LOCUS       NM_031409               3136 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens C-C motif chemokine receptor 6 (CCR6), transcript
            variant 2, mRNA.
ACCESSION   NM_031409
VERSION     NM_031409.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3136)
  AUTHORS   Singh,A., Kraaijeveld,A.O., Curaj,A., Wichapong,K., Hammerich,L.,
            de Jager,S.C.A., Bot,I., Atamas,S.P., van Berkel,T.J.C.,
            Jukema,J.W., Comerford,I., McColl,S.R., Mees,B., Heemskerk,J.W.M.,
            Nicolaes,G.A.F., Hackeng,T., Liehn,E.A., Tacke,F. and
            Biessen,E.A.L.
  TITLE     CCL18 aggravates atherosclerosis by inducing CCR6-dependent T-cell
            influx and polarization
  JOURNAL   Front Immunol 15, 1327051 (2024)
   PUBMED   38807599
  REMARK    GeneRIF: CCL18 aggravates atherosclerosis by inducing
            CCR6-dependent T-cell influx and polarization.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3136)
  AUTHORS   Yoo,K.D., Yu,M.Y., Kim,K.H., Lee,S., Park,E., Kang,S., Lim,D.H.,
            Lee,Y., Song,J., Kown,S., Kim,Y.C., Kim,D.K., Lee,J.S., Kim,Y.S.
            and Yang,S.H.
  TITLE     Role of the CCL20/CCR6 axis in tubular epithelial cell injury:
            Kidney-specific translational insights from acute kidney injury to
            chronic kidney disease
  JOURNAL   FASEB J 38 (2), e23407 (2024)
   PUBMED   38197598
  REMARK    GeneRIF: Role of the CCL20/CCR6 axis in tubular epithelial cell
            injury: Kidney-specific translational insights from acute kidney
            injury to chronic kidney disease.
REFERENCE   3  (bases 1 to 3136)
  AUTHORS   Hohne,K., Wagenknecht,A., Maier,C., Engelhard,P., Goldmann,T.,
            Schliessmann,S.J., Plones,T., Trepel,M., Eibel,H.,
            Muller-Quernheim,J. and Zissel,G.
  TITLE     Pro-Fibrotic Effects of CCL18 on Human Lung Fibroblasts Are
            Mediated via CCR6
  JOURNAL   Cells 13 (3), 238 (2024)
   PUBMED   38334630
  REMARK    GeneRIF: Pro-Fibrotic Effects of CCL18 on Human Lung Fibroblasts
            Are Mediated via CCR6.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3136)
  AUTHORS   Roghani,S.A., Lotfi,R., Soroush,M.G., Khorasanizadeh,A.,
            Feizollahi,P., Assar,S., Soufivand,P., Pournazari,M., Mohammadi
            Kish,Z. and Taghadosi,M.
  TITLE     Increased gene expression of CCR6 and RORgammat in peripheral blood
            cells of rheumatoid arthritis patients and their correlation with
            anti-cyclic citrullinated peptide and disease activity
  JOURNAL   Immun Inflamm Dis 11 (12), e1112 (2023)
   PUBMED   38156398
  REMARK    GeneRIF: Increased gene expression of CCR6 and RORgammat in
            peripheral blood cells of rheumatoid arthritis patients and their
            correlation with anti-cyclic citrullinated peptide and disease
            activity.
REFERENCE   5  (bases 1 to 3136)
  AUTHORS   Alfaro,R., Llorente,S., Gonzalez-Martinez,G., Jimenez-Coll,V.,
            Martinez-Banaclocha,H., Galian,J.A., Botella,C., Moya-Quiles,M.R.,
            de la Pena-Moral,J., Minguela,A., Legaz,I. and Muro,M.
  TITLE     Clinical Significance of the Pre-Transplant CXCR3 and CCR6
            Expression on T Cells In Kidney Graft Recipients
  JOURNAL   Transplant Proc 55 (1), 66-71 (2023)
   PUBMED   36621349
  REMARK    GeneRIF: Clinical Significance of the Pre-Transplant CXCR3 and CCR6
            Expression on T Cells In Kidney Graft Recipients.
