LOCUS       NM_174941               4583 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens CD163 molecule like 1 (CD163L1), transcript variant 2,
            mRNA.
ACCESSION   NM_174941
VERSION     NM_174941.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4583)
  AUTHORS   Schieffer,K.M., Emrich,S.M., Yochum,G.S. and Koltun,W.A.
  TITLE     CD163L1+CXCL10+ Macrophages are Enriched Within Colonic Lamina
            Propria of Diverticulitis Patients
  JOURNAL   J Surg Res 267, 527-535 (2021)
   PUBMED   34256195
  REMARK    GeneRIF: CD163L1(+)CXCL10(+) Macrophages are Enriched Within
            Colonic Lamina Propria of Diverticulitis Patients.
REFERENCE   2  (bases 1 to 4583)
  AUTHORS   Orvedahl,A., Sumpter,R. Jr., Xiao,G., Ng,A., Zou,Z., Tang,Y.,
            Narimatsu,M., Gilpin,C., Sun,Q., Roth,M., Forst,C.V., Wrana,J.L.,
            Zhang,Y.E., Luby-Phelps,K., Xavier,R.J., Xie,Y. and Levine,B.
  TITLE     Image-based genome-wide siRNA screen identifies selective autophagy
            factors
  JOURNAL   Nature 480 (7375), 113-117 (2011)
   PUBMED   22020285
REFERENCE   3  (bases 1 to 4583)
  AUTHORS   Brocheriou,I., Maouche,S., Durand,H., Braunersreuther,V., Le
            Naour,G., Gratchev,A., Koskas,F., Mach,F., Kzhyshkowska,J. and
            Ninio,E.
  TITLE     Antagonistic regulation of macrophage phenotype by M-CSF and
            GM-CSF: implication in atherosclerosis
  JOURNAL   Atherosclerosis 214 (2), 316-324 (2011)
   PUBMED   21159337
REFERENCE   4  (bases 1 to 4583)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 4583)
  AUTHORS   Van Gorp,H., Van Breedam,W., Van Doorsselaere,J., Delputte,P.L. and
            Nauwynck,H.J.
  TITLE     Identification of the CD163 protein domains involved in infection
            of the porcine reproductive and respiratory syndrome virus
  JOURNAL   J Virol 84 (6), 3101-3105 (2010)
   PUBMED   20032174
REFERENCE   6  (bases 1 to 4583)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   7  (bases 1 to 4583)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 4583)
  AUTHORS   Gronlund,J., Vitved,L., Lausen,M., Skjodt,K. and Holmskov,U.
  TITLE     Cloning of a novel scavenger receptor cysteine-rich type I
            transmembrane molecule (M160) expressed by human macrophages
  JOURNAL   J Immunol 165 (11), 6406-6415 (2000)
   PUBMED   11086079
REFERENCE   9  (bases 1 to 4583)
  AUTHORS   Stover,C.M., Schleypen,J., Gronlund,J., Speicher,M.R.,
            Schwaeble,W.J. and Holmskov,U.
  TITLE     Assignment of CD163B, the gene encoding M160, a novel scavenger
            receptor, to human chromosome 12p13.3 by in situ hybridization and
            somatic cell hybrid analysis
  JOURNAL   Cytogenet Cell Genet 90 (3-4), 246-247 (2000)
   PUBMED   11124526
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC131206.2, AC131207.4 and
            AC131205.3.
            
            On Feb 27, 2020 this sequence version replaced NM_174941.5.
