LOCUS       NM_006430               2376 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens chaperonin containing TCP1 subunit 4 (CCT4),
            transcript variant 1, mRNA.
ACCESSION   NM_006430
VERSION     NM_006430.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2376)
  AUTHORS   Tang,C., Li,C., Chen,C., Chen,T., Zhu,J., Sun,M., Wang,P. and
            Han,C.
  TITLE     LINC01234 promoted malignant behaviors of breast cancer cells via
            hsa-miR-30c-2-3p/CCT4/mTOR signaling pathway
  JOURNAL   Taiwan J Obstet Gynecol 63 (1), 46-56 (2024)
   PUBMED   38216268
  REMARK    GeneRIF: LINC01234 promoted malignant behaviors of breast cancer
            cells via hsa-miR-30c-2-3p/CCT4/mTOR signaling pathway.
REFERENCE   2  (bases 1 to 2376)
  AUTHORS   Fang,J., Ma,Y., Li,Y., Li,J., Zhang,X., Han,X., Ma,S. and Guan,F.
  TITLE     CCT4 knockdown enhances the sensitivity of cisplatin by inhibiting
            glycolysis in human esophageal squamous cell carcinomas
  JOURNAL   Mol Carcinog 61 (11), 1043-1055 (2022)
   PUBMED   36102200
  REMARK    GeneRIF: CCT4 knockdown enhances the sensitivity of cisplatin by
            inhibiting glycolysis in human esophageal squamous cell carcinomas.
REFERENCE   3  (bases 1 to 2376)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 2376)
  AUTHORS   Li,F., Liu,C.S., Wu,P., Ling,A.S., Pan,Q. and Li,X.N.
  TITLE     CCT4 suppression inhibits tumor growth in hepatocellular carcinoma
            by interacting with Cdc20
  JOURNAL   Chin Med J (Engl) 134 (22), 2721-2729 (2021)
   PUBMED   34732665
  REMARK    GeneRIF: CCT4 suppression inhibits tumor growth in hepatocellular
            carcinoma by interacting with Cdc20.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2376)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2376)
  AUTHORS   Won,K.A., Schumacher,R.J., Farr,G.W., Horwich,A.L. and Reed,S.I.
  TITLE     Maturation of human cyclin E requires the function of eukaryotic
            chaperonin CCT
  JOURNAL   Mol Cell Biol 18 (12), 7584-7589 (1998)
   PUBMED   9819444
REFERENCE   7  (bases 1 to 2376)
  AUTHORS   Melki,R., Batelier,G., Soulie,S. and Williams,R.C. Jr.
  TITLE     Cytoplasmic chaperonin containing TCP-1: structural and functional
            characterization
  JOURNAL   Biochemistry 36 (19), 5817-5826 (1997)
   PUBMED   9153422
REFERENCE   8  (bases 1 to 2376)
  AUTHORS   Nabetani,A., Hatada,I., Morisaki,H. and Mukai,T.
  TITLE     Chromosomal assignment and imprinting tests for the mouse delta
            subunit of the cytosolic chaperonin containing TCP-1 (Cct4) gene to
            proximal chromosome 11
  JOURNAL   Genomics 34 (2), 246-249 (1996)
   PUBMED   8661059
REFERENCE   9  (bases 1 to 2376)
  AUTHORS   Wu-Baer,F., Lane,W.S. and Gaynor,R.B.
  TITLE     Identification of a group of cellular cofactors that stimulate the
            binding of RNA polymerase II and TRP-185 to human immunodeficiency
            virus 1 TAR RNA
  JOURNAL   J Biol Chem 271 (8), 4201-4208 (1996)
   PUBMED   8626763
REFERENCE   10 (bases 1 to 2376)
  AUTHORS   Kubota,H., Hynes,G., Carne,A., Ashworth,A. and Willison,K.
  TITLE     Identification of six Tcp-1-related genes encoding divergent
            subunits of the TCP-1-containing chaperonin
  JOURNAL   Curr Biol 4 (2), 89-99 (1994)
   PUBMED   7953530
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB461009.1, BC106934.1, AI439570.1 and AC107081.5.
            
            On Nov 22, 2018 this sequence version replaced NM_006430.3.