REFERENCE   6  (bases 1 to 3136)
  AUTHORS   Baba,M., Imai,T., Nishimura,M., Kakizaki,M., Takagi,S.,
            Hieshima,K., Nomiyama,H. and Yoshie,O.
  TITLE     Identification of CCR6, the specific receptor for a novel
            lymphocyte-directed CC chemokine LARC
  JOURNAL   J Biol Chem 272 (23), 14893-14898 (1997)
   PUBMED   9169459
REFERENCE   7  (bases 1 to 3136)
  AUTHORS   Liao,F., Lee,H.H. and Farber,J.M.
  TITLE     Cloning of STRL22, a new human gene encoding a G-protein-coupled
            receptor related to chemokine receptors and located on chromosome
            6q27
  JOURNAL   Genomics 40 (1), 175-180 (1997)
   PUBMED   9070937
REFERENCE   8  (bases 1 to 3136)
  AUTHORS   Wagner,T., Tommerup,N., Wirth,J., Leffers,H., Zimmer,J., Back,E.,
            Weissenbach,J. and Scherer,G.
  TITLE     A somatic cell hybrid panel for distal 17q: GDIA1 maps to 17q25.3
  JOURNAL   Cytogenet Cell Genet 76 (3-4), 172-175 (1997)
   PUBMED   9186513
REFERENCE   9  (bases 1 to 3136)
  AUTHORS   Zaballos,A., Varona,R., Gutierrez,J., Lind,P. and Marquez,G.
  TITLE     Molecular cloning and RNA expression of two new human chemokine
            receptor-like genes
  JOURNAL   Biochem Biophys Res Commun 227 (3), 846-853 (1996)
   PUBMED   8886020
  REMARK    Erratum:[Biochem Biophys Res Commun 1997 Feb 13;231(2):519-20]
REFERENCE   10 (bases 1 to 3136)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA645096.1, BC037960.1 and
            AL121935.17.
            
            On Aug 13, 2020 this sequence version replaced NM_031409.3.
            
            Summary: This gene encodes a member of the beta chemokine receptor
            family, which is predicted to be a seven transmembrane protein
            similar to G protein-coupled receptors. The gene is preferentially
            expressed by immature dendritic cells and memory T cells. The
            ligand of this receptor is macrophage inflammatory protein 3 alpha
            (MIP-3 alpha). This receptor has been shown to be important for
            B-lineage maturation and antigen-driven B-cell differentiation, and
            it may regulate the migration and recruitment of dentritic and T
            cells during inflammatory and immunological responses.
            Alternatively spliced transcript variants that encode the same
            protein have been described for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (2) is the longer transcript.
            Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK223494.1, SRR18074968.4058689.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341935.10/ ENSP00000343952.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               DA645096.1         344-471
            129-1656            BC037960.1         110-1637
            1657-3136           AL121935.17        36763-38242
FEATURES             Location/Qualifiers
     source          1..3136
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q27"
     gene            1..3136
                     /gene="CCR6"
                     /gene_synonym="BN-1; C-C CKR-6; CC-CKR-6; CCR-6; CD196;
                     CKR-L3; CKRL3; CMKBR6; DCR2; DRY6; GPR29; GPRCY4; STRL22"
                     /note="C-C motif chemokine receptor 6"
                     /db_xref="GeneID:1235"
                     /db_xref="HGNC:HGNC:1607"
