LOCUS       NM_015622               2379 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens CCZ1 homolog, vacuolar protein trafficking and
            biogenesis associated (CCZ1), mRNA.
ACCESSION   NM_015622 XM_942308
VERSION     NM_015622.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2379)
  AUTHORS   Monteil,V., Kwon,H., John,L., Salata,C., Jonsson,G., Vorrink,S.U.,
            Appelberg,S., Youhanna,S., Dyczynski,M., Leopoldi,A., Leeb,N.,
            Volz,J., Hagelkruys,A., Kellner,M.J., Devignot,S., Michlits,G.,
            Foong-Sobis,M., Weber,F., Lauschke,V.M., Horn,M., Feldmann,H.,
            Elling,U., Penninger,J.M. and Mirazimi,A.
  TITLE     Identification of CCZ1 as an essential lysosomal trafficking
            regulator in Marburg and Ebola virus infections
  JOURNAL   Nat Commun 14 (1), 6785 (2023)
   PUBMED   37880247
  REMARK    GeneRIF: Identification of CCZ1 as an essential lysosomal
            trafficking regulator in Marburg and Ebola virus infections.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2379)
  AUTHORS   Vaites,L.P., Paulo,J.A., Huttlin,E.L. and Harper,J.W.
  TITLE     Systematic Analysis of Human Cells Lacking ATG8 Proteins Uncovers
            Roles for GABARAPs and the CCZ1/MON1 Regulator C18orf8/RMC1 in
            Macroautophagic and Selective Autophagic Flux
  JOURNAL   Mol Cell Biol 38 (1), e00392-17 (2017)
   PUBMED   29038162
  REMARK    GeneRIF: Authors identified C18orf8/RMC1 as a new subunit of the
            CCZ1-MON1 RAB7 guanine exchange factor (GEF) that positively
            regulates RAB7 recruitment to LE/autophagosomes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2379)
  AUTHORS   Gerondopoulos,A., Langemeyer,L., Liang,J.R., Linford,A. and
            Barr,F.A.
  TITLE     BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine
            nucleotide exchange factor
  JOURNAL   Curr Biol 22 (22), 2135-2139 (2012)
   PUBMED   23084991
REFERENCE   4  (bases 1 to 2379)
  AUTHORS   Piekarska,I., Kucharczyk,R., Mickowska,B., Rytka,J. and Rempola,B.
  TITLE     Mutants of the Saccharomyces cerevisiae VPS genes CCZ1 and YPT7 are
            blocked in different stages of sporulation
  JOURNAL   Eur J Cell Biol 89 (11), 780-787 (2010)
   PUBMED   20709422
  REMARK    GeneRIF: The CCZ1 gene is a member of the class B VPS (vacuolar
            protein sorting) genes and it is engaged in the last stage of
            delivery of multiple kinds of cargo to the yeast vacuole.
REFERENCE   5  (bases 1 to 2379)
  AUTHORS   Kinchen,J.M. and Ravichandran,K.S.
  TITLE     Identification of two evolutionarily conserved genes regulating
            processing of engulfed apoptotic cells
  JOURNAL   Nature 464 (7289), 778-782 (2010)
   PUBMED   20305638
REFERENCE   6  (bases 1 to 2379)
  AUTHORS   Choudhary,C., Kumar,C., Gnad,F., Nielsen,M.L., Rehman,M.,
            Walther,T.C., Olsen,J.V. and Mann,M.
  TITLE     Lysine acetylation targets protein complexes and co-regulates major
            cellular functions
  JOURNAL   Science 325 (5942), 834-840 (2009)
   PUBMED   19608861
REFERENCE   7  (bases 1 to 2379)
  AUTHORS   Gauci,S., Helbig,A.O., Slijper,M., Krijgsveld,J., Heck,A.J. and
            Mohammed,S.
  TITLE     Lys-N and trypsin cover complementary parts of the phosphoproteome
            in a refined SCX-based approach
  JOURNAL   Anal Chem 81 (11), 4493-4501 (2009)
   PUBMED   19413330
REFERENCE   8  (bases 1 to 2379)
  AUTHORS   Dephoure,N., Zhou,C., Villen,J., Beausoleil,S.A., Bakalarski,C.E.,
            Elledge,S.J. and Gygi,S.P.
  TITLE     A quantitative atlas of mitotic phosphorylation
  JOURNAL   Proc Natl Acad Sci U S A 105 (31), 10762-10767 (2008)
   PUBMED   18669648
REFERENCE   9  (bases 1 to 2379)
  AUTHORS   Cantin,G.T., Yi,W., Lu,B., Park,S.K., Xu,T., Lee,J.D. and
            Yates,J.R. 3rd.
  TITLE     Combining protein-based IMAC, peptide-based IMAC, and MudPIT for
            efficient phosphoproteomic analysis
  JOURNAL   J Proteome Res 7 (3), 1346-1351 (2008)
   PUBMED   18220336
REFERENCE   10 (bases 1 to 2379)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC067810.1, BI546694.1, CN310516.1, AF151801.1 and AC004983.3.
