LOCUS       NM_006016               3020 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens CD164 molecule (CD164), transcript variant 1, mRNA.
ACCESSION   NM_006016
VERSION     NM_006016.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3020)
  AUTHORS   Liu,J., Knopp,K.A., Rackaityte,E., Wang,C.Y., Laurie,M.T.,
            Sunshine,S., Puschnik,A.S. and DeRisi,J.L.
  TITLE     Genome-Wide Knockout Screen Identifies Human Sialomucin CD164 as an
            Essential Entry Factor for Lymphocytic Choriomeningitis Virus
  JOURNAL   mBio 13 (3), e0020522 (2022)
   PUBMED   35502904
  REMARK    GeneRIF: Genome-Wide Knockout Screen Identifies Human Sialomucin
            CD164 as an Essential Entry Factor for Lymphocytic Choriomeningitis
            Virus.
REFERENCE   2  (bases 1 to 3020)
  AUTHORS   Ozieblo,D., Lee,S.Y., Leja,M.L., Sarosiak,A., Baldyga,N.,
            Skarzynski,H., Kim,Y., Han,J.H., Yoo,H.S., Park,M.H., Choi,B.Y. and
            Oldak,M.
  TITLE     Update on CD164 and LMX1A genes to strengthen their causative role
            in autosomal dominant hearing loss
  JOURNAL   Hum Genet 141 (3-4), 445-453 (2022)
   PUBMED   35254497
  REMARK    GeneRIF: Update on CD164 and LMX1A genes to strengthen their
            causative role in autosomal dominant hearing loss.
REFERENCE   3  (bases 1 to 3020)
  AUTHORS   Bakkers,M.J.G., Moon-Walker,A., Herlo,R., Brusic,V., Stubbs,S.H.,
            Hastie,K.M., Saphire,E.O., Kirchhausen,T.L. and Whelan,S.P.J.
  TITLE     CD164 is a host factor for lymphocytic choriomeningitis virus entry
  JOURNAL   Proc Natl Acad Sci U S A 119 (10), e2119676119 (2022)
   PUBMED   35235462
  REMARK    GeneRIF: CD164 is a host factor for lymphocytic choriomeningitis
            virus entry.
REFERENCE   4  (bases 1 to 3020)
  AUTHORS   Zhang,X.W., Li,S.L., Zhang,D., Sun,X.L. and Zhai,H.J.
  TITLE     RP11-619L19.2 promotes colon cancer development by regulating the
            miR-1271-5p/CD164 axis
  JOURNAL   Oncol Rep 44 (6), 2419-2428 (2020)
   PUBMED   33125110
  REMARK    GeneRIF: RP11619L19.2 promotes colon cancer development by
            regulating the miR12715p/CD164 axis.
REFERENCE   5  (bases 1 to 3020)
  AUTHORS   Zhang,L., Wang,Y. and Su,H.
  TITLE     Long non-coding RNA LINC00152/miR-613/CD164 axis regulates cell
            proliferation, apoptosis, migration and invasion in glioma via
            PI3K/AKT pathway
  JOURNAL   Neoplasma 67 (4), 762-772 (2020)
   PUBMED   32726126
  REMARK    GeneRIF: Long non-coding RNA LINC00152/miR-613/CD164 axis regulates
            cell proliferation, apoptosis, migration and invasion in glioma via
            PI3K/AKT pathway.
REFERENCE   6  (bases 1 to 3020)
  AUTHORS   Doyonnas,R., Yi-Hsin Chan,J., Butler,L.H., Rappold,I.,
            Lee-Prudhoe,J.E., Zannettino,A.C., Simmons,P.J., Buhring,H.J.,
            Levesque,J.P. and Watt,S.M.
  TITLE     CD164 monoclonal antibodies that block hemopoietic progenitor cell
            adhesion and proliferation interact with the first mucin domain of
            the CD164 receptor
  JOURNAL   J Immunol 165 (2), 840-851 (2000)
   PUBMED   10878358
REFERENCE   7  (bases 1 to 3020)
  AUTHORS   Kurosawa,N., Kanemitsu,Y., Matsui,T., Shimada,K., Ishihama,H. and
            Muramatsu,T.
