LOCUS       NM_005125               1066 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens copper chaperone for superoxide dismutase (CCS), mRNA.
ACCESSION   NM_005125 XM_938909
VERSION     NM_005125.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1066)
  AUTHORS   Yang,Y., Hao,X., Zhang,J., Gao,T., Huo,M., Liu,W., Hu,T., Ma,T.,
            Yuan,B., Zhang,M., Teng,X., Yu,H., Huang,W. and Wang,Y.
  TITLE     The E3 ligase TRIM22 functions as a tumor suppressor in breast
            cancer by targeting CCS for proteasomal degradation to inhibit
            STAT3 signaling
  JOURNAL   Cancer Lett 600, 217157 (2024)
   PUBMED   39127340
  REMARK    GeneRIF: The E3 ligase TRIM22 functions as a tumor suppressor in
            breast cancer by targeting CCS for proteasomal degradation to
            inhibit STAT3 signaling.
REFERENCE   2  (bases 1 to 1066)
  AUTHORS   Lu,Y., Chan,Y.T., Wu,J., Feng,Z., Yuan,H., Li,Q., Xing,T., Xu,L.,
            Zhang,C., Tan,H.Y., Lee,T.K., Feng,Y. and Wang,N.
  TITLE     CRISPR/Cas9 screens unravel miR-3689a-3p regulating sorafenib
            resistance in hepatocellular carcinoma via suppressing
            CCS/SOD1-dependent mitochondrial oxidative stress
  JOURNAL   Drug Resist Updat 71, 101015 (2023)
   PUBMED   37924725
  REMARK    GeneRIF: CRISPR/Cas9 screens unravel miR-3689a-3p regulating
            sorafenib resistance in hepatocellular carcinoma via suppressing
            CCS/SOD1-dependent mitochondrial oxidative stress.
REFERENCE   3  (bases 1 to 1066)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 1066)
  AUTHORS   Grasso,M., Bond,G.J., Kim,Y.J., Boyd,S., Matson Dzebo,M.,
            Valenzuela,S., Tsang,T., Schibrowsky,N.A., Alwan,K.B.,
            Blackburn,N.J., Burslem,G.M., Wittung-Stafshede,P., Winkler,D.D.,
            Marmorstein,R. and Brady,D.C.
  TITLE     The copper chaperone CCS facilitates copper binding to MEK1/2 to
            promote kinase activation
  JOURNAL   J Biol Chem 297 (6), 101314 (2021)
   PUBMED   34715128
  REMARK    GeneRIF: The copper chaperone CCS facilitates copper binding to
            MEK1/2 to promote kinase activation.
REFERENCE   5  (bases 1 to 1066)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1066)
  AUTHORS   Lamb,A.L., Wernimont,A.K., Pufahl,R.A., O'Halloran,T.V. and
            Rosenzweig,A.C.
  TITLE     Crystal structure of the second domain of the human copper
            chaperone for superoxide dismutase
  JOURNAL   Biochemistry 39 (7), 1589-1595 (2000)
   PUBMED   10677207
REFERENCE   7  (bases 1 to 1066)
  AUTHORS   Rae,T.D., Schmidt,P.J., Pufahl,R.A., Culotta,V.C. and
            O'Halloran,T.V.
  TITLE     Undetectable intracellular free copper: the requirement of a copper
            chaperone for superoxide dismutase
  JOURNAL   Science 284 (5415), 805-808 (1999)
   PUBMED   10221913
REFERENCE   8  (bases 1 to 1066)
  AUTHORS   Rothstein,J.D., Dykes-Hoberg,M., Corson,L.B., Becker,M.,
            Cleveland,D.W., Price,D.L., Culotta,V.C. and Wong,P.C.
  TITLE     The copper chaperone CCS is abundant in neurons and astrocytes in
            human and rodent brain
  JOURNAL   J Neurochem 72 (1), 422-429 (1999)
   PUBMED   9886096
REFERENCE   9  (bases 1 to 1066)
  AUTHORS   Casareno,R.L., Waggoner,D. and Gitlin,J.D.
  TITLE     The copper chaperone CCS directly interacts with copper/zinc
            superoxide dismutase
  JOURNAL   J Biol Chem 273 (37), 23625-23628 (1998)
   PUBMED   9726962
REFERENCE   10 (bases 1 to 1066)
  AUTHORS   Culotta,V.C., Klomp,L.W., Strain,J., Casareno,R.L., Krems,B. and
            Gitlin,J.D.
  TITLE     The copper chaperone for superoxide dismutase
  JOURNAL   J Biol Chem 272 (38), 23469-23472 (1997)
   PUBMED   9295278
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001157.4 and AF002210.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005125.1.
