LOCUS       NM_003965               1700 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens C-C motif chemokine receptor like 2 (CCRL2),
            transcript variant 1, mRNA.
ACCESSION   NM_003965 NM_001097632 XM_001717282
VERSION     NM_003965.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1700)
  AUTHORS   Su,Z., Brooks,J., Pelker,J., Andreyeva,T., Sobon,H., Gifford,R.,
            Powers,M., Wang,J., Dower,C., Hegen,M., Messing,D., Sheehan,A.D.
            and Brennan,J.J.
  TITLE     Studies with neutralizing antibodies suggest CXCL8-mediated
            neutrophil activation is independent of C-C motif chemokine
            receptor-like 2 (CCRL2) ligand binding function
  JOURNAL   PLoS One 18 (1), e0280590 (2023)
   PUBMED   36662882
  REMARK    GeneRIF: Studies with neutralizing antibodies suggest
            CXCL8-mediated neutrophil activation is independent of C-C motif
            chemokine receptor-like 2 (CCRL2) ligand binding function.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1700)
  AUTHORS   Rawat,P., Brummel,S.S., Singh,K.K., Kim,J., Frazer,K.A.,
            Nichols,S., Seage,G.R., Williams,P.L., Van Dyke,R.B.,
            Harismendy,O., Trout,R.N. and Spector,S.A.
  TITLE     Genomics Links Inflammation With Neurocognitive Impairment in
            Children Living With Human Immunodeficiency Virus Type-1
  JOURNAL   J Infect Dis 224 (5), 870-880 (2021)
   PUBMED   33373444
  REMARK    GeneRIF: Genomics Links Inflammation With Neurocognitive Impairment
            in Children Living With Human Immunodeficiency Virus Type-1.
REFERENCE   3  (bases 1 to 1700)
  AUTHORS   Islam,S., Moni,M.A., Urmi,U.L., Tanaka,A. and Hoshino,H.
  TITLE     C-C Chemokine receptor-like 2 (CCRL2) acts as coreceptor for human
            immunodeficiency virus-2
  JOURNAL   Brief Bioinform 22 (4) (2021)
   PUBMED   33253374
  REMARK    GeneRIF: C-C Chemokine receptor-like 2 (CCRL2) acts as coreceptor
            for human immunodeficiency virus-2.
REFERENCE   4  (bases 1 to 1700)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1700)
  AUTHORS   Del Prete,A., Sozio,F., Schioppa,T., Ponzetta,A., Vermi,W.,
            Calza,S., Bugatti,M., Salvi,V., Bernardini,G., Benvenuti,F.,
            Vecchi,A., Bottazzi,B., Mantovani,A. and Sozzani,S.
  TITLE     The Atypical Receptor CCRL2 Is Essential for Lung Cancer Immune
            Surveillance
  JOURNAL   Cancer Immunol Res 7 (11), 1775-1788 (2019)
   PUBMED   31484658
  REMARK    GeneRIF: The Atypical Receptor CCRL2 Is Essential for Lung Cancer
            Immune Surveillance.
REFERENCE   6  (bases 1 to 1700)
  AUTHORS   Zabel,B.A., Nakae,S., Zuniga,L., Kim,J.Y., Ohyama,T., Alt,C.,
            Pan,J., Suto,H., Soler,D., Allen,S.J., Handel,T.M., Song,C.H.,
            Galli,S.J. and Butcher,E.C.
  TITLE     Mast cell-expressed orphan receptor CCRL2 binds chemerin and is
            required for optimal induction of IgE-mediated passive cutaneous
            anaphylaxis
  JOURNAL   J Exp Med 205 (10), 2207-2220 (2008)
   PUBMED   18794339
  REMARK    GeneRIF: Results identify chemerin as a natural nonsignaling
            protein ligand for both human and mouse CCRL2.
REFERENCE   7  (bases 1 to 1700)
  AUTHORS   Galligan,C.L., Matsuyama,W., Matsukawa,A., Mizuta,H., Hodge,D.R.,
            Howard,O.M. and Yoshimura,T.
