LOCUS       NM_203416               4071 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens CD163 molecule (CD163), transcript variant 2, mRNA.
ACCESSION   NM_203416
VERSION     NM_203416.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4071)
  AUTHORS   Hemida,A.S., Ahmed,M.M. and Tantawy,M.S.
  TITLE     HOXA9 and CD163 potentiate pancreatic ductal adenocarcinoma
            progression
  JOURNAL   Diagn Pathol 19 (1), 141 (2024)
   PUBMED   39462379
  REMARK    GeneRIF: HOXA9 and CD163 potentiate pancreatic ductal
            adenocarcinoma progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4071)
  AUTHORS   Sun,H., Wang,Z.Y., Han,Y., Wei,X.J., Wang,Y.C. and Yu,X.F.
  TITLE     CD163+ macrophage density in perimysial connective tissue
            associated with prognosis in IMNM
  JOURNAL   Ann Clin Transl Neurol 11 (5), 1267-1279 (2024)
   PUBMED   38651547
  REMARK    GeneRIF: CD163+ macrophage density in perimysial connective tissue
            associated with prognosis in IMNM.
REFERENCE   3  (bases 1 to 4071)
  AUTHORS   Jiang,Y., Sun,Z., Ge,Z., Tao,Z., Liu,M., Zhong,W., Dong,N., Xu,L.,
            Wang,H., Xu,Y. and Shen,X.
  TITLE     Differential expression of Semaphorin-7A /CD163-positive
            macrophages in large artery and cardiogenic stroke
  JOURNAL   BMC Neurol 24 (1), 70 (2024)
   PUBMED   38373967
  REMARK    GeneRIF: Differential expression of Semaphorin-7A /CD163-positive
            macrophages in large artery and cardiogenic stroke.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4071)
  AUTHORS   Tenggara,J.B., Rachman,A., Prihartono,J., Rachmadi,L.,
            Panigoro,S.S., Heriyanto,D.S., Sutandyo,N., Nasution,I.R.,
            Rahadiati,F.B., Steven,R., Betsy,R., Juanputra,S. and Sudoyo,A.W.
  TITLE     The relationship between high ratios of CD4/FOXP3 and CD8/CD163 and
            the improved survivability of metastatic triple-negative breast
            cancer patients: a multicenter cohort study
  JOURNAL   BMC Res Notes 17 (1), 44 (2024)
   PUBMED   38308298
  REMARK    GeneRIF: The relationship between high ratios of CD4/FOXP3 and
            CD8/CD163 and the improved survivability of metastatic
            triple-negative breast cancer patients: a multicenter cohort study.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4071)
  AUTHORS   Buechler,C., Ritter,M., Orso,E., Langmann,T., Klucken,J. and
            Schmitz,G.
  TITLE     Regulation of scavenger receptor CD163 expression in human
            monocytes and macrophages by pro- and antiinflammatory stimuli
  JOURNAL   J Leukoc Biol 67 (1), 97-103 (2000)
   PUBMED   10648003
REFERENCE   6  (bases 1 to 4071)
  AUTHORS   Stover,C.M., Schleypen,J., Gronlund,J., Speicher,M.R.,
            Schwaeble,W.J. and Holmskov,U.
  TITLE     Assignment of CD163B, the gene encoding M160, a novel scavenger
            receptor, to human chromosome 12p13.3 by in situ hybridization and
            somatic cell hybrid analysis
  JOURNAL   Cytogenet Cell Genet 90 (3-4), 246-247 (2000)
   PUBMED   11124526
REFERENCE   7  (bases 1 to 4071)
  AUTHORS   Van den Heuvel,M.M., Tensen,C.P., van As,J.H., Van den Berg,T.K.,
            Fluitsma,D.M., Dijkstra,C.D., Dopp,E.A., Droste,A., Van
            Gaalen,F.A., Sorg,C., Hogger,P. and Beelen,R.H.
  TITLE     Regulation of CD 163 on human macrophages: cross-linking of CD163
            induces signaling and activation
  JOURNAL   J Leukoc Biol 66 (5), 858-866 (1999)
   PUBMED   10577520
REFERENCE   8  (bases 1 to 4071)
  AUTHORS   Ritter,M., Buechler,C., Langmann,T. and Schmitz,G.
