LOCUS       NM_004357               1545 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens CD151 molecule (Raph blood group) (CD151), transcript
            variant 1, mRNA.
ACCESSION   NM_004357 NM_139031
VERSION     NM_004357.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1545)
  AUTHORS   Ciambella,C., Witt,H., Dickinson,C.M., Smith,M.L., Coburn,N.,
            Messina,N., Heffernan,D.S., Kim,M. and Reichner,J.S.
  TITLE     INHIBITION OF INTEGRIN VLA-3 AND TETRASPANIN CD151 PROTECTS AGAINST
            NEUTROPHIL-MEDIATED ENDOTHELIAL DAMAGE
  JOURNAL   Shock 62 (2), 165-172 (2024)
   PUBMED   38813923
  REMARK    GeneRIF: INHIBITION OF INTEGRIN VLA-3 AND TETRASPANIN CD151
            PROTECTS AGAINST NEUTROPHIL-MEDIATED ENDOTHELIAL DAMAGE.
REFERENCE   2  (bases 1 to 1545)
  AUTHORS   Chen,J., Ding,Y., Jiang,C., Qu,R., Wren,J.D., Georgescu,C.,
            Wang,X., Reuter,D.N., Liu,B., Giles,C.B., Mayr,C.H., Schiller,H.B.,
            Dai,J., Stipp,C.S., Subramaniyan,B., Wang,J., Zuo,H., Huang,C.,
            Fung,K.M., Rice,H.C., Sonnenberg,A., Wu,D., Walters,M.S.,
            Zhao,Y.Y., Kanie,T., Hays,F.A., Papin,J.F., Wang,D.W. and
            Zhang,X.A.
  TITLE     CD151 Maintains Endolysosomal Protein Quality to Inhibit Vascular
            Inflammation
  JOURNAL   Circ Res 134 (10), 1330-1347 (2024)
   PUBMED   38557119
  REMARK    GeneRIF: CD151 Maintains Endolysosomal Protein Quality to Inhibit
            Vascular Inflammation.
REFERENCE   3  (bases 1 to 1545)
  AUTHORS   Nakanishi-Koakutsu,M., Miki,K., Naka,Y., Sasaki,M., Wakimizu,T.,
            Napier,S.C., Okubo,C., Narita,M., Nishikawa,M., Hata,R.,
            Chonabayashi,K., Hotta,A., Imahashi,K., Nishimoto,T. and Yoshida,Y.
  TITLE     CD151 expression marks atrial- and ventricular- differentiation
            from human induced pluripotent stem cells
  JOURNAL   Commun Biol 7 (1), 231 (2024)
   PUBMED   38418926
  REMARK    GeneRIF: CD151 expression marks atrial- and ventricular-
            differentiation from human induced pluripotent stem cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1545)
  AUTHORS   Malla,R., Marni,R. and Chakraborty,A.
  TITLE     Exploring the role of CD151 in the tumor immune microenvironment:
            Therapeutic and clinical perspectives
  JOURNAL   Biochim Biophys Acta Rev Cancer 1878 (3), 188898 (2023)
   PUBMED   37094754
  REMARK    GeneRIF: Exploring the role of CD151 in the tumor immune
            microenvironment: Therapeutic and clinical perspectives.
            Review article
REFERENCE   5  (bases 1 to 1545)
  AUTHORS   Karamatic Crew,V., Burton,N., Kagan,A., Green,C.A., Levene,C.,
            Flinter,F., Brady,R.L., Daniels,G. and Anstee,D.J.
  TITLE     CD151, the first member of the tetraspanin (TM4) superfamily
            detected on erythrocytes, is essential for the correct assembly of
            human basement membranes in kidney and skin
  JOURNAL   Blood 104 (8), 2217-2223 (2004)
   PUBMED   15265795
  REMARK    GeneRIF: CD151 is essential for the proper assembly of the
            glomerular and tubular basement membrane in kidney, has functional
            significance in the skin, is probably a component of the inner ear,
            and could play a role in erythropoiesis
REFERENCE   6  (bases 1 to 1545)
  AUTHORS   Hasegawa,H., Kishimoto,K., Yanagisawa,K., Terasaki,H., Shimadzu,M.
            and Fujita,S.
  TITLE     Assignment of SFA-1 (PETA-3), a member of the transmembrane 4
            superfamily, to human chromosome 11p15.5 by fluorescence in situ
            hybridization
  JOURNAL   Genomics 40 (1), 193-196 (1997)
   PUBMED   9070943
REFERENCE   7  (bases 1 to 1545)
  AUTHORS   Hasegawa,H., Utsunomiya,Y., Kishimoto,K., Yanagisawa,K. and
            Fujita,S.
