LOCUS       NM_005582               5388 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens CD180 molecule (CD180), mRNA.
ACCESSION   NM_005582
VERSION     NM_005582.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5388)
  AUTHORS   Edwards,K., Lydyard,P.M., Kulikova,N., Tsertsvadze,T., Volpi,E.V.,
            Chiorazzi,N. and Porakishvili,N.
  TITLE     The role of CD180 in hematological malignancies and inflammatory
            disorders
  JOURNAL   Mol Med 29 (1), 97 (2023)
   PUBMED   37460961
  REMARK    GeneRIF: The role of CD180 in hematological malignancies and
            inflammatory disorders.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5388)
  AUTHORS   Biswas,M., Yamazaki,T., Tomono,S., Karnan,S., Takagi,H.,
            Ichimonji,I., Inui,M., Nagaoka,F., Hosokawa,Y. and
            Akashi-Takamura,S.
  TITLE     Cell surface expression of human RP105 depends on N-glycosylation
            of MD-1
  JOURNAL   FEBS Lett 596 (24), 3211-3231 (2022)
   PUBMED   35849076
  REMARK    GeneRIF: Cell surface expression of human RP105 depends on
            N-glycosylation of MD-1.
REFERENCE   3  (bases 1 to 5388)
  AUTHORS   Gautam,A., Sreedharanunni,S., Sachdeva,M.U.S., Rana,S., Kashyap,D.,
            Bose,P., Bal,A., Prakash,G., Malhotra,P., Das,R. and Varma,N.
  TITLE     The relative expression levels of CD148 and CD180 on clonal B cells
            and CD148/CD180 median fluorescence intensity ratios are useful in
            the characterization of mature B cell lymphoid neoplasms
            infiltrating blood and bone marrow - Results from a single centre
            pilot study
  JOURNAL   Int J Lab Hematol 43 (5), 1123-1131 (2021)
   PUBMED   33455071
  REMARK    GeneRIF: The relative expression levels of CD148 and CD180 on
            clonal B cells and CD148/CD180 median fluorescence intensity ratios
            are useful in the characterization of mature B cell lymphoid
            neoplasms infiltrating blood and bone marrow - Results from a
            single centre pilot study.
REFERENCE   4  (bases 1 to 5388)
  AUTHORS   Shcherbina,V., Gordiienko,I., Shlapatska,L., Gluzman,D. and
            Sidorenko,S.
  TITLE     CD150 and CD180 are negative regulators of IL-10 expression and
            secretion in chronic lymphocytic leukemia B cells
  JOURNAL   Neoplasma 68 (4), 760-769 (2021)
   PUBMED   33904315
  REMARK    GeneRIF: CD150 and CD180 are negative regulators of IL-10
            expression and secretion in chronic lymphocytic leukemia B cells.
REFERENCE   5  (bases 1 to 5388)
  AUTHORS   Hayden,Z., Erdo-Bonyar,S., Bone,B., Balazs,N., Bodo,K., Illes,Z.,
            Berki,T. and Simon,D.
  TITLE     Toll-Like Receptor Homolog CD180 Expression Is Diminished on
            Natural Autoantibody-Producing B Cells of Patients with Autoimmune
            CNS Disorders
  JOURNAL   J Immunol Res 2021, 9953317 (2021)
   PUBMED   34124274
  REMARK    GeneRIF: Toll-Like Receptor Homolog CD180 Expression Is Diminished
            on Natural Autoantibody-Producing B Cells of Patients with
            Autoimmune CNS Disorders.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5388)
  AUTHORS   Izmailova,E., Bertley,F.M., Huang,Q., Makori,N., Miller,C.J.,
            Young,R.A. and Aldovini,A.
  TITLE     HIV-1 Tat reprograms immature dendritic cells to express
            chemoattractants for activated T cells and macrophages
  JOURNAL   Nat Med 9 (2), 191-197 (2003)
   PUBMED   12539042
REFERENCE   7  (bases 1 to 5388)
  AUTHORS   Ogata,H., Su,I., Miyake,K., Nagai,Y., Akashi,S., Mecklenbrauker,I.,
            Rajewsky,K., Kimoto,M. and Tarakhovsky,A.
