LOCUS       NM_001394783            3358 bp    mRNA    linear   PRI 07-DEC-2024
DEFINITION  Homo sapiens C-C motif chemokine receptor 5 (CCR5), transcript
            variant C, mRNA.
ACCESSION   NM_001394783
VERSION     NM_001394783.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3358)
  AUTHORS   Deng,H., Xue,P., Zhou,X., Wang,Y. and Liu,W.
  TITLE     CCL4/CCR5 regulates chondrocyte biology and OA progression
  JOURNAL   Cytokine 183, 156746 (2024)
   PUBMED   39236430
  REMARK    GeneRIF: CCL4/CCR5 regulates chondrocyte biology and OA
            progression.
REFERENCE   2  (bases 1 to 3358)
  AUTHORS   Guigues,A., Gimenez,S., Mettling,C., Maurel,D., Doumazane,E.,
            Prezeau,L., Francois,V. and Corbeau,P.
  TITLE     The EBI2 receptor is coexpressed with CCR5 in CD4 + T cells and
            boosts HIV-1 R5 replication
  JOURNAL   AIDS 38 (10), 1449-1459 (2024)
   PUBMED   38770825
  REMARK    GeneRIF: The EBI2 receptor is coexpressed with CCR5 in CD4 + T
            cells and boosts HIV-1 R5 replication.
REFERENCE   3  (bases 1 to 3358)
  AUTHORS   Schlechter,B.L. and Stebbing,J.
  TITLE     CCR5 and CCL5 in metastatic colorectal cancer
  JOURNAL   J Immunother Cancer 12 (5), e008722 (2024)
   PUBMED   38719543
  REMARK    GeneRIF: CCR5 and CCL5 in metastatic colorectal cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3358)
  AUTHORS   Wang,L., Yukselten,Y., Nuwagaba,J. and Sutton,R.E.
  TITLE     JAK/STAT signaling pathway affects CCR5 expression in human CD4+ T
            cells
  JOURNAL   Sci Adv 10 (12), eadl0368 (2024)
   PUBMED   38507500
  REMARK    GeneRIF: JAK/STAT signaling pathway affects CCR5 expression in
            human CD4[+] T cells.
REFERENCE   5  (bases 1 to 3358)
  AUTHORS   Zhou,T.B., Jiang,Z.P., Zhou,J.F. and Su,N.
  TITLE     Relationship between chemokine receptor 5 Delta32/W gene
            polymorphism and lupus nephritis
  JOURNAL   Hum Immunol 75 (9), 968-972 (2014)
   PUBMED   25167769
  REMARK    GeneRIF: Studies indicate that chemokine receptor 5 Delta32/W gene
            polymorphism was not associated with lupus nephritis (LN) risk and
            might be no a significant genetic molecular marker to predict the
            systemic lupus erythematosus (SLE) patients developing into LN.
REFERENCE   6  (bases 1 to 3358)
  AUTHORS   Ahad,M.A., Missotten,T., Abdallah,A., Lympany,P.A. and Lightman,S.
  TITLE     Polymorphisms of chemokine and chemokine receptor genes in
            idiopathic immune-mediated posterior segment uveitis
  JOURNAL   Mol Vis 13, 388-396 (2007)
   PUBMED   17417600
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3358)
  AUTHORS   Madsen,H.O., Poulsen,K., Dahl,O., Clark,B.F. and Hjorth,J.P.
  TITLE     Retropseudogenes constitute the major part of the human elongation
            factor 1 alpha gene family
  JOURNAL   Nucleic Acids Res 18 (6), 1513-1516 (1990)
   PUBMED   2183196
REFERENCE   8  (bases 1 to 3358)
  AUTHORS   Whiteheart,S.W., Shenbagamurthi,P., Chen,L., Cotter,R.J. and
            Hart,G.W.
  TITLE     Murine elongation factor 1 alpha (EF-1 alpha) is
            posttranslationally modified by novel amide-linked
            ethanolamine-phosphoglycerol moieties. Addition of
            ethanolamine-phosphoglycerol to specific glutamic acid residues on
            EF-1 alpha
  JOURNAL   J Biol Chem 264 (24), 14334-14341 (1989)
   PUBMED   2569467
REFERENCE   9  (bases 1 to 3358)
  AUTHORS   Uetsuki,T., Naito,A., Nagata,S. and Kaziro,Y.
