LOCUS       NM_178329               1638 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens C-C motif chemokine receptor 3 (CCR3), transcript
            variant 2, mRNA.
ACCESSION   NM_178329
VERSION     NM_178329.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1638)
  AUTHORS   Sun,Z., Pan,L., Tian,A. and Chen,P.
  TITLE     Critically-ill COVID-19 susceptibility gene CCR3 shows natural
            selection in sub-Saharan Africans
  JOURNAL   Infect Genet Evol 121, 105594 (2024)
   PUBMED   38636619
  REMARK    GeneRIF: Critically-ill COVID-19 susceptibility gene CCR3 shows
            natural selection in sub-Saharan Africans.
REFERENCE   2  (bases 1 to 1638)
  AUTHORS   Wang,Z., Xu,H., Chen,M., Lu,Y., Zheng,L. and Ma,L.
  TITLE     CCL24/CCR3 axis plays a central role in angiotensin II-induced
            heart failure by stimulating M2 macrophage polarization and
            fibroblast activation
  JOURNAL   Cell Biol Toxicol 39 (4), 1413-1431 (2023)
   PUBMED   36131165
  REMARK    GeneRIF: CCL24/CCR3 axis plays a central role in angiotensin
            II-induced heart failure by stimulating M2 macrophage polarization
            and fibroblast activation.
REFERENCE   3  (bases 1 to 1638)
  AUTHORS   Onkanga,I.O., Sang,H., Hamilton,R., Ondigo,B.N., Jaoko,W.,
            Odiere,M.R. and Ganley-Leal,L.
  TITLE     CD193 (CCR3) expression by B cells correlates with reduced IgE
            production in paediatric schistosomiasis
  JOURNAL   Parasite Immunol 45 (5), e12979 (2023)
   PUBMED   36971331
  REMARK    GeneRIF: CD193 (CCR3) expression by B cells correlates with reduced
            IgE production in paediatric schistosomiasis.
REFERENCE   4  (bases 1 to 1638)
  AUTHORS   Kaibori,Y. and Nagakubo,D.
  TITLE     CCR3 blockage elicits polyploidization associated with the
            signatures of epithelial-mesenchymal transition in carcinoma cell
            lines
  JOURNAL   Cancer Gene Ther 30 (1), 137-148 (2023)
   PUBMED   36123391
  REMARK    GeneRIF: CCR3 blockage elicits polyploidization associated with the
            signatures of epithelial-mesenchymal transition in carcinoma cell
            lines.
REFERENCE   5  (bases 1 to 1638)
  AUTHORS   Li,W., Li,N., Yang,G. and Li,Y.
  TITLE     The rs13075270 and rs13092160 polymorphisms of CCR1 and CCR3 genes
            on oral aphthous-like lesions in PFAPA syndrome
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 67 (4), 328-333 (2022)
   PUBMED   35809272
  REMARK    GeneRIF: The rs13075270 and rs13092160 polymorphisms of CCR1 and
            CCR3 genes on oral aphthous-like lesions in PFAPA syndrome.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1638)
  AUTHORS   Combadiere,C., Ahuja,S.K. and Murphy,P.M.
  TITLE     Cloning and functional expression of a human eosinophil CC
            chemokine receptor
  JOURNAL   J Biol Chem 271 (18), 11034 (1996)
   PUBMED   8631926
  REMARK    Correction to:[J Biol Chem. 1995 Jul 14;270(28):16491-4. doi:
            10.1074/jbc.270.28.16491.. PMID: 7622448]
REFERENCE   7  (bases 1 to 1638)
  AUTHORS   Kitaura,M., Nakajima,T., Imai,T., Harada,S., Combadiere,C.,
            Tiffany,H.L., Murphy,P.M. and Yoshie,O.
  TITLE     Molecular cloning of human eotaxin, an eosinophil-selective CC
            chemokine, and identification of a specific eosinophil eotaxin
            receptor, CC chemokine receptor 3
  JOURNAL   J Biol Chem 271 (13), 7725-7730 (1996)
   PUBMED   8631813
REFERENCE   8  (bases 1 to 1638)
  AUTHORS   Ponath,P.D., Qin,S., Ringler,D.J., Clark-Lewis,I., Wang,J.,
            Kassam,N., Smith,H., Shi,X., Gonzalo,J.A., Newman,W.,
            Gutierrez-Ramos,J.C. and Mackay,C.R.
