LOCUS       NM_014406               2060 bp    mRNA    linear   PRI 16-JUN-2024
DEFINITION  Homo sapiens chaperonin containing TCP1 subunit 8 like 2 (CCT8L2),
            mRNA.
ACCESSION   NM_014406
VERSION     NM_014406.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2060)
  AUTHORS   Ostensson,M., Monten,C., Bacelis,J., Gudjonsdottir,A.H.,
            Adamovic,S., Ek,J., Ascher,H., Pollak,E., Arnell,H., Browaldh,L.,
            Agardh,D., Wahlstrom,J., Nilsson,S. and Torinsson-Naluai,A.
  TITLE     A possible mechanism behind autoimmune disorders discovered by
            genome-wide linkage and association analysis in celiac disease
  JOURNAL   PLoS One 8 (8), e70174 (2013)
   PUBMED   23936387
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2060)
  AUTHORS   Mukherjee,K., Conway de Macario,E., Macario,A.J. and Brocchieri,L.
  TITLE     Chaperonin genes on the rise: new divergent classes and intense
            duplication in human and other vertebrate genomes
  JOURNAL   BMC Evol Biol 10, 64 (2010)
   PUBMED   20193073
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2060)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC033797.1, BC022006.1 and AP000547.1.
            
            On May 17, 2019 this sequence version replaced NM_014406.4.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC033797.1, CR456508.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359963.4/ ENSP00000353048.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1859              BC033797.1         1-1859
            1860-2053           BC022006.1         1844-2037
            2054-2060           AP000547.1         102974-102980       c
FEATURES             Location/Qualifiers
     source          1..2060
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.1"
     gene            1..2060
                     /gene="CCT8L2"
                     /gene_synonym="CESK1"
                     /note="chaperonin containing TCP1 subunit 8 like 2"
                     /db_xref="GeneID:150160"
                     /db_xref="HGNC:HGNC:15553"
     exon            1..2060
                     /gene="CCT8L2"
                     /gene_synonym="CESK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             261..1934
                     /gene="CCT8L2"
                     /gene_synonym="CESK1"
                     /note="putative T-complex protein 1 subunit theta-like 2;
                     chaperonin containing TCP1, subunit 8 (theta)-like 2;
                     chaperonin containing T-complex polypeptide 1 subunit
                     8-like 2"
                     /codon_start=1
                     /product="T-complex protein 1 subunit theta-like 2"
                     /protein_id="NP_055221.1"
                     /db_xref="CCDS:CCDS13738.1"
                     /db_xref="GeneID:150160"
                     /db_xref="HGNC:HGNC:15553"
                     /translation="MDSTVPSALELPQRLALNPRESPRSPEEEEPHLLSSLAAVQTLA
                     SVIRPCYGPHGRQKFLVTMKGETVCTGCATAILRALELEHPAAWLLREAGQTQAENSG
                     DGTAFVVLLTEALLEQAEQLLKAGLPRPQLREAYATATAEVLATLPSLAIQSLGPLED
                     PSWALHSVMNTHTLSPMDHLTKLVAHACWAIKELDGSFKPERVGVCALPGGTLEDSCL
                     LPGLAISGKLCGQMATVLSGARVALFACPFGPAHPNAPATARLSSPADLAQFSKGSDQ