  TITLE     Isolation and characterization of the human chromosomal gene for
            polypeptide chain elongation factor-1 alpha
  JOURNAL   J Biol Chem 264 (10), 5791-5798 (1989)
   PUBMED   2564392
REFERENCE   10 (bases 1 to 3358)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC098613.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a member of the beta chemokine receptor
            family, which is predicted to be a seven transmembrane protein
            similar to G protein-coupled receptors. This protein is expressed
            by T cells and macrophages, and is known to be an important
            co-receptor for macrophage-tropic virus, including HIV, to enter
            host cells. Defective alleles of this gene have been associated
            with the HIV infection resistance. The ligands of this receptor
            include monocyte chemoattractant protein 2 (MCP-2), macrophage
            inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory
            protein 1 beta (MIP-1 beta) and regulated on activation normal T
            expressed and secreted protein (RANTES). Expression of this gene
            was also detected in a promyeloblastic cell line, suggesting that
            this protein may play a role in granulocyte lineage proliferation
            and differentiation. This gene is located at the chemokine receptor
            gene cluster region. An allelic polymorphism in this gene results
            in both functional and non-functional alleles; the reference genome
            represents the functional allele. Two transcript variants encoding
            the same protein have been found for this gene. [provided by
            RefSeq, Jul 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U54994.1, BC038398.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292303.5/ ENSP00000292303.4
            polymorphic pseudogene :: PMID: 17417600
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AC098613.2         27475-27517
            44-3358             AC098613.2         29421-32735
FEATURES             Location/Qualifiers
     source          1..3358
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..3358
                     /gene="CCR5"
                     /gene_synonym="CC-CKR-5; CCCKR5; CCR-5; CD195; CKR-5;
                     CKR5; CMKBR5; IDDM22"
                     /note="C-C motif chemokine receptor 5"
                     /db_xref="GeneID:1234"
                     /db_xref="HGNC:HGNC:1606"
                     /db_xref="MIM:601373"
     exon            1..43
                     /gene="CCR5"
                     /gene_synonym="CC-CKR-5; CCCKR5; CCR-5; CD195; CKR-5;
                     CKR5; CMKBR5; IDDM22"
                     /inference="alignment:Splign:2.1.0"
     exon            44..3358
                     /gene="CCR5"
                     /gene_synonym="CC-CKR-5; CCCKR5; CCR-5; CD195; CKR-5;
                     CKR5; CMKBR5; IDDM22"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1113
                     /gene="CCR5"
                     /gene_synonym="CC-CKR-5; CCCKR5; CCR-5; CD195; CKR-5;
                     CKR5; CMKBR5; IDDM22"
                     /note="chemr13; C-C motif chemokine receptor 5 A159A;
                     chemokine receptor CCR5; HIV-1 fusion coreceptor;
                     chemokine (C-C motif) receptor 5; chemokine recptor CCR5
                     Delta32; mutant C-C motif chemokine receptor"
                     /codon_start=1
                     /product="C-C chemokine receptor type 5"
                     /protein_id="NP_001381712.1"
                     /db_xref="CCDS:CCDS2739.1"
                     /db_xref="GeneID:1234"
                     /db_xref="HGNC:HGNC:1606"
                     /db_xref="MIM:601373"
                     /translation="MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFG
                     FVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQ
                     LLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFAS
                     LPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGIL
                     KTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLD
                     QAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPER
                     ASSVYTRSTGEQEISVGL"
     regulatory      3335..3340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCR5"
                     /gene_synonym="CC-CKR-5; CCCKR5; CCR-5; CD195; CKR-5;
                     CKR5; CMKBR5; IDDM22"
