LOCUS       NM_001145065            9420 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens coiled-coil serine rich protein 1 (CCSER1), transcript
            variant 1, mRNA.
ACCESSION   NM_001145065
VERSION     NM_001145065.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9420)
  AUTHORS   Santoliquido,B.M., Frenquelli,M., Contadini,C., Bestetti,S.,
            Gaviraghi,M., Barbieri,E., De Antoni,A., Albarello,L., Amabile,A.,
            Gardini,A., Lombardo,A., Doglioni,C., Provero,P., Soddu,S.,
            Cittaro,D. and Tonon,G.
  TITLE     Deletion of a pseudogene within a fragile site triggers the
            oncogenic expression of the mitotic CCSER1 gene
  JOURNAL   Life Sci Alliance 4 (8), e202101019 (2021)
   PUBMED   34187875
  REMARK    GeneRIF: Deletion of a pseudogene within a fragile site triggers
            the oncogenic expression of the mitotic CCSER1 gene.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9420)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 9420)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 9420)
  AUTHORS   Sugis,E., Dauvillier,J., Leontjeva,A., Adler,P., Hindie,V.,
            Moncion,T., Collura,V., Daudin,R., Loe-Mie,Y., Herault,Y.,
            Lambert,J.C., Hermjakob,H., Pupko,T., Rain,J.C., Xenarios,I.,
            Vilo,J., Simonneau,M. and Peterson,H.
  TITLE     HENA, heterogeneous network-based data set for Alzheimer's disease
  JOURNAL   Sci Data 6 (1), 151 (2019)
   PUBMED   31413325
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9420)
  AUTHORS   Lemaitre,R.N., King,I.B., Kabagambe,E.K., Wu,J.H., McKnight,B.,
            Manichaikul,A., Guan,W., Sun,Q., Chasman,D.I., Foy,M., Wang,L.,
            Zhu,J., Siscovick,D.S., Tsai,M.Y., Arnett,D.K., Psaty,B.M.,
            Djousse,L., Chen,Y.D., Tang,W., Weng,L.C., Wu,H., Jensen,M.K.,
            Chu,A.Y., Jacobs,D.R. Jr., Rich,S.S., Mozaffarian,D., Steffen,L.,
            Rimm,E.B., Hu,F.B., Ridker,P.M., Fornage,M. and Friedlander,Y.
  TITLE     Genetic loci associated with circulating levels of very long-chain
            saturated fatty acids
  JOURNAL   J Lipid Res 56 (1), 176-184 (2015)
   PUBMED   25378659
REFERENCE   6  (bases 1 to 9420)
  AUTHORS   Luykx,J.J., Bakker,S.C., Lentjes,E., Neeleman,M., Strengman,E.,
            Mentink,L., DeYoung,J., de Jong,S., Sul,J.H., Eskin,E., van
            Eijk,K., van Setten,J., Buizer-Voskamp,J.E., Cantor,R.M., Lu,A.,
            van Amerongen,M., van Dongen,E.P., Keijzers,P., Kappen,T.,
            Borgdorff,P., Bruins,P., Derks,E.M., Kahn,R.S. and Ophoff,R.A.
  TITLE     Genome-wide association study of monoamine metabolite levels in
            human cerebrospinal fluid
  JOURNAL   Mol Psychiatry 19 (2), 228-234 (2014)
   PUBMED   23319000
REFERENCE   7  (bases 1 to 9420)
  AUTHORS   Patel,K., Scrimieri,F., Ghosh,S., Zhong,J., Kim,M.S., Ren,Y.R.,
            Morgan,R.A., Iacobuzio-Donahue,C.A., Pandey,A. and Kern,S.E.
  TITLE     FAM190A deficiency creates a cell division defect
  JOURNAL   Am J Pathol 183 (1), 296-303 (2013)
   PUBMED   23665203
  REMARK    GeneRIF: FAM190A is a regulator or structural component required
            for normal mitosis and that both the rare truncating mutations and
            common in-frame deletion alteration of FAM190A may contribute to
            the chromosomal instability of cancer.
