LOCUS       NM_020406               2195 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens CD177 molecule (CD177), mRNA.
ACCESSION   NM_020406 XM_001133374 XM_001134248
VERSION     NM_020406.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2195)
  AUTHORS   Li,Y. and Wu,J.
  TITLE     CD177 is a novel IgG Fc receptor and CD177 genetic variants affect
            IgG-mediated function
  JOURNAL   Front Immunol 15, 1418539 (2024)
   PUBMED   39131159
  REMARK    GeneRIF: CD177 is a novel IgG Fc receptor and CD177 genetic
            variants affect IgG-mediated function.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2195)
  AUTHORS   Traum,A., Jehle,S., Waxmann,Y., Litmeyer,A.S., Berghofer,H.,
            Bein,G., Dammann,R., Perniss,A., Burg-Roderfeld,M., Sachs,U.J. and
            Bayat,B.
  TITLE     The CD177 c.1291A Allele Leads to a Loss of Membrane Expression and
            Mimics a CD177-Null Phenotype
  JOURNAL   Int J Mol Sci 25 (5), 2877 (2024)
   PUBMED   38474126
  REMARK    GeneRIF: The CD177 c.1291A Allele Leads to a Loss of Membrane
            Expression and Mimics a CD177-Null Phenotype.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2195)
  AUTHORS   Liao,W., Li,W., Li,Y., Liu,T., Wang,Y., Feng,D. and Shen,F.
  TITLE     Diagnostic, prognostic, and immunological roles of CD177 in
            cervical cancer
  JOURNAL   J Cancer Res Clin Oncol 149 (1), 173-189 (2023)
   PUBMED   36352147
  REMARK    GeneRIF: Diagnostic, prognostic, and immunological roles of CD177
            in cervical cancer.
REFERENCE   4  (bases 1 to 2195)
  AUTHORS   Marino,S.F., Jerke,U., Rolle,S., Daumke,O. and Kettritz,R.
  TITLE     Competitively disrupting the neutrophil-specific
            receptor-autoantigen CD177:proteinase 3 membrane complex reduces
            anti-PR3 antibody-induced neutrophil activation
  JOURNAL   J Biol Chem 298 (3), 101598 (2022)
   PUBMED   35063507
  REMARK    GeneRIF: Competitively disrupting the neutrophil-specific
            receptor-autoantigen CD177:proteinase 3 membrane complex reduces
            anti-PR3 antibody-induced neutrophil activation.
REFERENCE   5  (bases 1 to 2195)
  AUTHORS   Stroncek,D.F.
  TITLE     Neutrophil-specific antigen HNA-2a, NB1 glycoprotein, and CD177
  JOURNAL   Curr Opin Hematol 14 (6), 688-693 (2007)
   PUBMED   17898576
  REMARK    Review article
REFERENCE   6  (bases 1 to 2195)
  AUTHORS   Kissel,K., Scheffler,S., Kerowgan,M. and Bux,J.
  TITLE     Molecular basis of NB1 (HNA-2a, CD177) deficiency
  JOURNAL   Blood 99 (11), 4231-4233 (2002)
   PUBMED   12010833
REFERENCE   7  (bases 1 to 2195)
  AUTHORS   Temerinac,S., Klippel,S., Strunck,E., Roder,S., Lubbert,M.,
            Lange,W., Azemar,M., Meinhardt,G., Schaefer,H.E. and Pahl,H.L.
  TITLE     Cloning of PRV-1, a novel member of the uPAR receptor superfamily,
            which is overexpressed in polycythemia rubra vera
  JOURNAL   Blood 95 (8), 2569-2576 (2000)
   PUBMED   10753836
REFERENCE   8  (bases 1 to 2195)
  AUTHORS   Stroncek,D.F., Herr,G.P., Maguire,R.B., Eiber,G. and Clement,L.T.
  TITLE     Characterization of the neutrophil molecules identified by
            quinine-dependent antibodies from two patients
  JOURNAL   Transfusion 34 (11), 980-985 (1994)
   PUBMED   7974707
REFERENCE   9  (bases 1 to 2195)
  AUTHORS   Goldschmeding,R., van Dalen,C.M., Faber,N., Calafat,J.,
            Huizinga,T.W., van der Schoot,C.E., Clement,L.T. and von dem
            Borne,A.E.
  TITLE     Further characterization of the NB 1 antigen as a variably
            expressed 56-62 kD GPI-linked glycoprotein of plasma membranes and
            specific granules of neutrophils
  JOURNAL   Br J Haematol 81 (3), 336-345 (1992)
   PUBMED   1382544
REFERENCE   10 (bases 1 to 2195)
  AUTHORS   Lalezari,P., Murphy,G.B. and Allen,F.H. Jr.
  TITLE     NB1, a new neutrophil-specific antigen involved in the pathogenesis
            of neonatal neutropenia
  JOURNAL   J Clin Invest 50 (5), 1108-1115 (1971)
   PUBMED   5552408
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA728784.1, CD514938.1,
            BC029167.1, AY358932.1, AK225226.1, DB323632.1 and BU688145.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020406.3.