                     /db_xref="MIM:601835"
     exon            1..128
                     /gene="CCR6"
                     /gene_synonym="BN-1; C-C CKR-6; CC-CKR-6; CCR-6; CD196;
                     CKR-L3; CKRL3; CMKBR6; DCR2; DRY6; GPR29; GPRCY4; STRL22"
                     /inference="alignment:Splign:2.1.0"
     exon            129..234
                     /gene="CCR6"
                     /gene_synonym="BN-1; C-C CKR-6; CC-CKR-6; CCR-6; CD196;
                     CKR-L3; CKRL3; CMKBR6; DCR2; DRY6; GPR29; GPRCY4; STRL22"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1350
                     /gene="CCR6"
                     /gene_synonym="BN-1; C-C CKR-6; CC-CKR-6; CCR-6; CD196;
                     CKR-L3; CKRL3; CMKBR6; DCR2; DRY6; GPR29; GPRCY4; STRL22"
                     /note="chemokine receptor-like 3; chemokine (C-C) receptor
                     6; G protein-coupled receptor 29; seven-transmembrane
                     receptor, lymphocyte, 22; LARC receptor; chemokine (C-C
                     motif) receptor 6"
                     /codon_start=1
                     /product="C-C chemokine receptor type 6"
                     /protein_id="NP_113597.2"
                     /db_xref="CCDS:CCDS5298.1"
                     /db_xref="GeneID:1235"
                     /db_xref="HGNC:HGNC:1607"
                     /db_xref="MIM:601835"
                     /translation="MSGESMNFSDVFDSSEDYFVSVNTSYYSVDSEMLLCSLQEVRQF
                     SRLFVPIAYSLICVFGLLGNILVVITFAFYKKARSMTDVYLLNMAIADILFVLTLPFW
                     AVSHATGAWVFSNATCKLLKGIYAINFNCGMLLLTCISMDRYIAIVQATKSFRLRSRT
                     LPRSKIICLVVWGLSVIISSSTFVFNQKYNTQGSDVCEPKYQTVSEPIRWKLLMLGLE
                     LLFGFFIPLMFMIFCYTFIVKTLVQAQNSKRHKAIRVIIAVVLVFLACQIPHNMVLLV
                     TAANLGKMNRSCQSEKLIGYTKTVTEVLAFLHCCLNPVLYAFIGQKFRNYFLKILKDL
                     WCVRRKYKSSGFSCAGRYSENISRQTSETADNDNASSFTM"
     exon            235..3136
                     /gene="CCR6"
                     /gene_synonym="BN-1; C-C CKR-6; CC-CKR-6; CCR-6; CD196;
                     CKR-L3; CKRL3; CMKBR6; DCR2; DRY6; GPR29; GPRCY4; STRL22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3111..3116
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCR6"
                     /gene_synonym="BN-1; C-C CKR-6; CC-CKR-6; CCR-6; CD196;
                     CKR-L3; CKRL3; CMKBR6; DCR2; DRY6; GPR29; GPRCY4; STRL22"
                     /note="hexamer: AATAAA"
     polyA_site      3136
                     /gene="CCR6"
                     /gene_synonym="BN-1; C-C CKR-6; CC-CKR-6; CCR-6; CD196;
                     CKR-L3; CKRL3; CMKBR6; DCR2; DRY6; GPR29; GPRCY4; STRL22"
                     /note="major polyA site"
ORIGIN      
        1 gcttttttct taatgactgc tagaagctgc atcttattga cagatggtca tcacattggt
       61 gagctggagt catcagattg tggggcccgg agtgaggctg aagggagtgg atcagagcac
      121 tgcctgagag tcacctctac tttcctgcta ccgctgcctg tgagctgaag gggctgaacc
      181 atacactcct ttttctacaa ccagcttgca ttttttctgc ccacaatgag cggggaatca
      241 atgaatttca gcgatgtttt cgactccagt gaagattatt ttgtgtcagt caatacttca
      301 tattactcag ttgattctga gatgttactg tgctccttgc aggaggtcag gcagttctcc
      361 aggctatttg taccgattgc ctactccttg atctgtgtct ttggcctcct ggggaatatt
      421 ctggtggtga tcacctttgc tttttataag aaggccaggt ctatgacaga cgtctatctc
