg
      901 aaggtctcag ctgtgacttt ggcttatctg atcttctgcc tgtgttccct tgtgggcatt
      961 cttcatcttc aaagagccct ggtcctgagg aggaaaagaa agcgaatgac tgaccccacc
     1021 aggagattct tcaaagtgac gcctccccca ggaagcgggc cccagaacca gtacgggaac
     1081 gtgctgtctc tccccacacc cacctcaggc ctcggacgcg cccagcgttg ggccgcaggc
     1141 ctggggggca ctgccccgtc ttatggaaac ccgagcagcg acgtccaggc ggatggagcc
     1201 ttggggtccc ggagcccgcc gggagtgggc ccagaagaag aggaagggga gggctatgag
     1261 gaacctgaca gtgaggagga ctccgagttc tatgagaacg actccaacct tgggcaggac
     1321 cagctctccc aggatggcag cggctacgag aaccctgagg atgagcccct gggtcctgag
     1381 gatgaagact ccttctccaa cgctgagtct tatgagaacg aggatgaaga gctgacccag
     1441 ccggtcgcca ggacaatgga cttcctgagc cctcatgggt cagcctggga ccccagccgg
     1501 gaagcaacct ccctggggtc ccagtcctat gaggatatga gaggaatcct gtatgcagcc
     1561 ccccagctcc gctccattcg gggccagcct ggacccaatc atgaggaaga tgcagactct
     1621 tatgagaaca tggataatcc cgatgggcca gacccagcct ggggaggagg gggccgcatg
     1681 ggcacctgga gcaccaggtg atcctcaggt ggccagcctg gatctcctca agtccccaag
     1741 attcacacct gactctgaaa tctgaagacc tcgagcagat gatgccaacc tctggagcaa
     1801 tgttgcttag gatgtgtgca tgtgtgtaag tgtgtgtgtg tgtgtgtgtg tgtatacatg
     1861 ccagtgacac ttccagtccc ctttgtattc cttaaataaa ctcaatgagc tcttccaa
//
