LOCUS       NM_007053               1580 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens CD160 molecule (CD160), transcript variant 1, mRNA.
ACCESSION   NM_007053
VERSION     NM_007053.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1580)
  AUTHORS   Li,M., Wan,Z.X., Tang,Y.Y., Liang,X.H. and Tang,Y.L.
  TITLE     TIM-3/Galectin-9 and CD160 expression in salivary adenoid cystic
            carcinoma
  JOURNAL   Oral Dis 30 (4), 2262-2274 (2024)
   PUBMED   37455567
  REMARK    GeneRIF: TIM-3/Galectin-9 and CD160 expression in salivary adenoid
            cystic carcinoma.
REFERENCE   2  (bases 1 to 1580)
  AUTHORS   Liao,J., Lai,H., Liu,C., Zhang,X., Ou,Q., Li,Q., Li,Y., Wang,Z.,
            Liu,C., Wu,X., Wang,H., Yu,H., Sun,S., Zhao,X., Hu,Z., Zhang,Y.,
            Lin,Y., Yu,B., Huang,S. and Wang,J.
  TITLE     Plasma extracellular vesicle transcriptomics identifies CD160 for
            predicting immunochemotherapy efficacy in lung cancer
  JOURNAL   Cancer Sci 114 (7), 2774-2786 (2023)
   PUBMED   37014183
  REMARK    GeneRIF: Plasma extracellular vesicle transcriptomics identifies
            CD160 for predicting immunochemotherapy efficacy in lung cancer.
REFERENCE   3  (bases 1 to 1580)
  AUTHORS   Gauci,M.L., Giustiniani,J., Lepelletier,C., Garbar,C., Thonnart,N.,
            Dumaz,N., Foussat,A., Lebbe,C., Bensussan,A. and Marie-Cardine,A.
  TITLE     The soluble form of CD160 acts as a tumor mediator of immune escape
            in melanoma
  JOURNAL   Cancer Immunol Immunother 71 (11), 2731-2742 (2022)
   PUBMED   35428910
  REMARK    GeneRIF: The soluble form of CD160 acts as a tumor mediator of
            immune escape in melanoma.
REFERENCE   4  (bases 1 to 1580)
  AUTHORS   Yang,B., Zhai,F., An,H., Cao,Z., Liu,Y., Wang,R. and Cheng,X.
  TITLE     [Expression of CD160 in natural killer (NK) cells from patients
            with active tuberculosis and its relationship with cell functions]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 38 (10), 918-924 (2022)
   PUBMED   36163624
  REMARK    GeneRIF: [Expression of CD160 in natural killer (NK) cells from
            patients with active tuberculosis and its relationship with cell
            functions].
REFERENCE   5  (bases 1 to 1580)
  AUTHORS   Sun,Z., Li,Y., Zhang,Z., Fu,Y., Han,X., Hu,Q., Ding,H., Shang,H.
            and Jiang,Y.
  TITLE     CD160 Promotes NK Cell Functions by Upregulating Glucose Metabolism
            and Negatively Correlates With HIV Disease Progression
  JOURNAL   Front Immunol 13, 854432 (2022)
   PUBMED   36110864
  REMARK    GeneRIF: CD160 Promotes NK Cell Functions by Upregulating Glucose
            Metabolism and Negatively Correlates With HIV Disease Progression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1580)
  AUTHORS   Le Bouteiller,P., Barakonyi,A., Giustiniani,J., Lenfant,F.,
            Marie-Cardine,A., Aguerre-Girr,M., Rabot,M., Hilgert,I.,
            Mami-Chouaib,F., Tabiasco,J., Boumsell,L. and Bensussan,A.
  TITLE     Engagement of CD160 receptor by HLA-C is a triggering mechanism
            used by circulating natural killer (NK) cells to mediate
            cytotoxicity
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16963-16968 (2002)
   PUBMED   12486241
REFERENCE   7  (bases 1 to 1580)
  AUTHORS   Nikolova,M., Marie-Cardine,A., Boumsell,L. and Bensussan,A.