      481 ttgaacatgg ccattgcaga catcctcttt gttcttactc tcccattctg ggcagtgagt
      541 catgccaccg gtgcgtgggt tttcagcaat gccacgtgca agttgctaaa aggcatctat
      601 gccatcaact ttaactgcgg gatgctgctc ctgacttgca ttagcatgga ccggtacatc
      661 gccattgtac aggcgactaa gtcattccgg ctccgatcca gaacactacc gcgcagcaaa
      721 atcatctgcc ttgttgtgtg ggggctgtca gtcatcatct ccagctcaac ttttgtcttc
      781 aaccaaaaat acaacaccca aggcagcgat gtctgtgaac ccaagtacca gactgtctcg
      841 gagcccatca ggtggaagct gctgatgttg gggcttgagc tactctttgg tttctttatc
      901 cctttgatgt tcatgatatt ttgttacacg ttcattgtca aaaccttggt gcaagctcag
      961 aattctaaaa ggcacaaagc catccgtgta atcatagctg tggtgcttgt gtttctggct
     1021 tgtcagattc ctcataacat ggtcctgctt gtgacggctg caaatttggg taaaatgaac
     1081 cgatcctgcc agagcgaaaa gctaattggc tatacgaaaa ctgtcacaga agtcctggct
     1141 ttcctgcact gctgcctgaa ccctgtgctc tacgctttta ttgggcagaa gttcagaaac
     1201 tactttctga agatcttgaa ggacctgtgg tgtgtgagaa ggaagtacaa gtcctcaggc
     1261 ttctcctgtg ccgggaggta ctcagaaaac atttctcggc agaccagtga gaccgcagat
     1321 aacgacaatg cgtcgtcctt cactatgtga tagaaagctg agtctcccta aggcatgtgt
     1381 gaaacatact catagatgtt atgcaaaaaa aagtctatgg ccaggtatgc atggaaaatg
     1441 tgggaattaa gcaaaatcaa gcaagcctct ctcctgcggg acttaacgtg ctcatgggct
     1501 gtgtgatctc ttcagggtgg ggtggtctct gataggtagc attttccagc actttgcaag
     1561 gaatgttttg tagctctagg gtatatatcc gcctggcatt tcacaaaaca gcctttggga
     1621 aatgctgaat taaagtgaat tgttgacaaa tgtaaacatt ttcagaaata ttcatgaagc
     1681 ggtcacagat cacagtgtct tttggttaca gcacaaaatg atggcagtgg tttgaaaaac
     1741 taaaacagaa aaaaaaatgg aagccaacac atcactcatt ttaggcaaat gtttaaacat
     1801 ttttatctat cagaatgttt attgttgctg gttataagca gcaggattgg ccggctagtg
     1861 tttcctctca tttccctttg atacagtcaa caagcctgac cctgtaaaat ggaggtggaa
     1921 agacaagctc aagtgttcac aacctggaag tgcttcggga agaaggggac aatggcagaa
     1981 caggtgttgg tgacaattgt caccaattgg ataaagcagc tcaggttgta gtgggccatt
     2041 aggaaactgt cggtttgctt tgatttccct gggagctgtt ctctgtcgtg agtgtctctt
     2101 gtctaaacgt ccattaagct gagagtgcta tgaagacagg atctagaata atcttgctca
     2161 cagctgtgct ctgagtgcct agcggagttc cagcaaacaa aatggactca agagagattt
     2221 gattaatgaa tcgtaatgaa gttggggttt attgtacagt ttaaaatgtt agatgttttt
     2281 aattttttaa ataaatggaa tacttttttt ttttttttaa agaaagcaac tttactgaga
     2341 caatgtagaa agaagttttg ttccgtttct ttaatgtggt tgaagagcaa tgtgtggctg
     2401 aagacttttg ttatgaggag ctgcagatta gctaggggac agctggaatt atgctggctt
     2461 ctgataatta ttttaaaggg gtctgaaatt tgtgatggaa tcagatttta acagctctct
     2521 tcaatgacat agaaagttca tggaactcat gtttttaaag ggctatgtaa atatatgaac
     2581 attagaaaaa tagcaacttg tgttacaaaa atacaaacac atgttaggaa ggtactgtca
     2641 tgggctaggc atggtggctc acacctgtaa tcccagcatt ttgggaagct aagatgggtg
     2701 gatcacttga ggtcaggagt ttgagaccag cctggccaac atggcgaaac ccctctctac
     2761 taaaaataca aaaatttgcc aggcgtggtg gcgggtgcct gtaatcccag ctacttggga
     2821 ggctgaggca agagaatcgc ttgaacccag gaggcagagg ttgcagtgag ccgagatcgt
     2881 gccattgcac tccagcctgg gtgacaaagc gagactccat ctcaaaaaaa aaaaaaaaaa
     2941 aaaaggaaag aactgtcatg taaacatacc aacatgttta aacctgacaa tggtgttatt
     3001 tgaaacttta tattgttctt gtaagcttta actatatctc tctttaaaat gcaaaataat
     3061 gtcttaagat tcaaagtctg tatttttaaa gcatggcttt ggctttgcaa aataaaaaat
     3121 gtgttttgta catgaa
//