  TITLE     SFA-1, a novel cellular gene induced by human T-cell leukemia virus
            type 1, is a member of the transmembrane 4 superfamily
  JOURNAL   J Virol 70 (5), 3258-3263 (1996)
   PUBMED   8627808
  REMARK    Erratum:[J Virol 1997 Feb;71(2):1737]
REFERENCE   8  (bases 1 to 1545)
  AUTHORS   Fitter,S., Tetaz,T.J., Berndt,M.C. and Ashman,L.K.
  TITLE     Molecular cloning of cDNA encoding a novel platelet-endothelial
            cell tetra-span antigen, PETA-3
  JOURNAL   Blood 86 (4), 1348-1355 (1995)
   PUBMED   7632941
REFERENCE   9  (bases 1 to 1545)
  AUTHORS   So,J.Y. and Teng,J.
  TITLE     Epidermolysis Bullosa Simplex
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301543
REFERENCE   10 (bases 1 to 1545)
  AUTHORS   Ashman,L.K., Aylett,G.W., Mehrabani,P.A., Bendall,L.J., Niutta,S.,
            Cambareri,A.C., Cole,S.R. and Berndt,M.C.
  TITLE     The murine monoclonal antibody, 14A2.H1, identifies a novel
            platelet surface antigen
  JOURNAL   Br J Haematol 79 (2), 263-270 (1991)
   PUBMED   1958484
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AU099249.1, BC001374.2 and
            AK130369.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004357.4.
            
            Summary: The protein encoded by this gene is a member of the
            transmembrane 4 superfamily, also known as the tetraspanin family.
            Most of these members are cell-surface proteins that are
            characterized by the presence of four hydrophobic domains. The
            proteins mediate signal transduction events that play a role in the
            regulation of cell development, activation, growth and motility.
            This encoded protein is a cell surface glycoprotein that is known
            to complex with integrins and other transmembrane 4 superfamily
            proteins. It is involved in cellular processes including cell
            adhesion and may regulate integrin trafficking and/or function.
            This protein enhances cell motility, invasion and metastasis of
            cancer cells. Multiple alternatively spliced transcript variants
            that encode the same protein have been described for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) is the longest transcript. All
            variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.847874.1,
                                           SRR3476690.798941.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397420.9/ ENSP00000380565.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                AU099249.1         1-75
            76-722              BC001374.2         15-661
            723-1435            AK130369.1         1087-1799
            1436-1473           BC001374.2         1375-1412
            1474-1544           AK130369.1         1838-1908
            1545-1545           BC001374.2         1484-1484
FEATURES             Location/Qualifiers
     source          1..1545
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..1545
                     /gene="CD151"
                     /gene_synonym="EBS7; GP27; MER2; PETA-3; RAPH; SFA1;
                     TSPAN24"
                     /note="CD151 molecule (Raph blood group)"
                     /db_xref="GeneID:977"
                     /db_xref="HGNC:HGNC:1630"
                     /db_xref="MIM:602243"
     exon            1..75
                     /gene="CD151"
                     /gene_synonym="EBS7; GP27; MER2; PETA-3; RAPH; SFA1;
                     TSPAN24"
                     /inference="alignment:Splign:2.1.0"
     exon            76..137
                     /gene="CD151"
                     /gene_synonym="EBS7; GP27; MER2; PETA-3; RAPH; SFA1;
                     TSPAN24"
                     /inference="alignment:Splign:2.1.0"
     exon            138..228
                     /gene="CD151"
                     /gene_synonym="EBS7; GP27; MER2; PETA-3; RAPH; SFA1;
                     TSPAN24"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..906
                     /gene="CD151"
                     /gene_synonym="EBS7; GP27; MER2; PETA-3; RAPH; SFA1;
                     TSPAN24"
                     /note="CD151 antigen (Raph blood group); hemidesmosomal
                     tetraspanin CD151; platelet-endothelial cell tetraspan
                     antigen 3; platelet surface glycoprotein gp27; membrane
                     glycoprotein SFA-1; tspan-24; tetraspanin-24;
