LOCUS       NM_005201               1484 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens C-C motif chemokine receptor 8 (CCR8), mRNA.
ACCESSION   NM_005201
VERSION     NM_005201.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1484)
  AUTHORS   Hussain,K., Lim,H.D., Devkota,S.R., Kemp-Harper,B.K., Lane,J.R.,
            Canals,M., Pease,J.E. and Stone,M.J.
  TITLE     The chemokine receptor CCR8 is not a high-affinity receptor for the
            human chemokine CCL18
  JOURNAL   PLoS One 19 (9), e0305312 (2024)
   PUBMED   39259753
  REMARK    GeneRIF: The chemokine receptor CCR8 is not a high-affinity
            receptor for the human chemokine CCL18.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1484)
  AUTHORS   Peng,Q., Jiang,H., Cheng,X., Wang,N., Zhou,S., Zhang,Y., Yang,T.,
            Chen,Y., Zhang,W., Lv,S., Nan,W., Wang,J., Fan,G.H., Li,J. and
            Zhang,J.
  TITLE     Cryo-EM Structure and Biochemical Analysis of the Human Chemokine
            Receptor CCR8
  JOURNAL   Biochemistry 63 (15), 1892-1900 (2024)
   PUBMED   38985857
  REMARK    GeneRIF: Cryo-EM Structure and Biochemical Analysis of the Human
            Chemokine Receptor CCR8.
REFERENCE   3  (bases 1 to 1484)
  AUTHORS   Jiang,S., Lin,X., Wu,L., Wang,L., Wu,Y., Xu,Z. and Xu,F.
  TITLE     Unveiling the structural mechanisms of nonpeptide ligand
            recognition and activation in human chemokine receptor CCR8
  JOURNAL   Sci Adv 10 (5), eadj7500 (2024)
   PUBMED   38306437
  REMARK    GeneRIF: Unveiling the structural mechanisms of nonpeptide ligand
            recognition and activation in human chemokine receptor CCR8.
REFERENCE   4  (bases 1 to 1484)
  AUTHORS   Liu,L., Rangan,L., Vanalken,N., Kong,Q., Schlenner,S., De
            Jonghe,S., Schols,D. and Van Loy,T.
  TITLE     Development of a cellular model to study CCR8 signaling in
            tumor-infiltrating regulatory T cells
  JOURNAL   Cancer Immunol Immunother 73 (1), 11 (2024)
   PUBMED   38231448
  REMARK    GeneRIF: Development of a cellular model to study CCR8 signaling in
            tumor-infiltrating regulatory T cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1484)
  AUTHORS   Weaver,J.D., Stack,E.C., Bugge,J.A., Hu,C., McGrath,L., Mueller,A.,
            Wong,M., Klebanov,B., Rahman,T., Kaufman,R., Fregeau,C.,
            Spaulding,V., Priess,M., Legendre,K., Jaffe,S., Upadhyay,D.,
            Singh,A., Xu,C.A., Krukenberg,K., Zhang,Y., Ezzyat,Y., Saddier
            Axe,D., Kuhne,M.R., Meehl,M.A., Shaffer,D.R., Weist,B.M.,
            Wiederschain,D., Depis,F. and Gostissa,M.
  TITLE     Differential expression of CCR8 in tumors versus normal tissue
            allows specific depletion of tumor-infiltrating T regulatory cells
            by GS-1811, a novel Fc-optimized anti-CCR8 antibody
  JOURNAL   Oncoimmunology 11 (1), 2141007 (2022)
   PUBMED   36352891
  REMARK    GeneRIF: Differential expression of CCR8 in tumors versus normal
            tissue allows specific depletion of tumor-infiltrating T regulatory
            cells by GS-1811, a novel Fc-optimized anti-CCR8 antibody.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1484)
  AUTHORS   Roos,R.S., Loetscher,M., Legler,D.F., Clark-Lewis,I., Baggiolini,M.
            and Moser,B.
