LOCUS       NM_145257               5217 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens centriole, cilia and spindle associated protein
            (CCSAP), transcript variant 1, mRNA.
ACCESSION   NM_145257 XM_005273045
VERSION     NM_145257.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5217)
  AUTHORS   Bompard,G., van Dijk,J., Cau,J., Lannay,Y., Marcellin,G.,
            Lawera,A., van der Laan,S. and Rogowski,K.
  TITLE     CSAP Acts as a Regulator of TTLL-Mediated Microtubule Glutamylation
  JOURNAL   Cell Rep 25 (10), 2866-2877 (2018)
   PUBMED   30517872
  REMARK    GeneRIF: Binding of CSAP to TTLL5 promotes relocalization of TTLL5
            toward microtubules.
REFERENCE   2  (bases 1 to 5217)
  AUTHORS   Ohta,S., Hamada,M., Sato,N. and Toramoto,I.
  TITLE     Polyglutamylated Tubulin Binding Protein C1orf96/CSAP Is Involved
            in Microtubule Stabilization in Mitotic Spindles
  JOURNAL   PLoS One 10 (11), e0142798 (2015)
   PUBMED   26562023
  REMARK    GeneRIF: The tubulin binding protein CSAP associates with mitotic
            microtubules around centrosomes to stabilize mitotic microtubules
            during mitosis, ensuring proper bipolar spindle formation and
            maintenance.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5217)
  AUTHORS   Backer,C.B., Gutzman,J.H., Pearson,C.G. and Cheeseman,I.M.
  TITLE     CSAP localizes to polyglutamylated microtubules and promotes proper
            cilia function and zebrafish development
  JOURNAL   Mol Biol Cell 23 (11), 2122-2130 (2012)
   PUBMED   22493317
REFERENCE   4  (bases 1 to 5217)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL117350.12, BC071609.1, BC015419.1 and KF455154.1.
            
            On Nov 22, 2018 this sequence version replaced NM_145257.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC071609.1, ERR4352443.548574.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284617.7/ ENSP00000284617.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               AL117350.12        68640-68745         c
            107-265             BC071609.1         47-205
            266-1767            BC015419.1         134-1635
            1768-4770           AL117350.12        47160-50162         c
            4771-4771           KF455154.1         162-162             c
            4772-5217           AL117350.12        46713-47158         c
FEATURES             Location/Qualifiers
     source          1..5217
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.13"
     gene            1..5217
                     /gene="CCSAP"
                     /gene_synonym="C1orf96; CSAP"
                     /note="centriole, cilia and spindle associated protein"
                     /db_xref="GeneID:126731"
                     /db_xref="HGNC:HGNC:29578"
                     /db_xref="MIM:616762"
     exon            1..136
                     /gene="CCSAP"
                     /gene_synonym="C1orf96; CSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            137..551
                     /gene="CCSAP"
                     /gene_synonym="C1orf96; CSAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..997
                     /gene="CCSAP"
                     /gene_synonym="C1orf96; CSAP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     centriole and spindle-associated protein"
                     /codon_start=1
                     /product="centriole, cilia and spindle-associated protein
                     isoform 1"
                     /protein_id="NP_660300.3"
                     /db_xref="CCDS:CCDS1577.1"
                     /db_xref="GeneID:126731"
                     /db_xref="HGNC:HGNC:29578"
                     /db_xref="MIM:616762"
                     /translation="MSPGSGVKSEYMKRYQEPRWEEYGPCYRELLHYRLGRRLLEQAH