  TITLE     The toll-like receptor protein RP105 regulates lipopolysaccharide
            signaling in B cells
  JOURNAL   J Exp Med 192 (1), 23-29 (2000)
   PUBMED   10880523
REFERENCE   8  (bases 1 to 5388)
  AUTHORS   Miura,Y., Shimazu,R., Miyake,K., Akashi,S., Ogata,H., Yamashita,Y.,
            Narisawa,Y. and Kimoto,M.
  TITLE     RP105 is associated with MD-1 and transmits an activation signal in
            human B cells
  JOURNAL   Blood 92 (8), 2815-2822 (1998)
   PUBMED   9763566
REFERENCE   9  (bases 1 to 5388)
  AUTHORS   Miyake,K., Shimazu,R., Kondo,J., Niki,T., Akashi,S., Ogata,H.,
            Yamashita,Y., Miura,Y. and Kimoto,M.
  TITLE     Mouse MD-1, a molecule that is physically associated with RP105 and
            positively regulates its expression
  JOURNAL   J Immunol 161 (3), 1348-1353 (1998)
   PUBMED   9686597
REFERENCE   10 (bases 1 to 5388)
  AUTHORS   Miura,Y., Miyake,K., Yamashita,Y., Shimazu,R., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A., Inazawa,J., Abe,T. and Kimoto,M.
  TITLE     Molecular cloning of a human RP105 homologue and chromosomal
            localization of the mouse and human RP105 genes (Ly64 and LY64)
  JOURNAL   Genomics 38 (3), 299-304 (1996)
   PUBMED   8975706
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026445.5, AL544501.3, BP344300.1, BC109069.1, AL570708.3 and
            AW512119.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005582.2.
            
            Summary: CD180 is a cell surface molecule consisting of
            extracellular leucine-rich repeats (LRR) and a short cytoplasmic
            tail. The extracellular LRR is associated with a molecule called
            MD-1 and form the cell surface receptor complex, RP105/MD-1. It
            belongs to the family of pathogen receptors, Toll-like receptors
            (TLR). RP105/MD1, by working in concert with TLR4, controls B cell
            recognition and signaling of lipopolysaccharide (LPS), a membrane
            constituent of Gram-negative bacteria. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK313177.1, D83597.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256447.5/ ENSP00000256447.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC026445.5         66135-66144
            11-824              AL544501.3         1-814
            825-901             BP344300.1         477-553
            902-2432            BC109069.1         850-2380
            2433-2695           AL570708.3         1-263               c
            2696-2726           AW512119.1         10-40               c
            2727-5388           AC026445.5         80660-83321
FEATURES             Location/Qualifiers
     source          1..5388
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q12.3"
     gene            1..5388
                     /gene="CD180"
                     /gene_synonym="LY64; Ly78; RP105"
                     /note="CD180 molecule"
                     /db_xref="GeneID:4064"
                     /db_xref="HGNC:HGNC:6726"
                     /db_xref="MIM:602226"
     exon            1..248
                     /gene="CD180"
                     /gene_synonym="LY64; Ly78; RP105"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..2144