  TITLE     Genomic analysis of a murine cell-surface sialomucin, MGC-24/CD164
  JOURNAL   Eur J Biochem 265 (1), 466-472 (1999)
   PUBMED   10491205
REFERENCE   8  (bases 1 to 3020)
  AUTHORS   Zannettino,A.C., Buhring,H.J., Niutta,S., Watt,S.M., Benton,M.A.
            and Simmons,P.J.
  TITLE     The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein
            expressed by human hematopoietic progenitors and bone marrow
            stromal cells that serves as a potent negative regulator of
            hematopoiesis
  JOURNAL   Blood 92 (8), 2613-2628 (1998)
   PUBMED   9763543
REFERENCE   9  (bases 1 to 3020)
  AUTHORS   Watt,S.M., Buhring,H.J., Rappold,I., Chan,J.Y., Lee-Prudhoe,J.,
            Jones,T., Zannettino,A.C., Simmons,P.J., Doyonnas,R., Sheer,D. and
            Butler,L.H.
  TITLE     CD164, a novel sialomucin on CD34(+) and erythroid subsets, is
            located on human chromosome 6q21
  JOURNAL   Blood 92 (3), 849-866 (1998)
   PUBMED   9680353
REFERENCE   10 (bases 1 to 3020)
  AUTHORS   Masuzawa,Y., Miyauchi,T., Hamanoue,M., Ando,S., Yoshida,J.,
            Takao,S., Shimazu,H., Adachi,M. and Muramatsu,T.
  TITLE     A novel core protein as well as polymorphic epithelial mucin carry
            peanut agglutinin binding sites in human gastric carcinoma cells:
            sequence analysis and examination of gene expression
  JOURNAL   J Biochem 112 (5), 609-615 (1992)
   PUBMED   1478919
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL359711.18.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006016.5.
            
            Summary: This gene encodes a transmembrane sialomucin and cell
            adhesion molecule that regulates the proliferation, adhesion and
            migration of hematopoietic progenitor cells. The encoded protein
            also interacts with the C-X-C chemokine receptor type 4 and may
            regulate muscle development. Elevated expression of this gene has
            been observed in human patients with Sezary syndrome, a type of
            blood cancer, and a mutation in this gene may be associated with
            impaired hearing. [provided by RefSeq, Oct 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.888542.1,
                                           SRR1803616.179464.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03568911 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310786.10/ ENSP00000309376.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               AL359711.18        104644-104907       c
            265-348             AL359711.18        102019-102102       c
            349-420             AL359711.18        100340-100411       c
            421-459             AL359711.18        98514-98552         c
            460-516             AL359711.18        92851-92907         c
            517-3020            AL359711.18        88954-91457         c
FEATURES             Location/Qualifiers
     source          1..3020
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..3020
                     /gene="CD164"
                     /gene_synonym="DFNA66; endolyn; MGC-24; MGC-24v; MUC-24"
                     /note="CD164 molecule"
                     /db_xref="GeneID:8763"
                     /db_xref="HGNC:HGNC:1632"
                     /db_xref="MIM:603356"
     exon            1..264
