LOCUS       NM_000591               1356 bp    mRNA    linear   PRI 06-DEC-2024
DEFINITION  Homo sapiens CD14 molecule (CD14), transcript variant 1, mRNA.
ACCESSION   NM_000591
VERSION     NM_000591.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1356)
  AUTHORS   Magri,Z., Jetton,D., Muendlein,H.I., Connolly,W.M., Russell,H.,
            Smirnova,I., Sharma,S., Bunnell,S. and Poltorak,A.
  TITLE     CD14 is a decision-maker between Fas-mediated death and
            inflammation
  JOURNAL   Cell Rep 43 (9), 114685 (2024)
   PUBMED   39213151
  REMARK    GeneRIF: CD14 is a decision-maker between Fas-mediated death and
            inflammation.
REFERENCE   2  (bases 1 to 1356)
  AUTHORS   Persaud,A.T., Khela,J., Fernandes,C., Chaphekar,D., Burnie,J.,
            Tang,V.A., Colpitts,C.C. and Guzzo,C.
  TITLE     Virion-incorporated CD14 enables HIV-1 to bind LPS and initiate
            TLR4 signaling in immune cells
  JOURNAL   J Virol 98 (5), e0036324 (2024)
   PUBMED   38661384
  REMARK    GeneRIF: Virion-incorporated CD14 enables HIV-1 to bind LPS and
            initiate TLR4 signaling in immune cells.
REFERENCE   3  (bases 1 to 1356)
  AUTHORS   Li,J., Qiao,X. and Shang,J.
  TITLE     Association analysis between CD14 gene polymorphisms and
            peri-implantitis susceptibility in a Chinese population
  JOURNAL   Immun Inflamm Dis 12 (4), e1230 (2024)
   PUBMED   38629742
  REMARK    GeneRIF: Association analysis between CD14 gene polymorphisms and
            peri-implantitis susceptibility in a Chinese population.
REFERENCE   4  (bases 1 to 1356)
  AUTHORS   Zheng,M., Li,Z., Feng,Y., Hou,S., Zhang,J. and Kang,C.
  TITLE     The role of CD14 and CSF1R in osteoarthritis and gastritis
  JOURNAL   Medicine (Baltimore) 102 (43), e35567 (2023)
   PUBMED   37904379
  REMARK    GeneRIF: The role of CD14 and CSF1R in osteoarthritis and
            gastritis.
REFERENCE   5  (bases 1 to 1356)
  AUTHORS   Hubacek,J.A., Philipp,T., Majek,O., Dlouha,D., Adamkova,V. and
            Dusek,L.
  TITLE     CD14 Polymorphism Is Not Associated with SARS-CoV-2 Infection in
            Central European Population
  JOURNAL   Folia Biol (Praha) 69 (5-6), 181-185 (2023)
   PUBMED   38583179
  REMARK    GeneRIF: CD14 Polymorphism Is Not Associated with SARS-CoV-2
            Infection in Central European Population.
REFERENCE   6  (bases 1 to 1356)
  AUTHORS   Martin,T.R., Wurfel,M.M., Zanoni,I. and Ulevitch,R.
  TITLE     Targeting innate immunity by blocking CD14: Novel approach to
            control inflammation and organ dysfunction in COVID-19 illness
  JOURNAL   EBioMedicine 57, 102836 (2020)
   PUBMED   32574958
REFERENCE   7  (bases 1 to 1356)
  AUTHORS   Schumann,R.R., Leong,S.R., Flaggs,G.W., Gray,P.W., Wright,S.D.,
            Mathison,J.C., Tobias,P.S. and Ulevitch,R.J.
  TITLE     Structure and function of lipopolysaccharide binding protein
  JOURNAL   Science 249 (4975), 1429-1431 (1990)
   PUBMED   2402637
REFERENCE   8  (bases 1 to 1356)
  AUTHORS   Wright,S.D., Ramos,R.A., Tobias,P.S., Ulevitch,R.J. and
            Mathison,J.C.
  TITLE     CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS
            binding protein
  JOURNAL   Science 249 (4975), 1431-1433 (1990)
   PUBMED   1698311
REFERENCE   9  (bases 1 to 1356)
  AUTHORS   Ferrero,E. and Goyert,S.M.
  TITLE     Nucleotide sequence of the gene encoding the monocyte
            differentiation antigen, CD14
  JOURNAL   Nucleic Acids Res 16 (9), 4173 (1988)
   PUBMED   2453848
REFERENCE   10 (bases 1 to 1356)
  AUTHORS   Goyert,S.M., Ferrero,E., Rettig,W.J., Yenamandra,A.K., Obata,F. and
            Le Beau,M.M.
  TITLE     The CD14 monocyte differentiation antigen maps to a region encoding
            growth factors and receptors
  JOURNAL   Science 239 (4839), 497-500 (1988)
   PUBMED   2448876
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CF593452.1 and BC010507.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000591.3.
