LOCUS       NM_001256106            3542 bp    mRNA    linear   PRI 08-FEB-2025
DEFINITION  Homo sapiens CD101 molecule (CD101), transcript variant 2, mRNA.
ACCESSION   NM_001256106
VERSION     NM_001256106.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3542)
  AUTHORS   Richert-Spuhler,L.E., Mar,C.M., Shinde,P., Wu,F., Hong,T.,
            Greene,E., Hou,S., Thomas,K., Gottardo,R., Mugo,N., de Bruyn,G.,
            Celum,C., Baeten,J.M., Lingappa,J.R. and Lund,J.M.
  CONSRTM   Partners in Prevention HSV/HIV Transmission Study; and the Partners
            PrEP Study Teams
  TITLE     CD101 genetic variants modify regulatory and conventional T cell
            phenotypes and functions
  JOURNAL   Cell Rep Med 2 (6), 100322 (2021)
   PUBMED   34195685
  REMARK    GeneRIF: CD101 genetic variants modify regulatory and conventional
            T cell phenotypes and functions.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3542)
  AUTHORS   Wanga,V., Mackelprang,R.D., Thomas,K.K., Donnell,D., Cohen,C.R.,
            Mugo,N.R., Bukusi,E.A., de Bruyn,G., Irungu,E., Celum,C.,
            Baeten,J.M. and Lingappa,J.R.
  CONSRTM   Partners in Prevention HSV/HIV Transmission Study and the Partners
            PrEP Study
  TITLE     Brief Report: Bacterial Vaginosis and Risk of HIV Infection in the
            Context of CD101 Gene Variation
  JOURNAL   J Acquir Immune Defic Syndr 85 (5), 584-587 (2020)
   PUBMED   32976203
  REMARK    GeneRIF: Brief Report: Bacterial Vaginosis and Risk of HIV
            Infection in the Context of CD101 Gene Variation.
            Erratum:[J Acquir Immune Defic Syndr. 2021 Mar 1;86(3):387. doi:
            10.1097/QAI.0000000000002607.. PMID: 33560747]
REFERENCE   3  (bases 1 to 3542)
  AUTHORS   Mackelprang,R.D., Bamshad,M.J., Chong,J.X., Hou,X.,
            Buckingham,K.J., Shively,K., deBruyn,G., Mugo,N.R., Mullins,J.I.,
            McElrath,M.J., Baeten,J.M., Celum,C., Emond,M.J. and Lingappa,J.R.
  CONSRTM   Partners in Prevention HSV/HIV Transmission Study and the Partners
            PrEP Study Teams
  TITLE     Whole genome sequencing of extreme phenotypes identifies variants
            in CD101 and UBE2V1 associated with increased risk of sexually
            acquired HIV-1
  JOURNAL   PLoS Pathog 13 (11), e1006703 (2017)
   PUBMED   29108000
  REMARK    GeneRIF: variants in CD101 and UBE2V1 associated with increased
            risk of sexually acquired HIV-1
            Erratum:[PLoS Pathog. 2019 Feb 11;15(2):e1007588. doi:
            10.1371/journal.ppat.1007588.. PMID: 30742678]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3542)
  AUTHORS   Okuno,M., Kasahara,Y., Onodera,M., Takubo,N., Okajima,M., Suga,S.,
            Watanabe,N., Suzuki,J., Ayabe,T., Urakami,T., Kawamura,T.,
            Kikuchi,N., Yokota,I., Kikuchi,T., Amemiya,S., Nakabayashi,K.,
            Hayashi,K., Hata,K., Matsubara,Y., Ogata,T., Fukami,M. and
            Sugihara,S.
  TITLE     Nucleotide substitutions in CD101, the human homolog of a diabetes
            susceptibility gene in non-obese diabetic mouse, in patients with
            type 1 diabetes
  JOURNAL   J Diabetes Investig 8 (3), 286-294 (2017)
   PUBMED   27888582
  REMARK    GeneRIF: Study shows nucleotide substitutions in CD101, the human
            homolog of a diabetes susceptibility gene in non-obese diabetic
            mouse, in patients with type 1 diabetes. The results raise the
            possibility that CD101 is a susceptibility gene for type 1
            diabetes.