  TITLE     Genomic organization and chromosomal localization of the human
            CD163 (M130) gene: a member of the scavenger receptor cysteine-rich
            superfamily
  JOURNAL   Biochem Biophys Res Commun 260 (2), 466-474 (1999)
   PUBMED   10403791
REFERENCE   9  (bases 1 to 4071)
  AUTHORS   Droste,A., Sorg,C. and Hogger,P.
  TITLE     Shedding of CD163, a novel regulatory mechanism for a member of the
            scavenger receptor cysteine-rich family
  JOURNAL   Biochem Biophys Res Commun 256 (1), 110-113 (1999)
   PUBMED   10066432
REFERENCE   10 (bases 1 to 4071)
  AUTHORS   Law,S.K., Micklem,K.J., Shaw,J.M., Zhang,X.P., Dong,Y., Willis,A.C.
            and Mason,D.Y.
  TITLE     A new macrophage differentiation antigen which is a member of the
            scavenger receptor superfamily
  JOURNAL   Eur J Immunol 23 (9), 2320-2325 (1993)
   PUBMED   8370408
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB291765.1, BC051281.1,
            DA619387.1, DQ058615.1, AI129762.1 and AC131206.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 21, 2020 this sequence version replaced NM_203416.3.
            
            Summary: The protein encoded by this gene is a member of the
            scavenger receptor cysteine-rich (SRCR) superfamily, and is
            exclusively expressed in monocytes and macrophages. It functions as
            an acute phase-regulated receptor involved in the clearance and
            endocytosis of hemoglobin/haptoglobin complexes by macrophages, and
            may thereby protect tissues from free hemoglobin-mediated oxidative
            damage. This protein may also function as an innate immune sensor
            for bacteria and inducer of local inflammation. Alternatively
            spliced transcript variants encoding different isoforms have been
            described for this gene. [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (2), also known as short tail
            variant, uses an alternate splice site in the 3' coding region
            compared to variant 1. This results in a novel 3' coding region and
            3' UTR, compared to variant 1. It encodes isoform b which is
            shorter, and has a distinct C-terminus, compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK226017.1, Z22968.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000432237.3/ ENSP00000403885.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                DB291765.1         42-68
            28-1110             BC051281.1         1-1083
            1111-1111           DA619387.1         41-41
            1112-3521           DQ058615.1         1025-3434
            3522-3706           BC051281.1         3578-3762
            3707-4066           AI129762.1         1-360               c
            4067-4071           AC131206.2         54520-54524         c
FEATURES             Location/Qualifiers
     source          1..4071
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..4071
                     /gene="CD163"
                     /gene_synonym="M130; MM130; SCARI1"
                     /note="CD163 molecule"
                     /db_xref="GeneID:9332"
                     /db_xref="HGNC:HGNC:1631"
                     /db_xref="MIM:605545"
     exon            1..133
                     /gene="CD163"
                     /gene_synonym="M130; MM130; SCARI1"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..3453
                     /gene="CD163"
                     /gene_synonym="M130; MM130; SCARI1"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; macrophage-associated antigen; scavenger
