LOCUS       NM_005508               3025 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens C-C motif chemokine receptor 4 (CCR4), mRNA.
ACCESSION   NM_005508
VERSION     NM_005508.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3025)
  AUTHORS   Panek,W.K., Toedebusch,R.G., Mclaughlin,B.E., Dickinson,P.J., Van
            Dyke,J.E., Woolard,K.D., Berens,M.E., Lesniak,M.S., Sturges,B.K.,
            Vernau,K.M., Li,C., Miska,J. and Toedebusch,C.M.
  TITLE     The CCL2-CCR4 axis promotes Regulatory T cell trafficking to canine
            glioma tissues
  JOURNAL   J Neurooncol 169 (3), 647-658 (2024)
   PUBMED   39046599
  REMARK    GeneRIF: The CCL2-CCR4 axis promotes Regulatory T cell trafficking
            to canine glioma tissues.
REFERENCE   2  (bases 1 to 3025)
  AUTHORS   Burgess,H.M., Grande,R., Riccio,S., Dinesh,I., Winkler,G.S.,
            Depledge,D.P. and Mohr,I.
  TITLE     CCR4-NOT differentially controls host versus virus poly(a)-tail
            length and regulates HCMV infection
  JOURNAL   EMBO Rep 24 (12), e56327 (2023)
   PUBMED   37846490
  REMARK    GeneRIF: CCR4-NOT differentially controls host versus virus
            poly(a)-tail length and regulates HCMV infection.
REFERENCE   3  (bases 1 to 3025)
  AUTHORS   Knowles,C.M., Goich,D., Bloom,A.L.M., Kalem,M.C. and Panepinto,J.C.
  TITLE     Contributions of Ccr4 and Gcn2 to the Translational Response of C.
            neoformans to Host-Relevant Stressors and Integrated Stress
            Response Induction
  JOURNAL   mBio 14 (2), e0019623 (2023)
   PUBMED   37017529
  REMARK    GeneRIF: Contributions of Ccr4 and Gcn2 to the Translational
            Response of C. neoformans to Host-Relevant Stressors and Integrated
            Stress Response Induction.
REFERENCE   4  (bases 1 to 3025)
  AUTHORS   Khanam,A., Ghosh,A., Chua,J.V. and Kottilil,S.
  TITLE     Blockade of CCR4 breaks immune tolerance in chronic hepatitis B
            patients by modulating regulatory pathways
  JOURNAL   J Transl Med 21 (1), 271 (2023)
   PUBMED   37081509
  REMARK    GeneRIF: Blockade of CCR4 breaks immune tolerance in chronic
            hepatitis B patients by modulating regulatory pathways.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3025)
  AUTHORS   Sarkar,T., Dhar,S., Chakraborty,D., Pati,S., Bose,S., Panda,A.K.,
            Basak,U., Chakraborty,S., Mukherjee,S., Guin,A., Jana,K.,
            Sarkar,D.K. and Sa,G.
  TITLE     FOXP3/HAT1 Axis Controls Treg Infiltration in the Tumor
            Microenvironment by Inducing CCR4 Expression in Breast Cancer
  JOURNAL   Front Immunol 13, 740588 (2022)
   PUBMED   35222362
  REMARK    GeneRIF: FOXP3/HAT1 Axis Controls Treg Infiltration in the Tumor
            Microenvironment by Inducing CCR4 Expression in Breast Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3025)
  AUTHORS   Imai,T., Chantry,D., Raport,C.J., Wood,C.L., Nishimura,M.,
            Godiska,R., Yoshie,O. and Gray,P.W.
  TITLE     Macrophage-derived chemokine is a functional ligand for the CC
            chemokine receptor 4
  JOURNAL   J Biol Chem 273 (3), 1764-1768 (1998)
   PUBMED   9430724
REFERENCE   7  (bases 1 to 3025)
  AUTHORS   Imai,T., Baba,M., Nishimura,M., Kakizaki,M., Takagi,S. and
            Yoshie,O.
  TITLE     The T cell-directed CC chemokine TARC is a highly specific
            biological ligand for CC chemokine receptor 4
  JOURNAL   J Biol Chem 272 (23), 15036-15042 (1997)
   PUBMED   9169480
REFERENCE   8  (bases 1 to 3025)
  AUTHORS   Samson,M., Soularue,P., Vassart,G. and Parmentier,M.
  TITLE     The genes encoding the human CC-chemokine receptors CC-CKR1 to
            CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21.3-p24 region of
            chromosome 3
  JOURNAL   Genomics 36 (3), 522-526 (1996)
   PUBMED   8884276
  REMARK    GeneRIF: The human CCR4 gene is localized at Chr 3p24.
