LOCUS       NM_001123396            3531 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens C-C motif chemokine receptor 2 (CCR2), transcript
            variant B, mRNA.
ACCESSION   NM_001123396 NM_000648
VERSION     NM_001123396.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3531)
  AUTHORS   Bagheri,V., Khorramdelazad,H., Kafi,M. and Abbasifard,M.
  TITLE     Chemokine CCL2 and its receptor CCR2 in different age groups of
            patients with COVID-19
  JOURNAL   BMC Immunol 25 (1), 72 (2024)
   PUBMED   39455952
  REMARK    GeneRIF: Chemokine CCL2 and its receptor CCR2 in different age
            groups of patients with COVID-19.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3531)
  AUTHORS   Hurwitz,S.N., Kobulsky,D.R., Jung,S.K., Chia,J.J., Butler,J.M. and
            Kurre,P.
  TITLE     CCR2 cooperativity promotes hematopoietic stem cell homing to the
            bone marrow
  JOURNAL   Sci Adv 10 (38), eadq1476 (2024)
   PUBMED   39292787
  REMARK    GeneRIF: CCR2 cooperativity promotes hematopoietic stem cell homing
            to the bone marrow.
REFERENCE   3  (bases 1 to 3531)
  AUTHORS   Song,Z., Yao,W., Wang,X., Mo,Y., Liu,Z., Li,Q., Jiang,L., Wang,H.,
            He,H., Li,N., Zhang,Z., Lv,P., Zhang,Y., Yang,L. and Wang,Y.
  TITLE     The novel potential therapeutic target PSMP/MSMP promotes acute
            kidney injury via CCR2
  JOURNAL   Mol Ther 32 (7), 2248-2263 (2024)
   PUBMED   38796708
  REMARK    GeneRIF: The novel potential therapeutic target PSMP/MSMP promotes
            acute kidney injury via CCR2.
REFERENCE   4  (bases 1 to 3531)
  AUTHORS   Wang,M., Zhang,P.P., Zhu,Q., Hu,Z.L., Bai,X., Wu,Y.P. and Li,J.J.
  TITLE     [Expression of MCP-1 and CCR2 in Newly Diagnosed Diffuse Large
            B-Cell Lymphoma and Clinical Significance]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 32 (1), 112-119 (2024)
   PUBMED   38387908
  REMARK    GeneRIF: [Expression of MCP-1 and CCR2 in Newly Diagnosed Diffuse
            Large B-Cell Lymphoma and Clinical Significance].
REFERENCE   5  (bases 1 to 3531)
  AUTHORS   Tian,S., Chen,X., Wu,W., Lin,H., Qing,X., Liu,S., Wang,B., Xiao,Y.,
            Shao,Z. and Peng,Y.
  TITLE     Nucleus pulposus cells regulate macrophages in degenerated
            intervertebral discs via the integrated stress response-mediated
            CCL2/7-CCR2 signaling pathway
  JOURNAL   Exp Mol Med 56 (2), 408-421 (2024)
   PUBMED   38316963
  REMARK    GeneRIF: Nucleus pulposus cells regulate macrophages in degenerated
            intervertebral discs via the integrated stress response-mediated
            CCL2/7-CCR2 signaling pathway.
REFERENCE   6  (bases 1 to 3531)
  AUTHORS   Samson,M., Soularue,P., Vassart,G. and Parmentier,M.
  TITLE     The genes encoding the human CC-chemokine receptors CC-CKR1 to
            CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21.3-p24 region of
            chromosome 3
  JOURNAL   Genomics 36 (3), 522-526 (1996)
   PUBMED   8884276
REFERENCE   7  (bases 1 to 3531)
  AUTHORS   Combadiere,C., Ahuja,S.K., Van Damme,J., Tiffany,H.L., Gao,J.L. and
            Murphy,P.M.