                     receptor cysteine-rich type 1 protein M130; hemoglobin
                     scavenger receptor"
                     /codon_start=1
                     /product="scavenger receptor cysteine-rich type 1 protein
                     M130 isoform b precursor"
                     /protein_id="NP_981961.2"
                     /db_xref="CCDS:CCDS53742.1"
                     /db_xref="GeneID:9332"
                     /db_xref="HGNC:HGNC:1631"
                     /db_xref="MIM:605545"
                     /translation="MSKLRMVLLEDSGSADFRRHFVNLSPFTITVVLLLSACFVTSSL
                     GGTDKELRLVDGENKCSGRVEVKVQEEWGTVCNNGWSMEAVSVICNQLGCPTAIKAPG
                     WANSSAGSGRIWMDHVSCRGNESALWDCKHDGWGKHSNCTHQQDAGVTCSDGSNLEMR
                     LTRGGNMCSGRIEIKFQGRWGTVCDDNFNIDHASVICRQLECGSAVSFSGSSNFGEGS
                     GPIWFDDLICNGNESALWNCKHQGWGKHNCDHAEDAGVICSKGADLSLRLVDGVTECS
                     GRLEVRFQGEWGTICDDGWDSYDAAVACKQLGCPTAVTAIGRVNASKGFGHIWLDSVS
                     CQGHEPAIWQCKHHEWGKHYCNHNEDAGVTCSDGSDLELRLRGGGSRCAGTVEVEIQR
                     LLGKVCDRGWGLKEADVVCRQLGCGSALKTSYQVYSKIQATNTWLFLSSCNGNETSLW
                     DCKNWQWGGLTCDHYEEAKITCSAHREPRLVGGDIPCSGRVEVKHGDTWGSICDSDFS
                     LEAASVLCRELQCGTVVSILGGAHFGEGNGQIWAEEFQCEGHESHLSLCPVAPRPEGT
                     CSHSRDVGVVCSRYTEIRLVNGKTPCEGRVELKTLGAWGSLCNSHWDIEDAHVLCQQL
                     KCGVALSTPGGARFGKGNGQIWRHMFHCTGTEQHMGDCPVTALGASLCPSEQVASVIC
                     SGNQSQTLSSCNSSSLGPTRPTIPEESAVACIESGQLRLVNGGGRCAGRVEIYHEGSW
                     GTICDDSWDLSDAHVVCRQLGCGEAINATGSAHFGEGTGPIWLDEMKCNGKESRIWQC
                     HSHGWGQQNCRHKEDAGVICSEFMSLRLTSEASREACAGRLEVFYNGAWGTVGKSSMS
                     ETTVGVVCRQLGCADKGKINPASLDKAMSIPMWVDNVQCPKGPDTLWQCPSSPWEKRL
                     ASPSEETWITCDNKIRLQEGPTSCSGRVEIWHGGSWGTVCDDSWDLDDAQVVCQQLGC
                     GPALKAFKEAEFGQGTGPIWLNEVKCKGNESSLWDCPARRWGHSECGHKEDAAVNCTD
                     ISVQKTPQKATTGRSSRQSSFIAVGILGVVLLAIFVALFFLTKKRRQRQRLAVSSRGE
                     NLVHQIQYREMNSCLNADDLDLMNSSGGHSEPH"
     exon            134..220
                     /gene="CD163"
                     /gene_synonym="M130; MM130; SCARI1"
                     /inference="alignment:Splign:2.1.0"
     exon            221..544
                     /gene="CD163"
                     /gene_synonym="M130; MM130; SCARI1"
                     /inference="alignment:Splign:2.1.0"
     exon            545..865
                     /gene="CD163"
                     /gene_synonym="M130; MM130; SCARI1"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1186
                     /gene="CD163"
                     /gene_synonym="M130; MM130; SCARI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1507
                     /gene="CD163"
                     /gene_synonym="M130; MM130; SCARI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1822
                     /gene="CD163"
                     /gene_synonym="M130; MM130; SCARI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..2137
                     /gene="CD163"
                     /gene_synonym="M130; MM130; SCARI1"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2230
                     /gene="CD163"
                     /gene_synonym="M130; MM130; SCARI1"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..2545
                     /gene="CD163"
                     /gene_synonym="M130; MM130; SCARI1"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2866