                     APWLWDDWGPAGSSEDSASSESSGAGGPAPRCAPPSPPPPVEPATQEEAERRARGAPE
                     EQDAEAGDAEAEDAEDAALPALPVKDVEDKPEQQTRTRETDKSPTSTEPRQQPSALFA
                     RGNRKAVKSPQRSSSKIKENKHPFALYGWGEKQTDTGSQKTHNVCASAPVHEIHESAL
                     RAKNRRQVEKRKLVAQRQRAHSVDVEKNRKMKASSSENPWMTEYMRCYSARA"
     exon            552..820
                     /gene="CCSAP"
                     /gene_synonym="C1orf96; CSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            821..5217
                     /gene="CCSAP"
                     /gene_synonym="C1orf96; CSAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5198..5203
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCSAP"
                     /gene_synonym="C1orf96; CSAP"
                     /note="hexamer: AATAAA"
     polyA_site      5217
                     /gene="CCSAP"
                     /gene_synonym="C1orf96; CSAP"
                     /note="major polyA site"
ORIGIN      
        1 agctggagcg cgggccgccg cggcgacatc ttgctcagga ggaaagcgcg cgggagagcg
       61 agctgcgctt tagctgctgc gccacgcgcg cctcgggcct gggcgcagag gatcggccgg
      121 gcgcggcggg aaggaggctg cgggcagcga ggagcggctg gcgctcgagg cggcggacgg
      181 caccatgtcc ccggggagcg gggtgaagag cgagtacatg aagcgctacc aggagccgcg
      241 ctgggaggag tacgggccgt gctaccgcga gctgctgcac taccgcctag gccgccggct
      301 gctggagcag gcgcacgcgc cctggctctg ggacgactgg ggcccggccg gctcctcgga
      361 ggactcggcg tcgtcagagt cgtcgggcgc cgggggcccc gcaccccggt gcgccccgcc
      421 ctcgcccccg ccgcccgtag agccggcgac ccaggaggag gcggaacggc gggcgcgcgg
      481 ggccccggag gagcaggacg cggaggccgg ggacgcggag gccgaggacg cggaggacgc
      541 ggctctgcca gcactgccag tgaaagatgt agaagataaa cctgaacaac aaaccagaac
      601 aagagagact gacaaatcac ccaccagtac tgagcctcga cagcaaccaa gtgccttatt
      661 tgctagagga aacaggaaag cggtcaaaag tccccaaaga tcatcgagta aaataaaaga
      721 aaacaagcat ccatttgctc tttatggctg gggagaaaaa cagaccgata caggaagcca
      781 gaagactcac aacgtctgtg cgtccgctcc tgtgcacgag attcatgaat cagcattacg
      841 agccaagaac agaagacagg tggaaaaaag gaaactggtt gctcaaaggc agcgagctca
      901 ctctgtggat gtggagaaga acagaaagat gaaggcttcc tcctcagaga acccgtggat
      961 gacagaatac atgaggtgct attcggcaag agcttaaaga aacacttgcg tggacagcct
     1021 cttttaaaaa gtgtaaatga ctgaaaggaa aaacaaaaca aaaaccatca aaagaaacgg
     1081 acacaggttt aagaaaccaa ctgattatgc aaggtttttt ttagggaatt tgtaaaagat
     1141 tgttttattt tgatgaatat tggtcaccta cctcggcagt agggcagaca gttgaagcca
     1201 tagacatttg gttatttatg aagataattc cctaaatctt tgatattctt ataaggtttt
     1261 tgttttaaag catcttaatc ttttaagata ctgacaccaa atgcctttaa atggcaacag
     1321 atgcttacag ttcagtattc ttttcataag cttaggtaga gcctattatc atcttgttct
     1381 aaataacttt ccagattcca tagctataag atcattccat cctacagcat aagactcgtt
     1441 ttccttatat gccgttttgt ttgtgaaaga atatcaagtc aaaaatgagt gtcagcacta
     1501 ctactgattc catgtataat gaaagtagaa ctttgctagt tcctgaaaat ttttaactta
     1561 tttgtatttc agttcagcag catctttatg tagattgtga tatttaagaa ttatctgggc
     1621 tgggcgaggg tctctttttc tctttcagtg atcatctagg cagttattat ttaatagttt
     1681 aatagctcaa gtacattcca atagacgaag tgcacacaac acaatatgtg tgtacagtag
     1741 tagtaaagtt tcttttgagt agtcaaagac tcactttttt tattgccttt tttttttttt
     1801 ttaaagaata catactgtgg attcagtccc ttgtcacact tgaccttttg gcatacaccc
     1861 actgtggact tttgcctctt ctgtaatggc tggcaatgac atttcaaact tacaatctgg
     1921 aattgcactt ggtacattgg cattgcttgt tccactggga tggggaccag tgtgaagatg
     1981 cctgttagat agactgccca cccctacttt ctctttttct ttatagcact taacaataac
     2041 aaagtcttga tgatgtacag tattcaaact ttaggttgaa atacgttact ctttgattcc
     2101 tagccagtag atcttatcta cactttaatg ggagagaatg gtggtgtgtg ggtaggcaca
     2161 aatttatgta aatagtgctc cttctcttta gtatgtttgc tttgggggta gaaaaatggt