REFERENCE   5  (bases 1 to 3542)
  AUTHORS   Schey,R., Dornhoff,H., Baier,J.L., Purtak,M., Opoka,R.,
            Koller,A.K., Atreya,R., Rau,T.T., Daniel,C., Amann,K., Bogdan,C.
            and Mattner,J.
  TITLE     CD101 inhibits the expansion of colitogenic T cells
  JOURNAL   Mucosal Immunol 9 (5), 1205-1217 (2016)
   PUBMED   26813346
  REMARK    GeneRIF: In patients with intestinal bowel disease, a reduced CD101
            expression on peripheral and intestinal monocytes and CD4-positive
            Tcells correlated with enhanced IL-17 production and disease
            activity.
REFERENCE   6  (bases 1 to 3542)
  AUTHORS   Soares,L.R., Tsavaler,L., Rivas,A. and Engleman,E.G.
  TITLE     V7 (CD101) ligation inhibits TCR/CD3-induced IL-2 production by
            blocking Ca2+ flux and nuclear factor of activated T cell nuclear
            translocation
  JOURNAL   J Immunol 161 (1), 209-217 (1998)
   PUBMED   9647226
REFERENCE   7  (bases 1 to 3542)
  AUTHORS   Bagot,M., Martinel,I., Charue,D., Weill,F., Boulland,M.L.,
            Wechsler,J., Freeman,G.J., Bensussan,A. and Boumsell,L.
  TITLE     CD101 is expressed by skin dendritic cells. Role in T-lymphocyte
            activation
  JOURNAL   Tissue Antigens 50 (5), 439-448 (1997)
   PUBMED   9389317
REFERENCE   8  (bases 1 to 3542)
  AUTHORS   Soares,L.R., Rivas,A., Tsavaler,L. and Engleman,E.G.
  TITLE     Ligation of the V7 molecule on T cells blocks anergy induction
            through a CD28-independent mechanism
  JOURNAL   J Immunol 159 (3), 1115-1124 (1997)
   PUBMED   9233604
REFERENCE   9  (bases 1 to 3542)
  AUTHORS   Ruegg,C.L., Rivas,A., Madani,N.D., Zeitung,J., Laus,R. and
            Engleman,E.G.
  TITLE     V7, a novel leukocyte surface protein that participates in T cell
            activation. II. Molecular cloning and characterization of the V7
            gene
  JOURNAL   J Immunol 154 (9), 4434-4443 (1995)
   PUBMED   7722300
REFERENCE   10 (bases 1 to 3542)
  AUTHORS   Rivas,A., Ruegg,C.L., Zeitung,J., Laus,R., Warnke,R., Benike,C. and
            Engleman,E.G.
  TITLE     V7, a novel leukocyte surface protein that participates in T cell
            activation. I. Tissue distribution and functional studies
  JOURNAL   J Immunol 154 (9), 4423-4433 (1995)
   PUBMED   7722299
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL445231.8.