  TITLE     Up-regulated expression and activation of the orphan chemokine
            receptor, CCRL2, in rheumatoid arthritis
  JOURNAL   Arthritis Rheum 50 (6), 1806-1814 (2004)
   PUBMED   15188357
  REMARK    GeneRIF: CCRL2 expression is up-regulated on synovial neutrophils
            of rheumatoid arthritis patients
REFERENCE   8  (bases 1 to 1700)
  AUTHORS   Wittamer,V., Franssen,J.D., Vulcano,M., Mirjolet,J.F., Le Poul,E.,
            Migeotte,I., Brezillon,S., Tyldesley,R., Blanpain,C., Detheux,M.,
            Mantovani,A., Sozzani,S., Vassart,G., Parmentier,M. and Communi,D.
  TITLE     Specific recruitment of antigen-presenting cells by chemerin, a
            novel processed ligand from human inflammatory fluids
  JOURNAL   J Exp Med 198 (7), 977-985 (2003)
   PUBMED   14530373
REFERENCE   9  (bases 1 to 1700)
  AUTHORS   Fan,P., Kyaw,H., Su,K., Zeng,Z., Augustus,M., Carter,K.C. and Li,Y.
  TITLE     Cloning and characterization of a novel human chemokine receptor
  JOURNAL   Biochem Biophys Res Commun 243 (1), 264-268 (1998)
   PUBMED   9473515
REFERENCE   10 (bases 1 to 1700)
  AUTHORS   Daugherty,B.L. and Springer,M.S.
  TITLE     The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and
            CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21
  JOURNAL   Genomics 41 (2), 294-295 (1997)
   PUBMED   9143512
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF015525.1 and BC071682.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003965.4.
            
            Summary: This gene encodes a chemokine receptor like protein, which
            is predicted to be a seven transmembrane protein and most closely
            related to CCR1. Chemokines and their receptors mediated signal
            transduction are critical for the recruitment of effector immune
            cells to the site of inflammation. This gene is expressed at high
            levels in primary neutrophils and primary monocytes, and is further
            upregulated on neutrophil activation and during monocyte to
            macrophage differentiation. The function of this gene is unknown.
            This gene is mapped to the region where the chemokine receptor gene
            cluster is located. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the shortest
            transcript but encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF015525.1, SRR5189661.132309.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399036.4/ ENSP00000381994.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-663               AF015525.1         72-734
            664-1700            BC071682.1         646-1682
FEATURES             Location/Qualifiers
     source          1..1700
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..1700
                     /gene="CCRL2"
                     /gene_synonym="ACKR5; CKRX; CRAM; CRAM-A; CRAM-B; HCR"
                     /note="C-C motif chemokine receptor like 2"
                     /db_xref="GeneID:9034"
                     /db_xref="HGNC:HGNC:1612"
                     /db_xref="MIM:608379"
     exon            1..244
                     /gene="CCRL2"
                     /gene_synonym="ACKR5; CKRX; CRAM; CRAM-A; CRAM-B; HCR"
                     /inference="alignment:Splign:2.1.0"
     exon            245..1700
                     /gene="CCRL2"
                     /gene_synonym="ACKR5; CKRX; CRAM; CRAM-A; CRAM-B; HCR"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..1291
                     /gene="CCRL2"
                     /gene_synonym="ACKR5; CKRX; CRAM; CRAM-A; CRAM-B; HCR"
                     /note="isoform 1 is encoded by transcript variant 1; C-C