     2221 tttaacaaac actggtttcc atcaaatgaa tgatgtcttc tccatcctgt ggagacaaga
     2281 atctgctaga aggatatgtg ctaagttcct tataagagat aatggtgctc tgcctatgcc
     2341 agcttggcac ccgaagatgt gtgagtggac gtgaggctga gtattacctt agtatttttc
     2401 tctgggtctt tggaaaacca tagtcaattt ttagaacata ttgctttcat tccccataaa
     2461 ctcttcacac atgataactg tttaagcttt gaaaacacat actgaagtat tgtgagctta
     2521 aaaaaacttt ttaaatattt gcatagtttt gaggtgaatt tgtttcctta cagatctctc
     2581 ctaatcattg agatgtatat ttcaaaagag gaaattttac atgttgtcca aaacagcctt
     2641 gctagtaact ggtgaatttt ggtattaact attattaaag tctttaaacg acacaggtac
     2701 ctaaagatca ccttaatgtg gcaatttgtg atggtgtagc tagctgattg tgaaaactgt
     2761 tcctttaaag tcgcttcttg catgttcggt gttagtcatc cagctcaggc ttgtgttgca
     2821 gctgacaatc taggaaagac ggccttagag agtggtgcag gccccacact gacggactgc
     2881 cttagaaacc cgacttcctc tagactttga accgccagac ttttctcttg tttagaaaac
     2941 aaacttatat ttaatgtact tactacttaa aactccagac agagatataa tgtagaaggc
     3001 aaatattggc caattttttc ctctttttaa gtggaagaca aatgaacggg atttttaaag
     3061 tgcttttaaa gtgcatgaat ggttaataaa tcagtatgaa ttgtaagcct tcatcttaca
     3121 tccaagtcct tagttggtta gggtttcttt tctttctttt ttaaagagtg tcaattacct
     3181 tttgaacctg tgaaaatttg atagttgtta acagtctgat ggtcctaatt ctttcttttc
     3241 attctagaaa tgaatgtggt tgtaatcatg ttcctaattc ttgggacaac ctgcaagaca
     3301 gtgagacagt ttaaaaatta cctttcatgt tgaaaaagtc tgaaacagag aacccaatga
     3361 tatttaaaat aaatgctaca taaaactctt tttaaaattt tgattttaac ttaattaaaa
     3421 caatgtcata aatatgcttt ttgattttgt tactgctttt aatattaaag taatagaata
     3481 ttgaagcaat attgtctagc actctgctgg acattaagtc cgcgggagga gaagtgaaca
     3541 ggaatcgatt ctttgtcttt taactgccct tagttaggag atgttaaaat acttggcacc
     3601 tctggttata tgtatgttat gtgtgttctc ccccctaaaa tttctaagca catttattca
     3661 cttttaaaat gaatctttaa aagattatag ttagtagtta tagttaatat tctatttact
     3721 tggaaaaatg tgaataaatg gatcttcaaa agattcattt taaaaatgaa taaatgtata
     3781 ataggctata ggtgatctta cttgcgtatt aggtaggagg cacatattta taccatttca
     3841 tatgtaatat ctttgtcatt gtgtttcatc gaagatcaat tgctagcaac ttgaagggta
     3901 tttatacttg ggtcacttga actcagctga ctaaattgta agaacgagag caagcaagat
     3961 ggctgttatt ggaagccata acttccagaa gataattctg cacaattcgt aagttaaaaa
     4021 aaatctgtag ggtcttccac tatccttttt caggttgata atgctgttct gggcacacac
     4081 tttgtaaatg gaatgttatg gtacagtcgc ctctcagtat ccatggggca ttggttccag
     4141 gcctccctta ggatgccaaa ctccatggat actcaaaccc cttctataaa atggtgtagt
     4201 atttgcatat atcctagaca catcctcctg tatgctttaa atcatctcta gattacttaa
     4261 aatacctaat acaatgtaaa tgctctgtaa atagttgtta tactatattg tttagggaat
     4321 aatgacaagg aaaaaaaagc ctgtacatgt tcagcacaag tgaaaccatc ctttttgccc
     4381 ccaaatattt tcaatttgta tttggttgaa tccatggatg cagaactcac ggatacagag
     4441 ggccgactgt actttcttta aagtgttcaa aagtattact agcaaagagg aggaggagca
     4501 aagcatatat cagaagtaaa acaatttttc ttgttgactg ctttggtaaa aaacagtttg
     4561 atggatagtt ttacatttca ctggactaga taaaaaatgg tgctaatatt tatgtagctt
     4621 gatgctatag ttgctttggt atcaaactta atacctaacc catataagat ccttattata
     4681 taattttgtg atcagtaaaa tgatatttta aagagtgatc ttaaaaatat gacctggtca
     4741 ttgcacaacg tttgcatttg aaatgaattt ttgtactata gggtggatat ggagttattc
     4801 agtgcaagtg tgtgcttaat atcaaaccct atgcaaggag ctatgtctag atttttggtc
     4861 caaatttgcc tccttcaagc ctactagtgt gagatggaaa aaaatcgatt gctcttttaa
     4921 tattatttcc attttgaaat tctcgacact tgaatgaagg cagtagaggc ctctttttgg
     4981 atttctcttc taataacaaa actttattta gggaaggttt ccctgtgcta tcgtaagttt
     5041 gttttgagca ctgcattcac tttaaaattc tggaggaaca aaggctgggc acataatcac
     5101 aaagcccagg ccacacaata attcggggtt gtattttcta agaactatgt attgttttta
     5161 gcttatagtt aatattgtat ttacttggaa aaatgtgaat aaagttaatt aacatta
//