REFERENCE   8  (bases 1 to 9420)
  AUTHORS   Hart,A.B., Engelhardt,B.E., Wardle,M.C., Sokoloff,G., Stephens,M.,
            de Wit,H. and Palmer,A.A.
  TITLE     Genome-wide association study of d-amphetamine response in healthy
            volunteers identifies putative associations, including cadherin 13
            (CDH13)
  JOURNAL   PLoS One 7 (8), e42646 (2012)
   PUBMED   22952603
REFERENCE   9  (bases 1 to 9420)
  AUTHORS   Lantieri,F., Glessner,J.T., Hakonarson,H., Elia,J. and Devoto,M.
  TITLE     Analysis of GWAS top hits in ADHD suggests association to two
            polymorphisms located in genes expressed in the cerebellum
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 153B (6), 1127-1133 (2010)
   PUBMED   20607790
  REMARK    GeneRIF: Two SNPs located in genes coding for as yet
            uncharacterized proteins expressed in the cerebellum, XKR4 in
            8q12.1, and FAM190A in 4q22.1 suggest association with association
            with attention deficit hyperactivity disorder. [FAM190A]
REFERENCE   10 (bases 1 to 9420)
  AUTHORS   Camargo,L.M., Collura,V., Rain,J.C., Mizuguchi,K., Hermjakob,H.,
            Kerrien,S., Bonnert,T.P., Whiting,P.J. and Brandon,N.J.
  TITLE     Disrupted in Schizophrenia 1 Interactome: evidence for the close
            connectivity of risk genes and a potential synaptic basis for
            schizophrenia
  JOURNAL   Mol Psychiatry 12 (1), 74-86 (2007)
   PUBMED   17043677
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108038.3, DB027029.1, AB051467.1 and AC110774.3.
            
            On Jan 23, 2020 this sequence version replaced NM_001145065.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB051467.1, SRR1660809.246215.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2144335
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000509176.6/ ENSP00000425040.1
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               AC108038.3         25276-25414
            140-191             DB027029.1         1-52
            192-4455            AB051467.1         1-4264
            4456-9420           AC110774.3         57075-62039
FEATURES             Location/Qualifiers
     source          1..9420
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q22.1"
     gene            1..9420
                     /gene="CCSER1"
                     /gene_synonym="FAM190A"
                     /note="coiled-coil serine rich protein 1"
                     /db_xref="GeneID:401145"
                     /db_xref="HGNC:HGNC:29349"
                     /db_xref="MIM:618934"
     exon            1..438
                     /gene="CCSER1"
                     /gene_synonym="FAM190A"
                     /inference="alignment:Splign:2.1.0"
     exon            439..1803
                     /gene="CCSER1"
                     /gene_synonym="FAM190A"
                     /inference="alignment:Splign:2.1.0"
     CDS             480..3182
                     /gene="CCSER1"
                     /gene_synonym="FAM190A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM190A; family with sequence similarity 190,