  TITLE     Monocyte chemoattractant protein-3 is a functional ligand for CC
            chemokine receptors 1 and 2B
  JOURNAL   J Biol Chem 270 (50), 29671-29675 (1995)
   PUBMED   8530354
REFERENCE   8  (bases 1 to 3531)
  AUTHORS   Yamagami,S., Tokuda,Y., Ishii,K., Tanaka,H. and Endo,N.
  TITLE     cDNA cloning and functional expression of a human monocyte
            chemoattractant protein 1 receptor
  JOURNAL   Biochem Biophys Res Commun 202 (2), 1156-1162 (1994)
   PUBMED   8048929
REFERENCE   9  (bases 1 to 3531)
  AUTHORS   Charo,I.F., Myers,S.J., Herman,A., Franci,C., Connolly,A.J. and
            Coughlin,S.R.
  TITLE     Molecular cloning and functional expression of two monocyte
            chemoattractant protein 1 receptors reveals alternative splicing of
            the carboxyl-terminal tails
  JOURNAL   Proc Natl Acad Sci U S A 91 (7), 2752-2756 (1994)
   PUBMED   8146186
REFERENCE   10 (bases 1 to 3531)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC138069.3 and AC098613.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2020 this sequence version replaced NM_001123396.3.
            
            Summary: The protein encoded by this gene is a receptor for
            monocyte chemoattractant protein-1, a chemokine which specifically
            mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is
            involved in monocyte infiltration in inflammatory diseases such as
            rheumatoid arthritis as well as in the inflammatory response
            against tumors. The encoded protein mediates agonist-dependent
            calcium mobilization and inhibition of adenylyl cyclase. This
            protein can also be a coreceptor with CD4 for HIV-1 infection. This
            gene is located in the chemokine receptor gene cluster region of
            chromosome 3. [provided by RefSeq, Aug 2017].
            
            Transcript Variant: This variant (B) differs in the 3' UTR and 3'
            coding region, compared to variant A. The resulting isoform (B) is
            shorter and contains a distinct C-terminus, compared to isoform A.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.676364.1,
                                           SRR14038192.2151526.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000445132.3/ ENSP00000399285.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC138069.3         177330-177334
            6-67                AC098613.2         10645-10706
            68-3531             AC098613.2         14006-17469
FEATURES             Location/Qualifiers
     source          1..3531
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..3531
                     /gene="CCR2"
                     /gene_synonym="CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; CKR2;
                     CKR2A; CKR2B; CMKBR2; MCP-1-R; PCLUD"
                     /note="C-C motif chemokine receptor 2"
                     /db_xref="GeneID:729230"
                     /db_xref="HGNC:HGNC:1603"
                     /db_xref="MIM:601267"
     exon            1..67
                     /gene="CCR2"
                     /gene_synonym="CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; CKR2;
                     CKR2A; CKR2B; CMKBR2; MCP-1-R; PCLUD"
                     /inference="alignment:Splign:2.1.0"
     exon            68..3531
                     /gene="CCR2"
                     /gene_synonym="CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; CKR2;