                     /note="hexamer: AATAAA"
     polyA_site      3358
                     /gene="CCR5"
                     /gene_synonym="CC-CKR-5; CCCKR5; CCR-5; CD195; CKR-5;
                     CKR5; CMKBR5; IDDM22"
                     /note="major polyA site"
ORIGIN      
        1 agaagagctg agacatccgt tcccctacaa gaaactctcc ccgggtggaa caagatggat
       61 tatcaagtgt caagtccaat ctatgacatc aattattata catcggagcc ctgccaaaaa
      121 atcaatgtga agcaaatcgc agcccgcctc ctgcctccgc tctactcact ggtgttcatc
      181 tttggttttg tgggcaacat gctggtcatc ctcatcctga taaactgcaa aaggctgaag
      241 agcatgactg acatctacct gctcaacctg gccatctctg acctgttttt ccttcttact
      301 gtccccttct gggctcacta tgctgccgcc cagtgggact ttggaaatac aatgtgtcaa
      361 ctcttgacag ggctctattt tataggcttc ttctctggaa tcttcttcat catcctcctg
      421 acaatcgata ggtacctggc tgtcgtccat gctgtgtttg ctttaaaagc caggacggtc
      481 acctttgggg tggtgacaag tgtgatcact tgggtggtgg ctgtgtttgc gtctctccca
      541 ggaatcatct ttaccagatc tcaaaaagaa ggtcttcatt acacctgcag ctctcatttt
      601 ccatacagtc agtatcaatt ctggaagaat ttccagacat taaagatagt catcttgggg
      661 ctggtcctgc cgctgcttgt catggtcatc tgctactcgg gaatcctaaa aactctgctt
      721 cggtgtcgaa atgagaagaa gaggcacagg gctgtgaggc ttatcttcac catcatgatt
      781 gtttattttc tcttctgggc tccctacaac attgtccttc tcctgaacac cttccaggaa
      841 ttctttggcc tgaataattg cagtagctct aacaggttgg accaagctat gcaggtgaca
      901 gagactcttg ggatgacgca ctgctgcatc aaccccatca tctatgcctt tgtcggggag
      961 aagttcagaa actacctctt agtcttcttc caaaagcaca ttgccaaacg cttctgcaaa
     1021 tgctgttcta ttttccagca agaggctccc gagcgagcaa gctcagttta cacccgatcc
     1081 actggggagc aggaaatatc tgtgggcttg tgacacggac tcaagtgggc tggtgaccca
     1141 gtcagagttg tgcacatggc ttagttttca tacacagcct gggctggggg tggggtggga
     1201 gaggtctttt ttaaaaggaa gttactgtta tagagggtct aagattcatc catttatttg
     1261 gcatctgttt aaagtagatt agatctttta agcccatcaa ttatagaaag ccaaatcaaa
     1321 atatgttgat gaaaaatagc aaccttttta tctccccttc acatgcatca agttattgac
     1381 aaactctccc ttcactccga aagttcctta tgtatattta aaagaaagcc tcagagaatt
     1441 gctgattctt gagtttagtg atctgaacag aaataccaaa attatttcag aaatgtacaa
     1501 ctttttacct agtacaaggc aacatatagg ttgtaaatgt gtttaaaaca ggtctttgtc
     1561 ttgctatggg gagaaaagac atgaatatga ttagtaaaga aatgacactt ttcatgtgtg
     1621 atttcccctc caaggtatgg ttaataagtt tcactgactt agaaccaggc gagagacttg
     1681 tggcctggga gagctgggga agcttcttaa atgagaagga atttgagttg gatcatctat
     1741 tgctggcaaa gacagaagcc tcactgcaag cactgcatgg gcaagcttgg ctgtagaagg
     1801 agacagagct ggttgggaag acatggggag gaaggacaag gctagatcat gaagaacctt
     1861 gacggcattg ctccgtctaa gtcatgagct gagcagggag atcctggttg gtgttgcaga
     1921 aggtttactc tgtggccaaa ggagggtcag gaaggatgag catttagggc aaggagacca
     1981 ccaacagccc tcaggtcagg gtgaggatgg cctctgctaa gctcaaggcg tgaggatggg
     2041 aaggagggag gtattcgtaa ggatgggaag gagggaggta ttcgtgcagc atatgaggat
     2101 gcagagtcag cagaactggg gtggatttgg gttggaagtg agggtcagag aggagtcaga
     2161 gagaatccct agtcttcaag cagattggag aaacccttga aaagacatca agcacagaag
     2221 gaggaggagg aggtttaggt caagaagaag atggattggt gtaaaaggat gggtctggtt
     2281 tgcagagctt gaacacagtc tcacccagac tccaggctgt ctttcactga atgcttctga
     2341 cttcatagat ttccttccca tcccagctga aatactgagg ggtctccagg aggagactag
     2401 atttatgaat acacgaggta tgaggtctag gaacatactt cagctcacac atgagatcta
     2461 ggtgaggatt gattacctag tagtcatttc atgggttgtt gggaggattc tatgaggcaa
     2521 ccacaggcag catttagcac atactacaca ttcaataagc atcaaactct tagttactca
     2581 ttcagggata gcactgagca aagcattgag caaaggggtc ccatagaggt gagggaagcc
     2641 tgaaaaacta agatgctgcc tgcccagtgc acacaagtgt aggtatcatt ttctgcattt
     2701 aaccgtcaat aggcaaaggg gggaagggac atattcattt ggaaataagc tgccttgagc
     2761 cttaaaaccc acaaaagtac aatttaccag cctccgtatt tcagactgaa tgggggtggg
     2821 gggggcgcct taggtactta ttccagatgc cttctccaga caaaccagaa gcaacagaaa
     2881 aaatcgtctc tccctccctt tgaaatgaat atacccctta gtgtttgggt atattcattt
     2941 caaagggaga gagagaggtt tttttctgtt ctgtctcata tgattgtgca catacttgag
     3001 actgttttga atttggggga tggctaaaac catcatagta caggtaaggt gagggaatag
     3061 taagtggtga gaactactca gggaatgaag gtgtcagaat aataagaggt gctactgact
     3121 ttctcagcct ctgaatatga acggtgagca ttgtggctgt cagcaggaag caacgaaggg
     3181 aaatgtcttt ccttttgctc ttaagttgtg gagagtgcaa cagtagcata ggaccctacc
     3241 ctctgggcca agtcaaagac attctgacat cttagtattt gcatattctt atgtatgtga
     3301 aagttacaaa ttgcttgaaa gaaaatatgc atctaataaa aaacaccttc taaaataa
//