                     member A; serine-rich coiled-coil domain-containing
                     protein 1"
                     /codon_start=1
                     /product="serine-rich coiled-coil domain-containing
                     protein 1 isoform 1"
                     /protein_id="NP_001138537.1"
                     /db_xref="CCDS:CCDS47099.1"
                     /db_xref="GeneID:401145"
                     /db_xref="HGNC:HGNC:29349"
                     /db_xref="MIM:618934"
                     /translation="MGDSGSRRSTLVSRLPIFRRSINRRHDSLPSSPSSSNTVGVHSS
                     SPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEPKQEPTNQNLSISNGAQPGHSNMQK
                     LSLEEHIKTRGRHSVGFSSSRNKKITRSLTEDFEREKEHSTNKNVFINCLSSGKSEGD
                     DSGFTEDQTRRSVKQSTRKLLPKSFSSHYKFSKPVLQSQSISLVQQSEFSLEVTQYQE
                     REPVLVRASPSCSVDVTERAGSSLQSPLLSADLTTAQTPSEFLALTEDSVSEMDAFSK
                     SGSMASHCDNFGHNDSTSQMSLNSAAVTKTTTELTGTVPCAIMSPGKYRLEGQCSTES
                     NSLPETSAANQKEVLLQIAELPATSVSHSESNLPADSEREENIGLQNGETMLGTNSPR
                     KLGFYEQHKAIAEHVKGIHPISDSKIIPTSGDHHIFNKTSHGYEANPAKVLASSLSPF
                     REGRFIERRLRSSSEGTAGSSRMILKPKDGNIEEVNSLRKQRAGSSSSKMNSLDVLNN
                     LGSCELDEDDLMLDLEFLEEQSLHPSVCREDSYHSVVSCAAVVLTPMEPMIEMKKREE
                     PEFPEPSKQNLSLKLTKDVDQEARCSHISRMPNSPSADWPLQGVEENGGIDSLPFRLM
                     LQDCTAVKTLLLKMKRVLQESADMSPASSTTSLPVSPLTEEPVPFKDIMKDECSMLKL
                     QLKEKDELISQLQEELGKVRHLQKAFASRVDKSTQTELLCYDGLNLKRLETVQGGREA
                     TYRNRIVSQNLSTRDRKAIHTPTEDRFRYSAADQTSPYKNKTCQLPSLCLSNFLKDKE
                     LAEVIKHSRGTYETLTSDVTQNLRATVGQSSLKPTAKTEGLSTFLEKPKDQVATARQH
                     STFTGRFGQPPRGPISLHMYSRKNVFLHHNLHSTELQTLGQQDG"
     exon            1804..1988
                     /gene="CCSER1"
                     /gene_synonym="FAM190A"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2082
                     /gene="CCSER1"
                     /gene_synonym="FAM190A"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2203
                     /gene="CCSER1"
                     /gene_synonym="FAM190A"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2411
                     /gene="CCSER1"
                     /gene_synonym="FAM190A"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2489
                     /gene="CCSER1"
                     /gene_synonym="FAM190A"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2573
                     /gene="CCSER1"
                     /gene_synonym="FAM190A"
                     /inference="alignment:Splign:2.1.0"
     exon            2574..2651
                     /gene="CCSER1"
                     /gene_synonym="FAM190A"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..2696
                     /gene="CCSER1"
                     /gene_synonym="FAM190A"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..9420
                     /gene="CCSER1"