                     CKR2A; CKR2B; CMKBR2; MCP-1-R; PCLUD"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1201
                     /gene="CCR2"
                     /gene_synonym="CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; CKR2;
                     CKR2A; CKR2B; CMKBR2; MCP-1-R; PCLUD"
                     /note="isoform B is encoded by transcript variant B;
                     monocyte chemoattractant protein 1 receptor; monocyte
                     chemotactic protein 1 receptor; C-C chemokine receptor
                     type 2; MCP-1 receptor; chemokine (C-C motif) receptor 2"
                     /codon_start=1
                     /product="C-C chemokine receptor type 2 isoform B"
                     /protein_id="NP_001116868.1"
                     /db_xref="CCDS:CCDS46813.1"
                     /db_xref="GeneID:729230"
                     /db_xref="HGNC:HGNC:1603"
                     /db_xref="MIM:601267"
                     /translation="MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQL
                     LPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSA
                     ANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVT
                     SVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIM
                     VICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSN
                     CESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRRYLSVFFRKHITKRFCKQCPV
                     FYRETVDGVTSTNTPSTGEQEVSAGL"
     regulatory      3487..3492
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCR2"
                     /gene_synonym="CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; CKR2;
                     CKR2A; CKR2B; CMKBR2; MCP-1-R; PCLUD"
                     /note="hexamer: AATAAA"
     regulatory      3512..3517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCR2"
                     /gene_synonym="CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; CKR2;
                     CKR2A; CKR2B; CMKBR2; MCP-1-R; PCLUD"
                     /note="hexamer: GATAAA"
     polyA_site      3520
                     /gene="CCR2"
                     /gene_synonym="CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; CKR2;
                     CKR2A; CKR2B; CMKBR2; MCP-1-R; PCLUD"
                     /note="major polyA site"
     polyA_site      3531
                     /gene="CCR2"
                     /gene_synonym="CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; CKR2;
                     CKR2A; CKR2B; CMKBR2; MCP-1-R; PCLUD"
                     /note="major polyA site"
ORIGIN      
        1 agatctgttt ggttcagttg ctgagaagcc tgacatacca ggactgcctg agacaagcca
       61 caagctgaac agagaaagtg gattgaacaa ggacgcattt ccccagtaca tccacaacat
      121 gctgtccaca tctcgttctc ggtttatcag aaataccaac gagagcggtg aagaagtcac
      181 cacctttttt gattatgatt acggtgctcc ctgtcataaa tttgacgtga agcaaattgg
      241 ggcccaactc ctgcctccgc tctactcgct ggtgttcatc tttggttttg tgggcaacat
      301 gctggtcgtc ctcatcttaa taaactgcaa aaagctgaag tgcttgactg acatttacct
      361 gctcaacctg gccatctctg atctgctttt tcttattact ctcccattgt gggctcactc
      421 tgctgcaaat gagtgggtct ttgggaatgc aatgtgcaaa ttattcacag ggctgtatca
      481 catcggttat tttggcggaa tcttcttcat catcctcctg acaatcgata gatacctggc
      541 tattgtccat gctgtgtttg ctttaaaagc caggacggtc acctttgggg tggtgacaag
      601 tgtgatcacc tggttggtgg ctgtgtttgc ttctgtccca ggaatcatct ttactaaatg
      661 ccagaaagaa gattctgttt atgtctgtgg cccttatttt ccacgaggat ggaataattt