            
            On Oct 19, 2020 this sequence version replaced NM_001256106.2.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' UTR, compared to variant 1. Variants 1, 2 and 3 all
            encode isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC136484.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            MANE Ensembl match               :: ENST00000682167.1/
                                                ENSP00000508039.1
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AL445231.8         65666-65766
            102-482             AL445231.8         73756-74136
            483-899             AL445231.8         75456-75872
            900-1286            AL445231.8         77312-77698
            1287-1670           AL445231.8         80996-81379
            1671-2075           AL445231.8         82062-82466
            2076-2486           AL445231.8         85479-85889
            2487-2882           AL445231.8         89415-89810
            2883-3157           AL445231.8         97766-98040
            3158-3542           AL445231.8         100074-100458
FEATURES             Location/Qualifiers
     source          1..3542
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.1"
     gene            1..3542
                     /gene="CD101"
                     /gene_synonym="EWI-101; IGSF2; V7"
                     /note="CD101 molecule"
                     /db_xref="GeneID:9398"
                     /db_xref="HGNC:HGNC:5949"
                     /db_xref="MIM:604516"
     exon            1..101
                     /gene="CD101"
                     /gene_synonym="EWI-101; IGSF2; V7"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..3124
                     /gene="CD101"
                     /gene_synonym="EWI-101; IGSF2; V7"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2; leukocyte surface protein; immunoglobulin
                     superfamily member 2; cell surface glycoprotein V7;
                     glu-Trp-Ile EWI motif-containing protein 101"
                     /codon_start=1
                     /product="immunoglobulin superfamily member 2 isoform 1
                     precursor"
                     /protein_id="NP_001243035.1"
                     /db_xref="CCDS:CCDS891.1"
                     /db_xref="GeneID:9398"
                     /db_xref="HGNC:HGNC:5949"
                     /db_xref="MIM:604516"
                     /translation="MAGISYVASFFLLLTKLSIGQREVTVQKGPLFRAEGYPVSIGCN
                     VTGHQGPSEQHFQWSVYLPTNPTQEVQIISTKDAAFSYAVYTQRVRSGDVYVERVQGN
                     SVLLHISKLQMKDAGEYECHTPNTDEKYYGSYSAKTNLIVIPDTLSATMSSQTLGKEE
                     GEPLALTCEASKATAQHTHLSVTWYLTQDGGGSQATEIISLSKDFILVPGPLYTERFA
                     ASDVQLNKLGPTTFRLSIERLQSSDQGQLFCEATEWIQDPDETWMFITKKQTDQTTLR
                     IQPAVKDFQVNITADSLFAEGKPLELVCLVVSSGRDPQLQGIWFFNGTEIAHIDAGGV
                     LGLKNDYKERASQGELQVSKLGPKAFSLKIFSLGPEDEGAYRCVVAEVMKTRTGSWQV
                     LQRKQSPDSHVHLRKPAARSVVMSTKNKQQVVWEGETLAFLCKAGGAESPLSVSWWHI
                     PRDQTQPEFVAGMGQDGIVQLGASYGVPSYHGNTRLEKMDWATFQLEITFTAITDSGT
                     YECRVSEKSRNQARDLSWTQKISVTVKSLESSLQVSLMSRQPQVMLTNTFDLSCVVRA
                     GYSDLKVPLTVTWQFQPASSHIFHQLIRITHNGTIEWGNFLSRFQKKTKVSQSLFRSQ
                     LLVHDATEEETGVYQCEVEVYDRNSLYNNRPPRASAISHPLRIAVTLPESKLKVNSRS