                     /gene_synonym="FAM190A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9400..9405
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCSER1"
                     /gene_synonym="FAM190A"
                     /note="hexamer: AATAAA"
     polyA_site      9420
                     /gene="CCSER1"
                     /gene_synonym="FAM190A"
                     /note="major polyA site"
ORIGIN      
        1 acagccccgg agcgcggcct gccggggagg tggatctcgc gctccccaca cagtcacact
       61 ccgcgcactc acacacttgg aagcgcctcc ccacgtccct cccctgccct cctcttgctc
      121 tgctcttctc tccctcacca caaatagtcg ccgacctact gccaatccgc ctctcctctc
      181 tctctctctc tgtctcaaca tgactgactg ggaagcggtg gctcgggcag agcagctccg
      241 ctggcgcagg caggaggagc aggaggatta ttaaataacg cagctggact ctgtgcaact
      301 gggagtggag aggagcccaa cagccgagaa ggggagggag ggcagaggag ggggaccagg
      361 aaggacaccc ccgtgccccg aagacataaa tccctgagtg cccgggagga gccttaacaa
      421 gcgcacggag ccctcaaggc tgcaaagttg gctttcacag tgcaagcctt tgattcccaa
      481 tgggggactc aggatcaaga cgatctaccc tggtctcccg gttgccaata ttcagaagaa
      541 gtattaacag aagacatgat tctcttcctt cttcaccttc ttccagtaat acagttggtg
      601 tccacagttc ctctccttcc agcactaact caagctcagg tagcacaggt aaacggagga
      661 gcatattccg tactccttcc attagcttcc accataagaa ggggagtgag cctaagcaag
      721 agcctaccaa ccagaacctt agtatttcaa atggtgctca acctggtcac agcaatatgc
      781 agaaactgag tttggaagaa catattaaga ccaggggaag acattctgtt ggttttagta
      841 gttcacgaaa taagaagata acaagatctt tgacagagga ttttgaaagg gaaaaagagc
      901 actcaactaa caagaatgtc tttataaatt gtctaagttc tggcaaaagt gaaggggatg
      961 attctggttt cacagaagac caaactcgtc gttctgttaa gcagtcaaca aggaagctac
     1021 tccctaaatc tttttcatct cactataaat tttctaagcc agttctacag agccaatcca
     1081 tttcattggt acaacagtct gaattctcat tggaagttac acagtaccaa gagagagaac
     1141 ctgtattagt aagagcttcg ccatcctgtt ctgtggatgt aacagaacgg gcaggaagct
     1201 ctttacaatc tcctttgctt tctgctgatc ttaccacagc tcagacacct tcagaatttt
     1261 tagccttgac tgaagattct gtgtctgaaa tggatgcatt ttctaaaagt ggaagcatgg
     1321 catcccactg tgacaacttt ggccacaatg attctacctc tcagatgtcc ctcaattctg
     1381 ctgctgttac aaagacaaca acagaactta cgggaactgt tccctgtgca attatgtctc
     1441 ctgggaaata taggttagag ggtcaatgta gcactgaatc taattcatta ccggaaacct
     1501 ctgctgctaa tcagaaggaa gtgttattac aaattgctga actacctgct acaagtgtga
     1561 gccactcaga gagtaaccta ccagcagata gtgaaagaga agaaaatata gggttacaaa
     1621 atggtgaaac aatgctgggg acaaactccc caaggaaact tggattttat gagcaacata
     1681 aagcaatagc ggaacatgta aaagggatcc atcctatttc agattcaaag ataataccta
     1741 cttctggtga tcatcatatt tttaacaaaa catcacatgg atatgaagca aatcctgcca
     1801 aagttcttgc cagtagtctc agtccatttc gtgaaggaag atttatagag aggagactgc
     1861 gatcctcgtc agaaggcact gcagggagta gcagaatgat tttgaaaccg aaagatggaa
     1921 atatagaaga agttaatagt ttaagaaagc aaagagcagg ttcttcatct tcaaaaatga
     1981 acagtttgga tgttttgaat aatttgggat cttgtgaact ggatgaagat gatctaatgc
     2041 ttgatcttga atttttagag gaacagagtc ttcacccttc tgtttgccgg gaggactcat