            
            Summary: This gene encodes a member of the scavenger receptor
            cysteine-rich (SRCR) superfamily. Members of this family are
            secreted or membrane-anchored proteins mainly found in cells
            associated with the immune system. The SRCR family is defined by a
            100-110 amino acid SRCR domain, which may mediate protein-protein
            interaction and ligand binding. The encoded protein contains twelve
            SRCR domains, a transmembrane region and a cytoplasmic domain.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region compared to variant 1. The
            encoded isoform (2) is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF264014.1, SRR1803613.248299.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313599.8/ ENSP00000315945.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC131206.2         27806-27862         c
            58-150              AC131206.2         24863-24955         c
            151-471             AC131206.2         17083-17403         c
            472-792             AC131206.2         16125-16445         c
            793-1113            AC131207.4         34895-35215         c
            1114-1434           AC131207.4         31898-32218         c
            1435-1755           AC131207.4         26627-26947         c
            1756-2076           AC131207.4         24458-24778         c
            2077-2397           AC131207.4         7341-7661           c
            2398-2712           AC131207.4         4063-4377           c
            2713-3027           AC131207.4         3644-3958           c
            3028-3120           AC131207.4         3194-3286           c
            3121-3435           AC131207.4         2805-3119           c
            3436-3756           AC131205.3         1-321
            3757-4065           AC131205.3         3976-4284
            4066-4098           AC131205.3         4676-4708
            4099-4209           AC131205.3         5444-5554
            4210-4305           AC131205.3         6310-6405
            4306-4412           AC131205.3         16155-16261
            4413-4583           AC131205.3         18511-18681
FEATURES             Location/Qualifiers
     source          1..4583
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..4583
                     /gene="CD163L1"
                     /gene_synonym="CD163B; M160; SCARI2; STAR; WC1"
                     /note="CD163 molecule like 1"
                     /db_xref="GeneID:283316"
                     /db_xref="HGNC:HGNC:30375"
                     /db_xref="MIM:606079"
     exon            1..57
                     /gene="CD163L1"
                     /gene_synonym="CD163B; M160; SCARI2; STAR; WC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..4388
                     /gene="CD163L1"
                     /gene_synonym="CD163B; M160; SCARI2; STAR; WC1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; CD163 antigen-like 1; CD163 antigen B;
                     scavenger receptor cysteine-rich type 1 protein M160"
                     /codon_start=1
                     /product="scavenger receptor cysteine-rich type 1 protein
                     M160 isoform 2 precursor"
                     /protein_id="NP_777601.3"
                     /db_xref="CCDS:CCDS8577.1"
                     /db_xref="GeneID:283316"
                     /db_xref="HGNC:HGNC:30375"
                     /db_xref="MIM:606079"
                     /translation="MMLPQNSWHIDFGRCCCHQNLFSAVVTCILLLNSCFLISSFNGT
                     DLELRLVNGDGPCSGTVEVKFQGQWGTVCDDGWNTTASTVVCKQLGCPFSFAMFRFGQ
                     AVTRHGKIWLDDVSCYGNESALWECQHREWGSHNCYHGEDVGVNCYGEANLGLRLVDG