                     QVQELSINSNTDIECSILSRSNGNLQLAIIWYFSPVSTNASWLKILEMDQTNVIKTGD
                     EFHTPQRKQKFHTEKVSQDLFQLHILNVEDSDRGKYHCAVEEWLLSTNGTWHKLGEKK
                     SGLTELKLKPTGSKVRVSKVYWTENVTEHREVAIRCSLESVGSSATLYSVMWYWNREN
                     SGSKLLVHLQHDGLLEYGEEGLRRHLHCYRSSSTDFVLKLHQVEMEDAGMYWCRVAEW
                     QLHGHPSKWINQASDESQRMVLTVLPSEPTLPSRICSSAPLLYFLFICPFVLLLLLLI
                     SLLCLYWKARKLSTLRSNTRKEKALWVDLKEAGGVTTNRREDEEEDEGN"
     exon            102..482
                     /gene="CD101"
                     /gene_synonym="EWI-101; IGSF2; V7"
                     /inference="alignment:Splign:2.1.0"
     exon            483..899
                     /gene="CD101"
                     /gene_synonym="EWI-101; IGSF2; V7"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1286
                     /gene="CD101"
                     /gene_synonym="EWI-101; IGSF2; V7"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1670
                     /gene="CD101"
                     /gene_synonym="EWI-101; IGSF2; V7"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..2075
                     /gene="CD101"
                     /gene_synonym="EWI-101; IGSF2; V7"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2486
                     /gene="CD101"
                     /gene_synonym="EWI-101; IGSF2; V7"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..2882
                     /gene="CD101"
                     /gene_synonym="EWI-101; IGSF2; V7"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..3157
                     /gene="CD101"
                     /gene_synonym="EWI-101; IGSF2; V7"
                     /inference="alignment:Splign:2.1.0"
     exon            3158..3542
                     /gene="CD101"
                     /gene_synonym="EWI-101; IGSF2; V7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3505..3510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD101"
                     /gene_synonym="EWI-101; IGSF2; V7"
                     /note="hexamer: AGTAAA"
     polyA_site      3542
                     /gene="CD101"
                     /gene_synonym="EWI-101; IGSF2; V7"
                     /note="major polyA site"
ORIGIN      
        1 actcaacctc tgaatgttag tgacactatt gggacgaaaa aggactgtgc tggcccaaat
       61 ggcaggcatc tcatatgtgg catctttctt tctccttctg actaagctca gcattggcca
      121 gagagaagta acagttcaga aaggaccact gtttagagct gaaggttacc cagtcagcat
      181 tggctgcaat gtaactggcc accagggacc ttctgagcag catttccagt ggtctgttta
      241 cctgccgaca aacccgaccc aggaagtcca gatcattagc accaaggatg ctgccttctc
      301 ttacgcagta tatacgcagc gggtgcgaag cggagacgtc tacgtggaga gggtccaggg
      361 caactcagtc ttgttgcaca tctcaaaact ccagatgaag gatgctggcg agtatgagtg
      421 tcacacacca aacactgatg agaaatacta tggaagttac agtgcaaaga ctaatctaat
      481 tgttattcca gataccctct ctgccaccat gagttctcag actctcggta aggaggaagg
      541 tgagccatta gccctcacct gtgaggcatc caaagccaca gcccaacata ctcacctctc
      601 tgtcacctgg tacctaacac aggatggagg aggaagccaa gccactgaga ttatttctct
      661 ctccaaagat tttatattgg tccctgggcc cttgtataca gagcggtttg cagccagtga
      721 cgtacagctc aacaaactgg gacccactac attcaggctg tccatagaga ggctccagtc
      781 ctcagatcag ggtcagctgt tctgtgaggc aacggaatgg attcaggatc cagatgaaac
      841 ttggatgttc atcaccaaaa agcagaccga tcaaaccact ctgaggatcc agccagcagt