                     /gene="CD180"
                     /gene_synonym="LY64; Ly78; RP105"
                     /note="CD180 antigen; lymphocyte antigen-64,
                     radioprotective, 105kDa; radioprotective 105 kDa protein;
                     lymphocyte antigen 64"
                     /codon_start=1
                     /product="CD180 antigen precursor"
                     /protein_id="NP_005573.2"
                     /db_xref="CCDS:CCDS3992.1"
                     /db_xref="GeneID:4064"
                     /db_xref="HGNC:HGNC:6726"
                     /db_xref="MIM:602226"
                     /translation="MAFDVSCFFWVVLFSAGCKVITSWDQMCIEKEANKTYNCENLGL
                     SEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQ
                     LSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNH
                     ISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGA
                     FDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSV
                     ESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFD
                     QLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQL
                     KNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVL
                     NLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGL
                     LSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIYLNLAANSINIISPRLLPIL
                     SQQSTINLSHNPLDCTCSNIHFLTWYKENLHKLEGSEETTCANPPSLRGVKLSDVKLS
                     CGITAIGIFFLIVFLLLLAILLFFAVKYLLRWKYQHI"
     exon            249..415
                     /gene="CD180"
                     /gene_synonym="LY64; Ly78; RP105"
                     /inference="alignment:Splign:2.1.0"
     exon            416..5388
                     /gene="CD180"
                     /gene_synonym="LY64; Ly78; RP105"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2705..2710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD180"
                     /gene_synonym="LY64; Ly78; RP105"
                     /note="hexamer: AAGAAA"
     polyA_site      2726
                     /gene="CD180"
                     /gene_synonym="LY64; Ly78; RP105"
                     /note="major polyA site"
     regulatory      3434..3439
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD180"
                     /gene_synonym="LY64; Ly78; RP105"
                     /note="hexamer: AATAAA"
     polyA_site      3454
                     /gene="CD180"
                     /gene_synonym="LY64; Ly78; RP105"
     regulatory      5370..5375
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD180"
                     /gene_synonym="LY64; Ly78; RP105"
                     /note="hexamer: TATAAA"
     polyA_site      5388
                     /gene="CD180"
                     /gene_synonym="LY64; Ly78; RP105"
ORIGIN      
        1 acagagccac agaatgctga gcagtcaaca gcatttcttg ttccaagatc acccttctga
       61 gtacctctct ggctgccaaa ttgccagggc cttcacagtt tgattccatt tctcagctcc
      121 aagcattagg taaacccacc aagcaatcct agcctgtgat ggcgtttgac gtcagctgct
      181 tcttttgggt ggtgctgttt tctgccggct gtaaagtcat cacctcctgg gatcagatgt
      241 gcattgagaa agaagccaac aaaacatata actgtgaaaa tttaggtctc agtgaaatcc