            
            Summary: The chaperonin containing TCP1 (MIM 186980) complex (CCT),
            also called the TCP1 ring complex, consists of 2 back-to-back
            rings, each containing 8 unique but homologous subunits, such as
            CCT4. CCT assists the folding of newly translated polypeptide
            substrates through multiple rounds of ATP-driven release and
            rebinding of partially folded intermediate forms. Substrates of CCT
            include the cytoskeletal proteins actin (see MIM 102560) and
            tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330)
            (Won et al., 1998 [PubMed 9819444]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.125403.1,
                                           SRR1803617.1740.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394440.8/ ENSP00000377958.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                DB461009.1         18-66
            50-1895             BC106934.1         1-1846
            1896-2334           AI439570.1         4-442               c
            2335-2376           AC107081.5         46205-46246         c
FEATURES             Location/Qualifiers
     source          1..2376
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p15"
     gene            1..2376
                     /gene="CCT4"
                     /gene_synonym="CCT-DELTA; Cctd; SRB"
                     /note="chaperonin containing TCP1 subunit 4"
                     /db_xref="GeneID:10575"
                     /db_xref="HGNC:HGNC:1617"
                     /db_xref="MIM:605142"
     exon            1..276
                     /gene="CCT4"
                     /gene_synonym="CCT-DELTA; Cctd; SRB"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1769
                     /gene="CCT4"
                     /gene_synonym="CCT-DELTA; Cctd; SRB"
                     /note="isoform a is encoded by transcript variant 1;
                     chaperonin containing t-complex polypeptide 1, delta
                     subunit; T-complex protein 1 subunit delta; TCP-1-delta;
                     stimulator of TAR RNA-binding; chaperonin containing TCP1,
                     subunit 4 (delta); chaperonin containing T-complex
                     polypeptide 1 subunit 4"
                     /codon_start=1
                     /product="T-complex protein 1 subunit delta isoform a"
                     /protein_id="NP_006421.2"
                     /db_xref="CCDS:CCDS33206.1"
                     /db_xref="GeneID:10575"
                     /db_xref="HGNC:HGNC:1617"
                     /db_xref="MIM:605142"
                     /translation="MPENVAPRSGATAGAAGGRGKGAYQDRDKPAQIRFSNISAAKAV
                     ADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLHPAARMLVELSKAQDIEA
                     GDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGIEILTDMSRPVELSDR
                     ETLLNSATTSLNSKVVSQYSSLLSPMSVNAVMKVIDPATATSVDLRDIKIVKKLGGTI
                     DDCELVEGLVLTQKVSNSGITRVEKAKIGLIQFCLSAPKTDMDNQIVVSDYAQMDRVL
                     REERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNKMKIMVIKDIEREDIE
                     FICKTIGTKPVAHIDQFTADMLGSAELAEEVNLNGSGKLLKITGCASPGKTVTIVVRG
                     SNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMESYC
                     VRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTAGINVRKGGISNILEELV
                     VQPLLVSVSALTLATETVRSILKIDDVVNTR"
     exon            277..329
                     /gene="CCT4"
                     /gene_synonym="CCT-DELTA; Cctd; SRB"
                     /inference="alignment:Splign:2.1.0"
     exon            330..419
                     /gene="CCT4"
                     /gene_synonym="CCT-DELTA; Cctd; SRB"
                     /inference="alignment:Splign:2.1.0"
     exon            420..528
                     /gene="CCT4"
                     /gene_synonym="CCT-DELTA; Cctd; SRB"
                     /inference="alignment:Splign:2.1.0"
     exon            529..671
                     /gene="CCT4"
                     /gene_synonym="CCT-DELTA; Cctd; SRB"
                     /inference="alignment:Splign:2.1.0"
     exon            672..793
                     /gene="CCT4"
                     /gene_synonym="CCT-DELTA; Cctd; SRB"
                     /inference="alignment:Splign:2.1.0"
     exon            794..926
                     /gene="CCT4"
                     /gene_synonym="CCT-DELTA; Cctd; SRB"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1066
                     /gene="CCT4"
                     /gene_synonym="CCT-DELTA; Cctd; SRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1163
                     /gene="CCT4"
                     /gene_synonym="CCT-DELTA; Cctd; SRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1274
                     /gene="CCT4"
                     /gene_synonym="CCT-DELTA; Cctd; SRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1405
                     /gene="CCT4"
                     /gene_synonym="CCT-DELTA; Cctd; SRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1640