            
            On May 17, 2019 this sequence version replaced NM_015622.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF151801.1, SRR3476690.884824.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325974.9/ ENSP00000325681.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                BC067810.1         34-102
            70-589              BI546694.1         85-604
            590-837             BC067810.1         623-870
            838-1021            CN310516.1         553-736
            1022-1410           AF151801.1         1089-1477
            1411-1803           BC067810.1         1444-1836
            1804-2379           AC004983.3         37193-37768         c
FEATURES             Location/Qualifiers
     source          1..2379
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.1"
     gene            1..2379
                     /gene="CCZ1"
                     /gene_synonym="C7orf28A; CCZ1A; CGI-43; H_DJ1163J12.2"
                     /note="CCZ1 homolog, vacuolar protein trafficking and
                     biogenesis associated"
                     /db_xref="GeneID:51622"
                     /db_xref="HGNC:HGNC:21691"
                     /db_xref="MIM:620660"
     exon            1..187
                     /gene="CCZ1"
                     /gene_synonym="C7orf28A; CCZ1A; CGI-43; H_DJ1163J12.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1516
                     /gene="CCZ1"
                     /gene_synonym="C7orf28A; CCZ1A; CGI-43; H_DJ1163J12.2"
                     /note="H_NH0577018.2; CCZ1 vacuolar protein trafficking
                     and biogenesis associated homolog"
                     /codon_start=1
                     /product="vacuolar fusion protein CCZ1 homolog"
                     /protein_id="NP_056437.4"
                     /db_xref="CCDS:CCDS34597.1"
                     /db_xref="GeneID:51622"
                     /db_xref="HGNC:HGNC:21691"
                     /db_xref="MIM:620660"
                     /translation="MAAAAAGAGSGPWAAQEKQFPPALLSFFIYNPRFGPREGQEENK
                     ILFYHPNEVEKNEKIRNVGLCEAIVQFTRTFSPSKPAKSLHTQKNRQFFNEPEENFWM
                     VMVVRNPIIEKQSKDGKPVIEYQEEELLDKVYSSVLRQCYSMYKLFNGTFLKAMEDGG
                     VKLLKERLEKFFHRYLQTLHLQSCDLLDIFGGISFFPLDKMTYLKIQSFINRMEESLN
                     IVKYTAFLYNDQLIWSGLEQDDMRILYKYLTTSLFPRHIEPELAGRDSPIRAEMPGNL
                     QHYGRFLTGPLNLNDPDAKCRFPKIFVNTDDTYEELHLIVYKAMSAAVCFMIDASVHP
                     TLDFCRRLDSIVGPQLTVLASDICEQFNINKRMSGSEKEPQFKFIYFNHMNLAEKSTV
                     HMRKTPSVSLTSVHPDLMKILGDINSDFTRVDEDEEIIVKAMSDYWVVGKKSDRRELY
                     VILNQKNANLIEVNEEVKKLCATQFNNIFFLD"
     exon            188..285
                     /gene="CCZ1"
                     /gene_synonym="C7orf28A; CCZ1A; CGI-43; H_DJ1163J12.2"
                     /inference="alignment:Splign:2.1.0"
     exon            286..379
                     /gene="CCZ1"
                     /gene_synonym="C7orf28A; CCZ1A; CGI-43; H_DJ1163J12.2"
                     /inference="alignment:Splign:2.1.0"
     exon            380..457
                     /gene="CCZ1"
                     /gene_synonym="C7orf28A; CCZ1A; CGI-43; H_DJ1163J12.2"
                     /inference="alignment:Splign:2.1.0"
     exon            458..505
                     /gene="CCZ1"
                     /gene_synonym="C7orf28A; CCZ1A; CGI-43; H_DJ1163J12.2"
                     /inference="alignment:Splign:2.1.0"
     exon            506..589
                     /gene="CCZ1"
                     /gene_synonym="C7orf28A; CCZ1A; CGI-43; H_DJ1163J12.2"
                     /inference="alignment:Splign:2.1.0"
     exon            590..765
                     /gene="CCZ1"
                     /gene_synonym="C7orf28A; CCZ1A; CGI-43; H_DJ1163J12.2"
                     /inference="alignment:Splign:2.1.0"
     exon            766..847
                     /gene="CCZ1"
                     /gene_synonym="C7orf28A; CCZ1A; CGI-43; H_DJ1163J12.2"
                     /inference="alignment:Splign:2.1.0"
     exon            848..909
                     /gene="CCZ1"
                     /gene_synonym="C7orf28A; CCZ1A; CGI-43; H_DJ1163J12.2"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1021
                     /gene="CCZ1"