     2101 atcactctgt cgtctcatgt gccgcagtag ttcttactcc tatggaacca atgatagaaa
     2161 tgaagaaaag agaagaacca gaatttcctg agccttccaa acagaatctt tccctgaaat
     2221 taacaaagga cgttgatcaa gaagccaggt gttcccacat cagccgaatg cccaacagtc
     2281 catctgcgga ttggcctcta caaggtgtgg aagaaaacgg aggcatagat tctctgccat
     2341 tcagactgat gttacaggac tgcacggcag tcaagacgtt attattaaag atgaagagag
     2401 ttcttcaaga gagtgcagac atgagtccag caagcagtac cacgtcactt cctgttagtc
     2461 ctcttactga agagccagtg cctttcaagg atataatgaa agatgaatgc tcgatgctca
     2521 agctgcagct gaaagagaag gatgaactca tttcccaact tcaggaagag ctgggaaaag
     2581 tccggcattt acagaaggct tttgcttcaa gagtagataa atccacacag actgaactac
     2641 tatgctatga tggtttaaac ttgaaaagac tagagacagt acaaggaggg agagaggcta
     2701 catatcgaaa tcgaattgtg agccaaaatc tcagcacaag ggacagaaaa gcaatacata
     2761 ctcccaccga ggaccgtttt aggtattcgg cagcggacca gacaagcccc tacaaaaaca
     2821 agacctgtca actcccaagt ctctgtttaa gtaatttcct gaaggacaag gaactagcag
     2881 aagttatcaa acattcaaga ggaacttatg aaaccctcac ttcagacgtt acacagaact
     2941 tacgggccac cgttgggcag agctctctga agccaacagc taagacagaa gggctctcca
     3001 cgttcttaga gaaaccaaag gaccaagttg ctacggcccg acagcattcg acctttacag
     3061 gcaggtttgg acagccaccc agagggccaa tctctttaca catgtacagc aggaagaatg
     3121 tgtttctcca ccacaattta cacagcactg agctgcaaac tctaggccag caggatgggt
     3181 aattaaatca ccgtattcct gtctttgggt aggataaaga tggttagtgt ttctcgtgca
     3241 tagttcatat taaaattgtc atgtactttt tcttacattt tagttataaa cagagttgtg
     3301 ttgttgggtt ttttttctta gtcataaaca aagacttgtg ggtttttttt ttccaagagt
     3361 gaaagtttga gcatgttaat tgaactaggt tgcattgcct tgaagacttt actatatagg
     3421 tgtataataa atgggaccat catgatcgtt tatatagtcc ataatttatt tattttttat
     3481 ctctatcact tactgatatg cattaaggtt tcagaagata atatcaaata gcaatctgtt
     3541 cactgttaat ggtgttacta taaaagtaga cctgatgaaa aatagataaa ggaattataa
     3601 agaattttaa attatataat taatagaagg aggaaaaaag agaaatgtta acgtcttata
     3661 tttggtggta tatttatttg aagaatgtgg cttgcttgca tgtaacctag agatgtgttt
     3721 gtctctatta catacattca agctcatctt gtgatactag taagggggaa atggctgtat
     3781 tttttttcct ttaaacgttt agttcatact agttcacaaa ggatttcaga cagagtaatt
     3841 gctagccaaa tagagaatga cagctctgat ctttgaaaaa ttttgctttt agtttttgtt
     3901 attgatgttg aagtaccgtg acataacaca aggtgataaa gttggttgaa ttttgtcaga
     3961 tgatgcataa atactgacat gctatattct ttgagccact gtcatggcaa tataaacatt
     4021 ttttcaaaat ttcaaggatg aaacatccta agaaaattat tctttttctt tactttcctt
     4081 attttttaaa atgttctttt ttatgtaaat ccaattttgg tttatataca tcaacccata
     4141 tctataattt tatgaactga agaacagaaa gtcagtattt tagtagccag catacaatat
     4201 tctgactatg cagaaatcta gatttggaac aaaagtaaag taaatgtgaa cattggcaat
     4261 ttaatcttag aaataagctt ctaacaggaa tatttaaaac ccatttgatg gcaaatattt
     4321 ctctttgaca aataaggccc aaatatgtta taatatgtta tatacttatg tgcactttag
     4381 atcaatatat gaattgatct atggataatt ccatcatgtt caattagtag cagagcagaa
     4441 tcaaagagta caattgaata cataaataaa taatttttaa aagactaata ggaatcaagg
     4501 ctgcagtttt cttatacaca tcagagctgt taagtacatc cacattagcc atagtccatg