                     /gene="CD164"
                     /gene_synonym="DFNA66; endolyn; MGC-24; MGC-24v; MUC-24"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..683
                     /gene="CD164"
                     /gene_synonym="DFNA66; endolyn; MGC-24; MGC-24v; MUC-24"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CD164 antigen, sialomucin; sialomucin core
                     protein 24; multi-glycosylated core protein 24"
                     /codon_start=1
                     /product="sialomucin core protein 24 isoform 1 precursor"
                     /protein_id="NP_006007.2"
                     /db_xref="CCDS:CCDS5073.1"
                     /db_xref="GeneID:8763"
                     /db_xref="HGNC:HGNC:1632"
                     /db_xref="MIM:603356"
                     /translation="MSRLSRSLLWAATCLGVLCVLSADKNTTQHPNVTTLAPISNVTS
                     APVTSLPLVTTPAPETCEGRNSCVSCFNVSVVNTTCFWIECKDESYCSHNSTVSDCQV
                     GNTTDFCSVSTATPVPTANSTAKPTVQPSPSTTSKTVTTSGTTNNTVTPTSQPVRKST
                     FDAASFIGGIVLVLGVQAVIFFLYKFCKSKERNYHTL"
     exon            265..348
                     /gene="CD164"
                     /gene_synonym="DFNA66; endolyn; MGC-24; MGC-24v; MUC-24"
                     /inference="alignment:Splign:2.1.0"
     exon            349..420
                     /gene="CD164"
                     /gene_synonym="DFNA66; endolyn; MGC-24; MGC-24v; MUC-24"
                     /inference="alignment:Splign:2.1.0"
     exon            421..459
                     /gene="CD164"
                     /gene_synonym="DFNA66; endolyn; MGC-24; MGC-24v; MUC-24"
                     /inference="alignment:Splign:2.1.0"
     exon            460..516
                     /gene="CD164"
                     /gene_synonym="DFNA66; endolyn; MGC-24; MGC-24v; MUC-24"
                     /inference="alignment:Splign:2.1.0"
     exon            517..3020
                     /gene="CD164"
                     /gene_synonym="DFNA66; endolyn; MGC-24; MGC-24v; MUC-24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2235..2240
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD164"
                     /gene_synonym="DFNA66; endolyn; MGC-24; MGC-24v; MUC-24"
                     /note="hexamer: ATTAAA"
     polyA_site      2255
                     /gene="CD164"
                     /gene_synonym="DFNA66; endolyn; MGC-24; MGC-24v; MUC-24"
                     /note="major polyA site"
     regulatory      2994..2999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD164"
                     /gene_synonym="DFNA66; endolyn; MGC-24; MGC-24v; MUC-24"
                     /note="hexamer: AATAAA"
     polyA_site      3020
                     /gene="CD164"
                     /gene_synonym="DFNA66; endolyn; MGC-24; MGC-24v; MUC-24"
                     /note="major polyA site"
ORIGIN      
        1 agtctcggag gcggcgccgc aggggattga ggggttgact gagcgttgcg agccttagct
       61 ttctcccgaa cgccagcgct gaggacacga tgtcgcggct ctcccgctca ctgctttggg
      121 ccgccacctg cctgggcgtg ctctgcgtgc tgtccgcgga caagaacacg acccagcacc
      181 cgaacgtgac gactttagcg cccatctcca acgtaacctc ggcgccggtg acgtccctcc
      241 cgctggtcac cactccggca ccagaaacct gtgaaggtcg aaacagctgc gtttcctgtt
      301 ttaatgttag cgttgttaat actacctgct tttggataga atgtaaagat gagagctatt
