LOCUS       NM_006429               1847 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens chaperonin containing TCP1 subunit 7 (CCT7),
            transcript variant 1, mRNA.
ACCESSION   NM_006429
VERSION     NM_006429.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1847)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 1847)
  AUTHORS   Huang,X., Wang,H., Xu,F., Lv,L., Wang,R., Jiang,B., Liu,T., Hu,H.
            and Jiang,Y.
  TITLE     Overexpression of chaperonin containing TCP1 subunit 7 has
            diagnostic and prognostic value for hepatocellular carcinoma
  JOURNAL   Aging (Albany NY) 14 (2), 747-769 (2022)
   PUBMED   35073517
  REMARK    GeneRIF: Overexpression of chaperonin containing TCP1 subunit 7 has
            diagnostic and prognostic value for hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 1847)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1847)
  AUTHORS   Okitsu,Y., Nagano,M., Yamagata,T., Ito,C., Toshimori,K., Dohra,H.,
            Fujii,W. and Yogo,K.
  TITLE     Dlec1 is required for spermatogenesis and male fertility in mice
  JOURNAL   Sci Rep 10 (1), 18883 (2020)
   PUBMED   33144677
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1847)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 1847)
  AUTHORS   Imai,Y., Soda,M., Murakami,T., Shoji,M., Abe,K. and Takahashi,R.
  TITLE     A product of the human gene adjacent to parkin is a component of
            Lewy bodies and suppresses Pael receptor-induced cell death
  JOURNAL   J Biol Chem 278 (51), 51901-51910 (2003)
   PUBMED   14532270
REFERENCE   7  (bases 1 to 1847)
  AUTHORS   Yokota,S., Yanagi,H., Yura,T. and Kubota,H.
  TITLE     Cytosolic chaperonin-containing t-complex polypeptide 1 changes the
            content of a particular subunit species concomitant with substrate
            binding and folding activities during the cell cycle
  JOURNAL   Eur J Biochem 268 (17), 4664-4673 (2001)
   PUBMED   11532003
  REMARK    GeneRIF: Functional characterization of the CCT complex and its
            subunits in mouse.
REFERENCE   8  (bases 1 to 1847)
  AUTHORS   Won,K.A., Schumacher,R.J., Farr,G.W., Horwich,A.L. and Reed,S.I.
  TITLE     Maturation of human cyclin E requires the function of eukaryotic
            chaperonin CCT
  JOURNAL   Mol Cell Biol 18 (12), 7584-7589 (1998)
   PUBMED   9819444
REFERENCE   9  (bases 1 to 1847)
  AUTHORS   Liou,A.K. and Willison,K.R.
  TITLE     Elucidation of the subunit orientation in CCT (chaperonin
            containing TCP1) from the subunit composition of CCT
            micro-complexes
  JOURNAL   EMBO J 16 (14), 4311-4316 (1997)
   PUBMED   9250675
REFERENCE   10 (bases 1 to 1847)
  AUTHORS   Hynes,G., Celis,J.E., Lewis,V.A., Carne,A., U,S., Lauridsen,J.B.
            and Willison,K.R.
  TITLE     Analysis of chaperonin-containing TCP-1 subunits in the human
            keratinocyte two-dimensional protein database: further
            characterisation of antibodies to individual subunits
  JOURNAL   Electrophoresis 17 (11), 1720-1727 (1996)
   PUBMED   8982604
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC395264.1, BC019296.1,
            AK098825.1 and CX781741.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006429.3.