  TITLE     Identification of CCR8, the receptor for the human CC chemokine
            I-309
  JOURNAL   J Biol Chem 272 (28), 17251-17254 (1997)
   PUBMED   9211859
REFERENCE   7  (bases 1 to 1484)
  AUTHORS   Tiffany,H.L., Lautens,L.L., Gao,J.L., Pease,J., Locati,M.,
            Combadiere,C., Modi,W., Bonner,T.I. and Murphy,P.M.
  TITLE     Identification of CCR8: a human monocyte and thymus receptor for
            the CC chemokine I-309
  JOURNAL   J Exp Med 186 (1), 165-170 (1997)
   PUBMED   9207005
REFERENCE   8  (bases 1 to 1484)
  AUTHORS   Samson,M., Stordeur,P., Labbe,O., Soularue,P., Vassart,G. and
            Parmentier,M.
  TITLE     Molecular cloning and chromosomal mapping of a novel human gene,
            ChemR1, expressed in T lymphocytes and polymorphonuclear cells and
            encoding a putative chemokine receptor
  JOURNAL   Eur J Immunol 26 (12), 3021-3028 (1996)
   PUBMED   8977299
REFERENCE   9  (bases 1 to 1484)
  AUTHORS   Zaballos,A., Varona,R., Gutierrez,J., Lind,P. and Marquez,G.
  TITLE     Molecular cloning and RNA expression of two new human chemokine
            receptor-like genes
  JOURNAL   Biochem Biophys Res Commun 227 (3), 846-853 (1996)
   PUBMED   8886020
  REMARK    Erratum:[Biochem Biophys Res Commun 1997 Feb 13;231(2):519-20]
REFERENCE   10 (bases 1 to 1484)
  AUTHORS   Napolitano,M., Zingoni,A., Bernardini,G., Spinetti,G., Nista,A.,
            Storlazzi,C.T., Rocchi,M. and Santoni,A.
  TITLE     Molecular cloning of TER1, a chemokine receptor-like gene expressed
            by lymphoid tissues
  JOURNAL   J Immunol 157 (7), 2759-2763 (1996)
   PUBMED   8816377
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK314957.1, BC107159.1 and
            AC104850.2.
            
            On May 17, 2019 this sequence version replaced NM_005201.3.
            
            Summary: This gene encodes a member of the beta chemokine receptor
            family, which is predicted to be a seven transmembrane protein
            similar to G protein-coupled receptors. Chemokines and their
            receptors are important for the migration of various cell types
            into the inflammatory sites. This receptor protein preferentially
            expresses in the thymus. I-309, thymus activation-regulated
            cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1
            beta) have been identified as ligands of this receptor. Studies of
            this receptor and its ligands suggested its role in regulation of
            monocyte chemotaxis and thymic cell apoptosis. More specifically,
            this receptor may contribute to the proper positioning of activated
            T cells within the antigenic challenge sites and specialized areas
            of lymphoid tissues. This gene is located at the chemokine receptor
            gene cluster region. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The genomic coordinates used for
            the transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC107159.1, D49919.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326306.5/ ENSP00000326432.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1203              AK314957.1         6-1208
            1204-1315           BC107159.1         1140-1251
            1316-1484           AC104850.2         118710-118878
FEATURES             Location/Qualifiers
     source          1..1484
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.1"
     gene            1..1484
                     /gene="CCR8"
                     /gene_synonym="CC-CKR-8; CCR-8; CDw198; CKRL1; CMKBR8;
                     CMKBRL2; CY6; GPRCY6; TER1"
                     /note="C-C motif chemokine receptor 8"
                     /db_xref="GeneID:1237"
                     /db_xref="HGNC:HGNC:1609"
