LOCUS       NM_005998               1977 bp    mRNA    linear   PRI 13-JAN-2025
DEFINITION  Homo sapiens chaperonin containing TCP1 subunit 3 (CCT3),
            transcript variant 1, mRNA.
ACCESSION   NM_005998
VERSION     NM_005998.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1977)
  AUTHORS   Wang,J., Guan,X., Shang,N., Wu,D., Liu,Z., Guan,Z., Zhang,Z.,
            Jin,Z., Wei,X., Liu,X., Song,M., Zhu,W. and Dai,G.
  TITLE     Dysfunction of CCT3-associated network signals for the critical
            state during progression of hepatocellular carcinoma
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (4), 167054 (2024)
   PUBMED   38360074
  REMARK    GeneRIF: Dysfunction of CCT3-associated network signals for the
            critical state during progression of hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 1977)
  AUTHORS   Liu,H., Jiang,Y., Lu,J., Peng,C., Ling,Z., Chen,Y., Chen,D.,
            Tong,R., Zheng,S. and Wu,J.
  TITLE     m6A-modification regulated circ-CCT3 acts as the sponge of
            miR-378a-3p to promote hepatocellular carcinoma progression
  JOURNAL   Epigenetics 18 (1), 2204772 (2023)
   PUBMED   37092305
  REMARK    GeneRIF: m[6]A-modification regulated circ-CCT3 acts as the sponge
            of miR-378a-3p to promote hepatocellular carcinoma progression.
REFERENCE   3  (bases 1 to 1977)
  AUTHORS   Luo,L., Xie,Q., Wu,Y., Li,P., Qin,F., Liao,D. and Wang,K.
  TITLE     Circular RNA CCT3 is a unique molecular marker in bladder cancer
  JOURNAL   BMC Cancer 23 (1), 977 (2023)
   PUBMED   37833621
  REMARK    GeneRIF: Circular RNA CCT3 is a unique molecular marker in bladder
            cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1977)
  AUTHORS   Iglesias-Martinez,L.F., Rauch,N., Wynne,K., McCann,B., Kolch,W. and
            Rauch,J.
  TITLE     Interactome dynamics of RAF1-BRAF kinase monomers and dimers
  JOURNAL   Sci Data 10 (1), 203 (2023)
   PUBMED   37045861
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1977)
  AUTHORS   Zebol,J.R., Hewitt,N.M., Moretti,P.A., Lynn,H.E., Lake,J.A., Li,P.,
            Vadas,M.A., Wattenberg,B.W. and Pitson,S.M.
  TITLE     The CCT/TRiC chaperonin is required for maturation of sphingosine
            kinase 1
  JOURNAL   Int J Biochem Cell Biol 41 (4), 822-827 (2009)
   PUBMED   18775504
REFERENCE   6  (bases 1 to 1977)
  AUTHORS   Wong,N., Chan,A., Lee,S.W., Lam,E., To,K.F., Lai,P.B., Li,X.N.,
            Liew,C.T. and Johnson,P.J.
  TITLE     Positional mapping for amplified DNA sequences on 1q21-q22 in
            hepatocellular carcinoma indicates candidate genes over-expression
  JOURNAL   J Hepatol 38 (3), 298-306 (2003)
   PUBMED   12586295
  REMARK    GeneRIF: Among ten hepatocellular carcinoma cases with amplicon
            1q21-q22, significant gene expression level of JTB, SHC1, CCT3 and
            COPA in the tumors than the paired adjacent non-malignant liver
            tissues.
REFERENCE   7  (bases 1 to 1977)
  AUTHORS   Feldman,D.E., Thulasiraman,V., Ferreyra,R.G. and Frydman,J.
  TITLE     Formation of the VHL-elongin BC tumor suppressor complex is
            mediated by the chaperonin TRiC
  JOURNAL   Mol Cell 4 (6), 1051-1061 (1999)
   PUBMED   10635329
REFERENCE   8  (bases 1 to 1977)
  AUTHORS   Walkley,N.A., Demaine,A.G. and Malik,A.N.
  TITLE     Cloning, structure and mRNA expression of human Cctg, which encodes
            the chaperonin subunit CCT gamma
  JOURNAL   Biochem J 313 (Pt 2) (Pt 2), 381-389 (1996)
   PUBMED   8573069
REFERENCE   9  (bases 1 to 1977)
  AUTHORS   Sevigny,G., Joly,E.C., Bibor-Hardy,V. and Lemieux,N.
  TITLE     Assignment of the human homologue of the mTRiC-P5 gene (TRIC5) to
            band 1q23 by fluorescence in situ hybridization
  JOURNAL   Genomics 22 (3), 634-636 (1994)
   PUBMED   8001976
REFERENCE   10 (bases 1 to 1977)
  AUTHORS   Kubota,H., Hynes,G., Carne,A., Ashworth,A. and Willison,K.
  TITLE     Identification of six Tcp-1-related genes encoding divergent
            subunits of the TCP-1-containing chaperonin
  JOURNAL   Curr Biol 4 (2), 89-99 (1994)
   PUBMED   7953530
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG476176.1, AB208882.1 and
            AK126400.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005998.4.
