LOCUS       NM_001838               2173 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens C-C motif chemokine receptor 7 (CCR7), transcript
            variant 1, mRNA.
ACCESSION   NM_001838
VERSION     NM_001838.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2173)
  AUTHORS   Niemietz,P., Peiseler,M., Kohlhepp,M., Horn,P., Matchett,K.,
            Wang,Y., Haas,L., Zhang,T., Bruneau,A., Guillot,A., Berger,H.,
            Liepelt,A., Warzecha,K., Demske,C., Mockel,D., Lammers,T.,
            Henderson,N., Heymann,F. and Tacke,F.
  TITLE     C-C chemokine receptor type 7 (CCR7) regulates hepatic CD8 + T cell
            homeostasis and response to acute liver injury
  JOURNAL   Hepatology 80 (5), 1104-1119 (2024)
   PUBMED   38231043
  REMARK    GeneRIF: C-C chemokine receptor type 7 (CCR7) regulates hepatic CD8
            + T cell homeostasis and response to acute liver injury.
REFERENCE   2  (bases 1 to 2173)
  AUTHORS   Gao,J., Wang,Z., Lin,S., Tian,Y., Wu,H., Li,Z. and Liu,F.
  TITLE     CCR7/DUSP1 signaling Axis mediates iCAF to regulates head and neck
            squamous cell carcinoma growth
  JOURNAL   Cell Signal 122, 111305 (2024)
   PUBMED   39067836
  REMARK    GeneRIF: CCR7/DUSP1 signaling Axis mediates iCAF to regulates head
            and neck squamous cell carcinoma growth.
REFERENCE   3  (bases 1 to 2173)
  AUTHORS   Cardona,C.I., Rodriguez,A., Torres,V.C., Sanchez,A., Torres,A.,
            Vazquez,A.E., Wagler,A.E., Brissette,M.A., Bill,C.A. and Vines,C.M.
  TITLE     C-C Chemokine Receptor 7 Promotes T-Cell Acute Lymphoblastic
            Leukemia Invasion of the Central Nervous System via beta2-Integrins
  JOURNAL   Int J Mol Sci 25 (17), 9649 (2024)
   PUBMED   39273598
  REMARK    GeneRIF: C-C Chemokine Receptor 7 Promotes T-Cell Acute
            Lymphoblastic Leukemia Invasion of the Central Nervous System via
            beta2-Integrins.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2173)
  AUTHORS   Geraldo,L.H., Garcia,C., Xu,Y., Leser,F.S., Grimaldi,I., de Camargo
            Magalhaes,E.S., Dejaegher,J., Solie,L., Pereira,C.M., Correia,A.H.,
            De Vleeschouwer,S., Tavitian,B., Canedo,N.H.S., Mathivet,T.,
            Thomas,J.L., Eichmann,A. and Lima,F.R.S.
  TITLE     CCL21-CCR7 signaling promotes microglia/macrophage recruitment and
            chemotherapy resistance in glioblastoma
  JOURNAL   Cell Mol Life Sci 80 (7), 179 (2023)
   PUBMED   37314567
  REMARK    GeneRIF: CCL21-CCR7 signaling promotes microglia/macrophage
            recruitment and chemotherapy resistance in glioblastoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2173)
  AUTHORS   Moschovakis,G.L. and Forster,R.
  TITLE     Multifaceted activities of CCR7 regulate T-cell homeostasis in
            health and disease
  JOURNAL   Eur J Immunol 42 (8), 1949-1955 (2012)
   PUBMED   22700449
  REMARK    Review article
REFERENCE   6  (bases 1 to 2173)
  AUTHORS   Yoshida,R., Imai,T., Hieshima,K., Kusuda,J., Baba,M., Kitaura,M.,
            Nishimura,M., Kakizaki,M., Nomiyama,H. and Yoshie,O.
  TITLE     Molecular cloning of a novel human CC chemokine EBI1-ligand
            chemokine that is a specific functional ligand for EBI1, CCR7
  JOURNAL   J Biol Chem 272 (21), 13803-13809 (1997)
   PUBMED   9153236
REFERENCE   7  (bases 1 to 2173)
  AUTHORS   Burgstahler,R., Kempkes,B., Steube,K. and Lipp,M.
  TITLE     Expression of the chemokine receptor BLR2/EBI1 is specifically
            transactivated by Epstein-Barr virus nuclear antigen 2
  JOURNAL   Biochem Biophys Res Commun 215 (2), 737-743 (1995)
   PUBMED   7488016
REFERENCE   8  (bases 1 to 2173)
  AUTHORS   Schweickart,V.L., Raport,C.J., Godiska,R., Byers,M.G., Eddy,R.L.