                     chemokine receptor-like 2; chemokine receptor X; chemokine
                     receptor CCR11; putative MCP-1 chemokine receptor;
                     atypical chemokine receptor 5; chemokine (C-C motif)
                     receptor-like 2"
                     /codon_start=1
                     /product="C-C chemokine receptor-like 2 isoform 1"
                     /protein_id="NP_003956.2"
                     /db_xref="CCDS:CCDS43079.1"
                     /db_xref="GeneID:9034"
                     /db_xref="HGNC:HGNC:1612"
                     /db_xref="MIM:608379"
                     /translation="MANYTLAPEDEYDVLIEGELESDEAEQCDKYDAQALSAQLVPSL
                     CSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAGGDPM
                     CKILIGLYFVGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLAWVTAI
                     LATLPEFVVYKPQMEDQKYKCAFSRTPFLPADETFWKHFLTLKMNISVLVLPLFIFTF
                     LYVQMRKTLRFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDCKSSY
                     NLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYLCRCFHLRSNTPLQPRGQSAQGTS
                     REEPDHSTEV"
     regulatory      1677..1682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCRL2"
                     /gene_synonym="ACKR5; CKRX; CRAM; CRAM-A; CRAM-B; HCR"
                     /note="hexamer: AATAAA"
     polyA_site      1700
                     /gene="CCRL2"
                     /gene_synonym="ACKR5; CKRX; CRAM; CRAM-A; CRAM-B; HCR"
                     /note="major polyA site"
ORIGIN      
        1 agacgcttca gagatcctct ggaggcctgg gggagctttt gagtacttta tttcagttgg
       61 tccctgagct cggtgagtgg ggcgggtaga gccaccaggg gaatcaacag tggtttctcg
      121 tgcccctcag ggtcaggagc agtctgatca aaaggagggc atccactgtc cggggccatt
      181 cccacagctc ccggatgctg ggtctggagg ctgcgccctt cccctgcagg agctcagccc
      241 agtgggcagt ctgaagatgg ccaattacac gctggcacca gaggatgaat atgatgtcct
      301 catagaaggt gaactggaga gcgatgaggc agagcaatgt gacaagtatg acgcccaggc
      361 actctcagcc cagctggtgc catcactctg ctctgctgtg tttgtgatcg gtgtcctgga
      421 caatctcctg gttgtgctta tcctggtaaa atataaagga ctcaaacgcg tggaaaatat
      481 ctatcttcta aacttggcag tttctaactt gtgtttcttg cttaccctgc ccttctgggc
      541 tcatgctggg ggcgatccca tgtgtaaaat tctcattgga ctgtacttcg tgggcctgta
      601 cagtgagaca tttttcaatt gccttctgac tgtgcaaagg tacctagtgt ttttgcacaa
      661 gggaaacttt ttctcagcca ggaggagggt gccctgtggc atcattacaa gtgtcctggc
      721 atgggtaaca gccattctgg ccactttgcc tgaattcgtg gtttataaac ctcagatgga
      781 agaccagaaa tacaagtgtg catttagcag aactcccttc ctgccagctg atgagacatt
      841 ctggaagcat tttctgactt taaaaatgaa catttcggtt cttgtcctcc ccctatttat
      901 ttttacattt ctctatgtgc aaatgagaaa aacactaagg ttcagggagc agaggtatag
      961 ccttttcaag cttgtttttg ccataatggt agtcttcctt ctgatgtggg cgccctacaa
     1021 tattgcattt ttcctgtcca ctttcaaaga acacttctcc ctgagtgact gcaagagcag
     1081 ctacaatctg gacaaaagtg ttcacatcac taaactcatc gccaccaccc actgctgcat
     1141 caaccctctc ctgtatgcgt ttcttgatgg gacatttagc aaatacctct gccgctgttt
     1201 ccatctgcgt agtaacaccc cacttcaacc cagggggcag tctgcacaag gcacatcgag
     1261 ggaagaacct gaccattcca ccgaagtgta aactagcatc caccaaatgc aagaagaata
     1321 aacatggatt ttcatctttc tgcattattt catgtaaatt ttctacacat ttgtatacaa
     1381 aatcggatac aggaagaaaa gggagaggtg agctaacatt tgctaagcac tgaatttgtc
     1441 tcaggcaccg tgcaaggctc tttacaaacg tgagctcctt cgcctcctac cacttgtcca
     1501 tagtgtggat aggactagtc tcatttctct gagaagaaaa ctaaggcgcg gaaatttgtc
     1561 taagatcaca taactaggaa gtggcagaac tgattctcca gccctggtag catttgctca
     1621 gagcctacgc ttggtccaga acatcaaact ccaaaccctg gggacaaacg acatgaaata
     1681 aatgtatttt aaaacatcta
//