            
            Summary: This gene encodes a molecular chaperone that is a member
            of the chaperonin containing TCP1 complex (CCT), also known as the
            TCP1 ring complex (TRiC). This complex consists of two identical
            stacked rings, each containing eight different proteins. Unfolded
            polypeptides enter the central cavity of the complex and are folded
            in an ATP-dependent manner. The complex folds various proteins,
            including actin and tubulin. Alternative splicing results in
            multiple transcript variants. Related pseudogenes have been
            identified on chromosomes 5 and 6. [provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088351.1, SRR1163655.168021.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258091.10/ ENSP00000258091.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                DC395264.1         71-118
            49-1381             BC019296.1         34-1366
            1382-1846           AK098825.1         786-1250
            1847-1847           CX781741.1         247-247
FEATURES             Location/Qualifiers
     source          1..1847
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.2"
     gene            1..1847
                     /gene="CCT7"
                     /gene_synonym="CCTETA; CCTH; NIP7-1; TCP1ETA"
                     /note="chaperonin containing TCP1 subunit 7"
                     /db_xref="GeneID:10574"
                     /db_xref="HGNC:HGNC:1622"
                     /db_xref="MIM:605140"
     exon            1..77
                     /gene="CCT7"
                     /gene_synonym="CCTETA; CCTH; NIP7-1; TCP1ETA"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1703
                     /gene="CCT7"
                     /gene_synonym="CCTETA; CCTH; NIP7-1; TCP1ETA"
                     /note="isoform a is encoded by transcript variant 1;
                     chaperonin containing t-complex polypeptide 1, eta
                     subunit; T-complex protein 1 subunit eta; HIV-1 Nef
                     interacting protein; CCT-eta; TCP-1-eta; chaperonin
                     containing T-complex polypeptide 1 subunit 7"
                     /codon_start=1
                     /product="T-complex protein 1 subunit eta isoform a"
                     /protein_id="NP_006420.1"
                     /db_xref="CCDS:CCDS46336.1"
                     /db_xref="GeneID:10574"
                     /db_xref="HGNC:HGNC:1622"
                     /db_xref="MIM:605140"
                     /translation="MMPTPVILLKEGTDSSQGIPQLVSNISACQVIAEAVRTTLGPRG
                     MDKLIVDGRGKATISNDGATILKLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAA
                     EFLKQVKPYVEEGLHPQIIIRAFRTATQLAVNKIKEIAVTVKKADKVEQRKLLEKCAM
                     TALSSKLISQQKAFFAKMVVDAVMMLDDLLQLKMIGIKKVQGGALEDSQLVAGVAFKK
                     TFSYAGFEMQPKKYHNPKIALLNVELELKAEKDNAEIRVHTVEDYQAIVDAEWNILYD
                     KLEKIHHSGAKVVLSKLPIGDVATQYFADRDMFCAGRVPEEDLKRTMMACGGSIQTSV
                     NALSADVLGRCQVFEETQIGGERYNFFTGCPKAKTCTFILRGGAEQFMEETERSLHDA
                     IMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALEIIPRQLC
                     DNAGFDATNILNKLRARHAQGGTWYGVDINNEDIADNFEAFVWEPAMVRINALTAASE
                     AACLIVSVDETIKNPRSTVDAPTAAGRGRGRGRPH"
     exon            78..231
                     /gene="CCT7"
                     /gene_synonym="CCTETA; CCTH; NIP7-1; TCP1ETA"
                     /inference="alignment:Splign:2.1.0"
     exon            232..338
                     /gene="CCT7"
                     /gene_synonym="CCTETA; CCTH; NIP7-1; TCP1ETA"
                     /inference="alignment:Splign:2.1.0"
     exon            339..464
                     /gene="CCT7"
                     /gene_synonym="CCTETA; CCTH; NIP7-1; TCP1ETA"
                     /inference="alignment:Splign:2.1.0"
     exon            465..517
                     /gene="CCT7"