                     platelet-endothelial tetraspan antigen 3"
                     /codon_start=1
                     /product="CD151 antigen"
                     /protein_id="NP_004348.2"
                     /db_xref="CCDS:CCDS7719.1"
                     /db_xref="GeneID:977"
                     /db_xref="HGNC:HGNC:1630"
                     /db_xref="MIM:602243"
                     /translation="MGEFNEKKTTCGTVCLKYLLFTYNCCFWLAGLAVMAVGIWTLAL
                     KSDYISLLASGTYLATAYILVVAGTVVMVTGVLGCCATFKERRNLLRLYFILLLIIFL
                     LEIIAGILAYAYYQQLNTELKENLKDTMTKRYHQPGHEAVTSAVDQLQQEFHCCGSNN
                     SQDWRDSEWIRSQEAGGRVVPDSCCKTVVALCGQRDHASNIYKVEGGCITKLETFIQE
                     HLRVIGAVGIGIACVQVFGMIFTCCLYRSLKLEHY"
     exon            229..420
                     /gene="CD151"
                     /gene_synonym="EBS7; GP27; MER2; PETA-3; RAPH; SFA1;
                     TSPAN24"
                     /inference="alignment:Splign:2.1.0"
     exon            421..495
                     /gene="CD151"
                     /gene_synonym="EBS7; GP27; MER2; PETA-3; RAPH; SFA1;
                     TSPAN24"
                     /inference="alignment:Splign:2.1.0"
     exon            496..600
                     /gene="CD151"
                     /gene_synonym="EBS7; GP27; MER2; PETA-3; RAPH; SFA1;
                     TSPAN24"
                     /inference="alignment:Splign:2.1.0"
     exon            601..759
                     /gene="CD151"
                     /gene_synonym="EBS7; GP27; MER2; PETA-3; RAPH; SFA1;
                     TSPAN24"
                     /inference="alignment:Splign:2.1.0"
     exon            760..846
                     /gene="CD151"
                     /gene_synonym="EBS7; GP27; MER2; PETA-3; RAPH; SFA1;
                     TSPAN24"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1545
                     /gene="CD151"
                     /gene_synonym="EBS7; GP27; MER2; PETA-3; RAPH; SFA1;
                     TSPAN24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1525..1530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD151"
                     /gene_synonym="EBS7; GP27; MER2; PETA-3; RAPH; SFA1;
                     TSPAN24"
                     /note="hexamer: AATAAA"
     polyA_site      1545
                     /gene="CD151"
                     /gene_synonym="EBS7; GP27; MER2; PETA-3; RAPH; SFA1;
                     TSPAN24"
                     /note="major polyA site"
ORIGIN      
        1 attctcagcg ctgggagccg ccgcccccgc agctgctgcc gccgccgcca gggcccggac
       61 tcggacgcgt ggtagcctag agtcctgggg agcttctgtc cacctgtcct gcagaggagt
      121 cgtttccagc ccggctgccc caggatgggt gagttcaacg agaagaagac aacatgtggc
      181 accgtttgcc tcaagtacct gctgtttacc tacaattgct gcttctggct ggctggcctg
      241 gctgtcatgg cagtgggcat ctggacgctg gccctcaaga gtgactacat cagcctgctg
      301 gcctcaggca cctacctggc cacagcctac atcctggtgg tggcgggcac tgtcgtcatg
      361 gtgactgggg tcttgggctg ctgcgccacc ttcaaggagc gtcggaacct gctgcgcctg
      421 tacttcatcc tgctcctcat catctttctg ctggagatca tcgctggtat cctcgcctac
      481 gcctactacc agcagctgaa cacggagctc aaggagaacc tgaaggacac catgaccaag
      541 cgctaccacc agccgggcca tgaggctgtg accagcgctg tggaccagct gcagcaggag
      601 ttccactgct gtggcagcaa caactcacag gactggcgag acagtgagtg gatccgctca
      661 caggaggccg gtggccgtgt ggtcccagac agctgctgca agacggtggt ggctctttgt
      721 gggcagcgag accatgcctc caacatctac aaggtggagg gcggctgcat caccaagttg
      781 gagaccttca tccaggagca cctgagggtc attggggctg tggggatcgg cattgcctgt
      841 gtgcaggtct ttggcatgat cttcacgtgc tgcctgtaca ggagtctcaa gctggagcac
      901 tactgaccct gccttgggcc ttgctgctgc tgcacccaac tactgagctg agaccactga
      961 gtaccagggg ctgggctccc tgatgacacc caccctgtgc catcaccata acctctgggg
     1021 accccaacct cagaggcagc ttcaagtgcc ttttgctgcg caccaatgcc cagcagggga
     1081 ggtgaggggg gctggcgggg cgaagtttgg ggggtgtttt gtggggctcc ccagacacac
     1141 tctctgcctg gtggtcagat gcaggttgga aggggccttg ctgagtggcg caaggccgag
     1201 cgttcccagc agggggagaa acccttcaca ccccaggccc ttcaggaact ggggccttgc
     1261 cttgcagcca catggcccca tcccagttgg ggaagccagg tgagctctga cccttgggcc
     1321 tgggcctctg cccctcccaa cccagccctc gtctccctcg acagcgcccc tgctgtcttc
     1381 cccaccgcag tcaccaccac ccgaaatgcc acgtggtcac tgtgcactgc cctgttcatg
     1441 tgcctctgcg gggcagggcc ttcctggttt tgttcactgc tgtacccaga tgcctacaac
     1501 catccctgcc acatacaggt gctcaataaa cacttgtaga gcaga
//