                     /gene="CCT4"
                     /gene_synonym="CCT-DELTA; Cctd; SRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1754
                     /gene="CCT4"
                     /gene_synonym="CCT-DELTA; Cctd; SRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..2376
                     /gene="CCT4"
                     /gene_synonym="CCT-DELTA; Cctd; SRB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1934..1939
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCT4"
                     /gene_synonym="CCT-DELTA; Cctd; SRB"
                     /note="hexamer: ATTAAA"
     polyA_site      1958
                     /gene="CCT4"
                     /gene_synonym="CCT-DELTA; Cctd; SRB"
                     /note="major polyA site"
     regulatory      2008..2013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCT4"
                     /gene_synonym="CCT-DELTA; Cctd; SRB"
                     /note="hexamer: AATAAA"
     regulatory      2018..2023
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCT4"
                     /gene_synonym="CCT-DELTA; Cctd; SRB"
                     /note="hexamer: AATAAA"
     polyA_site      2027
                     /gene="CCT4"
                     /gene_synonym="CCT-DELTA; Cctd; SRB"
     polyA_site      2036
                     /gene="CCT4"
                     /gene_synonym="CCT-DELTA; Cctd; SRB"
                     /note="major polyA site"
     regulatory      2317..2322
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCT4"
                     /gene_synonym="CCT-DELTA; Cctd; SRB"
                     /note="hexamer: AATAAA"
     polyA_site      2334
                     /gene="CCT4"
                     /gene_synonym="CCT-DELTA; Cctd; SRB"
     regulatory      2355..2360
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCT4"
                     /gene_synonym="CCT-DELTA; Cctd; SRB"
                     /note="hexamer: AACAAA"
     polyA_site      2376
                     /gene="CCT4"
                     /gene_synonym="CCT-DELTA; Cctd; SRB"
ORIGIN      
        1 cttctccgcc tccgcctcct cccgacgccg gcgccgcttt ctggaaggtt cgtgaaggca
       61 gtgagggctt accgttatta cactgcggcc ggccagaatc cgggtccatc cgtccttccc
      121 gagccaaccc agacacagcg gagtttgcca tgcccgagaa tgtggcaccc cggagcgggg
      181 cgactgccgg ggctgccggc ggccgcggga aaggcgccta tcaggaccgc gacaagccag
      241 cccagatccg cttcagcaac atttccgccg ccaaagcggt tgctgatgct attagaacaa
      301 gccttggacc aaaaggaatg gataaaatga ttcaagatgg aaaaggtgat gtaaccatta
      361 caaatgatgg tgctaccatt ctgaaacaaa tgcaagtatt acatccagca gccagaatgc
      421 tggtggagct gtctaaggct caagatatag aagcaggaga tggcaccaca tcagtagtca
      481 tcattgctgg ctccctctta gattcttgta ccaagcttct tcagaaaggg attcatccaa
      541 ccatcatttc tgagtcattc cagaaggccc tggaaaaggg cattgaaatc ttgactgaca
      601 tgtctcgacc tgtggaactg agtgacagag aaactttgtt aaatagtgca accacttcac
      661 tgaactcaaa ggtggtttct cagtattcaa gtctgctttc tccaatgagt gtaaatgcag
      721 tgatgaaagt gattgaccca gccacagcca ccagtgtaga tcttagagat attaaaatag
      781 ttaagaagct tggtgggaca attgatgact gtgagttggt ggaagggctg gttctcaccc
      841 aaaaagtgtc aaattctggc ataaccagag ttgaaaaggc caagattggg cttattcagt
      901 tttgcttatc tgctcccaaa acagacatgg ataatcaaat agtggtttct gactatgccc
      961 agatggaccg agtgctgcga gaagagagag cctatatttt aaatttagtg aagcaaatta
     1021 aaaaaacagg atgtaatgtc cttctcatac agaaatctat tctaagagat gctcttagtg
     1081 atcttgcatt acactttctg aataaaatga agatcatggt gattaaggat attgaaagag
     1141 aagacattga attcatttgt aagacaattg gaaccaagcc agttgctcat attgaccaat
     1201 ttactgctga catgctgggt tctgctgagt tagctgagga ggtcaattta aatggttctg
     1261 gcaaactgct caagattaca ggctgtgcca gccctggaaa aacagttaca attgttgttc
     1321 gtggttctaa caaactggtg attgaagaag ctgagcgctc cattcatgat gccctatgtg
     1381 ttattcgttg tttagtgaag aagagggctc ttattgcagg aggtggtgct ccagaaatag
     1441 agttggccct acgattaact gaatattcac gaacactgag tggtatggaa tcctactgcg
     1501 ttcgtgcttt tgcagatgct atggaggtca ttccatctac actagctgaa aatgccggcc
     1561 tgaatcccat ttctacagta acagaactaa gaaaccggca tgcccaggga gaaaaaactg
     1621 caggcattaa tgtccgaaag ggtggtattt ccaacatttt ggaggaactg gttgtccagc
     1681 ctctgttggt atcagtcagt gctctgactc ttgcaactga aactgttcgg agcattctga
     1741 aaatagatga tgtggtaaac actcgataat ctggataact gactagcacc attatgatca
     1801 ccagtattgt ggctggaatg gaagaagatc accttggtgt tccttgtttg gaagattatt
     1861 tcctctgaat ttctgggctt ggtcttccag ttggcatttg cctgaagttg tattgaaaca
     1921 atttaatgaa aatattaaat atttggtttc aaaaggcaga tttatcttct cccaacattc
     1981 tgttatttct gatacttttg aaaaactaat aaaaactaat aaaagaagcg taaaaagtga
     2041 gtttacatgt tgaggaaaaa aatggcccaa tatgctcatc actgataaat gctccctggc
     2101 cttaaaaact accaacatat aatatatatg ctgtcttaaa agttaatgat ccaagtggca
     2161 cctctctgaa cctactttgg cttgggaggc tgcccagtta aaacaaaaat aagttaatgg
     2221 tacagaaaga gaatgaaaaa tgaaagcctc cttttatcct atcatcctaa ttccttttcc
     2281 cagtaataat gactgctgtg ttggattcct tctgcaaata aaagtgtata catatatgta
     2341 gcaaatctta cttaaacaaa agggtttctt aactaa
//