                     /gene_synonym="CCTETA; CCTH; NIP7-1; TCP1ETA"
                     /inference="alignment:Splign:2.1.0"
     exon            518..689
                     /gene="CCT7"
                     /gene_synonym="CCTETA; CCTH; NIP7-1; TCP1ETA"
                     /inference="alignment:Splign:2.1.0"
     exon            690..854
                     /gene="CCT7"
                     /gene_synonym="CCTETA; CCTH; NIP7-1; TCP1ETA"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1043
                     /gene="CCT7"
                     /gene_synonym="CCTETA; CCTH; NIP7-1; TCP1ETA"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1141
                     /gene="CCT7"
                     /gene_synonym="CCTETA; CCTH; NIP7-1; TCP1ETA"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1274
                     /gene="CCT7"
                     /gene_synonym="CCTETA; CCTH; NIP7-1; TCP1ETA"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1481
                     /gene="CCT7"
                     /gene_synonym="CCTETA; CCTH; NIP7-1; TCP1ETA"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1847
                     /gene="CCT7"
                     /gene_synonym="CCTETA; CCTH; NIP7-1; TCP1ETA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1829..1834
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCT7"
                     /gene_synonym="CCTETA; CCTH; NIP7-1; TCP1ETA"
                     /note="hexamer: AATAAA"
     polyA_site      1847
                     /gene="CCT7"
                     /gene_synonym="CCTETA; CCTH; NIP7-1; TCP1ETA"
                     /note="major polyA site"
ORIGIN      
        1 attgtgggtt gctgggcggc ccggtctcgg agaagagggg agagtggcgg gccgctgaat
       61 aagcttccaa aatgatgccc acaccagtta tcctattgaa agaggggact gatagctccc
      121 aaggcatccc ccagcttgtg agtaacatca gtgcctgcca ggtgattgct gaggctgtaa
      181 gaactaccct gggtccccgt ggcatggaca agcttattgt agatggcaga ggcaaagcaa
      241 caatttctaa tgatggggcc acaattctga aacttcttga tgttgtccat cctgcagcaa
      301 agactttggt agacattgcc aaatcccaag atgctgaggt gggtgatggc accacctcag
      361 tgaccttgct ggctgcagag tttctgaagc aggtgaaacc ctatgtggag gaaggtttac
      421 acccccagat catcattcga gctttccgca cagccaccca gctggcagtt aacaagatca
      481 aagagattgc tgtgaccgtg aagaaggcag ataaagtgga gcagaggaag ctgctggaaa
      541 agtgtgccat gaccgctctg agctccaagc tgatctccca gcagaaagct ttctttgcta
      601 agatggtggt ggatgcagtg atgatgctcg atgatttgct gcagcttaaa atgattggaa
      661 tcaagaaggt acagggtgga gccctcgagg attctcagct ggtagctggt gttgcattca
      721 agaagacttt ctcttacgct gggtttgaaa tgcaacccaa aaagtaccac aatcccaaga
      781 ttgccctttt gaatgtcgag ctcgagttga aagctgagaa agacaatgct gagataagag
      841 tccacacagt tgaggattat caggcaattg ttgatgctga gtggaacatt ctctatgaca
      901 agttagagaa gatccatcat tctggagcca aagttgtctt gtccaaactc cccattgggg
      961 atgtggccac ccagtacttt gctgacaggg acatgttctg tgctggccga gtacctgagg
     1021 aggatctgaa gaggacaatg atggcctgtg gaggctcaat ccagaccagt gtgaatgctc
     1081 tgtcagcaga tgtgctgggt cgatgccagg tgtttgaaga gacccagatt ggaggcgaga
     1141 ggtacaattt ttttactggc tgccccaagg ccaagacatg caccttcatt ctccgtggcg
     1201 gcgccgagca gtttatggag gagacagagc ggtccctgca tgatgccatc atgatcgtca
     1261 ggagggccat caagaatgat tcagtggtgg ctggtggcgg ggccattgag atggaactct
     1321 ccaagtacct gcgggattac tcaaggacta ttccaggaaa acagcagctg ttgattgggg
     1381 catatgccaa ggccttggag attatcccac gccagctgtg tgacaatgct ggctttgatg
     1441 ccacaaacat tctcaacaag ctgcgggctc ggcatgccca ggggggtaca tggtatggag
     1501 tagacatcaa caacgaggac attgctgaca actttgaagc tttcgtgtgg gagccagcta
     1561 tggtgcggat caatgcgctg acagcagcct ctgaggctgc gtgcctgatc gtgtctgtag
     1621 atgaaaccat caagaacccc cgctcgactg tggatgctcc cacagcagca ggccggggcc
     1681 gtggtcgtgg ccgcccccac tgagaggcac cccacccatc acatggctgg ctggctgctg
     1741 ggtgcactta ccctccttgg cttggttact tcattttaca aggaaggggt agtaattggc
     1801 ccactctctt cttactggag gctatttaaa taaaatgtaa gacttca
//