            
            Summary: This gene encodes a glycosyl-phosphatidylinositol
            (GPI)-linked cell surface glycoprotein that plays a role in
            neutrophil activation. The protein can bind platelet endothelial
            cell adhesion molecule-1 and function in neutrophil transmigration.
            Mutations in this gene are associated with myeloproliferative
            diseases. Over-expression of this gene has been found in patients
            with polycythemia rubra vera. Autoantibodies against the protein
            may result in pulmonary transfusion reactions, and it may be
            involved in Wegener's granulomatosis. A related pseudogene, which
            is adjacent to this gene on chromosome 19, has been identified.
            [provided by RefSeq, Apr 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.936123.1,
                                           SRR1803617.216737.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000618265.5/ ENSP00000479536.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                DA728784.1         28-52
            26-745              CD514938.1         1-720
            746-1070            BC029167.1         735-1059
            1071-1599           AY358932.1         1058-1586
            1600-2083           AK225226.1         1600-2083
            2084-2179           DB323632.1         16-111              c
            2180-2195           BU688145.1         17-32               c
FEATURES             Location/Qualifiers
     source          1..2195
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..2195
                     /gene="CD177"
                     /gene_synonym="HNA-2a; HNA2A; NB1; NB1 GP; PRV-1; PRV1"
                     /note="CD177 molecule"
                     /db_xref="GeneID:57126"
                     /db_xref="HGNC:HGNC:30072"
                     /db_xref="MIM:162860"
     exon            1..81
                     /gene="CD177"
                     /gene_synonym="HNA-2a; HNA2A; NB1; NB1 GP; PRV-1; PRV1"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1343
                     /gene="CD177"
                     /gene_synonym="HNA-2a; HNA2A; NB1; NB1 GP; PRV-1; PRV1"
                     /note="CD177 antigen; cell surface receptor; NB1
                     glycoprotein; human neutrophil alloantigen 2a;
                     polycythemia rubra vera protein 1"
                     /codon_start=1
                     /product="CD177 antigen precursor"
                     /protein_id="NP_065139.2"
                     /db_xref="CCDS:CCDS62700.1"
                     /db_xref="GeneID:57126"
                     /db_xref="HGNC:HGNC:30072"
                     /db_xref="MIM:162860"
                     /translation="MSAVLLLALLGFILPLPGVQALLCQFGTVQHVWKVSDLPRQWTP
                     KNTSCDSGLGCQDTLMLIESGPQVSLVLSKGCTEAKDQEPRVTEHRMGPGLSLISYTF
                     VCRQEDFCNNLVNSLPLWAPQPPADPGSLRCPVCLSMEGCLEGTTEEICPKGTTHCYD
                     GLLRLRGGGIFSNLRVQGCMPQPVCNLLNGTQEIGPVGMTENCDMKDFLTCHRGTTIM
                     THGNLAQEPTDWTTSNTEMCEVGQVCQETLLLLDVGLTSTLVGTKGCSTVGAQNSQKT
                     TIHSAPPGVLVASYTHFCSSDLCNSASSSSVLLNSLPPQAAPVPGDRQCPTCVQPLGT
                     CSSGSPRMTCPRGATHCYDGYIHLSGGGLSTKMSIQGCVAQPSSFLLNHTRQIGIFSA
                     REKRDVQPPASQHEGGGAEGLESLTWGVGLALAPALWWGVVCPSC"
     exon            82..222
                     /gene="CD177"
                     /gene_synonym="HNA-2a; HNA2A; NB1; NB1 GP; PRV-1; PRV1"
                     /inference="alignment:Splign:2.1.0"
     exon            223..408
                     /gene="CD177"
                     /gene_synonym="HNA-2a; HNA2A; NB1; NB1 GP; PRV-1; PRV1"
                     /inference="alignment:Splign:2.1.0"
     exon            409..531
                     /gene="CD177"
                     /gene_synonym="HNA-2a; HNA2A; NB1; NB1 GP; PRV-1; PRV1"
                     /inference="alignment:Splign:2.1.0"
     exon            532..648
                     /gene="CD177"
                     /gene_synonym="HNA-2a; HNA2A; NB1; NB1 GP; PRV-1; PRV1"
                     /inference="alignment:Splign:2.1.0"
     exon            649..789
                     /gene="CD177"