      301 ctgacactct accaaacaca acagaatttt tggaattcag ctttaatttt ttgcctacaa
      361 ttcacaatag aaccttcagc agactcatga atcttacctt tttggattta actaggtgcc
      421 agattaactg gatacatgaa gacacttttc aaagccatca tcaattaagc acacttgtgt
      481 taactggaaa tcccctgata ttcatggcag aaacatcgct taatgggccc aagtcactga
      541 agcatctttt cttaatccaa acgggaatat ccaatctcga gtttattcca gtgcacaatc
      601 tggaaaactt ggaaagcttg tatcttggaa gcaaccatat ttcctccatt aagttcccca
      661 aagacttccc agcacggaat ctgaaagtac tggattttca gaataatgct atacactaca
      721 tctctagaga agacatgagg tctctggagc aggccatcaa cctaagcctg aacttcaatg
      781 gcaataatgt taaaggtatt gagcttgggg cttttgattc aacgatcttc caaagtttga
      841 actttggagg aactccaaat ttgtctgtta tattcaatgg tctgcagaac tctactactc
      901 agtctctctg gctgggaaca tttgaggaca ttgatgacga agatattagt tcagccatgc
      961 tcaagggact ctgtgaaatg tctgttgaga gcctcaacct gcaggaacac cgcttctctg
     1021 acatctcatc caccacattt cagtgcttca cccaactcca agaattggat ctgacagcaa
     1081 ctcacttgaa agggttaccc tctgggatga agggtctgaa cttgctcaag aaattagttc
     1141 tcagtgtaaa tcatttcgat caattgtgtc aaatcagtgc tgccaatttc ccctccctta
     1201 cacacctcta catcagaggc aacgtgaaga aacttcacct tggtgttggc tgcttggaga
     1261 aactaggaaa ccttcagaca cttgatttaa gccataatga catagaggct tctgactgct
     1321 gcagtctgca actcaaaaac ctgtcccact tgcaaacctt aaacctgagc cacaatgagc
     1381 ctcttggtct ccagagtcag gcattcaaag aatgtcctca gctagaactc ctcgatttgg
     1441 catttacccg cttacacatt aatgctccac aaagtccctt ccaaaacctc catttccttc
     1501 aggttctgaa tctcacttac tgcttccttg ataccagcaa tcagcatctt ctagcaggcc
     1561 taccagttct ccggcatctc aacttaaaag ggaatcactt tcaagatggg actatcacga
     1621 agaccaacct acttcagacc gtgggcagct tggaggttct gattttgtcc tcttgtggtc
     1681 tcctctctat agaccagcaa gcattccaca gcttgggaaa aatgagccat gtagacttaa
     1741 gccacaacag cctgacatgc gacagcattg attctcttag ccatcttaag ggaatctacc
     1801 tcaatctggc tgccaacagc attaacatca tctcaccccg tctcctccct atcttgtccc
     1861 agcagagcac cattaattta agtcataacc ccctggactg cacttgctcg aatattcatt
     1921 tcttaacatg gtacaaagaa aacctgcaca aacttgaagg ctcggaggag accacgtgtg
     1981 caaacccgcc atctctaagg ggagttaagc tatctgatgt caagctttcc tgtgggatta
     2041 cagccatagg cattttcttt ctcatagtat ttctattatt gttggctatt ctgctatttt
     2101 ttgcagttaa ataccttctc aggtggaaat accaacacat ttagtgctga aggtttccag
     2161 agaaagcaaa taagtgtgct tagcaaaatt gctctaagtg aaagaactgt catctgctgg
     2221 tgaccagacc agacttttca gattgcttcc tggaactggg cagggactca ctgtgctttt
     2281 ctgagcttct tactcctgtg agtcccagag ctaaagaacc ttctaggcaa gtacaccgaa
     2341 tgactcagtc cagagggtca gatgctgctg tgagaggcac agagcccttt ccgcatgtgg
     2401 aagagtggga ggaagcagag ggagggactg ggcagggact gccggccccg gagtctccca
     2461 cagggaggcc attccccttc tactcaccga catccctccc agcaccacac accccgcccc
     2521 tgaaaggaga tcatcagccc ccacaatttg tcagagctga agccagccca ctacccaccc
     2581 ccactacagc attgtgcttg ggtctgggtt ctcagtaatg tagccatttg agaaacttac
     2641 ttggggacaa agtctcaatc cttattttaa atgaaaaaag aaaagaaaag cataataaat
     2701 ttaaaagaaa aggctgagaa atgaaacttg gtatcaaatc gactccatta atcttcttaa
     2761 tccttaggtc tgtaaggtct ctgtaatgcc cctagggtgt gaatggctat aaaaaataga