  TITLE     Cloning of the human eosinophil chemoattractant, eotaxin.
            Expression, receptor binding, and functional properties suggest a
            mechanism for the selective recruitment of eosinophils
  JOURNAL   J Clin Invest 97 (3), 604-612 (1996)
   PUBMED   8609214
REFERENCE   9  (bases 1 to 1638)
  AUTHORS   Post,T.W., Bozic,C.R., Rothenberg,M.E., Luster,A.D., Gerard,N. and
            Gerard,C.
  TITLE     Molecular characterization of two murine eosinophil beta chemokine
            receptors
  JOURNAL   J Immunol 155 (11), 5299-5305 (1995)
   PUBMED   7594543
REFERENCE   10 (bases 1 to 1638)
  AUTHORS   Combadiere,C., Ahuja,S.K. and Murphy,P.M.
  TITLE     Cloning and functional expression of a human eosinophil CC
            chemokine receptor
  JOURNAL   J Biol Chem 270 (28), 16491-16494 (1995)
   PUBMED   7622448
  REMARK    Erratum:[J Biol Chem 1995 Dec 15;270(50):30235]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104439.2 and BC130320.1.
            
            On Nov 22, 2018 this sequence version replaced NM_178329.2.
            
            Summary: The protein encoded by this gene is a receptor for C-C
            type chemokines. It belongs to family 1 of the G protein-coupled
            receptors. This receptor binds and responds to a variety of
            chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3
            (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in
            eosinophils and basophils, and is also detected in TH1 and TH2
            cells, as well as in airway epithelial cells. This receptor may
            contribute to the accumulation and activation of eosinophils and
            other inflammatory cells in the allergic airway. It is also known
            to be an entry co-receptor for HIV-1. This gene and seven other
            chemokine receptor genes form a chemokine receptor gene cluster on
            the chromosomal region 3p21. Alternatively spliced transcript
            variants have been described. [provided by RefSeq, Sep 2009].
            
            Transcript Variant: This variant (2) lacks an internal exon in the
            5' UTR, as compared to variant 1. Both variants encode the same
            isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF224495.1, BC110297.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: locus in the vicinity of
                                      disease-associated variant(s)
            MANE Ensembl match     :: ENST00000395940.3/ ENSP00000379271.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC104439.2         167489-167498
            11-1352             BC130320.1         1-1342
            1353-1638           AC104439.2         191450-191735
FEATURES             Location/Qualifiers
     source          1..1638
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..1638
                     /gene="CCR3"
                     /gene_synonym="C C CKR3; CC-CKR-3; CD193; CKR 3; CKR3;
                     CMKBR3"
                     /note="C-C motif chemokine receptor 3"
                     /db_xref="GeneID:1232"
                     /db_xref="HGNC:HGNC:1604"
                     /db_xref="MIM:601268"
     exon            1..79
                     /gene="CCR3"
                     /gene_synonym="C C CKR3; CC-CKR-3; CD193; CKR 3; CKR3;
                     CMKBR3"
                     /inference="alignment:Splign:2.1.0"
     exon            80..1638
                     /gene="CCR3"
                     /gene_synonym="C C CKR3; CC-CKR-3; CD193; CKR 3; CKR3;
                     CMKBR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1158
                     /gene="CCR3"
                     /gene_synonym="C C CKR3; CC-CKR-3; CD193; CKR 3; CKR3;
                     CMKBR3"
                     /note="isoform 1 is encoded by transcript variant 2;
                     eosinophil CC chemokine receptor 3; b-chemokine receptor;
                     eosinophil eotaxin receptor; C-C chemokine receptor type