                     /gene="CD163"
                     /gene_synonym="M130; MM130; SCARI1"
                     /inference="alignment:Splign:2.1.0"
     exon            2867..3175
                     /gene="CD163"
                     /gene_synonym="M130; MM130; SCARI1"
                     /inference="alignment:Splign:2.1.0"
     exon            3176..3214
                     /gene="CD163"
                     /gene_synonym="M130; MM130; SCARI1"
                     /inference="alignment:Splign:2.1.0"
     exon            3215..3334
                     /gene="CD163"
                     /gene_synonym="M130; MM130; SCARI1"
                     /inference="alignment:Splign:2.1.0"
     exon            3335..3430
                     /gene="CD163"
                     /gene_synonym="M130; MM130; SCARI1"
                     /inference="alignment:Splign:2.1.0"
     exon            3431..3484
                     /gene="CD163"
                     /gene_synonym="M130; MM130; SCARI1"
                     /inference="alignment:Splign:2.1.0"
     exon            3485..4071
                     /gene="CD163"
                     /gene_synonym="M130; MM130; SCARI1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3682..3687
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD163"
                     /gene_synonym="M130; MM130; SCARI1"
                     /note="hexamer: AATAAA"
     polyA_site      3711
                     /gene="CD163"
                     /gene_synonym="M130; MM130; SCARI1"
                     /note="major polyA site"
     regulatory      4034..4039
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD163"
                     /gene_synonym="M130; MM130; SCARI1"
                     /note="hexamer: AATAAA"
     polyA_site      4071
                     /gene="CD163"
                     /gene_synonym="M130; MM130; SCARI1"
                     /note="major polyA site"
ORIGIN      
        1 agaattctta gttgttttct ttagaagaac atttctaggg aataatacaa gaagatttag
       61 gaatcattga agttataaat ctttggaatg agcaaactca gaatggtgct acttgaagac
      121 tctggatctg ctgacttcag aagacatttt gtcaacttga gtcccttcac cattactgtg
      181 gtcttacttc tcagtgcctg ttttgtcacc agttctcttg gaggaacaga caaggagctg
      241 aggctagtgg atggtgaaaa caagtgtagc gggagagtgg aagtgaaagt ccaggaggag
      301 tggggaacgg tgtgtaataa tggctggagc atggaagcgg tctctgtgat ttgtaaccag
      361 ctgggatgtc caactgctat caaagcccct ggatgggcta attccagtgc aggttctgga
      421 cgcatttgga tggatcatgt ttcttgtcgt gggaatgagt cagctctttg ggattgcaaa
      481 catgatggat ggggaaagca tagtaactgt actcaccaac aagatgctgg agtgacctgc
      541 tcagatggat ccaatttgga aatgaggctg acgcgtggag ggaatatgtg ttctggaaga
      601 atagagatca aattccaagg acggtgggga acagtgtgtg atgataactt caacatagat
      661 catgcatctg tcatttgtag acaacttgaa tgtggaagtg ctgtcagttt ctctggttca
      721 tctaattttg gagaaggctc tggaccaatc tggtttgatg atcttatatg caacggaaat
      781 gagtcagctc tctggaactg caaacatcaa ggatggggaa agcataactg tgatcatgct
      841 gaggatgctg gagtgatttg ctcaaaggga gcagatctga gcctgagact ggtagatgga
      901 gtcactgaat gttcaggaag attagaagtg agattccaag gagaatgggg gacaatatgt
      961 gatgacggct gggacagtta cgatgctgct gtggcatgca agcaactggg atgtccaact
     1021 gccgtcacag ccattggtcg agttaacgcc agtaagggat ttggacacat ctggcttgac
     1081 agcgtttctt gccagggaca tgaacctgct atctggcaat gtaaacacca tgaatgggga
     1141 aagcattatt gcaatcacaa tgaagatgct ggcgtgacat gttctgatgg atcagatctg
     1201 gagctaagac ttagaggtgg aggcagccgc tgtgctggga cagttgaggt ggagattcag