     2821 acccaccccc aaggtttaga atttcttcca catttgcctc actcagttca gaaaccaggc
     2881 aggctctctc tgcctatctg gtgttctggc tcttatgtta cagatcctaa cttgcaggtg
     2941 ggctgtgacc caaaatgctc ttctcatttg ggcatccggt tcttagaagt ctcttttcca
     3001 gaagaactgt gaaataaatc gtggtttggt tctcaggctt gcccttaaaa gcctatttgc
     3061 ttcggagagc atttgaatta gcacatttac gtgaaaatga ggaagaaggc atccctgcat
     3121 gctagctgtt gggaacacag taaagctggc ttagtgagaa gtggtttctg ttgaggctgg
     3181 ggatgtcacc aaaggtcaca ccagccatgg acaggggcct gaaccactga atgcagatag
     3241 acaaagagca atgtcatgac ttaggcttaa agggccatac tcacacaggc ctgtatcttc
     3301 tgaagtcttg attgccagac aagcttggcg ggagctcctg gactcaagtg gtgcattgtt
     3361 ctgttcaata accaatttta gggtagagat agagatggta acttatagtt atgaaattct
     3421 gataagctaa caaaataaaa atggatccaa ccaatcagaa tatattagtc cttaagttga
     3481 aggcatacta gtgggacatc ataacagagt gaaaacttgg gggtcatcct ttttgtctct
     3541 tcgcccccag gaaaagcagg gcaggcaggg aacagcagtg ggtgaacctc ttctctgctc
     3601 agggatttca ggccttcaca cttgctcttt cctttgcctc taagatgctg ccattggcct
     3661 ccaaatggct ccttccttca tcttgagatt tcagtgctaa tattttctcc tttgagggat
     3721 ttcttctctg acctagctaa tccaaagcaa cctctatgcc tcacctggtt ttattatctt
     3781 tataatgctt atcagtgttt ggaattaact tcttcatttg ttttaattag tttctcttgt
     3841 cttgtctctc ccaaatacaa gtgccatgag agggtctttg cctaaagata ccctagaaca
     3901 tgcctgggac atagtaagga ctctctctct ctctctccat atgtgtgtgt gtgtgtatgt
     3961 gtgtgtatgt gtgtgtgtat atatatatat aatttttttt ttgagactga ttcttgctct
     4021 gtcgcccagg ctggagtgct atagtgcaat cttggctcac tgtaacctcc gcctcccagg
     4081 ttccagcgat tctcctgcct cagcctcctg agtagctggg attacaggcg cccaccacca
     4141 cgcctggcta atttttgtat ttttagtaga gacagggttt caccatgttg gccaggctgg
     4201 tcttgaactc ctgacctcaa gtgatctgcc cgcctcggcc tcccaaagtg ctgggattac
     4261 agatgagagc catcgtgccc ggccaagatt caatatattt ttaatatgtg ctgatccctg
     4321 agcctttatt agctcctagt tctgccacca tgcctatgct gctgactctt agctcctgac
     4381 ctctccacgg tttcctgggc ctcccacatg tttttcactg gcatctccta gggaagtttt
     4441 tacaaaatgg attcccaggc ctcaccccca gatactgaga ttctgttgga ctgaggttgg
     4501 ctcagggttc ccagccaaat gattccatgt aaaatgtgga aggtccaaac tctaagaatc
     4561 cagtcttaga cagcaccaac ccattgagtc cctgcatatt ctgtcacagg taagctcttt
     4621 cttgccttag ggatttaagc tgcagatgga aaatactaat tgctgattta ccaacccata
     4681 gacatactgc cctccataat atttaatatg taacttggaa aaacgaaaca attctgtaga
     4741 aaacctctga tgtgaattac atcacactaa caatgaaagg ggcccaggcc ttagcaaagc
     4801 ataattgccc atcctgcttt cacttctcag gcccgctccc ttccatgcga tgcagcttgc
     4861 tgctccgtaa ctgatctaag gctttgtgac agctcctctg ttttaagcaa cagtaaattc
     4921 accccacaaa gtcagaaagg gagcttgttg atggctgctg tcaattttat tgctttaacc
     4981 tgtttactag gatagactct gtaacatggt gtgtttattg gttttatgta ttgcatgttg
     5041 ttgctgctct gacaagctac tcctataaaa atgtgttatt attgcacgat gtagctcagt
     5101 gagctgaccc tgcatttcaa agggtactgg agcaaatagc actgaagtcc ataaaagctg
     5161 actggcctcc atcacagagg actctctgca tgagctgcaa ctcctacaac ccaggagaga
     5221 attacacctt tccctgtgcc agcagccact gcttagtaca gcacagccct tgaacacagg
     5281 caatatctgt aaaattccaa gacagaaaac tgtcgtgcca ttcttatttg tccaactctc
     5341 caatcagtgt agtttgcaat tttgatgttt ataaaagtat gaaacaaa
//
