LOCUS       NM_178328               1786 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens C-C motif chemokine receptor 3 (CCR3), transcript
            variant 3, mRNA.
ACCESSION   NM_178328
VERSION     NM_178328.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1786)
  AUTHORS   Sun,Z., Pan,L., Tian,A. and Chen,P.
  TITLE     Critically-ill COVID-19 susceptibility gene CCR3 shows natural
            selection in sub-Saharan Africans
  JOURNAL   Infect Genet Evol 121, 105594 (2024)
   PUBMED   38636619
  REMARK    GeneRIF: Critically-ill COVID-19 susceptibility gene CCR3 shows
            natural selection in sub-Saharan Africans.
REFERENCE   2  (bases 1 to 1786)
  AUTHORS   Wang,Z., Xu,H., Chen,M., Lu,Y., Zheng,L. and Ma,L.
  TITLE     CCL24/CCR3 axis plays a central role in angiotensin II-induced
            heart failure by stimulating M2 macrophage polarization and
            fibroblast activation
  JOURNAL   Cell Biol Toxicol 39 (4), 1413-1431 (2023)
   PUBMED   36131165
  REMARK    GeneRIF: CCL24/CCR3 axis plays a central role in angiotensin
            II-induced heart failure by stimulating M2 macrophage polarization
            and fibroblast activation.
REFERENCE   3  (bases 1 to 1786)
  AUTHORS   Onkanga,I.O., Sang,H., Hamilton,R., Ondigo,B.N., Jaoko,W.,
            Odiere,M.R. and Ganley-Leal,L.
  TITLE     CD193 (CCR3) expression by B cells correlates with reduced IgE
            production in paediatric schistosomiasis
  JOURNAL   Parasite Immunol 45 (5), e12979 (2023)
   PUBMED   36971331
  REMARK    GeneRIF: CD193 (CCR3) expression by B cells correlates with reduced
            IgE production in paediatric schistosomiasis.
REFERENCE   4  (bases 1 to 1786)
  AUTHORS   Kaibori,Y. and Nagakubo,D.
  TITLE     CCR3 blockage elicits polyploidization associated with the
            signatures of epithelial-mesenchymal transition in carcinoma cell
            lines
  JOURNAL   Cancer Gene Ther 30 (1), 137-148 (2023)
   PUBMED   36123391
  REMARK    GeneRIF: CCR3 blockage elicits polyploidization associated with the
            signatures of epithelial-mesenchymal transition in carcinoma cell
            lines.
REFERENCE   5  (bases 1 to 1786)
  AUTHORS   Li,W., Li,N., Yang,G. and Li,Y.
  TITLE     The rs13075270 and rs13092160 polymorphisms of CCR1 and CCR3 genes
            on oral aphthous-like lesions in PFAPA syndrome
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 67 (4), 328-333 (2022)
   PUBMED   35809272
  REMARK    GeneRIF: The rs13075270 and rs13092160 polymorphisms of CCR1 and
            CCR3 genes on oral aphthous-like lesions in PFAPA syndrome.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1786)
  AUTHORS   Combadiere,C., Ahuja,S.K. and Murphy,P.M.
  TITLE     Cloning and functional expression of a human eosinophil CC
            chemokine receptor
  JOURNAL   J Biol Chem 271 (18), 11034 (1996)
   PUBMED   8631926
  REMARK    Correction to:[J Biol Chem. 1995 Jul 14;270(28):16491-4. doi:
            10.1074/jbc.270.28.16491.. PMID: 7622448]
REFERENCE   7  (bases 1 to 1786)
  AUTHORS   Kitaura,M., Nakajima,T., Imai,T., Harada,S., Combadiere,C.,
            Tiffany,H.L., Murphy,P.M. and Yoshie,O.
  TITLE     Molecular cloning of human eotaxin, an eosinophil-selective CC
            chemokine, and identification of a specific eosinophil eotaxin
            receptor, CC chemokine receptor 3
  JOURNAL   J Biol Chem 271 (13), 7725-7730 (1996)
   PUBMED   8631813
REFERENCE   8  (bases 1 to 1786)
  AUTHORS   Ponath,P.D., Qin,S., Ringler,D.J., Clark-Lewis,I., Wang,J.,
            Kassam,N., Smith,H., Shi,X., Gonzalo,J.A., Newman,W.,
            Gutierrez-Ramos,J.C. and Mackay,C.R.