     4561 caaattgaaa ctgtcatacc tactgcatga tctgtttccc ttgcattttc taacagaatc
     4621 tgtcagcgtg cacaagcaag atgaacaaag ggaaattgag atagcagttt tagcatggca
     4681 tctgacaact tgcttaaatt aaagctgtgt gcaaaatgca tctcctatta taaaaatgta
     4741 tttgtgccct gtgctttggg gaaaagccat tagacactcc acccctgagc tttaactact
     4801 gaactttgat acatttgcaa acttagattg gaactgataa agtaaggagt cgagtggata
     4861 tgttgtactt gtaattttgg ttttccaaag gaacacacat gtgcatcaag gcagacattt
     4921 gccaaatgtt ttctttcttt gcgtgtttgt aattctgcca aaagagaaca atatacactg
     4981 caaattgctt gacttaatga gattgccatc taaagttccc accatacttt ggaagctata
     5041 atgatcatgc agatatacac tttgggctgg gcaatattta agaaatgata ggaaaataga
     5101 aaaatcatga ttattaattg tggaattcag cttgatttgt cctaaatgtt ggtgtctgtt
     5161 gctagagtat tttaaatctg tacataaata agcatgataa aataatcaag gattttttcc
     5221 caggatatgg aagaactatg tatcacaaat aatgtttttg atttggactt ttggagttga
     5281 tagttttgtt ttcctggaag atagactttt gaattatact ttataaaaat aatctattta
     5341 tagaagatct gtcatttaat agacatttta agagatgttt taaacgctag tattttcttg
     5401 aaaaatcttt tttaaagctg aatcattcaa aagaaaacct ggattaaaca gttcgatttt
     5461 aaaaggaagg gtattttttg gaaatatcat cttaaagctg ttttgtatca gtattttcaa
     5521 cattgttata atattatttg taatactaag tgtaactcag gcctggagaa ggtgtaagcc
     5581 cactatgcta atgtacatca gtaactgtaa aacaggggtt ctttgtaagt tcctcttgtg
     5641 tatatatagt aacttataac aatggcatgt gggcattctt tcagtgaatt gctttctttg
     5701 tactaaaatc tctagttttc taagacagtt ccatgtataa aaatgattta tgcatttctc
     5761 caaggcggta catatccaaa gacatgacac cagggggaaa aagtgcttgt ttttctgatg
     5821 gaagcagtgg tcttttcttt tctttcctct ttcttttgtg catgtgtatg tgtagctaag
     5881 cctaaataac cctgtaaaat ttctgctgca aattgtctct tctgaattta gaatgtgttt
     5941 taaaggaaca cttaggaaga gaaatacctt gaagaaaagc tgtttccacc tgaaataaac
     6001 tgttcccatt tttataatta ttggaacatg aaactgtatt tctatgaact caatgatttt
     6061 tttccataaa attatatgct aagagagtca ccacaaaact atgaattctc tcccgaatta
     6121 tttttgcttc tttggagcac catagtcttt gttcaaatca caacatgaaa ctgttgctgc
     6181 aatgctaaag atgtgaatcc accactatca atacggtcag ggtaaaacct ggagccacat
     6241 gttattcaag ttatttttgt tatctaatga ttgacatgaa aataaaatag taagccaata
     6301 ttaatttgta ggcatagttg ccccacttaa agtgtttaca aagattttca tgattaatct
     6361 gggtttatga tttaatccta actcattgtc attatttcct gaatgttgaa ctcccattat
     6421 aggaaattcc acattttgtt ttgttttctt tgtcttgttt aatagagata ataaccatac
     6481 acccctctcc agaaaaaagt ttttaaaaat tattatgata tatttaagat tcacatgccc
     6541 aggataaatg attacattcc actagccctc tcaaaaactt tcttggcaac ttagttgttg
     6601 attaaacagt aggaacagtt tgctgaatgg ttaggattat ctctgcacat cattcgtcat
     6661 catcagcttc tcattataaa gaaatagtaa cccatagcag tggataattt ggaatactta
     6721 gcataatctc ataattataa tctaaatttt tactactttt tcactttcag aacttaacat
     6781 tctaaacagc tatagaagga agtggttcaa aataacccta agattccatt gaaacatata
     6841 cacacagatg aaactagaaa agaaagggca atacatgtga agatgatatc tatgattgcc
     6901 attcatgtta ctgaatcaca tgccccataa tcagaagctt ttcccttatt gataatatta
     6961 gctcaaatgt agcacccatt catttatacc aggattttga ttgctatcta agacttgact