                     LLEKQVGQLAAAGINVAVVLGEVDEETLTLADKYGIVVIQARSWMEIIYLSEVLDTPL
                     LPRLLPPQRPGKCQRVYRQELGDGLAVVFEWECTGTPALTVVLRGATTQGLRSAEQAV
                     YHGIDAYFQLCQDPRLIPGAGATEMALAKMLSDKGSRLEGPSGPAFLAFAWALKYLPK
                     TLAENAGLAVSDVMAEMSGVHQGGNLLMGVGTEGIINVAQEGVWDTLIVKAQGFRAVA
                     EVVLQLVTVDEIVVAKKSPTHQEIWNPDSKKTKKHPPPVETKKILGLNN"
     regulatory      2036..2041
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCT8L2"
                     /gene_synonym="CESK1"
                     /note="hexamer: AATAAA"
     polyA_site      2060
                     /gene="CCT8L2"
                     /gene_synonym="CESK1"
                     /note="major polyA site"
ORIGIN      
        1 gttgagaggc cccaagaccc agttccttta cagaatcaac cctggggtgg ctttaggact
       61 gggctctttg gagctcatcc ttggacccac agtggagtgc tggtccgtgc tgatgtcttc
      121 agataccaat caatgggcat ttggctcctt gcttccactg acctcttgag tactttcaac
      181 gatcggtgtc aggagtgccc cagctgctgt ttctagagca tctctgcaac ccacggtggc
      241 ctctcctctc tctgcgggcc atggacagca cagtcccttc agccctggag ctgccccagc
      301 ggctggcact gaacccaagg gagagcccga ggagtccaga agaggaggag ccccacctgc
      361 tgagcagctt ggctgcagtc cagaccctgg ccagtgtcat ccggccttgc tatggccccc
      421 acggccggca gaagttcctg gtgaccatga aaggagaaac agtgtgcacg gggtgtgcca
      481 ctgccatcct cagggccctg gagctggagc acccagcagc atggctcctc cgggaagcag
      541 gacaaaccca ggcagagaat agtggggacg gcacagcctt cgtggttctg ctgacggaag
      601 ccttgctgga acaggcagag cagctgctga aggctggcct gcctcgcccg cagctccggg
      661 aggcctacgc cacggccact gcagaggtcc tggccacact gccctccctg gccatccaat
      721 ctctggggcc tttggaagat ccatcctggg ccctccattc tgtgatgaat acccacaccc
      781 tgtcccccat ggaccacttg accaagctgg tggcccacgc ctgctgggct atcaaggaac
      841 tagacggcag cttcaagcct gagcgtgttg gggtgtgcgc gctgcccggg gggacactgg
      901 aggattcctg cctcctcccg gggttagcaa tatctgggaa gctctgtggg caaatggcca
      961 cagtgttaag tggtgccagg gtggctctct ttgcttgccc ctttggtcct gcccatccaa
     1021 atgcaccagc aacggcccgt ctttctagtc ctgctgatct agctcaattt agtaaaggaa
     1081 gcgatcaatt actagaaaag caagtaggcc agctagcagc tgcaggaatt aatgtggcag
     1141 tggtgttggg ggaggtcgac gaggagaccc tcacactggc ggacaagtat ggcatcgtgg
     1201 tgattcaagc taggtcttgg atggagatca tttacctgag tgaggtgttg gacacacctc
     1261 tgctgcctcg tctgctccct ccccagaggc caggcaagtg ccagagggtt tacaggcagg
     1321 agctgggaga tggtttggct gtggtatttg aatgggaatg tacaggcaca cctgccctca
     1381 ctgtggttct caggggagcc accacccagg ggctgcggag tgcagagcag gccgtctacc
     1441 acggcattga tgcctatttc cagctatgtc aagatcccag actgattcca ggagctgggg
     1501 ccacagaaat ggctttggca aaaatgcttt ctgataaagg aagcagattg gaagggccca
     1561 gtgggcctgc attcctagca tttgcctggg ccctgaagta tcttcctaaa actttggcag
     1621 agaatgcagg cttagctgtc tcagacgtga tggcagaaat gagtggagtg caccaaggtg
     1681 ggaacctcct aatgggtgtg ggaactgaag ggataataaa tgtggcccag gaaggggtgt
     1741 gggacaccct aatagtcaaa gcccaaggat ttcgagcagt ggctgaggtg gtgctacagc
     1801 tcgtgactgt agatgaaatc gtagtggcca agaaaagtcc cacacatcag gagatctgga
     1861 atcctgactc taagaagaca aagaaacacc cacctcctgt ggaaacaaaa aaaatccttg
     1921 gattgaataa ctagtgatac cctcaataaa acagggattg ccaagaaggg aacaatcacc
     1981 ccaaaaatga atgtttgcct ttattccgtg tttggtactt gattcacttt ctttaaataa
     2041 aaacatgaag gaacataaaa
//