                     /gene_synonym="HNA-2a; HNA2A; NB1; NB1 GP; PRV-1; PRV1"
                     /inference="alignment:Splign:2.1.0"
     exon            790..975
                     /gene="CD177"
                     /gene_synonym="HNA-2a; HNA2A; NB1; NB1 GP; PRV-1; PRV1"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1110
                     /gene="CD177"
                     /gene_synonym="HNA-2a; HNA2A; NB1; NB1 GP; PRV-1; PRV1"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..2195
                     /gene="CD177"
                     /gene_synonym="HNA-2a; HNA2A; NB1; NB1 GP; PRV-1; PRV1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1580..1585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD177"
                     /gene_synonym="HNA-2a; HNA2A; NB1; NB1 GP; PRV-1; PRV1"
                     /note="hexamer: AATACA"
     polyA_site      1604
                     /gene="CD177"
                     /gene_synonym="HNA-2a; HNA2A; NB1; NB1 GP; PRV-1; PRV1"
                     /note="major polyA site"
     regulatory      2171..2176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD177"
                     /gene_synonym="HNA-2a; HNA2A; NB1; NB1 GP; PRV-1; PRV1"
                     /note="hexamer: AATACA"
     polyA_site      2195
                     /gene="CD177"
                     /gene_synonym="HNA-2a; HNA2A; NB1; NB1 GP; PRV-1; PRV1"
                     /note="major polyA site"
ORIGIN      
        1 agaaagagat taccagccac agacgggtca tgagcgcggt attactgctg gccctcctgg
       61 ggttcatcct cccactgcca ggagtgcagg cgctgctctg ccagtttggg acagttcagc
      121 atgtgtggaa ggtgtccgac ctgccccggc aatggacccc taagaacacc agctgcgaca
      181 gcggcttggg gtgccaggac acgttgatgc tcattgagag cggaccccaa gtgagcctgg
      241 tgctctccaa gggctgcacg gaggccaagg accaggagcc ccgcgtcact gagcaccgga
      301 tgggccccgg cctctccctg atctcctaca ccttcgtgtg ccgccaggag gacttctgca
      361 acaacctcgt taactccctc ccgctttggg ccccacagcc cccagcagac ccaggatcct
      421 tgaggtgccc agtctgcttg tctatggaag gctgtctgga ggggacaaca gaagagatct
      481 gccccaaggg gaccacacac tgttatgatg gcctcctcag gctcagggga ggaggcatct
      541 tctccaatct gagagtccag ggatgcatgc cccagccagt ttgcaacctg ctcaatggga
      601 cacaggaaat tgggcccgtg ggtatgactg agaactgcga tatgaaagat tttctgacct
      661 gtcatcgggg gaccaccatt atgacacacg gaaacttggc tcaagaaccc actgattgga
      721 ccacatcgaa taccgagatg tgcgaggtgg ggcaggtgtg tcaggagacg ctgctgctcc
      781 tagatgtagg actcacatca accctggtgg ggacaaaagg ctgcagcact gttggggctc
      841 aaaattccca gaagaccacc atccactcag cccctcctgg ggtgcttgtg gcctcctata
      901 cccacttctg ctcctcggac ctgtgcaata gtgccagcag cagcagcgtt ctgctgaact
      961 ccctccctcc tcaagctgcc cctgtcccag gagaccggca gtgtcctacc tgtgtgcagc
     1021 cccttggaac ctgttcaagt ggctcccccc gaatgacctg ccccaggggc gccactcatt
     1081 gttatgatgg gtacattcat ctctcaggag gtgggctgtc caccaaaatg agcattcagg
     1141 gctgcgtggc ccaaccttcc agcttcttgt tgaaccacac cagacaaatc gggatcttct
     1201 ctgcgcgtga gaagcgtgat gtgcagcctc ctgcctctca gcatgaggga ggtggggctg
     1261 agggcctgga gtctctcact tggggggtgg ggctggcact ggccccagcg ctgtggtggg
     1321 gagtggtttg cccttcctgc taactctatt acccccacga ttcttcaccg ctgctgacca
     1381 cccacactca acctccctct gacctcataa cctaatggcc ttggacacca gattctttcc
     1441 cattctgtcc atgaatcatc ttccccacac acaatcattc atatctactc acctaacagc
     1501 aacactgggg agagcctgga gcatccggac ttgccctatg ggagagggga cgctggagga
     1561 gtggctgcat gtatctgata atacagaccc tgtcctttct cccagtgctg ggatttctcc
     1621 atgtgagggg gcagcaggac acccagggat ctagcgtggg ggaggagagg agcctaatga
     1681 gaaaatgacc atctaaagcc tgcccttcat tggtctggtt cacgtctcca aaccagcttg
     1741 gatggtagca gagacttcag ggtgctccag ccaaacgtat ttgggcatca ccatgacctg
     1801 ggaggggaag atgcactgag acgtatgagg cttccagcct agcagccagg gccctagcac
     1861 aaacaggagg ctcgccccat ctgagcaact gcaggagagg ttagtacagt catgcattgc
     1921 ttaacgacag ggacgtgtcg ttagaaatgt gtcgttaggt gattttatga ccataggaac
     1981 attgtagcgt gcacttacac caacccagat ggtacagccc aatacacacc caggatggac
     2041 gctagagtcg actgctccta ggctacaagc ctgcagtgca tgttatggtg tgaatactgc
     2101 aggcaatctt aacaccacgg caagtatttg tgcatctaca cacatctaaa catagaaaag
     2161 gtacagcata aatacactat tgtcatctca gcaga
//