REFERENCE   9  (bases 1 to 3025)
  AUTHORS   Hoogewerf,A., Black,D., Proudfoot,A.E., Wells,T.N. and Power,C.A.
  TITLE     Molecular cloning of murine CC CKR-4 and high affinity binding of
            chemokines to murine and human CC CKR-4
  JOURNAL   Biochem Biophys Res Commun 218 (1), 337-343 (1996)
   PUBMED   8573157
REFERENCE   10 (bases 1 to 3025)
  AUTHORS   Power,C.A., Meyer,A., Nemeth,K., Bacon,K.B., Hoogewerf,A.J.,
            Proudfoot,A.E. and Wells,T.N.
  TITLE     Molecular cloning and functional expression of a novel CC chemokine
            receptor cDNA from a human basophilic cell line
  JOURNAL   J Biol Chem 270 (33), 19495-19500 (1995)
   PUBMED   7642634
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC071751.1 and AC137560.2.
            
            On May 17, 2019 this sequence version replaced NM_005508.4.
            
            Summary: The protein encoded by this gene belongs to the
            G-protein-coupled receptor family . It is a receptor for the CC
            chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group
            of small polypeptide, structurally related molecules that regulate
            cell trafficking of various types of leukocytes. The chemokines
            also play fundamental roles in the development, homeostasis, and
            function of the immune system, and they have effects on cells of
            the central nervous system as well as on endothelial cells involved
            in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292674.1, DB158068.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330953.6/ ENSP00000332659.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1587              BC071751.1         71-1657
            1588-3025           AC137560.2         9275-10712
FEATURES             Location/Qualifiers
     source          1..3025
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.3"
     gene            1..3025
                     /gene="CCR4"
                     /gene_synonym="CC-CKR-4; CD194; ChemR13; CKR4; CMKBR4;
                     HGCN:14099; K5-5"
                     /note="C-C motif chemokine receptor 4"
                     /db_xref="GeneID:1233"
                     /db_xref="HGNC:HGNC:1605"
                     /db_xref="MIM:604836"
     exon            1..47
                     /gene="CCR4"
                     /gene_synonym="CC-CKR-4; CD194; ChemR13; CKR4; CMKBR4;
                     HGCN:14099; K5-5"
                     /inference="alignment:Splign:2.1.0"
     exon            48..3025
                     /gene="CCR4"
                     /gene_synonym="CC-CKR-4; CD194; ChemR13; CKR4; CMKBR4;
                     HGCN:14099; K5-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1181
                     /gene="CCR4"
                     /gene_synonym="CC-CKR-4; CD194; ChemR13; CKR4; CMKBR4;
                     HGCN:14099; K5-5"
                     /EC_number="3.1.13.4"
                     /note="chemokine (C-C) receptor 4; CCR-4; C-C CKR-4;
                     chemokine (C-C motif) receptor 4"
                     /codon_start=1
                     /product="C-C chemokine receptor type 4"
                     /protein_id="NP_005499.1"
                     /db_xref="CCDS:CCDS2656.1"
                     /db_xref="GeneID:1233"
                     /db_xref="HGNC:HGNC:1605"
                     /db_xref="MIM:604836"
                     /translation="MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPP
                     LYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQ
                     WVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLA
                     TWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIM
                     LFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDC
                     TFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGL
                     LQIYSADTPSSSYTQSTMDHDLHDAL"
ORIGIN      
        1 ggcattgcct cacagacctt cctcagagcc gctttcagaa aagcaagctg cttctggttg
       61 ggcccagacc tgccttgagg agcctgtaga gttaaaaaat gaaccccacg gatatagcag
      121 acaccaccct cgatgaaagc atatacagca attactatct gtatgaaagt atccccaagc
      181 cttgcaccaa agaaggcatc aaggcatttg gggagctctt cctgccccca ctgtattcct
      241 tggtttttgt atttggtctg cttggaaatt ctgtggtggt tctggtcctg ttcaaataca
      301 agcggctcag gtccatgact gatgtgtacc tgctcaacct tgccatctcg gatctgctct
      361 tcgtgttttc cctccctttt tggggctact atgcagcaga ccagtgggtt tttgggctag
      421 gtctgtgcaa gatgatttcc tggatgtact tggtgggctt ttacagtggc atattctttg
      481 tcatgctcat gagcattgat agatacctgg caattgtgca cgcggtgttt tccttgaggg
      541 caaggacctt gacttatggg gtcatcacca gtttggctac atggtcagtg gctgtgttcg
      601 cctcccttcc tggctttctg ttcagcactt gttatactga gcgcaaccat acctactgca
      661 aaaccaagta ctctctcaac tccacgacgt ggaaggttct cagctccctg gaaatcaaca
      721 ttctcggatt ggtgatcccc ttagggatca tgctgttttg ctactccatg atcatcagga
      781 ccttgcagca ttgtaaaaat gagaagaaga acaaggcggt gaagatgatc tttgccgtgg
      841 tggtcctctt ccttgggttc tggacacctt acaacatagt gctcttccta gagaccctgg
      901 tggagctaga agtccttcag gactgcacct ttgaaagata cttggactat gccatccagg
      961 ccacagaaac tctggctttt gttcactgct gccttaatcc catcatctac ttttttctgg
     1021 gggagaaatt tcgcaagtac atcctacagc tcttcaaaac ctgcaggggc ctttttgtgc
     1081 tctgccaata ctgtgggctc ctccaaattt actctgctga cacccccagc tcatcttaca
     1141 cgcagtccac catggatcat gatctccatg atgctctgta gaaaaatgaa atggtgaaat
     1201 gcagagtcaa tgaactttcc acattcagag cttacttaaa attgtatttt agtaagagat
     1261 tcctgagcca gtgtcaggag gaaggcttac acccacagtg gaaagacagc ttctcatcct
     1321 gcaggcagct ttttctctcc cactagacaa gtccagcctg gcaagggttc acctgggctg
     1381 aggcatcctt cctcacacca ggcttgcctg caggcatgag tcagtctgat gagaactctg
     1441 agcagtgctt gaatgaagtt gtaggtaata ttgcaaggca aagactattc ccttctaacc
     1501 tgaactgatg ggtttctcca gagggaattg cagagtactg gctgatggag taaatcgcta
     1561 ccttttgctg tggcaaatgg gccctctaat taatttcttg cttttgcgga acaatataga
     1621 taactgtttt tctaataaca tatctcaggc aaagtatatt ccattgagcc agatgtatga
     1681 agaaacaatt agcgaagtga tgaaaccaga tctcaattat ttattgtaaa ggattatctg
     1741 ttaattgaaa ccaaactttt tatactgata taagggtaag gatatgaaga cattagccaa
     1801 ggtctgcttt ccaaacgtga actacaaggc attcaaaatc caaacatatt tatgaaaatt
     1861 caaacacagt ttctcacttg tttgtggaca tgttttgttc taattttaac agaggaatat
     1921 taaaaaattt taaataggct gggcacggtg gcctgtaatc ccagcactgt gggaggccaa
     1981 ggtgggcgga tcacctgagg tcaggagttc gagaccagcc tggccaacat ggagaaaccc
     2041 tgtctctact aaaaaataca aaattagcca ggtgtggtgg cgcatgcctg taatcccagc
     2101 tactcaggag gctgaggctg gagaataact tgaatccggg aggtggaggt tgcggtgagc
     2161 cgagatcgcg ccattgtact ccaacctggg caaaaagagc gaaactctgt ctcaaaaaaa
     2221 aaaaaaaaaa attaaataat acataggcca agaatacatt tatttgaggt catttacttg
     2281 tttttttttt tttttttttt tttgagatgg aatcttgctc tgtcacccag tctggagtgc
     2341 agtggcgcga tctcggctca ctgcaagctc tgcctcacgg gttcgcacca ttctcctgcc
     2401 tcagcctccc aagtaggtgg gactacaggc acctgccccc atgcctggct aattttttgt
     2461 attttcagta gagatggggt ttcaccatgt tagcaaggat ggttttaatc tcctgacctc
     2521 gtgatccacc cgcctcggcc tcccaaagtg ctgggattac aggtgtgagc catcacgccc
     2581 ggccacttgt ttatttttta ttttatttta ttttattttt gagatggagt ctcactctgt
     2641 cacccaagct ggagtgcagt ggcactcggt tcactgcaaa gtctgcctcc caggttcaag
     2701 cgattctcct gcctcagctt ctcaagcagc tgggattaga ggtgtgcacc actacgccag
     2761 gctaattttt gtatttttag tagagatggg gtttcaccat attggccagg ctagtcttga
     2821 actcctgacc tcaggtgatc tgcctgcttc agcctcccaa agtgctggga ttacaggcgt
     2881 gagccacctc gcccagccaa ggtcttttac ttgtttataa acagtctctt cataattaaa
     2941 attaaggatt aataaagtat gacaatacct ccttaatcat tttgaagtgc ctgctatcaa
     3001 ttgaaataaa aacaatcaac taaaa
//