  TITLE     Cloning of the human eosinophil chemoattractant, eotaxin.
            Expression, receptor binding, and functional properties suggest a
            mechanism for the selective recruitment of eosinophils
  JOURNAL   J Clin Invest 97 (3), 604-612 (1996)
   PUBMED   8609214
REFERENCE   9  (bases 1 to 1786)
  AUTHORS   Post,T.W., Bozic,C.R., Rothenberg,M.E., Luster,A.D., Gerard,N. and
            Gerard,C.
  TITLE     Molecular characterization of two murine eosinophil beta chemokine
            receptors
  JOURNAL   J Immunol 155 (11), 5299-5305 (1995)
   PUBMED   7594543
REFERENCE   10 (bases 1 to 1786)
  AUTHORS   Combadiere,C., Ahuja,S.K. and Murphy,P.M.
  TITLE     Cloning and functional expression of a human eosinophil CC
            chemokine receptor
  JOURNAL   J Biol Chem 270 (28), 16491-16494 (1995)
   PUBMED   7622448
  REMARK    Erratum:[J Biol Chem 1995 Dec 15;270(50):30235]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104439.2 and AF262301.1.
            
            Summary: The protein encoded by this gene is a receptor for C-C
            type chemokines. It belongs to family 1 of the G protein-coupled
            receptors. This receptor binds and responds to a variety of
            chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3
            (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in
            eosinophils and basophils, and is also detected in TH1 and TH2
            cells, as well as in airway epithelial cells. This receptor may
            contribute to the accumulation and activation of eosinophils and
            other inflammatory cells in the allergic airway. It is also known
            to be an entry co-receptor for HIV-1. This gene and seven other
            chemokine receptor genes form a chemokine receptor gene cluster on
            the chromosomal region 3p21. Alternatively spliced transcript
            variants have been described. [provided by RefSeq, Sep 2009].
            
            Transcript Variant: This variant (3) has an alternate internal
            exon, which includes an upstream in-frame AUG start codon, as
            compared to variant 1. The resulting isoform (2) has a longer
            N-terminus, as compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF262301.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2145893,
                                           SAMEA2149876 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related :: locus in the vicinity of disease-associated
                                   variant(s)
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 5' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AC104439.2         167410-167488
            80-479              AF262301.1         1-400
            480-1786            AC104439.2         190429-191735
FEATURES             Location/Qualifiers
     source          1..1786
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..1786
                     /gene="CCR3"
                     /gene_synonym="C C CKR3; CC-CKR-3; CD193; CKR 3; CKR3;
                     CMKBR3"
                     /note="C-C motif chemokine receptor 3"
                     /db_xref="GeneID:1232"
                     /db_xref="HGNC:HGNC:1604"
                     /db_xref="MIM:601268"
     exon            1..158
                     /gene="CCR3"
                     /gene_synonym="C C CKR3; CC-CKR-3; CD193; CKR 3; CKR3;
                     CMKBR3"
                     /inference="alignment:Splign:2.1.0"
     exon            159..227
                     /gene="CCR3"
                     /gene_synonym="C C CKR3; CC-CKR-3; CD193; CKR 3; CKR3;
                     CMKBR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1306
                     /gene="CCR3"
                     /gene_synonym="C C CKR3; CC-CKR-3; CD193; CKR 3; CKR3;
                     CMKBR3"
                     /note="isoform 2 is encoded by transcript variant 3;
                     eosinophil CC chemokine receptor 3; b-chemokine receptor;
                     eosinophil eotaxin receptor; C-C chemokine receptor type
                     3; CCR-3; C-C CKR-3; chemokine (C-C motif) receptor 3"
                     /codon_start=1