      901 gaaagatttt caagtcaaca ttacagctga cagcttgttt gctgaaggga aacccttaga
      961 actggtttgc ctggttgtaa gcagtggccg tgacccacag cttcaaggca tttggttctt
     1021 caatgggact gaaattgctc acattgatgc tggtggagtc ctgggcctga agaatgacta
     1081 caaagagaga gcaagtcaag gagagctcca ggtttcaaag ttaggcccca aggctttctc
     1141 tctcaagatc ttctctctgg gcccagagga tgaaggcgcc tacagatgtg tggtagcaga
     1201 ggtcatgaaa acacgcacag gttcctggca ggtgcttcag agaaagcagt caccagacag
     1261 ccacgtgcac ctgaggaagc cagcagcaag aagtgtggtc atgtctacca agaacaagca
     1321 gcaagttgtg tgggaaggag agacactcgc ctttctctgt aaggctggtg gagctgaaag
     1381 tcccctgtct gtgagctggt ggcacatccc acgggaccag acacagcccg agtttgtggc
     1441 tggcatgggg caggatggca ttgtgcagct gggtgcctcc tatggggtac ccagttacca
     1501 tggcaacaca aggctggaga aaatggactg ggccaccttc cagctggaga tcaccttcac
     1561 tgccatcaca gacagtggca catatgagtg cagagtatct gagaagtctc ggaaccaggc
     1621 cagagatctg agctggactc agaagatttc agttactgta aagtctctgg agtcaagttt
     1681 acaagttagt ctgatgagcc gtcagccgca agtgatgtta accaacacct ttgacctgtc
     1741 ctgtgtcgtg agggccggtt actctgacct caaggtgcca ctcactgtga cgtggcagtt
     1801 ccagccagct agctctcaca tcttccacca gcttattcga atcacccaca atggcactat
     1861 tgaatggggg aatttcctat cccggttcca aaagaagacg aaagtgtcgc agtctttatt
     1921 tcgttcacaa ctcctagtcc atgatgccac tgaggaagag acaggagtgt atcagtgtga
     1981 agtagaagtt tatgacagaa attccctata caacaaccgc cccccgaggg cttctgccat
     2041 ctctcaccca ctgaggatag ccgtcacttt accagagagc aagctaaaag tgaattcaag
     2101 gagtcaagtc caagagctct ccatcaactc caacactgat atagaatgta gcatcttgtc
     2161 ccggtccaat ggaaaccttc agttagccat tatttggtat ttttctcctg tttccactaa
     2221 tgcctcttgg ctaaagatcc tggagatgga ccaaaccaat gttataaaaa ctggggatga
     2281 gtttcacacc ccacagagaa aacaaaaatt tcatactgag aaggtttccc aagacttatt
     2341 tcagctgcac attctgaatg tggaagacag cgatcggggc aaatatcact gtgctgtgga
     2401 ggaatggctc ctgtctacaa atggcacttg gcacaagctt ggagaaaaga agtcaggact
     2461 aacagaattg aaactcaagc ccacaggaag taaggtacgt gtctccaaag tgtactggac
     2521 cgaaaatgtg actgagcaca gagaagtggc catccgctgc agcctggaga gtgtaggcag
     2581 ctcagccact ctgtactctg tgatgtggta ctggaacaga gaaaactctg gaagtaaatt
     2641 gctggtgcac ttgcaacatg atggcttgct ggagtatggg gaagaggggc tcaggaggca
     2701 cctgcactgt taccgttcat cctctacaga ctttgtcctg aagcttcatc aggtggagat
     2761 ggaggatgca ggaatgtact ggtgtagggt ggcagagtgg cagctccatg gacacccaag
     2821 caagtggatt aatcaagcat ccgatgagtc acagcggatg gtgctcacgg tgctgccttc
     2881 agagcccacg cttccttcca ggatctgctc ctcggcccct ttactctatt tcctgttcat
     2941 ctgtcccttc gtcctgctcc tccttctgct catctccctc ctctgcttat actggaaggc
     3001 caggaagttg tcaacactgc gttccaacac acggaaagaa aaagctctct gggtggactt
     3061 gaaagaggct ggaggtgtga ccacaaatag gagggaagac gaggaggaag atgaaggcaa
     3121 ctgaatccca agaggcacct gcagccagga aggaaagctt cctgccttgc tgcctgtttc
     3181 ttcccaagcc ccgtgtggaa tgtggtgacc tagtcacctg gaaccagctc ctgacagacc
     3241 ccggcaactt ctagatgaac ccaagtgaac tttcctcatt accatcctga agtcactacc
     3301 ccagggggag ctatagcttc atgaccgtaa catgtgacct gtgtgctggc aggacgactc
     3361 actgcggctg cgccactggg acccctcccc tacatgcacc aatgcactct ctcccctctc
     3421 catcacccca taaaaccctc ctgtcacttt ccttcagaga caccgctttg gagagtattc
     3481 ccagcgctct ccttgcttgt gacaagtaaa aaaaaaaaaa aactcctttt catcaaaact
     3541 ca
//