            
            Summary: The protein encoded by this gene is a molecular chaperone
            that is a member of the chaperonin containing TCP1 complex (CCT),
            also known as the TCP1 ring complex (TRiC). This complex consists
            of two identical stacked rings, each containing eight different
            proteins. Unfolded polypeptides enter the central cavity of the
            complex and are folded in an ATP-dependent manner. The complex
            folds various proteins, including actin and tubulin. Alternate
            transcriptional splice variants have been characterized for this
            gene. In addition, a pseudogene of this gene has been found on
            chromosome 8. [provided by RefSeq, Aug 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.302350.1,
                                           SRR3476690.513171.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295688.8/ ENSP00000295688.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BG476176.1         125-135
            12-1976             AB208882.1         1-1965
            1977-1977           AK126400.1         1887-1887
FEATURES             Location/Qualifiers
     source          1..1977
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1977
                     /gene="CCT3"
                     /gene_synonym="CCT-gamma; CCTG; NEDSVH; PIG48;
                     TCP-1-gamma; TRIC5"
                     /note="chaperonin containing TCP1 subunit 3"
                     /db_xref="GeneID:7203"
                     /db_xref="HGNC:HGNC:1616"
                     /db_xref="MIM:600114"
     exon            1..139
                     /gene="CCT3"
                     /gene_synonym="CCT-gamma; CCTG; NEDSVH; PIG48;
                     TCP-1-gamma; TRIC5"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1746
                     /gene="CCT3"
                     /gene_synonym="CCT-gamma; CCTG; NEDSVH; PIG48;
                     TCP-1-gamma; TRIC5"
                     /note="isoform a is encoded by transcript variant 1; TCP1
                     (t-complex-1) ring complex, polypeptide 5; T-complex
                     protein 1, gamma subunit; T-complex protein 1 subunit
                     gamma; hTRiC5; chaperonin containing TCP1, subunit 3
                     (gamma); chaperonin containing T-complex polypeptide 1
                     subunit 3"
                     /codon_start=1
                     /product="T-complex protein 1 subunit gamma isoform a"
                     /protein_id="NP_005989.3"
                     /db_xref="CCDS:CCDS1140.2"
                     /db_xref="GeneID:7203"
                     /db_xref="HGNC:HGNC:1616"
                     /db_xref="MIM:600114"
                     /translation="MMGHRPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPK
                     SMMKMLLDPMGGIVMTNDGNAILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILA
                     GEMLSVAEHFLEQQMHPTVVISAYRKALDDMISTLKKISIPVDISDSDMMLNIINSSI
                     TTKAISRWSSLACNIALDAVKMVQFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGV
                     MINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIQ
                     QLCEDIIQLKPDVVITEKGISDLAQHYLMRANITAIRRVRKTDNNRIARACGARIVSR
                     PEELREDDVGTGAGLLEIKKIGDEYFTFITDCKDPKACTILLRGASKEILSEVERNLQ
                     DAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAVAQALEVIPRT
                     LIQNCGASTIRLLTSLRAKHTQENCETWGVNGETGTLVDMKELGIWEPLAVKLQTYKT
                     AVETAVLLLRIDDIVSGHKKKGDDQSRQGGAPDAGQE"
     exon            140..201
                     /gene="CCT3"
                     /gene_synonym="CCT-gamma; CCTG; NEDSVH; PIG48;
                     TCP-1-gamma; TRIC5"
                     /inference="alignment:Splign:2.1.0"
     exon            202..252
                     /gene="CCT3"
                     /gene_synonym="CCT-gamma; CCTG; NEDSVH; PIG48;
                     TCP-1-gamma; TRIC5"
                     /inference="alignment:Splign:2.1.0"
     exon            253..315
                     /gene="CCT3"
                     /gene_synonym="CCT-gamma; CCTG; NEDSVH; PIG48;
                     TCP-1-gamma; TRIC5"
                     /inference="alignment:Splign:2.1.0"
     exon            316..412
                     /gene="CCT3"
                     /gene_synonym="CCT-gamma; CCTG; NEDSVH; PIG48;
                     TCP-1-gamma; TRIC5"
                     /inference="alignment:Splign:2.1.0"
     exon            413..530
                     /gene="CCT3"
                     /gene_synonym="CCT-gamma; CCTG; NEDSVH; PIG48;
                     TCP-1-gamma; TRIC5"
