LOCUS       NM_016602               1773 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens C-C motif chemokine receptor 10 (CCR10), mRNA.
ACCESSION   NM_016602
VERSION     NM_016602.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1773)
  AUTHORS   Luo,Y., Zhou,F., Wang,X., Yang,R., Li,Y., Wu,X. and Ye,B.
  TITLE     Inhibition of cc chemokine receptor 10 ameliorates osteoarthritis
            via inhibition of the phosphoinositide-3-kinase/Akt/mammalian
            target of rapamycin pathway
  JOURNAL   J Orthop Surg Res 19 (1), 158 (2024)
   PUBMED   38429844
  REMARK    GeneRIF: Inhibition of cc chemokine receptor 10 ameliorates
            osteoarthritis via inhibition of the
            phosphoinositide-3-kinase/Akt/mammalian target of rapamycin
            pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1773)
  AUTHORS   Dhanushkodi,N.R., Prakash,S., Quadiri,A., Zayou,L., Srivastava,R.,
            Tran,J., Dang,V., Shaik,A.M., Chilukurri,A., Suzer,B., Vera,P.,
            Sun,M., Nguyen,P., Lee,A., Salem,A., Loi,J., Singer,M.,
            Nakayama,T., Vahed,H., Nesburn,A.B. and BenMohamed,L.
  TITLE     Mucosal CCL28 Chemokine Improves Protection against Genital Herpes
            through Mobilization of Antiviral Effector Memory CCR10+CD44+
            CD62L-CD8+ T Cells and Memory CCR10+B220+CD27+ B Cells into the
            Infected Vaginal Mucosa
  JOURNAL   J Immunol 211 (1), 118-129 (2023)
   PUBMED   37222480
  REMARK    GeneRIF: Mucosal CCL28 Chemokine Improves Protection against
            Genital Herpes through Mobilization of Antiviral Effector Memory
            CCR10+CD44+ CD62L-CD8+ T Cells and Memory CCR10+B220+CD27+ B Cells
            into the Infected Vaginal Mucosa.
REFERENCE   3  (bases 1 to 1773)
  AUTHORS   Li,B., Wei,C., Zhong,Y., Huang,J. and Li,R.
  TITLE     The CCL27-CCR10 axis contributes to promoting proliferation,
            migration, and invasion of lung squamous cell carcinoma
  JOURNAL   Histol Histopathol 38 (3), 349-357 (2023)
   PUBMED   36169116
  REMARK    GeneRIF: The CCL27-CCR10 axis contributes to promoting
            proliferation, migration, and invasion of lung squamous cell
            carcinoma.
REFERENCE   4  (bases 1 to 1773)
  AUTHORS   Chen,Z., Haus,J.M., Chen,L., Jiang,Y., Sverdlov,M., DiPietro,L.A.,
            Xiong,N., Wu,S.C., Koh,T.J. and Minshall,R.D.
  TITLE     Inhibition of CCL28/CCR10-Mediated eNOS Downregulation Improves
            Skin Wound Healing in the Obesity-Induced Mouse Model of Type 2
            Diabetes
  JOURNAL   Diabetes 71 (10), 2166-2180 (2022)
   PUBMED   35899992
  REMARK    GeneRIF: Inhibition of CCL28/CCR10-Mediated eNOS Downregulation
            Improves Skin Wound Healing in the Obesity-Induced Mouse Model of
            Type 2 Diabetes.
REFERENCE   5  (bases 1 to 1773)
  AUTHORS   Gomes,A.M.C., Farias,G.B., Dias-Silva,M., Laia,J., Trombetta,A.C.,
            Godinho-Santos,A., Rosmaninho,P., Santos,D.F., Conceicao,C.M.,
            Costa-Reis,R., Adao-Serrano,M., Mota,C., Almeida,A.R.M., Sousa,A.E.
            and Fernandes,S.M.
  TITLE     SARS-CoV2 pneumonia recovery is linked to expansion of innate
            lymphoid cells type 2 expressing CCR10
  JOURNAL   Eur J Immunol 51 (12), 3194-3201 (2021)
   PUBMED   34564853
  REMARK    GeneRIF: SARS-CoV2 pneumonia recovery is linked to expansion of
            innate lymphoid cells type 2 expressing CCR10.