     1261 agactgttag ggaaggtgtg tgacagaggc tggggactga aagaagctga tgtggtttgc
     1321 aggcagctgg gatgtggatc tgcactcaaa acatcttatc aagtgtactc caaaatccag
     1381 gcaacaaaca catggctgtt tctaagtagc tgtaacggaa atgaaacttc tctttgggac
     1441 tgcaagaact ggcaatgggg tggacttacc tgtgatcact atgaagaagc caaaattacc
     1501 tgctcagccc acagggaacc cagactggtt ggaggggaca ttccctgttc tggacgtgtt
     1561 gaagtgaagc atggtgacac gtggggctcc atctgtgatt cggacttctc tctggaagct
     1621 gccagcgttc tatgcaggga attacagtgt ggcacagttg tctctatcct ggggggagct
     1681 cactttggag agggaaatgg acagatctgg gctgaagaat tccagtgtga gggacatgag
     1741 tcccatcttt cactctgccc agtagcaccc cgcccagaag gaacttgtag ccacagcagg
     1801 gatgttggag tagtctgctc aagatacaca gaaattcgct tggtgaatgg caagaccccg
     1861 tgtgagggca gagtggagct caaaacgctt ggtgcctggg gatccctctg taactctcac
     1921 tgggacatag aagatgccca tgttctttgc cagcagctta aatgtggagt tgccctttct
     1981 accccaggag gagcacgttt tggaaaagga aatggtcaga tctggaggca tatgtttcac
     2041 tgcactggga ctgagcagca catgggagat tgtcctgtaa ctgctctagg tgcttcatta
     2101 tgtccttcag agcaagtggc ctctgtaatc tgctcaggaa accagtccca aacactgtcc
     2161 tcgtgcaatt catcgtcttt gggcccaaca aggcctacca ttccagaaga aagtgctgtg
     2221 gcctgcatag agagtggtca acttcgcctg gtaaatggag gaggtcgctg tgctgggaga
     2281 gtagagatct atcatgaggg ctcctggggc accatctgtg atgacagctg ggacctgagt
     2341 gatgcccacg tggtttgcag acagctgggc tgtggagagg ccattaatgc cactggttct
     2401 gctcattttg gggaaggaac agggcccatc tggctggatg agatgaaatg caatggaaaa
     2461 gaatcccgca tttggcagtg ccattcacac ggctgggggc agcaaaattg caggcacaag
     2521 gaggatgcgg gagttatctg ctcagaattc atgtctctga gactgaccag tgaagccagc
     2581 agagaggcct gtgcagggcg tctggaagtt ttttacaatg gagcttgggg cactgttggc
     2641 aagagtagca tgtctgaaac cactgtgggt gtggtgtgca ggcagctggg ctgtgcagac
     2701 aaagggaaaa tcaaccctgc atctttagac aaggccatgt ccattcccat gtgggtggac
     2761 aatgttcagt gtccaaaagg acctgacacg ctgtggcagt gcccatcatc tccatgggag
     2821 aagagactgg ccagcccctc ggaggagacc tggatcacat gtgacaacaa gataagactt
     2881 caggaaggac ccacttcctg ttctggacgt gtggagatct ggcatggagg ttcctggggg
     2941 acagtgtgtg atgactcttg ggacttggac gatgctcagg tggtgtgtca acaacttggc
     3001 tgtggtccag ctttgaaagc attcaaagaa gcagagtttg gtcaggggac tggaccgata
     3061 tggctcaatg aagtgaagtg caaagggaat gagtcttcct tgtgggattg tcctgccaga
     3121 cgctggggcc atagtgagtg tgggcacaag gaagacgctg cagtgaattg cacagatatt
     3181 tcagtgcaga aaaccccaca aaaagccaca acaggtcgct catcccgtca gtcatccttt
     3241 attgcagtcg ggatccttgg ggttgttctg ttggccattt tcgtcgcatt attcttcttg
     3301 actaaaaagc gaagacagag acagcggctt gcagtttcct caagaggaga gaacttagtc
     3361 caccaaattc aataccggga gatgaattct tgcctgaatg cagatgatct ggacctaatg
     3421 aattcctcag gaggccattc tgagccacac tgaaaaggaa aatgggaatt tataacccag
     3481 tgagttcagc ctttaagata ccttgatgaa gacctggact attgaatgga gcagaaattc
     3541 acctctctca ctgactatta cagttgcatt tttatggagt tcttcttctc ctaggattcc
     3601 taagactgct gctgaattta taaaaattaa gtttgtgaat gtgactactt agtggtgtat
     3661 atgagacttt caagggaatt aaataaataa ataagaatgt tattgatttg agtttgcttt
     3721 aattacttgt ccttaattct attaatttct aaatgggctt cctaattttt tgtagagttt
     3781 cctagatgta ttataatgtg ttttatttga cagtgtttca atttgcatat acagtactgt
     3841 atattttttc ttatttggtt tgaataattt tcctattacc aaataaaaat aaatttattt
     3901 ttactttagt ttttctaaga caggaaaagt taatgatatt gaagggtctg taaataatat
     3961 atggctaact ttataaggca tgactcacaa cgattcttta actgcttttt gttactgtaa
     4021 ttctgttcac tagaataaaa tgcagagcca cacctggtga gggcacaaag a
//
