LOCUS       NM_001123041            2323 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens C-C motif chemokine receptor 2 (CCR2), transcript
            variant A, mRNA.
ACCESSION   NM_001123041 NM_000647 XM_001133430 XM_001133431
VERSION     NM_001123041.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2323)
  AUTHORS   Bagheri,V., Khorramdelazad,H., Kafi,M. and Abbasifard,M.
  TITLE     Chemokine CCL2 and its receptor CCR2 in different age groups of
            patients with COVID-19
  JOURNAL   BMC Immunol 25 (1), 72 (2024)
   PUBMED   39455952
  REMARK    GeneRIF: Chemokine CCL2 and its receptor CCR2 in different age
            groups of patients with COVID-19.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2323)
  AUTHORS   Hurwitz,S.N., Kobulsky,D.R., Jung,S.K., Chia,J.J., Butler,J.M. and
            Kurre,P.
  TITLE     CCR2 cooperativity promotes hematopoietic stem cell homing to the
            bone marrow
  JOURNAL   Sci Adv 10 (38), eadq1476 (2024)
   PUBMED   39292787
  REMARK    GeneRIF: CCR2 cooperativity promotes hematopoietic stem cell homing
            to the bone marrow.
REFERENCE   3  (bases 1 to 2323)
  AUTHORS   Song,Z., Yao,W., Wang,X., Mo,Y., Liu,Z., Li,Q., Jiang,L., Wang,H.,
            He,H., Li,N., Zhang,Z., Lv,P., Zhang,Y., Yang,L. and Wang,Y.
  TITLE     The novel potential therapeutic target PSMP/MSMP promotes acute
            kidney injury via CCR2
  JOURNAL   Mol Ther 32 (7), 2248-2263 (2024)
   PUBMED   38796708
  REMARK    GeneRIF: The novel potential therapeutic target PSMP/MSMP promotes
            acute kidney injury via CCR2.
REFERENCE   4  (bases 1 to 2323)
  AUTHORS   Wang,M., Zhang,P.P., Zhu,Q., Hu,Z.L., Bai,X., Wu,Y.P. and Li,J.J.
  TITLE     [Expression of MCP-1 and CCR2 in Newly Diagnosed Diffuse Large
            B-Cell Lymphoma and Clinical Significance]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 32 (1), 112-119 (2024)
   PUBMED   38387908
  REMARK    GeneRIF: [Expression of MCP-1 and CCR2 in Newly Diagnosed Diffuse
            Large B-Cell Lymphoma and Clinical Significance].
REFERENCE   5  (bases 1 to 2323)
  AUTHORS   Tian,S., Chen,X., Wu,W., Lin,H., Qing,X., Liu,S., Wang,B., Xiao,Y.,
            Shao,Z. and Peng,Y.
  TITLE     Nucleus pulposus cells regulate macrophages in degenerated
            intervertebral discs via the integrated stress response-mediated
            CCL2/7-CCR2 signaling pathway
  JOURNAL   Exp Mol Med 56 (2), 408-421 (2024)
   PUBMED   38316963
  REMARK    GeneRIF: Nucleus pulposus cells regulate macrophages in degenerated
            intervertebral discs via the integrated stress response-mediated
            CCL2/7-CCR2 signaling pathway.
REFERENCE   6  (bases 1 to 2323)
  AUTHORS   Samson,M., Soularue,P., Vassart,G. and Parmentier,M.
  TITLE     The genes encoding the human CC-chemokine receptors CC-CKR1 to
            CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21.3-p24 region of
            chromosome 3
  JOURNAL   Genomics 36 (3), 522-526 (1996)
   PUBMED   8884276
REFERENCE   7  (bases 1 to 2323)
  AUTHORS   Combadiere,C., Ahuja,S.K., Van Damme,J., Tiffany,H.L., Gao,J.L. and
            Murphy,P.M.
  TITLE     Monocyte chemoattractant protein-3 is a functional ligand for CC
            chemokine receptors 1 and 2B
  JOURNAL   J Biol Chem 270 (50), 29671-29675 (1995)
   PUBMED   8530354
REFERENCE   8  (bases 1 to 2323)
  AUTHORS   Yamagami,S., Tokuda,Y., Ishii,K., Tanaka,H. and Endo,N.
  TITLE     cDNA cloning and functional expression of a human monocyte
            chemoattractant protein 1 receptor
  JOURNAL   Biochem Biophys Res Commun 202 (2), 1156-1162 (1994)
   PUBMED   8048929
REFERENCE   9  (bases 1 to 2323)
  AUTHORS   Charo,I.F., Myers,S.J., Herman,A., Franci,C., Connolly,A.J. and
            Coughlin,S.R.