                     NNSCSGRVEVKFQERWGTICDDGWNLNTAAVVCRQLGCPSSFISSGVVNSPAVLRPIW
                     LDDILCQGNELALWNCRHRGWGNHDCSHNEDVTLTCYDSSDLELRLVGGTNRCMGRVE
                     LKIQGRWGTVCHHKWNNAAADVVCKQLGCGTALHFAGLPHLQSGSDVVWLDGVSCSGN
                     ESFLWDCRHSGTVNFDCLHQNDVSVICSDGADLELRLADGSNNCSGRVEVRIHEQWWT
                     ICDQNWKNEQALVVCKQLGCPFSVFGSRRAKPSNEARDIWINSISCTGNESALWDCTY
                     DGKAKRTCFRRSDAGVICSDKADLDLRLVGAHSPCYGRLEVKYQGEWGTVCHDRWSTR
                     NAAVVCKQLGCGKPLHVFGMTYFKEASGPIWLDDVSCIGNESNIWDCEHSGWGKHNCV
                     HREDVIVTCSGDATWGLRLVGGSNRCSGRLEVYFQGRWGTVCDDGWNSKAAAVVCSQL
                     DCPSSIIGMGLGNASTGYGKIWLDDVSCDGDESDLWSCRNSGWGNNDCSHSEDVGVIC
                     SDASDMELRLVGGSSRCAGKVEVNVQGAVGILCANGWGMNIAEVVCRQLECGSAIRVS
                     REPHFTERTLHILMSNSGCTGGEASLWDCIRWEWKQTACHLNMEASLICSAHRQPRLV
                     GADMPCSGRVEVKHADTWRSVCDSDFSLHAANVLCRELNCGDAISLSVGDHFGKGNGL
                     TWAEKFQCEGSETHLALCPIVQHPEDTCIHSREVGVVCSRYTDVRLVNGKSQCDGQVE
                     INVLGHWGSLCDTHWDPEDARVLCRQLSCGTALSTTGGKYIGERSVRVWGHRFHCLGN
                     ESLLDNCQMTVLGAPPCIHGNTVSVICTGSLTQPLFPCLANVSDPYLSAVPEGSALIC
                     LEDKRLRLVDGDSRCAGRVEIYHDGFWGTICDDGWDLSDAHVVCQKLGCGVAFNATVS
                     AHFGEGSGPIWLDDLNCTGMESHLWQCPSRGWGQHDCRHKEDAGVICSEFTALRLYSE
                     TETESCAGRLEVFYNGTWGSVGRRNITTAIAGIVCRQLGCGENGVVSLAPLSKTGSGF
                     MWVDDIQCPKTHISIWQCLSAPWERRISSPAEETWITCEDRIRVRGGDTECSGRVEIW
                     HAGSWGTVCDDSWDLAEAEVVCQQLGCGSALAALRDASFGQGTGTIWLDDMRCKGNES
                     FLWDCHAKPWGQSDCGHKEDAGVRCSGQSLKSLNASSGHLALILSSIFGLLLLVLFIL
                     FLTWCRVQKQKHLPLRVSTRRRGSLEENLFHEMETCLKREDPHGTRTSDDTPNHGCED
                     ASDTSLLGVLPASEATK"
     exon            58..150
                     /gene="CD163L1"
                     /gene_synonym="CD163B; M160; SCARI2; STAR; WC1"
                     /inference="alignment:Splign:2.1.0"
     exon            151..471
                     /gene="CD163L1"
                     /gene_synonym="CD163B; M160; SCARI2; STAR; WC1"
                     /inference="alignment:Splign:2.1.0"
     exon            472..792
                     /gene="CD163L1"
                     /gene_synonym="CD163B; M160; SCARI2; STAR; WC1"
                     /inference="alignment:Splign:2.1.0"
     exon            793..1113
                     /gene="CD163L1"
                     /gene_synonym="CD163B; M160; SCARI2; STAR; WC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1434
                     /gene="CD163L1"
                     /gene_synonym="CD163B; M160; SCARI2; STAR; WC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1755
                     /gene="CD163L1"
                     /gene_synonym="CD163B; M160; SCARI2; STAR; WC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..2076
                     /gene="CD163L1"
                     /gene_synonym="CD163B; M160; SCARI2; STAR; WC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2397
                     /gene="CD163L1"
                     /gene_synonym="CD163B; M160; SCARI2; STAR; WC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2712
                     /gene="CD163L1"
                     /gene_synonym="CD163B; M160; SCARI2; STAR; WC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..3027
                     /gene="CD163L1"
                     /gene_synonym="CD163B; M160; SCARI2; STAR; WC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3028..3120
                     /gene="CD163L1"
                     /gene_synonym="CD163B; M160; SCARI2; STAR; WC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3121..3435
                     /gene="CD163L1"