            Jr., Shows,T.B. and Gray,P.W.
  TITLE     Cloning of human and mouse EBI1, a lymphoid-specific
            G-protein-coupled receptor encoded on human chromosome 17q12-q21.2
  JOURNAL   Genomics 23 (3), 643-650 (1994)
   PUBMED   7851893
REFERENCE   9  (bases 1 to 2173)
  AUTHORS   Birkenbach,M., Josefsen,K., Yalamanchili,R., Lenoir,G. and Kieff,E.
  TITLE     Epstein-Barr virus-induced genes: first lymphocyte-specific G
            protein-coupled peptide receptors
  JOURNAL   J Virol 67 (4), 2209-2220 (1993)
   PUBMED   8383238
REFERENCE   10 (bases 1 to 2173)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from L31581.1 and BC035343.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001838.3.
            
            Summary: The protein encoded by this gene is a member of the G
            protein-coupled receptor family. This receptor was identified as a
            gene induced by the Epstein-Barr virus (EBV), and is thought to be
            a mediator of EBV effects on B lymphocytes. This receptor is
            expressed in various lymphoid tissues and activates B and T
            lymphocytes. It has been shown to control the migration of memory T
            cells to inflamed tissues, as well as stimulate dendritic cell
            maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has
            been reported to be a specific ligand of this receptor. Signals
            mediated by this receptor regulate T cell homeostasis in lymph
            nodes, and may also function in the activation and polarization of
            T cells, and in chronic inflammation pathogenesis. Alternative
            splicing of this gene results in multiple transcript variants.
            [provided by RefSeq, Sep 2014].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK127810.1, L08176.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000246657.2/ ENSP00000246657.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1338              L31581.1           4-1341
            1339-2173           BC035343.1         1317-2151
FEATURES             Location/Qualifiers
     source          1..2173
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..2173
                     /gene="CCR7"
                     /gene_synonym="BLR2; CC-CKR-7; CCR-7; CD197; CDw197;
                     CMKBR7; EBI1"
                     /note="C-C motif chemokine receptor 7"
                     /db_xref="GeneID:1236"
                     /db_xref="HGNC:HGNC:1608"
                     /db_xref="MIM:600242"
     exon            1..73
                     /gene="CCR7"
                     /gene_synonym="BLR2; CC-CKR-7; CCR-7; CD197; CDw197;
                     CMKBR7; EBI1"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1200
                     /gene="CCR7"
                     /gene_synonym="BLR2; CC-CKR-7; CCR-7; CD197; CDw197;
                     CMKBR7; EBI1"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; C-C chemokine receptor type 7; chemokine (C-C
                     motif) receptor 7; MIP-3 beta receptor; EBV-induced G
                     protein-coupled receptor 1; Epstein-Barr virus induced
                     gene 1; lymphocyte-specific G protein-coupled peptide
                     receptor; CC chemokine receptor 7; Bukitt's lymphoma
                     receptor 2; Epstein-Barr virus-induced G-protein coupled
                     receptor 1"
                     /codon_start=1
                     /product="C-C chemokine receptor type 7 isoform a
                     precursor"
                     /protein_id="NP_001829.1"
                     /db_xref="CCDS:CCDS11369.1"
                     /db_xref="GeneID:1236"
                     /db_xref="HGNC:HGNC:1608"
                     /db_xref="MIM:600242"
                     /translation="MDLGKPMKSVLVVALLVIFQVCLCQDEVTDDYIGDNTTVDYTLF
                     ESLCSKKDVRNFKAWFLPIMYSIICFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNLAV
                     ADILFLLTLPFWAYSAAKSWVFGVHFCKLIFAIYKMSFFSGMLLLLCISIDRYVAIVQ
                     AVSAHRHRARVLLISKLSCVGIWILATVLSIPELLYSDLQRSSSEQAMRCSLITEHVE
                     AFITIQVAQMVIGFLVPLLAMSFCYLVIIRTLLQARNFERNKAIKVIIAVVVVFIVFQ
                     LPYNGVVLAQTVANFNITSSTCELSKQLNIAYDVTYSLACVRCCVNPFLYAFIGVKFR
                     NDLFKLFKDLGCLSQEQLRQWSSCRHIRRSSMSVEAETTTTFSP"
     exon            74..123
                     /gene="CCR7"
                     /gene_synonym="BLR2; CC-CKR-7; CCR-7; CD197; CDw197;
                     CMKBR7; EBI1"
                     /inference="alignment:Splign:2.1.0"
     exon            124..2173
                     /gene="CCR7"
                     /gene_synonym="BLR2; CC-CKR-7; CCR-7; CD197; CDw197;
                     CMKBR7; EBI1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2143..2148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCR7"
                     /gene_synonym="BLR2; CC-CKR-7; CCR-7; CD197; CDw197;
                     CMKBR7; EBI1"
                     /note="hexamer: AAGAAA"
     polyA_site      2173
                     /gene="CCR7"
                     /gene_synonym="BLR2; CC-CKR-7; CCR-7; CD197; CDw197;
                     CMKBR7; EBI1"
                     /note="major polyA site"
ORIGIN      
        1 agacaggggt agtgcgaggc cgggcacagc cttcctgtgt ggttttaccg cccagagagc
       61 gtcatggacc tggggaaacc aatgaaaagc gtgctggtgg tggctctcct tgtcattttc
      121 caggtatgcc tgtgtcaaga tgaggtcacg gacgattaca tcggagacaa caccacagtg
      181 gactacactt tgttcgagtc tttgtgctcc aagaaggacg tgcggaactt taaagcctgg
      241 ttcctcccta tcatgtactc catcatttgt ttcgtgggcc tactgggcaa tgggctggtc
      301 gtgttgacct atatctattt caagaggctc aagaccatga ccgataccta cctgctcaac
      361 ctggcggtgg cagacatcct cttcctcctg acccttccct tctgggccta cagcgcggcc
      421 aagtcctggg tcttcggtgt ccacttttgc aagctcatct ttgccatcta caagatgagc
      481 ttcttcagtg gcatgctcct acttctttgc atcagcattg accgctacgt ggccatcgtc
      541 caggctgtct cagctcaccg ccaccgtgcc cgcgtccttc tcatcagcaa gctgtcctgt
      601 gtgggcatct ggatactagc cacagtgctc tccatcccag agctcctgta cagtgacctc
      661 cagaggagca gcagtgagca agcgatgcga tgctctctca tcacagagca tgtggaggcc
      721 tttatcacca tccaggtggc ccagatggtg atcggctttc tggtccccct gctggccatg
      781 agcttctgtt accttgtcat catccgcacc ctgctccagg cacgcaactt tgagcgcaac
      841 aaggccatca aggtgatcat cgctgtggtc gtggtcttca tagtcttcca gctgccctac
      901 aatggggtgg tcctggccca gacggtggcc aacttcaaca tcaccagtag cacctgtgag
      961 ctcagtaagc aactcaacat cgcctacgac gtcacctaca gcctggcctg cgtccgctgc
     1021 tgcgtcaacc ctttcttgta cgccttcatc ggcgtcaagt tccgcaacga tctcttcaag
     1081 ctcttcaagg acctgggctg cctcagccag gagcagctcc ggcagtggtc ttcctgtcgg
     1141 cacatccggc gctcctccat gagtgtggag gccgagacca ccaccacctt ctccccatag
     1201 gcgactcttc tgcctggact agagggacct ctcccagggt ccctggggtg gggataggga
     1261 gcagatgcaa tgactcagga catccccccg ccaaaagctg ctcagggaaa agcagctctc
     1321 ccctcagagt gcaagcccct gctccagaag atagcttcac cccaatccca gctacctcaa
     1381 ccaatgccaa aaaaagacag ggctgataag ctaacaccag acagacaaca ctgggaaaca
     1441 gaggctattg tcccctaaac caaaaactga aagtgaaagt ccagaaactg ttcccacctg
     1501 ctggagtgaa ggggccaagg agggtgagtg caaggggcgt gggagtggcc tgaagagtcc
     1561 tctgaatgaa ccttctggcc tcccacagac tcaaatgctc agaccagctc ttccgaaaac
     1621 caggccttat ctccaagacc agagatagtg gggagacttc ttggcttggt gaggaaaagc
     1681 ggacatcagc tggtcaaaca aactctctga acccctccct ccatcgtttt cttcactgtc
     1741 ctccaagcca gcgggaatgg cagctgccac gccgccctaa aagcacactc atcccctcac
     1801 ttgccgcgtc gccctcccag gctctcaaca ggggagagtg tggtgtttcc tgcaggccag
     1861 gccagctgcc tccgcgtgat caaagccaca ctctgggctc cagagtgggg atgacatgca
     1921 ctcagctctt ggctccactg ggatgggagg agaggacaag ggaaatgtca ggggcgggga
     1981 gggtgacagt ggccgcccaa ggcccacgag cttgttcttt gttctttgtc acagggactg
     2041 aaaacctctc ctcatgttct gctttcgatt cgttaagaga gcaacatttt acccacacac
     2101 agataaagtt ttcccttgag gaaacaacag ctttaaaaga aaaagaaaaa aaaagtcttt
     2161 ggtaaatggc aaa
//