  TITLE     Molecular cloning and functional expression of two monocyte
            chemoattractant protein 1 receptors reveals alternative splicing of
            the carboxyl-terminal tails
  JOURNAL   Proc Natl Acad Sci U S A 91 (7), 2752-2756 (1994)
   PUBMED   8146186
REFERENCE   10 (bases 1 to 2323)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC418358.1, BC126452.1,
            AV715904.1, BX101672.1, BQ027284.1 and AC098613.2.
            
            On Aug 13, 2020 this sequence version replaced NM_001123041.2.
            
            Summary: The protein encoded by this gene is a receptor for
            monocyte chemoattractant protein-1, a chemokine which specifically
            mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is
            involved in monocyte infiltration in inflammatory diseases such as
            rheumatoid arthritis as well as in the inflammatory response
            against tumors. The encoded protein mediates agonist-dependent
            calcium mobilization and inhibition of adenylyl cyclase. This
            protein can also be a coreceptor with CD4 for HIV-1 infection. This
            gene is located in the chemokine receptor gene cluster region of
            chromosome 3. [provided by RefSeq, Aug 2017].
            
            Transcript Variant: This variant (A) represents the longer
            transcript and encodes the longer isoform (A).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.3891863.1,
                                           SRR14038195.1289755.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                DC418358.1         77-160
            85-1415             BC126452.1         1-1331
            1416-1776           AV715904.1         103-463
            1777-2163           BX101672.1         305-691
            2164-2305           BQ027284.1         18-159              c
            2306-2323           AC098613.2         17452-17469
FEATURES             Location/Qualifiers
     source          1..2323
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..2323
                     /gene="CCR2"
                     /gene_synonym="CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; CKR2;
                     CKR2A; CKR2B; CMKBR2; MCP-1-R; PCLUD"
                     /note="C-C motif chemokine receptor 2"
                     /db_xref="GeneID:729230"
                     /db_xref="HGNC:HGNC:1603"
                     /db_xref="MIM:601267"
     exon            1..67
                     /gene="CCR2"
                     /gene_synonym="CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; CKR2;
                     CKR2A; CKR2B; CMKBR2; MCP-1-R; PCLUD"
                     /inference="alignment:Splign:2.1.0"
     exon            68..1059
                     /gene="CCR2"
                     /gene_synonym="CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; CKR2;
                     CKR2A; CKR2B; CMKBR2; MCP-1-R; PCLUD"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1243
                     /gene="CCR2"
                     /gene_synonym="CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; CKR2;
                     CKR2A; CKR2B; CMKBR2; MCP-1-R; PCLUD"
                     /note="isoform A is encoded by transcript variant A;
                     monocyte chemoattractant protein 1 receptor; monocyte
                     chemotactic protein 1 receptor; C-C chemokine receptor
                     type 2; MCP-1 receptor; chemokine (C-C motif) receptor 2"
                     /codon_start=1
                     /product="C-C chemokine receptor type 2 isoform A"
                     /protein_id="NP_001116513.2"
                     /db_xref="CCDS:CCDS43078.1"
                     /db_xref="GeneID:729230"
                     /db_xref="HGNC:HGNC:1603"
                     /db_xref="MIM:601267"
                     /translation="MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQL
                     LPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSA
                     ANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVT
                     SVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIM
                     VICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSN
                     CESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGG
                     PGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA"
     exon            1060..2323
                     /gene="CCR2"
                     /gene_synonym="CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; CKR2;
                     CKR2A; CKR2B; CMKBR2; MCP-1-R; PCLUD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2279..2284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCR2"
                     /gene_synonym="CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; CKR2;
                     CKR2A; CKR2B; CMKBR2; MCP-1-R; PCLUD"
                     /note="hexamer: AATAAA"
     regulatory      2304..2309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCR2"
                     /gene_synonym="CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; CKR2;
                     CKR2A; CKR2B; CMKBR2; MCP-1-R; PCLUD"
                     /note="hexamer: GATAAA"
     polyA_site      2312
                     /gene="CCR2"
                     /gene_synonym="CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; CKR2;
                     CKR2A; CKR2B; CMKBR2; MCP-1-R; PCLUD"
                     /note="major polyA site"
     polyA_site      2323
                     /gene="CCR2"
                     /gene_synonym="CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; CKR2;
                     CKR2A; CKR2B; CMKBR2; MCP-1-R; PCLUD"
                     /note="major polyA site"
ORIGIN      
        1 agatctgttt ggttcagttg ctgagaagcc tgacatacca ggactgcctg agacaagcca
       61 caagctgaac agagaaagtg gattgaacaa ggacgcattt ccccagtaca tccacaacat
      121 gctgtccaca tctcgttctc ggtttatcag aaataccaac gagagcggtg aagaagtcac
      181 cacctttttt gattatgatt acggtgctcc ctgtcataaa tttgacgtga agcaaattgg
      241 ggcccaactc ctgcctccgc tctactcgct ggtgttcatc tttggttttg tgggcaacat
      301 gctggtcgtc ctcatcttaa taaactgcaa aaagctgaag tgcttgactg acatttacct
      361 gctcaacctg gccatctctg atctgctttt tcttattact ctcccattgt gggctcactc
      421 tgctgcaaat gagtgggtct ttgggaatgc aatgtgcaaa ttattcacag ggctgtatca
      481 catcggttat tttggcggaa tcttcttcat catcctcctg acaatcgata gatacctggc
      541 tattgtccat gctgtgtttg ctttaaaagc caggacggtc acctttgggg tggtgacaag
      601 tgtgatcacc tggttggtgg ctgtgtttgc ttctgtccca ggaatcatct ttactaaatg
      661 ccagaaagaa gattctgttt atgtctgtgg cccttatttt ccacgaggat ggaataattt
      721 ccacacaata atgaggaaca ttttggggct ggtcctgccg ctgctcatca tggtcatctg
      781 ctactcggga atcctgaaaa ccctgcttcg gtgtcgaaac gagaagaaga ggcatagggc
      841 agtgagagtc atcttcacca tcatgattgt ttactttctc ttctggactc cctataatat
      901 tgtcattctc ctgaacacct tccaggaatt cttcggcctg agtaactgtg aaagcaccag
      961 tcaactggac caagccacgc aggtgacaga gactcttggg atgactcact gctgcatcaa
     1021 tcccatcatc tatgccttcg ttggggagaa gttcagaagc ctttttcaca tagctcttgg
     1081 ctgtaggatt gccccactcc aaaaaccagt gtgtggaggt ccaggagtga gaccaggaaa
     1141 gaatgtgaaa gtgactacac aaggactcct cgatggtcgt ggaaaaggaa agtcaattgg
     1201 cagagcccct gaagccagtc ttcaggacaa agaaggagcc tagagacaga aatgacagat
     1261 ctctgctttg gaaatcacac gtctggcttc acagatgtgt gattcacagt gtgaatcttg
     1321 gtgtctacgt taccaggcag gaaggctgag aggagagaga ctccagctgg gttggaaaac
     1381 agtattttcc aaactacctt ccagttcctc atttttgaat acaggcatag agttcagact
     1441 ttttttaaat agtaaaaata aaattaaagc tgaaaactgc aacttgtaaa tgtggtaaag
     1501 agttagtttg agttactatc atgtcaaacg tgaaaatgct gtattagtca cagagataat
     1561 tctagctttg agcttaagaa ttttgagcag gtggtatgtt tgggagactg ctgagtcaac
     1621 ccaatagttg ttgattggca ggagttggaa gtgtgtgatc tgtgggcaca ttagcctatg
     1681 tgcatgcagc atctaagtaa tgatgtcgtt tgaatcacag tatacgctcc atcgctgtca
     1741 tctcagctgg atctccattc tctcaggctt gctgccaaaa gccttttgtg ttttgttttg
     1801 tatcattatg aagtcatgcg tttaatcaca ttcgagtgtt tcagtgcttc gcagatgtcc
     1861 ttgatgctca tattgttccc tattttgcca gtgggaactc ctaaatcaag ttggcttcta
     1921 atcaaagctt ttaaacccta ttggtaaaga atggaaggtg gagaagctcc ctgaagtaag
     1981 caaagacttt cctcttagtc gagccaagtt aagaatgttc ttatgttgcc cagtgtgttt
     2041 ctgatctgat gcaagcaaga aacactgggc ttctagaacc aggcaacttg ggaactagac
     2101 tcccaagctg gactatggct ctactttcag gccacatggc taaagaaggt ttcagaaaga
     2161 agtggggaca gagcagaact ttcaccttca tatatttgta tgatcctaat gaatgcataa
     2221 aatgttaagt tgatggtgat gaaatgtaaa tactgttttt aacaactatg atttggaaaa
     2281 taaatcaatg ctataactat gttgataaaa gatttaaaaa caa
//