                     /gene_synonym="CD163B; M160; SCARI2; STAR; WC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3436..3756
                     /gene="CD163L1"
                     /gene_synonym="CD163B; M160; SCARI2; STAR; WC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3757..4065
                     /gene="CD163L1"
                     /gene_synonym="CD163B; M160; SCARI2; STAR; WC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4066..4098
                     /gene="CD163L1"
                     /gene_synonym="CD163B; M160; SCARI2; STAR; WC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4099..4209
                     /gene="CD163L1"
                     /gene_synonym="CD163B; M160; SCARI2; STAR; WC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4210..4305
                     /gene="CD163L1"
                     /gene_synonym="CD163B; M160; SCARI2; STAR; WC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4306..4412
                     /gene="CD163L1"
                     /gene_synonym="CD163B; M160; SCARI2; STAR; WC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4413..4583
                     /gene="CD163L1"
                     /gene_synonym="CD163B; M160; SCARI2; STAR; WC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4551..4556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD163L1"
                     /gene_synonym="CD163B; M160; SCARI2; STAR; WC1"
                     /note="hexamer: AATAAA"
     polyA_site      4583
                     /gene="CD163L1"
                     /gene_synonym="CD163B; M160; SCARI2; STAR; WC1"
                     /note="major polyA site"
ORIGIN      
        1 aggactcagg aagagataga cccataatga tgctgcctca aaactcgtgg catattgatt
       61 ttggaagatg ctgctgtcat cagaaccttt tctctgctgt ggtaacttgc atcctgctcc
      121 tgaattcctg ctttctcatc agcagtttta atggaacaga tttggagttg aggctggtca
      181 atggagacgg tccctgctct gggacagtgg aggtgaaatt ccagggacag tgggggactg
      241 tgtgtgatga tgggtggaac actactgcct caactgtcgt gtgcaaacag cttggatgtc
      301 cattttcttt cgccatgttt cgttttggac aagccgtgac tagacatgga aaaatttggc
      361 ttgatgatgt ttcctgttat ggaaatgagt cagctctctg ggaatgtcaa caccgggaat
      421 ggggaagcca taactgttat catggagaag atgttggtgt gaactgttat ggtgaagcca
      481 atctgggttt gaggctagtg gatggaaaca actcctgttc agggagagtg gaggtgaaat
      541 tccaagaaag gtggggaact atatgtgatg atgggtggaa cttgaatact gctgccgtgg
      601 tgtgcaggca actaggatgt ccatcttctt ttatttcttc tggagttgtt aatagccctg
      661 ctgtattgcg ccccatttgg ctggatgaca ttttatgcca ggggaatgag ttggcactct
      721 ggaattgcag acatcgtgga tggggaaatc atgactgcag tcacaatgag gatgtcacat
      781 taacttgtta tgatagtagt gatcttgaac taaggcttgt aggtggaact aaccgctgta
      841 tggggagagt agagctgaaa atccaaggaa ggtgggggac cgtatgccac cataagtgga
      901 acaatgctgc agctgatgtc gtatgcaagc agttgggatg tggaaccgca cttcacttcg
      961 ctggcttgcc tcatttgcag tcagggtctg atgttgtatg gcttgatggt gtctcctgct
     1021 ccggtaatga atcttttctt tgggactgca gacattccgg aaccgtcaat tttgactgtc
     1081 ttcatcaaaa cgatgtgtct gtgatctgct cagatggagc agatttggaa ctgcgactag
     1141 cagatggaag taacaattgt tcagggagag tagaggtgag aattcatgaa cagtggtgga
     1201 caatatgtga ccagaactgg aagaatgaac aagcccttgt ggtttgtaag cagctaggat
     1261 gtccgttcag cgtctttggc agtcgtcgtg ctaaacctag taatgaagct agagacattt
     1321 ggataaacag catatcttgc actgggaatg agtcagctct ctgggactgc acatatgatg
     1381 gaaaagcaaa gcgaacatgc ttccgaagat cagatgctgg agtaatttgt tctgataagg
     1441 cagatctgga cctaaggctt gtcggggctc atagcccctg ttatgggaga ttggaggtga
     1501 aataccaagg agagtggggg actgtgtgtc atgacagatg gagcacaagg aatgcagctg
     1561 ttgtttgtaa acaattggga tgtggaaagc ctttgcatgt gtttggtatg acctatttta