            
            Summary: The protein encoded by this gene is a surface antigen that
            is preferentially expressed on monocytes/macrophages. It cooperates
            with other proteins to mediate the innate immune response to
            bacterial lipopolysaccharide, and to viruses. This gene has been
            identified as a target candidate in the treatment of
            SARS-CoV-2-infected patients to potentially lessen or inhibit a
            severe inflammatory response. Alternative splicing results in
            multiple transcript variants encoding the same protein. [provided
            by RefSeq, Aug 2020].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript. Variants 1-4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.112247.1,
                                           SRR3476690.979747.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: relevant for COVID-19 treatment
            MANE Ensembl match     :: ENST00000302014.11/ ENSP00000304236.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               CF593452.1         527-699
            174-1356            BC010507.2         175-1357
FEATURES             Location/Qualifiers
     source          1..1356
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..1356
                     /gene="CD14"
                     /note="CD14 molecule"
                     /db_xref="GeneID:929"
                     /db_xref="HGNC:HGNC:1628"
                     /db_xref="MIM:158120"
     exon            1..107
                     /gene="CD14"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1232
                     /gene="CD14"
                     /note="monocyte differentiation antigen CD14; myeloid
                     cell-specific leucine-rich glycoprotein; my23 antigen"
                     /codon_start=1
                     /product="monocyte differentiation antigen CD14 precursor"
                     /protein_id="NP_000582.1"
                     /db_xref="CCDS:CCDS4232.1"
                     /db_xref="GeneID:929"
                     /db_xref="HGNC:HGNC:1628"
                     /db_xref="MIM:158120"
                     /translation="MERASCLLLLLLPLVHVSATTPEPCELDDEDFRCVCNFSEPQPD
                     WSEAFQCVSAVEVEIHAGGLNLEPFLKRVDADADPRQYADTVKALRVRRLTVGAAQVP
                     AQLLVGALRVLAYSRLKELTLEDLKITGTMPPLPLEATGLALSSLRLRNVSWATGRSW
                     LAELQQWLKPGLKVLSIAQAHSPAFSCEQVRAFPALTSLDLSDNPGLGERGLMAALCP
                     HKFPAIQNLALRNTGMETPTGVCAALAAAGVQPHSLDLSHNSLRATVNPSAPRCMWSS
                     ALNSLNLSFAGLEQVPKGLPAKLRVLDLSCNRLNRAPQPDELPEVDNLTLDGNPFLVP
                     GTALPHEGSMNSGVVPACARSTLSVGVSGTLVLLQGARGFA"
     exon            108..1356
                     /gene="CD14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1338..1343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD14"
                     /note="hexamer: ATTAAA"
     polyA_site      1356
                     /gene="CD14"
                     /note="major polyA site"
ORIGIN      
        1 acaagtgtga agcctggaag ccggcgggtg ccgctgtgta ggaaagaagc taaagcactt
       61 ccagagcctg tccggagctc agaggttcgg aagacttatc gaccatggag cgcgcgtcct
      121 gcttgttgct gctgctgctg ccgctggtgc acgtctctgc gaccacgcca gaaccttgtg
      181 agctggacga tgaagatttc cgctgcgtct gcaacttctc cgaacctcag cccgactggt
      241 ccgaagcctt ccagtgtgtg tctgcagtag aggtggagat ccatgccggc ggtctcaacc
      301 tagagccgtt tctaaagcgc gtcgatgcgg acgccgaccc gcggcagtat gctgacacgg
      361 tcaaggctct ccgcgtgcgg cggctcacag tgggagccgc acaggttcct gctcagctac
      421 tggtaggcgc cctgcgtgtg ctagcgtact cccgcctcaa ggaactgacg ctcgaggacc
      481 taaagataac cggcaccatg cctccgctgc ctctggaagc cacaggactt gcactttcca
      541 gcttgcgcct acgcaacgtg tcgtgggcga cagggcgttc ttggctcgcc gagctgcagc
      601 agtggctcaa gccaggcctc aaggtactga gcattgccca agcacactcg cctgcctttt
      661 cctgcgaaca ggttcgcgcc ttcccggccc ttaccagcct agacctgtct gacaatcctg
      721 gactgggcga acgcggactg atggcggctc tctgtcccca caagttcccg gccatccaga
      781 atctagcgct gcgcaacaca ggaatggaga cgcccacagg cgtgtgcgcc gcactggcgg
      841 cggcaggtgt gcagccccac agcctagacc tcagccacaa ctcgctgcgc gccaccgtaa
      901 accctagcgc tccgagatgc atgtggtcca gcgccctgaa ctccctcaat ctgtcgttcg
      961 ctgggctgga acaggtgcct aaaggactgc cagccaagct cagagtgctc gatctcagct
     1021 gcaacagact gaacagggcg ccgcagcctg acgagctgcc cgaggtggat aacctgacac
     1081 tggacgggaa tcccttcctg gtccctggaa ctgccctccc ccacgagggc tcaatgaact
     1141 ccggcgtggt cccagcctgt gcacgttcga ccctgtcggt gggggtgtcg ggaaccctgg
     1201 tgctgctcca aggggcccgg ggctttgcct aagatccaag acagaataat gaatggactc
     1261 aaactgcctt ggcttcaggg gagtcccgtc aggacgttga ggacttttcg accaattcaa
     1321 ccctttgccc cacctttatt aaaatcttaa acaacg
//