      361 gttcacataa ctcaacagtt agtgattgtc aagtggggaa cacgacagac ttctgttccg
      421 tttccacggc cactccagtg ccaacagcca attctacagc taaacccaca gttcagccct
      481 ccccttctac aacttccaag acagttacta catcaggtac aacaaataac actgtgactc
      541 caacctcaca acctgtgcga aagtctacct ttgatgcagc cagtttcatt ggaggaattg
      601 tcctggtctt gggtgtgcag gctgtaattt tctttcttta taaattctgc aaatctaaag
      661 aacgaaatta ccacactctg taaacagacc cattgaatta ataaggactg gtgattcatt
      721 tgtgtaactc actgaagcca aaatactatc ttttaagatg tcccacatgg aagacgctat
      781 tccaggatct ttaaatttcc atggatgcat ataggatgtt tgggagcatc atccgtgaag
      841 aaaaaatcaa ttaaatcatt gtgttcaaca ggaatattta aaatattctg catgaatcct
      901 gtggctgtct tattttaaat agctgctgct gtgggattat attttttttc cttaacatgc
      961 caaatataac tttctgaaag tgatggaaaa tgttgtcttg tgcagacaac atcatggctc
     1021 ttggcagttt aaatttagta attttaattt agtgaacaga attgagaaga acgtgccaaa
     1081 tgagaatcaa ttaggtggat ttttggctgt catttcaaaa gtggaataaa tttattaatt
     1141 tagtagtact aaatggtatc cttagattaa aattttgtgc ttgataacag ctgttttttc
     1201 tacattagaa ataagatgcc acacaaggaa ctacattcca gatttaaaga aatgaaagga
     1261 taccattagt gtgtataaca gattattgtt catacttgta aagcatctta tgtcattgag
     1321 aatataaaga acagtgcctt agaagacagt gaaaggtaag ctctagctta atgtctatga
     1381 tttgttcttt gacattaagg aaggtaagga ttggtcagag gatgtaactt gatgtgagca
     1441 gtagtaaacc tgttttagat atcatactgt taatatttta ttgaaaattt atttcagagc
     1501 ggagaaactt aagctaaagt ctgttataca gaattgaaag ccttcgtatc ttgaacctcc
     1561 caacattttt cttatggctg ttgaaaagta tagagctaaa ttgatttaat tacactttcc
     1621 tttgtacttt aaaaaaaagt atgctagcac tattgtacct tgaaaggatt tccaccagac
     1681 tgtcttgagt agtgacttct ttggtgaggc aagaaggata tacattattt tagaatcatt
     1741 tactatttaa atgagacaat catattattt tagaatcatt tattttaaat gagacaatca
     1801 ttttaagttt taagataaca gaagtgacca atgtaatttc acaacaccta aggatttttt
     1861 ggttgatcag gttactgtag atttttactg attgtcctgg atgaatagac tgtgcttttt
     1921 ctttttctct cccttccttc ttggtttccc atagtataat aagcatgcat actttaactt
     1981 ctatagtttt ctcctttaga gggtcgtctt cagttttaga ggtttacttc tcccttgcct
     2041 ttgactcatt ggactagtgc agaggcttta agtagtttaa aatgggcttt tgcttttcta
     2101 ggtcattaac gttttttatt tagtttcttt agccaatagt ggctgagttt cgcacttgat
     2161 tttcaatatt ttatagtaag aaatgacaaa ctgctttgtt tcatttcata aacaaactct
     2221 gcatttagat aactattaaa ggttgttaag atgaagattt actgtttctt tgttactcgt
     2281 tggtacagct gtttgtttta cttgcacatt tgtacatata cttaatgttt tcaagtgcct
     2341 taattgttta aaatctctgg cttcaaagtt tcttggggaa aggtcggttt acctcacatt
     2401 ttttgtttcc attagtaata ttctaggtac ctcacaaaat gtattatggt gccatggctg
     2461 ttagttttta gtgagtgctg taggattaat tcgaaaatag gcagaattcc attcctccca
     2521 aggtggcaaa aattagctat actgatgtaa ttgtcattta cctgggtatg aattccctga
     2581 cacacattca tgtcaacata tgtagcaaat tttgtgaaaa cataacaatt tgaagcttct
     2641 gtaattttga gcactgctct aacaacaagc ataatataaa attagttaga ttttgcaagt
     2701 ctacaaatga gctcttgcaa cagaactcac agccttttta cttttttccc ctaactttag
     2761 caatgtagta tcttgagcca ttaatttttg ggttttttta aaatccagaa ggtatataga
     2821 aaccttttca gatttttcat ctgatttgtt cttgcagatg ttcttctatc aaatacctta
     2881 ttttacctta cagatatttg ttgcacaggc agatactgct gtatttagac atttctattt
     2941 cagttcatta aaaactgcaa aaccaatctg tatcatgtac caaactgact taaaataaat
     3001 ctacatgttt attgaattaa
//