                     /product="C-C chemokine receptor type 3 isoform 2"
                     /protein_id="NP_847898.1"
                     /db_xref="CCDS:CCDS54574.1"
                     /db_xref="GeneID:1232"
                     /db_xref="HGNC:HGNC:1604"
                     /db_xref="MIM:601268"
                     /translation="MPFGIRMLLRAHKPGSSRRSEMTTSLDTVETFGTTSYYDDVGLL
                     CEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDL
                     LFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAV
                     FALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRH
                     FHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPY
                     NVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLR
                     HFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF"
     exon            228..1786
                     /gene="CCR3"
                     /gene_synonym="C C CKR3; CC-CKR-3; CD193; CKR 3; CKR3;
                     CMKBR3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1668..1673
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCR3"
                     /gene_synonym="C C CKR3; CC-CKR-3; CD193; CKR 3; CKR3;
                     CMKBR3"
                     /note="hexamer: AATAAA"
     polyA_site      1692
                     /gene="CCR3"
                     /gene_synonym="C C CKR3; CC-CKR-3; CD193; CKR 3; CKR3;
                     CMKBR3"
                     /note="major polyA site"
     regulatory      1766..1771
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCR3"
                     /gene_synonym="C C CKR3; CC-CKR-3; CD193; CKR 3; CKR3;
                     CMKBR3"
                     /note="hexamer: AATAAA"
     polyA_site      1784
                     /gene="CCR3"
                     /gene_synonym="C C CKR3; CC-CKR-3; CD193; CKR 3; CKR3;
                     CMKBR3"
                     /note="major polyA site"
ORIGIN      
        1 ctgatggtat ctctgtttca ggagtggtga cgcctaagct atcactggac atatcaagga
       61 cttcactaaa ttagcaggta ccactggtct tcttgtgctt atccgggcaa gaacttatcg
      121 aaatacaata gaagttttta cttagaagag attttcagct gctgtggatt ggattatgcc
      181 atttggaata agaatgctgt taagagcaca caagccaggt tcctcaagga gaagtgaaat
      241 gacaacctca ctagatacag ttgagacctt tggtaccaca tcctactatg atgacgtggg
      301 cctgctctgt gaaaaagctg ataccagagc actgatggcc cagtttgtgc ccccgctgta
      361 ctccctggtg ttcactgtgg gcctcttggg caatgtggtg gtggtgatga tcctcataaa
      421 atacaggagg ctccgaatta tgaccaacat ctacctgctc aacctggcca tttcggacct
      481 gctcttcctc gtcacccttc cattctggat ccactatgtc agggggcata actgggtttt
      541 tggccatggc atgtgtaagc tcctctcagg gttttatcac acaggcttgt acagcgagat
      601 ctttttcata atcctgctga caatcgacag gtacctggcc attgtccatg ctgtgtttgc
      661 ccttcgagcc cggactgtca cttttggtgt catcaccagc atcgtcacct ggggcctggc
      721 agtgctagca gctcttcctg aatttatctt ctatgagact gaagagttgt ttgaagagac
      781 tctttgcagt gctctttacc cagaggatac agtatatagc tggaggcatt tccacactct
      841 gagaatgacc atcttctgtc tcgttctccc tctgctcgtt atggccatct gctacacagg
      901 aatcatcaaa acgctgctga ggtgccccag taaaaaaaag tacaaggcca tccggctcat
      961 ttttgtcatc atggcggtgt ttttcatttt ctggacaccc tacaatgtgg ctatccttct
     1021 ctcttcctat caatccatct tatttggaaa tgactgtgag cggagcaagc atctggacct
     1081 ggtcatgctg gtgacagagg tgatcgccta ctcccactgc tgcatgaacc cggtgatcta
     1141 cgcctttgtt ggagagaggt tccggaagta cctgcgccac ttcttccaca ggcacttgct
     1201 catgcacctg ggcagataca tcccattcct tcctagtgag aagctggaaa gaaccagctc
     1261 tgtctctcca tccacagcag agccggaact ctctattgtg ttttaggtca gatgcagaaa
     1321 attgcctaaa gaggaaggac caaggagatg aagcaaacac attaagcctt ccacactcac
     1381 ctctaaaaca gtccttcaaa cttccagtgc aacactgaag ctcttgaaga cactgaaata
     1441 tacacacagc agtagcagta gatgcatgta ccctaaggtc attaccacag gccaggggct
     1501 gggcagcgta ctcatcatca accctaaaaa gcagagcttt gcttctctct ctaaaatgag
     1561 ttacctacat tttaatgcac ctgaatgtta gatagttact atatgccgct acaaaaaggt
     1621 aaaacttttt atattttata cattaacttc agccagctat tgatataaat aaaacatttt
     1681 cacacaatac aataagttaa ctattttatt ttctaatgtg cctagttctt tccctgctta
     1741 atgaaaagct tgttttttca gtgtgaataa ataatcgtaa gcaaca
//