      721 ccacacaata atgaggaaca ttttggggct ggtcctgccg ctgctcatca tggtcatctg
      781 ctactcggga atcctgaaaa ccctgcttcg gtgtcgaaac gagaagaaga ggcatagggc
      841 agtgagagtc atcttcacca tcatgattgt ttactttctc ttctggactc cctataatat
      901 tgtcattctc ctgaacacct tccaggaatt cttcggcctg agtaactgtg aaagcaccag
      961 tcaactggac caagccacgc aggtgacaga gactcttggg atgactcact gctgcatcaa
     1021 tcccatcatc tatgccttcg ttggggagaa gttcagaagg tatctctcgg tgttcttccg
     1081 aaagcacatc accaagcgct tctgcaaaca atgtccagtt ttctacaggg agacagtgga
     1141 tggagtgact tcaacaaaca cgccttccac tggggagcag gaagtctcgg ctggtttata
     1201 aaacgaggag cagtttgatt gttgtttata aagggagata acaatctgta tataacaaca
     1261 aacttcaagg gtttgttgaa caatagaaac ctgtaaagca ggtgcccagg aacctcaggg
     1321 ctgtgtgtac taatacagac tatgtcaccc aatgcatatc caacatgtgc tcagggaata
     1381 atccagaaaa actgtgggta gagactttga ctctccagaa agctcatctc agctcctgaa
     1441 aaatgcctca ttaccttgtg ctaatcctct ttttctagtc ttcataattt cttcactcaa
     1501 tctctgattc tgtcaatgtc ttgaaatcaa gggccagctg gaggtgaaga agagaatgtg
     1561 acaggcacag atgaatggga gtgagggata gtggggtcag ggctgagagg agaaggaggg
     1621 agacatgagc atggctgagc ctggacaaag acaaaggtga gcaaagggct cacgcattca
     1681 gccaggagat gatactggtc cttagcccca tctgccacgt gtatttaacc ttgaagggtt
     1741 caccaggtca gggagagttt gggaactgca ataacctggg agttttggtg gagtccgatg
     1801 attctctttt gcataagtgc atgacatatt tttgctttat tacagtttat ctatggcacc
     1861 catgcacctt acatttgaaa tctatgaaat atcatgctcc attgttcaga tgcttcttag
     1921 gccacatccc cctgtctaaa aattcagaaa atttttgttt ataaaagatg cattatctat
     1981 gatatgctaa tatatgtata tgcaatatat ataggctctt gcttgatctc tccaggaggt
     2041 agtgattatg agaagggggt ggagaatgat gagttccttc accaggagca aaggacgggg
     2101 atcgtgtgga accactgcag aactatttcc gaaatcaact aagtggagag agccaggaag
     2161 gctgcatcag aacccagtaa agcttcttgt ctggatctga gctggtttgt tttgtgcttg
     2221 cttttccctg ccttgccact cccctcactc ttctcttttc cccacagcct ttttcacata
     2281 gctcttggct gtaggattgc cccactccaa aaaccagtgt gtggaggtcc aggagtgaga
     2341 ccaggaaaga atgtgaaagt gactacacaa ggactcctcg atggtcgtgg aaaaggaaag
     2401 tcaattggca gagcccctga agccagtctt caggacaaag aaggagccta gagacagaaa
     2461 tgacagatct ctgctttgga aatcacacgt ctggcttcac agatgtgtga ttcacagtgt
     2521 gaatcttggt gtctacgtta ccaggcagga aggctgagag gagagagact ccagctgggt
     2581 tggaaaacag tattttccaa actaccttcc agttcctcat ttttgaatac aggcatagag
     2641 ttcagacttt ttttaaatag taaaaataaa attaaagctg aaaactgcaa cttgtaaatg
     2701 tggtaaagag ttagtttgag ttactatcat gtcaaacgtg aaaatgctgt attagtcaca
     2761 gagataattc tagctttgag cttaagaatt ttgagcaggt ggtatgtttg ggagactgct
     2821 gagtcaaccc aatagttgtt gattggcagg agttggaagt gtgtgatctg tgggcacatt
     2881 agcctatgtg catgcagcat ctaagtaatg atgtcgtttg aatcacagta tacgctccat
     2941 cgctgtcatc tcagctggat ctccattctc tcaggcttgc tgccaaaagc cttttgtgtt
     3001 ttgttttgta tcattatgaa gtcatgcgtt taatcacatt cgagtgtttc agtgcttcgc
     3061 agatgtcctt gatgctcata ttgttcccta ttttgccagt gggaactcct aaatcaagtt
     3121 ggcttctaat caaagctttt aaaccctatt ggtaaagaat ggaaggtgga gaagctccct
     3181 gaagtaagca aagactttcc tcttagtcga gccaagttaa gaatgttctt atgttgccca
     3241 gtgtgtttct gatctgatgc aagcaagaaa cactgggctt ctagaaccag gcaacttggg
     3301 aactagactc ccaagctgga ctatggctct actttcaggc cacatggcta aagaaggttt
     3361 cagaaagaag tggggacaga gcagaacttt caccttcata tatttgtatg atcctaatga
     3421 atgcataaaa tgttaagttg atggtgatga aatgtaaata ctgtttttaa caactatgat
     3481 ttggaaaata aatcaatgct ataactatgt tgataaaaga tttaaaaaca a
//