                     3; CCR-3; C-C CKR-3; chemokine (C-C motif) receptor 3"
                     /codon_start=1
                     /product="C-C chemokine receptor type 3 isoform 1"
                     /protein_id="NP_847899.1"
                     /db_xref="CCDS:CCDS2738.1"
                     /db_xref="GeneID:1232"
                     /db_xref="HGNC:HGNC:1604"
                     /db_xref="MIM:601268"
                     /translation="MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLV
                     FTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFG
                     HGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGL
                     AVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAIC
                     YTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERS
                     KHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSE
                     KLERTSSVSPSTAEPELSIVF"
     regulatory      1520..1525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCR3"
                     /gene_synonym="C C CKR3; CC-CKR-3; CD193; CKR 3; CKR3;
                     CMKBR3"
                     /note="hexamer: AATAAA"
     polyA_site      1544
                     /gene="CCR3"
                     /gene_synonym="C C CKR3; CC-CKR-3; CD193; CKR 3; CKR3;
                     CMKBR3"
                     /note="major polyA site"
     regulatory      1618..1623
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCR3"
                     /gene_synonym="C C CKR3; CC-CKR-3; CD193; CKR 3; CKR3;
                     CMKBR3"
                     /note="hexamer: AATAAA"
     polyA_site      1636
                     /gene="CCR3"
                     /gene_synonym="C C CKR3; CC-CKR-3; CD193; CKR 3; CKR3;
                     CMKBR3"
                     /note="major polyA site"
ORIGIN      
        1 accactggtc ttcttgtgct tatccgggca agaacttatc gaaatacaat agaagttttt
       61 acttagaaga gattttcagg gagaagtgaa atgacaacct cactagatac agttgagacc
      121 tttggtacca catcctacta tgatgacgtg ggcctgctct gtgaaaaagc tgataccaga
      181 gcactgatgg cccagtttgt gcccccgctg tactccctgg tgttcactgt gggcctcttg
      241 ggcaatgtgg tggtggtgat gatcctcata aaatacagga ggctccgaat tatgaccaac
      301 atctacctgc tcaacctggc catttcggac ctgctcttcc tcgtcaccct tccattctgg
      361 atccactatg tcagggggca taactgggtt tttggccatg gcatgtgtaa gctcctctca
      421 gggttttatc acacaggctt gtacagcgag atctttttca taatcctgct gacaatcgac
      481 aggtacctgg ccattgtcca tgctgtgttt gcccttcgag cccggactgt cacttttggt
      541 gtcatcacca gcatcgtcac ctggggcctg gcagtgctag cagctcttcc tgaatttatc
      601 ttctatgaga ctgaagagtt gtttgaagag actctttgca gtgctcttta cccagaggat
      661 acagtatata gctggaggca tttccacact ctgagaatga ccatcttctg tctcgttctc
      721 cctctgctcg ttatggccat ctgctacaca ggaatcatca aaacgctgct gaggtgcccc
      781 agtaaaaaaa agtacaaggc catccggctc atttttgtca tcatggcggt gtttttcatt
      841 ttctggacac cctacaatgt ggctatcctt ctctcttcct atcaatccat cttatttgga
      901 aatgactgtg agcggagcaa gcatctggac ctggtcatgc tggtgacaga ggtgatcgcc
      961 tactcccact gctgcatgaa cccggtgatc tacgcctttg ttggagagag gttccggaag
     1021 tacctgcgcc acttcttcca caggcacttg ctcatgcacc tgggcagata catcccattc
     1081 cttcctagtg agaagctgga aagaaccagc tctgtctctc catccacagc agagccggaa
     1141 ctctctattg tgttttaggt cagatgcaga aaattgccta aagaggaagg accaaggaga
     1201 tgaagcaaac acattaagcc ttccacactc acctctaaaa cagtccttca aacttccagt
     1261 gcaacactga agctcttgaa gacactgaaa tatacacaca gcagtagcag tagatgcatg
     1321 taccctaagg tcattaccac aggccagggg ctgggcagcg tactcatcat caaccctaaa
     1381 aagcagagct ttgcttctct ctctaaaatg agttacctac attttaatgc acctgaatgt
     1441 tagatagtta ctatatgccg ctacaaaaag gtaaaacttt ttatatttta tacattaact
     1501 tcagccagct attgatataa ataaaacatt ttcacacaat acaataagtt aactatttta
     1561 ttttctaatg tgcctagttc tttccctgct taatgaaaag cttgtttttt cagtgtgaat
     1621 aaataatcgt aagcaaca
//