  TITLE     BY55/CD160 acts as a co-receptor in TCR signal transduction of a
            human circulating cytotoxic effector T lymphocyte subset lacking
            CD28 expression
  JOURNAL   Int Immunol 14 (5), 445-451 (2002)
   PUBMED   11978774
  REMARK    GeneRIF: BY55 functions as a co-receptor in TCR signal transduction
            of a human cytotoxic effector T lymphocyte subset lacking CD28
            expression
REFERENCE   8  (bases 1 to 1580)
  AUTHORS   Agrawal,S., Marquet,J., Freeman,G.J., Tawab,A., Bouteiller,P.L.,
            Roth,P., Bolton,W., Ogg,G., Boumsell,L. and Bensussan,A.
  TITLE     Cutting edge: MHC class I triggering by a novel cell surface ligand
            costimulates proliferation of activated human T cells
  JOURNAL   J Immunol 162 (3), 1223-1226 (1999)
   PUBMED   9973372
REFERENCE   9  (bases 1 to 1580)
  AUTHORS   Anumanthan,A., Bensussan,A., Boumsell,L., Christ,A.D.,
            Blumberg,R.S., Voss,S.D., Patel,A.T., Robertson,M.J., Nadler,L.M.
            and Freeman,G.J.
  TITLE     Cloning of BY55, a novel Ig superfamily member expressed on NK
            cells, CTL, and intestinal intraepithelial lymphocytes
  JOURNAL   J Immunol 161 (6), 2780-2790 (1998)
   PUBMED   9743336
REFERENCE   10 (bases 1 to 1580)
  AUTHORS   Bensussan,A., Gluckman,E., el Marsafy,S., Schiavon,V., Mansur,I.G.,
            Dausset,J., Boumsell,L. and Carosella,E.
  TITLE     BY55 monoclonal antibody delineates within human cord blood and
            bone marrow lymphocytes distinct cell subsets mediating cytotoxic
            activity
  JOURNAL   Proc Natl Acad Sci U S A 91 (19), 9136-9140 (1994)
   PUBMED   8090781
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD638675.1, BC014465.1, AC242845.1 and AA463248.1.
            
            On May 17, 2019 this sequence version replaced NM_007053.3.
            
            Summary: CD160 is an 27 kDa glycoprotein which was initially
            identified with the monoclonal antibody BY55. Its expression is
            tightly associated with peripheral blood NK cells and CD8 T
            lymphocytes with cytolytic effector activity. The cDNA sequence of
            CD160 predicts a cysteine-rich,
            glycosylphosphatidylinositol-anchored protein of 181 amino acids
            with a single Ig-like domain weakly homologous to KIR2DL4 molecule.
            CD160 is expressed at the cell surface as a tightly
            disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs
            of 1.5 and 1.6 kb whose expression was highly restricted to
            circulating NK and T cells, spleen and small intestine. Within NK
            cells CD160 is expressed by CD56dimCD16+ cells whereas among
            circulating T cells its expression is mainly restricted to TCRgd
            bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In
            tissues, CD160 is expressed on all intestinal intraepithelial
            lymphocytes. CD160 shows a broad specificity for binding to both
            classical and nonclassical MHC class I molecules. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014465.1, AF060981.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369288.7/ ENSP00000358294.1
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                CD638675.1         57-77
            22-1446             BC014465.1         1-1425
            1447-1455           AC242845.1         194566-194574
            1456-1580           AA463248.1         151-275
FEATURES             Location/Qualifiers
     source          1..1580
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.1"
     gene            1..1580
                     /gene="CD160"
                     /gene_synonym="BY55; NK1; NK28"
                     /note="CD160 molecule"
                     /db_xref="GeneID:11126"
                     /db_xref="HGNC:HGNC:17013"
                     /db_xref="MIM:604463"
     exon            1..61
                     /gene="CD160"
                     /gene_synonym="BY55; NK1; NK28"
                     /inference="alignment:Splign:2.1.0"