                     /inference="alignment:Splign:2.1.0"
     exon            531..717
                     /gene="CCT3"
                     /gene_synonym="CCT-gamma; CCTG; NEDSVH; PIG48;
                     TCP-1-gamma; TRIC5"
                     /inference="alignment:Splign:2.1.0"
     exon            718..867
                     /gene="CCT3"
                     /gene_synonym="CCT-gamma; CCTG; NEDSVH; PIG48;
                     TCP-1-gamma; TRIC5"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1000
                     /gene="CCT3"
                     /gene_synonym="CCT-gamma; CCTG; NEDSVH; PIG48;
                     TCP-1-gamma; TRIC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1082
                     /gene="CCT3"
                     /gene_synonym="CCT-gamma; CCTG; NEDSVH; PIG48;
                     TCP-1-gamma; TRIC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1263
                     /gene="CCT3"
                     /gene_synonym="CCT-gamma; CCTG; NEDSVH; PIG48;
                     TCP-1-gamma; TRIC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1509
                     /gene="CCT3"
                     /gene_synonym="CCT-gamma; CCTG; NEDSVH; PIG48;
                     TCP-1-gamma; TRIC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1641
                     /gene="CCT3"
                     /gene_synonym="CCT-gamma; CCTG; NEDSVH; PIG48;
                     TCP-1-gamma; TRIC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1977
                     /gene="CCT3"
                     /gene_synonym="CCT-gamma; CCTG; NEDSVH; PIG48;
                     TCP-1-gamma; TRIC5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1958..1963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCT3"
                     /gene_synonym="CCT-gamma; CCTG; NEDSVH; PIG48;
                     TCP-1-gamma; TRIC5"
                     /note="hexamer: ATTAAA"
     polyA_site      1977
                     /gene="CCT3"
                     /gene_synonym="CCT-gamma; CCTG; NEDSVH; PIG48;
                     TCP-1-gamma; TRIC5"
                     /note="major polyA site"
ORIGIN      
        1 gtaagccctg aggaggcagc gttttctggg cttctgtctg gttctctctc tccagaaggt
       61 tctgccggtt cccccagctc tgggtacccg gctctgcatc gcgtcgccat gatgggccat
      121 cgtccagtgc tcgtgctcag ccagaacaca aagcgtgaat ccggaagaaa agttcaatct
      181 ggaaacatca atgctgccaa gactattgca gatatcatcc gaacatgttt gggacccaag
      241 tccatgatga agatgctttt ggacccaatg ggaggcattg tgatgaccaa tgatggcaat
      301 gccattcttc gagagattca agtccagcat ccagcggcca agtccatgat cgaaattagc
      361 cggacccagg atgaagaggt tggagatggg accacatcag taattattct tgcaggggaa
      421 atgctgtctg tagctgagca cttcctggag cagcagatgc acccaacagt ggtgatcagt
      481 gcttaccgca aggcattgga tgatatgatc agcaccctaa agaaaataag tatcccagtc
      541 gacatcagtg acagtgatat gatgctgaac atcatcaaca gctctattac taccaaagcc
      601 atcagtcggt ggtcatcttt ggcttgcaac attgccctgg atgctgtcaa gatggtacag
      661 tttgaggaga atggtcggaa agagattgac ataaaaaaat atgcaagagt ggaaaagata
      721 cctggaggca tcattgaaga ctcctgtgtc ttgcgtggag tcatgattaa caaggatgtg
      781 acccatccac gtatgcggcg ctatatcaag aaccctcgca ttgtgctgct ggattcttct
      841 ctggaataca agaaaggaga aagccagact gacattgaga ttacacgaga ggaggacttc
      901 acccgaattc tccagatgga ggaagagtac atccagcagc tctgtgagga cattatccaa
      961 ctgaagcccg atgtggtcat cactgaaaag ggcatctcag atttagctca gcactacctt
     1021 atgcgggcca atatcacagc catccgcaga gtccggaaga cagacaataa tcgcattgct
     1081 agagcctgtg gggcccggat agtcagccga ccagaggaac tgagagaaga tgatgttgga
     1141 acaggagcag gcctgttgga aatcaagaaa attggagatg aatactttac tttcatcact
     1201 gactgcaaag accccaaggc ctgcaccatt ctcctccggg gggctagcaa agagattctc
     1261 tcggaagtag aacgcaacct ccaggatgcc atgcaagtgt gtcgcaatgt tctcctggac
     1321 cctcagctgg tgccaggggg tggggcctcc gagatggctg tggcccatgc cttgacagaa
     1381 aaatccaagg ccatgactgg tgtggaacaa tggccataca gggctgttgc ccaggcccta
     1441 gaggtcattc ctcgtaccct gatccagaac tgtggggcca gcaccatccg tctacttacc
     1501 tcccttcggg ccaagcacac ccaggagaac tgtgagacct ggggtgtaaa tggtgagacg
     1561 ggtactttgg tggacatgaa ggaactgggc atatgggagc cattggctgt gaagctgcag
     1621 acttataaga cagcagtgga gacggcagtt ctgctactgc gaattgatga catcgtttca
     1681 ggccacaaaa agaaaggcga tgaccagagc cggcaaggcg gggctcctga tgctggccag
     1741 gagtgagtgc taggcaaggc tacttcaatg cacagaacca gcagagtctc cccttttcct
     1801 gagccagagt gccaggaaca ctgtggacgt ctttgttcag aagggatcag gttggggggc
     1861 agcccccagt ccctttctgt cccagctcag ttttccaaaa gacactgaca tgtaattctt
     1921 ctctattgta aggtttccat ttagtttgct tccgatgatt aaatctaagt catttga
//