     1621 aagaagcatc aggacctatt tggctggatg acgtttcttg cattggaaat gagtcaaata
     1681 tctgggactg tgaacacagt ggatggggaa agcataattg tgtacacaga gaggatgtga
     1741 ttgtaacctg ctcaggtgat gcaacatggg gcctgaggct ggtgggcggc agcaaccgct
     1801 gctcgggaag actggaggtg tactttcaag gacggtgggg cacagtgtgt gatgacggct
     1861 ggaacagtaa agctgcagct gtggtgtgta gccagctgga ctgcccatct tctatcattg
     1921 gcatgggtct gggaaacgct tctacaggat atggaaaaat ttggctcgat gatgtttcct
     1981 gtgatggaga tgagtcagat ctctggtcat gcaggaacag tgggtgggga aataatgact
     2041 gcagtcacag tgaagatgtt ggagtgatct gttctgatgc atcggatatg gagctgaggc
     2101 ttgtgggtgg aagcagcagg tgtgctggaa aagttgaggt gaatgtccag ggtgccgtgg
     2161 gaattctgtg tgctaatggc tggggaatga acattgctga agttgtttgc aggcaacttg
     2221 aatgtgggtc tgcaatcagg gtctccagag agcctcattt cacagaaaga acattacaca
     2281 tcttaatgtc gaattctggc tgcactggag gggaagcctc tctctgggat tgtatacgat
     2341 gggagtggaa acagactgcg tgtcatttaa atatggaagc aagtttgatc tgctcagccc
     2401 acaggcagcc caggctggtt ggagctgata tgccctgctc tggacgtgtt gaagtgaaac
     2461 atgcagacac atggcgctct gtctgtgatt ctgatttctc tcttcatgct gccaatgtgc
     2521 tgtgcagaga attaaactgt ggagatgcca tatctctttc tgtgggagat cactttggaa
     2581 aagggaatgg tctaacttgg gccgaaaagt tccagtgtga agggagtgaa actcaccttg
     2641 cattatgccc cattgttcaa catccggaag acacttgtat ccacagcaga gaagttggag
     2701 ttgtctgttc ccgatataca gatgtccgac ttgtgaatgg caaatcccag tgtgacgggc
     2761 aagtggagat caacgtgctt ggacactggg gctcactgtg tgacacccac tgggacccag
     2821 aagatgcccg tgttctatgc agacagctca gctgtgggac tgctctctca accacaggag
     2881 gaaaatatat tggagaaaga agtgttcgtg tgtggggaca caggtttcat tgcttaggga
     2941 atgagtcact tctggataac tgtcaaatga cagttcttgg agcacctccc tgtatccatg
     3001 gaaatactgt ctctgtgatc tgcacaggaa gcctgaccca gccactgttt ccatgcctcg
     3061 caaatgtatc tgacccatat ttgtctgcag ttccagaggg cagtgctttg atctgcttag
     3121 aggacaaacg gctccgccta gtggatgggg acagccgctg tgccgggaga gtagagatct
     3181 atcacgacgg cttctggggc accatctgtg atgacggctg ggacctgagc gatgcccacg
     3241 tggtgtgtca aaagctgggc tgtggagtgg ccttcaatgc cacggtctct gctcactttg
     3301 gggaggggtc agggcccatc tggctggatg acctgaactg cacaggaatg gagtcccact
     3361 tgtggcagtg cccttcccgc ggctgggggc agcacgactg caggcacaag gaggacgcag
     3421 gggtcatctg ctcagaattc acagccttga ggctctacag tgaaactgaa acagagagct
     3481 gtgctgggag attggaagtc ttctataacg ggacctgggg cagcgtcggc aggaggaaca
     3541 tcaccacagc catagcaggc attgtgtgca ggcagctggg ctgtggggag aatggagttg
     3601 tcagcctcgc ccctttatct aagacaggct ctggtttcat gtgggtggat gacattcagt
     3661 gtcctaaaac gcatatctcc atatggcagt gcctgtctgc cccatgggag cgaagaatct
     3721 ccagcccagc agaagagacc tggatcacat gtgaagatag aataagagtg cgtggaggag
     3781 acaccgagtg ctctgggaga gtggagatct ggcacgcagg ctcctggggc acagtgtgtg
     3841 atgactcctg ggacctggcc gaggcggaag tggtgtgtca gcagctgggc tgtggctctg
     3901 ctctggctgc cctgagggac gcttcgtttg gccagggaac tggaaccatc tggttggatg
     3961 acatgcggtg caaaggaaat gagtcatttc tatgggactg tcacgccaaa ccctggggac
     4021 agagtgactg tggacacaag gaagatgctg gcgtgaggtg ctctggacag tcgctgaaat
     4081 cactgaatgc ctcctcaggt catttagcac ttattttatc cagtatcttt gggctccttc
     4141 tcctggttct gtttattcta tttctcacgt ggtgccgagt tcagaaacaa aaacatctgc
     4201 ccctcagagt ttcaaccaga aggaggggtt ctctcgagga gaatttattc catgagatgg
     4261 agacctgcct caagagagag gacccacatg ggacaagaac ctcagatgac acccccaacc
     4321 atggttgtga agatgctagc gacacatcgc tgttgggagt tcttcctgcc tctgaagcca
     4381 caaaatgact ttagacttcc agggctcacc agatcaacct ctaaatatct ttgaaggaga
     4441 caacaacttt taaatgaata aagaggaagt caagttgccc tatggaaaac ttgtccaaat
     4501 aacatttctt gaacaatagg agaacagcta aattgataaa gactggtgat aataaaaatt
     4561 gaattatgta tatcactgtt aaa
//