                     /db_xref="MIM:601834"
     exon            1..121
                     /gene="CCR8"
                     /gene_synonym="CC-CKR-8; CCR-8; CDw198; CKRL1; CMKBR8;
                     CMKBRL2; CY6; GPRCY6; TER1"
                     /inference="alignment:Splign:2.1.0"
     exon            122..1484
                     /gene="CCR8"
                     /gene_synonym="CC-CKR-8; CCR-8; CDw198; CKRL1; CMKBR8;
                     CMKBRL2; CY6; GPRCY6; TER1"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..1203
                     /gene="CCR8"
                     /gene_synonym="CC-CKR-8; CCR-8; CDw198; CKRL1; CMKBR8;
                     CMKBRL2; CY6; GPRCY6; TER1"
                     /note="CC-chemokine receptor chemr1; chemokine (C-C)
                     receptor 8; chemokine (C-C) receptor-like 2; CC chemokine
                     receptor 8; chemokine receptor-like 1; CC chemokine
                     receptor CHEMR1; chemokine (C-C motif) receptor 8"
                     /codon_start=1
                     /product="C-C chemokine receptor type 8"
                     /protein_id="NP_005192.1"
                     /db_xref="CCDS:CCDS2684.1"
                     /db_xref="GeneID:1237"
                     /db_xref="HGNC:HGNC:1609"
                     /db_xref="MIM:601834"
                     /translation="MDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCL
                     LFVFSLLGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFG
                     TVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLT
                     AIMATIPLLVFYQVASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCY
                     IKILHQLKRCQNHNKTKAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQ
                     QLTYATHVTEIISFTHCCVNPVIYAFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRES
                     CEKSSSCQQHSSRSSSVDYIL"
ORIGIN      
        1 gtagtgggag gatacctcca gagaggctgc tgctcattga gctgcactca catgaggata
       61 cagactttgt gaagaaggaa ttggcaacac tgaaacctcc agaacaaagg ctgtcactaa
      121 ggtcccgctg ccttgatgga ttatacactt gacctcagtg tgacaacagt gaccgactac
      181 tactaccctg atatcttctc aagcccctgt gatgcggaac ttattcagac aaatggcaag
      241 ttgctccttg ctgtctttta ttgcctcctg tttgtattca gtcttctggg aaacagcctg
      301 gtcatcctgg tccttgtggt ctgcaagaag ctgaggagca tcacagatgt atacctcttg
      361 aacctggccc tgtctgacct gctttttgtc ttctccttcc cctttcagac ctactatctg
      421 ctggaccagt gggtgtttgg gactgtaatg tgcaaagtgg tgtctggctt ttattacatt
      481 ggcttctaca gcagcatgtt tttcatcacc ctcatgagtg tggacaggta cctggctgtt
      541 gtccatgccg tgtatgccct aaaggtgagg acgatcagga tgggcacaac gctgtgcctg
      601 gcagtatggc taaccgccat tatggctacc atcccattgc tagtgtttta ccaagtggcc
      661 tctgaagatg gtgttctaca gtgttattca ttttacaatc aacagacttt gaagtggaag
      721 atcttcacca acttcaaaat gaacatttta ggcttgttga tcccattcac catctttatg
      781 ttctgctaca ttaaaatcct gcaccagctg aagaggtgtc aaaaccacaa caagaccaag
      841 gccatcaggt tggtgctcat tgtggtcatt gcatctttac ttttctgggt cccattcaac
      901 gtggttcttt tcctcacttc cttgcacagt atgcacatct tggatggatg tagcataagc
      961 caacagctga cttatgccac ccatgtcaca gaaatcattt cctttactca ctgctgtgtg
     1021 aaccctgtta tctatgcttt tgttggggag aagttcaaga aacacctctc agaaatattt
     1081 cagaaaagtt gcagccaaat cttcaactac ctaggaagac aaatgcctag ggagagctgt
     1141 gaaaagtcat catcctgcca gcagcactcc tcccgttcct ccagcgtaga ctacattttg
     1201 tgaggatcaa tgaagactaa atataaaaaa cattttcttg aatggcatgc tagtagcagt
     1261 gagcaaaggt gtgggtgtga aaggtttcca aaaaaagttc agcatgaagg atgccatata
     1321 tgttgttgcc aacacttgga acacaatgac taaagacata gttgtgcatg cctggcacaa
     1381 catcaagcct gtgattgtgt ttattgatga tgttgaacaa gtggtaactt taaaggattc
     1441 tgtatgccaa gtgaaaaaaa aagatgtctg acctccttac atat
//