            
            Summary: Copper chaperone for superoxide dismutase specifically
            delivers Cu to copper/zinc superoxide dismutase and may activate
            copper/zinc superoxide dismutase through direct insertion of the Cu
            cofactor. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.638477.1,
                                           SRR1163655.337609.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000533244.6/ ENSP00000436318.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AP001157.4         12289-12322
            35-1066             AF002210.1         1-1032
FEATURES             Location/Qualifiers
     source          1..1066
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..1066
                     /gene="CCS"
                     /note="copper chaperone for superoxide dismutase"
                     /db_xref="GeneID:9973"
                     /db_xref="HGNC:HGNC:1613"
                     /db_xref="MIM:603864"
     exon            1..116
                     /gene="CCS"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..902
                     /gene="CCS"
                     /note="superoxide dismutase copper chaperone"
                     /codon_start=1
                     /product="copper chaperone for superoxide dismutase"
                     /protein_id="NP_005116.1"
                     /db_xref="CCDS:CCDS8146.1"
                     /db_xref="GeneID:9973"
                     /db_xref="HGNC:HGNC:1613"
                     /db_xref="MIM:603864"
                     /translation="MASDSGNQGTLCTLEFAVQMTCQSCVDAVRKSLQGVAGVQDVEV
                     HLEDQMVLVHTTLPSQEVQALLEGTGRQAVLKGMGSGQLQNLGAAVAILGGPGTVQGV
                     VRFLQLTPERCLIEGTIDGLEPGLHGLHVHQYGDLTNNCNSCGNHFNPDGASHGGPQD
                     SDRHRGDLGNVRADADGRAIFRMEDEQLKVWDVIGRSLIIDEGEDDLGRGGHPLSKIT
                     GNSGERLACGIIARSAGLFQNPKQICSCDGLTIWEERGRPIAGKGRKESAQPPAHL"
     exon            117..189
                     /gene="CCS"
                     /inference="alignment:Splign:2.1.0"
     exon            190..327
                     /gene="CCS"
                     /inference="alignment:Splign:2.1.0"
     exon            328..505
                     /gene="CCS"
                     /inference="alignment:Splign:2.1.0"
     exon            506..566
                     /gene="CCS"
                     /inference="alignment:Splign:2.1.0"
     exon            567..644
                     /gene="CCS"
                     /inference="alignment:Splign:2.1.0"
     exon            645..748
                     /gene="CCS"
                     /inference="alignment:Splign:2.1.0"
     exon            749..1066
                     /gene="CCS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1041..1046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCS"
                     /note="hexamer: AATGAA"
     polyA_site      1066
                     /gene="CCS"
                     /note="major polyA site"
ORIGIN      
        1 agtccccgcg acgccgcgct ggttggtgct cctgcgccgg aggagttctg cgtctcgggg
       61 tggtgactgg gtccagaatg gcttcggatt cggggaacca ggggaccctc tgcacgttgg
      121 agttcgcggt gcagatgacc tgtcagagct gtgtggacgc ggtgcgcaaa tccctgcaag
      181 gggtggcagg tgtccaggat gtggaggtgc acttggagga ccagatggtc ttggtacaca
      241 ccactctacc cagccaggag gtgcaggctc tcctggaagg cacggggcgg caggcggtac
      301 tcaagggcat gggcagcggc cagttgcaga atctgggggc agcagtggcc atcctggggg
      361 ggcctggcac cgtgcagggg gtggtgcgct tcctacagct gacccctgag cgctgcctca
      421 tcgagggaac tattgacggc ctggagcctg ggctgcatgg actccacgtc catcagtacg
      481 gggaccttac aaacaactgc aacagctgtg ggaatcactt taaccctgat ggagcatctc
      541 atgggggccc ccaggactct gaccggcacc gcggagacct gggcaatgtc cgtgctgatg
      601 ctgacggccg cgccatcttc agaatggagg atgagcagct gaaggtgtgg gatgtgattg
      661 gccgcagcct gattattgat gagggagaag atgacctggg ccggggaggc catcccttat
      721 ccaagatcac agggaactcc ggggagaggt tggcctgtgg catcattgca cgctccgctg
      781 gccttttcca gaaccccaag cagatctgct cttgcgatgg cctcaccatc tgggaggagc
      841 gaggccggcc catcgctggc aagggccgaa aggagtcagc gcagccccct gcccaccttt
      901 gagcaggacc tcaccttggc tctgttgctg tcctccaggg cgagcacttt ccacttccag
      961 agggggccag agggactttg cctgcccagt ctttggagag ctcagtacag ggcaggagct
     1021 gctgtggtgt tcccttggca aatgaaagtt ttattttcgt ttggga
//