                     /gene_synonym="C7orf28A; CCZ1A; CGI-43; H_DJ1163J12.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1055
                     /gene="CCZ1"
                     /gene_synonym="C7orf28A; CCZ1A; CGI-43; H_DJ1163J12.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1173
                     /gene="CCZ1"
                     /gene_synonym="C7orf28A; CCZ1A; CGI-43; H_DJ1163J12.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1332
                     /gene="CCZ1"
                     /gene_synonym="C7orf28A; CCZ1A; CGI-43; H_DJ1163J12.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1460
                     /gene="CCZ1"
                     /gene_synonym="C7orf28A; CCZ1A; CGI-43; H_DJ1163J12.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..2379
                     /gene="CCZ1"
                     /gene_synonym="C7orf28A; CCZ1A; CGI-43; H_DJ1163J12.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1779..1784
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCZ1"
                     /gene_synonym="C7orf28A; CCZ1A; CGI-43; H_DJ1163J12.2"
                     /note="hexamer: AATAAA"
     polyA_site      1803
                     /gene="CCZ1"
                     /gene_synonym="C7orf28A; CCZ1A; CGI-43; H_DJ1163J12.2"
                     /note="major polyA site"
ORIGIN      
        1 gttttagccg gtggctgctg tctctgggcg ggccgtggga ggctcccgag gtgggggccg
       61 gggcgggatg gctgcagcgg cggccggggc cgggagcggg ccctgggcgg cccaggagaa
      121 gcagttcccg ccggcgctgc tgagtttctt catctacaac ccgcgcttcg ggccgcgcga
      181 aggacaggag gaaaataaga ttttatttta tcatccaaat gaggtagaaa agaatgagaa
      241 gattagaaat gtcggattgt gtgaagctat tgtacagttt acaaggacat ttagcccatc
      301 aaaacctgca aaatctttac atacacagaa gaacagacag ttcttcaatg aaccagaaga
      361 aaatttctgg atggtcatgg ttgttcggaa tcctataatt gaaaaacaga gtaaagatgg
      421 aaaaccagtt attgaatatc aagaggagga gttgttggac aaggtttata gctcggtgct
      481 gcggcagtgc tacagcatgt acaagctttt taatggtaca tttctgaaag ccatggaaga
      541 cggaggcgtc aagcttctga aagaaagatt agagaaattc ttccatcggt atttgcaaac
      601 gctacatttg cagtcatgtg acctacttga catttttggt ggaatcagct tcttcccgtt
      661 ggataaaatg acttatttga aaatccagtc ctttattaat agaatggagg aaagcctgaa
      721 tatagtcaaa tacactgctt ttctctataa cgatcagctc atctggagtg gattagaaca
      781 agatgacatg agaattttat acaaatacct taccacctcc ctttttccaa ggcacatcga
      841 acctgagtta gcaggaaggg attctccaat aagagcagaa atgccaggaa atcttcaaca
      901 ctatggaaga tttcttaccg gacccttgaa cctcaatgat ccagatgcaa aatgcagatt
      961 ccccaaaatt tttgtaaata cagatgacac ttatgaagag ctccatttaa tcgtttataa
     1021 ggccatgagt gcggctgtgt gctttatgat cgacgcctct gtccacccaa cgttggattt
     1081 ttgccgaaga ctggacagca tcgttgggcc ccagctcaca gtgctggcct ctgacatctg
     1141 tgaacagttt aacatcaaca agaggatgtc cgggtctgag aaagaacccc agtttaagtt
     1201 tatctacttc aaccacatga atctcgccga gaagagcaca gttcacatga ggaaaacgcc
     1261 cagcgtgtcg ctcacttccg tgcacccgga tttaatgaag attctcggtg acatcaacag
     1321 tgactttacc agagtggatg aagatgagga gatcattgtg aaggccatga gtgattactg
     1381 ggttgttgga aagaagtctg atcggcggga gctctatgtt attttgaatc aaaaaaatgc
     1441 aaacctgatt gaagtaaatg aagaggtcaa gaaactttgt gcaacgcagt tcaacaacat
     1501 cttcttcttg gattgacgga tgacggctca ccgagagcat atctaaaaaa cactctgcaa
     1561 acatttggtc acatgcaagt tagtggtcat atgacggact gcattcagga caagggtaaa
     1621 gcaatacttg ctttgaagaa tcacatttcg actcggtctg ctgatctgag gtttttagat
     1681 tttaaatatt tatgtggaat taattaaagg tagttggcta tatcgctatc atttcattct
     1741 tttgacatta tgtgaatatt ttactggaaa ataagactaa taaattgtta aaagttttta
     1801 aaattctggt ttggtgttga gtctctctcc tgctgcctat ttatagatta cactggccac
     1861 cagctccgtg acccaggctg gaatgcaatg gctcactgca gcctcaacct cctgagctca
     1921 agcaatcctc ccacctcagc ctcccaagaa gctagaacca catgtacaca ccaccacggt
     1981 cggctgatgt tttaattttg cagagatggg ggggtctcac tatgttgccc aggctggtct
     2041 cgaactcccg taatccagcc atgtaggaaa cctgagatgc agtgggccaa ggggtatgtt
     2101 aaaacactgt gacgagttca gtgctaagaa ctgtaatgct caggaaatct tacagcacgt
     2161 gccatcctaa gcctgtgtgt gtgtcctcgt gtctctctac tttttcttct tcttgctggt
     2221 gatggtcttg ctggatgggg acacggtcac atcctccttg ggagggtcca gtatgaggtg
     2281 agaggatgac acgtctgccg gctccttgag cactgtgatg tccacctcat agtcatgtct
     2341 cttggcctct tcctctctca agatgaagat gttcagcct
//