     7021 ttatttaggc attattatca gatcctgtta tgtattttca tatgcatata tatatttttg
     7081 tataagaagt atttcaatca catgtaatat tcttgggaaa tttacctctc ctagagttta
     7141 agctttttaa aacatgtctt gtttctttct catgtggtaa atttatcatg acaactctag
     7201 gctgtagaag gcgtaatata aaatacaaac tagttttggt tcttataaaa ggctgatttc
     7261 agttaagact ggtcattttt ttaaaaagct gaattacact gtagtataaa agcaaacagt
     7321 caactaagca accaaacaaa acagctctct tctttaataa tattcatcat tgccaaatgt
     7381 ttatttttga aattttgttc tgtgccaact tgtttcacca tgttaaactg catacatacc
     7441 catgaactat ttatttacaa tacatttgat ctcgttaaga ccccagttct atttccaagg
     7501 catgcagccc aaaaccaaaa agttaaaaga tgataacact ctgtggttga attacctatg
     7561 gaaaagaatg aaggcagttc actctgttta agatgtggag aatttcctac aaatagttaa
     7621 ggtgaaataa aatcattaat agagagtagg ttccttccat ttgagtaagt gatctagaat
     7681 atgggatacc acggttcttt ttagagcatt ttcagtgtag cctcattaac ttctccaatt
     7741 taatacgaca tacatacttc ttccacctga acataaaatt caagaatagg agcatcctac
     7801 atctttcatt ctttccaaac attacctctt tagtaaattc gggttgctat aacaaaatac
     7861 catggactgg gtgactaaac aacagtcact tgtgtctcaa gttctggagg ctaggaagtc
     7921 taagattagg gtggggcaga ataaattatt ggtgaggatc tgcttcctga tttgcatgtt
     7981 ggagaaaggg ctctggcctc ttcctcttct aataactaca ataatttcat catgggggcc
     8041 ccaccctcat aatctcatct aaacctaatt acttcccaag cgccccaact tcaagcacca
     8101 tcacactggg ggttagggct tcaacatatg aatttggggg gggatataaa aatttagttt
     8161 atagcactca ttttcaggtc aaagagccca cttccctaat cacatacttc aataactagt
     8221 taggtaatta ttgttttact cttttgtaga ttagatcaga gacattaggt aacttgtcca
     8281 ggacacacaa catgcatttt taattaaatt ggatttaata acccttgaac tttccattta
     8341 tatcatgctt atctccagaa taggatctct cctaaggagg cagagtgatt taaacaaaca
     8401 tgtgctgctt caatctcctt tactcctaaa cttccattga tattgctagg gacaaaaaat
     8461 taagcaatga tctattttag gaaatcaaaa tactgttcat tgaaaagcag ttttaaaaca
     8521 attattgaca tttaataaat acagaatttt cagagggcat ctcttctatt tcaaggttac
     8581 ctcccagaaa aactgacatt ctaattttct tctcttgaaa gcaattagaa aaaatgctaa
     8641 gaaatgattt tatatttttt aaagtagagg gccaatgaag tgtctaacaa aaggaaagca
     8701 tacagtaaat gaaaaataaa ctagttatca gattgtctta tatctttcct tcataggaca
     8761 ttgatacaga catcatcaaa ttcctgtttg tattgcctta tacatactta aaaaacaaga
     8821 tatttacaaa aatattttag atattcctgt ctaggaacta aaattacagc tgatttagaa
     8881 tttgcttaat tattcagaag gaattgaagt gaaatgagga atacaaattt acttgtccta
     8941 aatttttaaa taaaatgtat tatattttgt agtcaattat atataccaaa ataatgtctg
     9001 aataagacgt aatcctgtca tgagttctct cttccaaaaa agaatgcaag agaattgatt
     9061 atcttagtta gaccccattt ttaaggaaaa aatacaccct gtatgataca ttcttagata
     9121 tatgggtttg agattattaa cattgataat agttttttta attcatcatc tctaaaactc
     9181 taaaacttta gtgagaaaga taataaatag aaaattaccc tggaaattaa aatttttagc
     9241 aatattgaat acagtagtat aattttttgt ggctcttgat ttcctaagaa aaatagtgat
     9301 ttttatttaa tgaaaatttc tcaatttggt taatattcta agaaaagatt gatatattta
     9361 agcatggtga ttagaaaaat atgcatattt cctgctcata ataaatttta aaacaacaaa
//