     exon            62..167
                     /gene="CD160"
                     /gene_synonym="BY55; NK1; NK28"
                     /inference="alignment:Splign:2.1.0"
     exon            168..312
                     /gene="CD160"
                     /gene_synonym="BY55; NK1; NK28"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..785
                     /gene="CD160"
                     /gene_synonym="BY55; NK1; NK28"
                     /note="natural killer cell receptor, immunoglobulin
                     superfamily member; CD160 antigen; natural killer cell
                     receptor BY55; CD160-delta Ig"
                     /codon_start=1
                     /product="CD160 antigen precursor"
                     /protein_id="NP_008984.1"
                     /db_xref="CCDS:CCDS72861.1"
                     /db_xref="GeneID:11126"
                     /db_xref="HGNC:HGNC:17013"
                     /db_xref="MIM:604463"
                     /translation="MLLEPGRGCCALAILLAIVDIQSGGCINITSSASQEGTRLNLIC
                     TVWHKKEEAEGFVVFLCKDRSGDCSPETSLKQLRLKRDPGIDGVGEISSQLMFTISQV
                     TPLHSGTYQCCARSQKSGIRLQGHFFSILFTETGNYTVTGLKQRQHLEFSHNEGTLSS
                     GFLQEKVWVMLVTSLVALQAL"
     exon            313..639
                     /gene="CD160"
                     /gene_synonym="BY55; NK1; NK28"
                     /inference="alignment:Splign:2.1.0"
     exon            640..777
                     /gene="CD160"
                     /gene_synonym="BY55; NK1; NK28"
                     /inference="alignment:Splign:2.1.0"
     exon            778..1580
                     /gene="CD160"
                     /gene_synonym="BY55; NK1; NK28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1427..1432
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD160"
                     /gene_synonym="BY55; NK1; NK28"
                     /note="hexamer: AATAAA"
     polyA_site      1446
                     /gene="CD160"
                     /gene_synonym="BY55; NK1; NK28"
                     /note="major polyA site"
ORIGIN      
        1 gagagccatt tcaacgtgag cccccagtct gagaacaaga aagaagaact tctgtctcga
       61 gggtctcact gtcaaccagg ccagagtgca gtgaagatca tacctcacta catccgtgaa
      121 ctcccgggct cctcccacct aagtctcttg agtagctggg acttcaggag actgaagcca
      181 aggataccag cagagccaac atttgcttca agttcctggg cctgctgaca gcgtgcagga
      241 tgctgttgga acccggcaga ggctgctgtg ccctggccat cctgctggca attgtggaca
      301 tccagtctgg tggatgcatt aacatcacca gctcagcttc ccaggaagga acgcgactaa
      361 acttaatctg tactgtatgg cataagaaag aagaggctga ggggtttgta gtgtttttgt
      421 gcaaggacag gtctggagac tgttctcctg agaccagttt aaaacagctg agacttaaaa
      481 gggatcctgg gatagatggt gttggtgaaa tatcatctca gttgatgttc accataagcc
      541 aagtcacacc gttgcacagt gggacctacc agtgttgtgc cagaagccag aagtcaggta
      601 tccgccttca gggccatttt ttctccattc tattcacaga gacagggaac tacacagtga
      661 cgggattgaa acaaagacaa caccttgagt tcagccataa tgaaggcact ctcagttcag
      721 gcttcctaca agaaaaggtc tgggtaatgc tggtcaccag ccttgtggcc cttcaagctt
      781 tgtaagcctt gtgccaaaag aaacttttaa aacagctaca gcaagatgag tctgactatg
      841 gcttagtatc tttctcatta caataggcac agagaagaat gcaacagggc acaggggaag
      901 agatgctaaa tataccaaga atctgtggaa atataagctg gggcaaatca gtgtaatcct
      961 tgactttgct cctcaccatc agggcaaact tgccttcttc cctcctaagc tccagtaaat
     1021 aaacagaaca gctttcacca aagtgggtag tatagtcctc aaatatcgga taaatatatg
     1081 cgtttttgta ccccagaaaa acttttcctc cctcttcatc aacatagtaa aataagtcaa
     1141 acaaaatgag aacaccaaat tttgggggaa taaattttta tttaacactg caaaggaaag
     1201 agagagaaaa caagcaaaga taggtaggac agaaaggaag acagccagat ccagtgattg
     1261 acttggcatg aaaatgagaa aatgcagaca gacctcaaca ttcaacaaca tccatacagc
     1321 actgctggag gaagaggaag atttgtgcag accaagagca ccacagacta caactgccca
     1381 gcttcatcta aatacttgtt aacctctttg gtcatttctc tttttaaata aatgcccata
     1441 gcagtatttg gagtcttttc ttttctccta aatccacaaa ctctcttctt tctctttgga
     1501 cagatgacct cttgtcatag ttaagcagag agtgggcagg atattcctga taggaggaac
     1561 tacatgaata aaggggtaag
//