REFERENCE   6  (bases 1 to 1773)
  AUTHORS   Homey,B., Wang,W., Soto,H., Buchanan,M.E., Wiesenborn,A.,
            Catron,D., Muller,A., McClanahan,T.K., Dieu-Nosjean,M.C.,
            Orozco,R., Ruzicka,T., Lehmann,P., Oldham,E. and Zlotnik,A.
  TITLE     Cutting edge: the orphan chemokine receptor G protein-coupled
            receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27
            (CTACK/ALP/ILC)
  JOURNAL   J Immunol 164 (7), 3465-3470 (2000)
   PUBMED   10725697
REFERENCE   7  (bases 1 to 1773)
  AUTHORS   Jarmin,D.I., Rits,M., Bota,D., Gerard,N.P., Graham,G.J.,
            Clark-Lewis,I. and Gerard,C.
  TITLE     Cutting edge: identification of the orphan receptor
            G-protein-coupled receptor 2 as CCR10, a specific receptor for the
            chemokine ESkine
  JOURNAL   J Immunol 164 (7), 3460-3464 (2000)
   PUBMED   10725696
REFERENCE   8  (bases 1 to 1773)
  AUTHORS   Gosling,J., Dairaghi,D.J., Wang,Y., Hanley,M., Talbot,D., Miao,Z.
            and Schall,T.J.
  TITLE     Cutting edge: identification of a novel chemokine receptor that
            binds dendritic cell- and T cell-active chemokines including ELC,
            SLC, and TECK
  JOURNAL   J Immunol 164 (6), 2851-2856 (2000)
   PUBMED   10706668
REFERENCE   9  (bases 1 to 1773)
  AUTHORS   Bonini,J.A., Martin,S.K., Dralyuk,F., Roe,M.W., Philipson,L.H. and
            Steiner,D.F.
  TITLE     Cloning, expression, and chromosomal mapping of a novel human
            CC-chemokine receptor (CCR10) that displays high-affinity binding
            for MCP-1 and MCP-3
  JOURNAL   DNA Cell Biol 16 (10), 1249-1256 (1997)
   PUBMED   9364936
REFERENCE   10 (bases 1 to 1773)
  AUTHORS   Marchese,A., Docherty,J.M., Nguyen,T., Heiber,M., Cheng,R.,
            Heng,H.H., Tsui,L.C., Shi,X., George,S.R. and O'Dowd,B.F.
  TITLE     Cloning of human genes encoding novel G protein-coupled receptors
  JOURNAL   Genomics 23 (3), 609-618 (1994)
   PUBMED   7851889
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC100793.8, BC098132.1, BM930170.1 and CA423133.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016602.2.
            
            Summary: Chemokines are a group of small (approximately 8 to 14
            kD), mostly basic, structurally related molecules that regulate
            cell trafficking of various types of leukocytes through
            interactions with a subset of 7-transmembrane, G protein-coupled
            receptors. Chemokines also play fundamental roles in the
            development, homeostasis, and function of the immune system, and
            they have effects on cells of the central nervous system as well as
            on endothelial cells involved in angiogenesis or angiostasis.
            Chemokines are divided into 2 major subfamilies, CXC and CC, based
            on the arrangement of the first 2 of the 4 conserved cysteine
            residues; the 2 cysteines are separated by a single amino acid in
            CXC chemokines and are adjacent in CC chemokines. CCR10 is the
            receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions
            are involved in T cell-mediated skin inflammation (Homey et al.,
            2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.270356.1,
                                           SRR1163658.477114.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332438.4/ ENSP00000332504.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC100793.8         19601-19616         c
            17-1227             BC098132.1         1-1211
            1228-1256           BM930170.1         566-594
            1257-1257           BM930170.1         596-596
            1258-1260           CA423133.1         529-531             c
            1261-1773           AC100793.8         16662-17174         c
FEATURES             Location/Qualifiers
     source          1..1773
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..1773
                     /gene="CCR10"
                     /gene_synonym="GPR2"
                     /note="C-C motif chemokine receptor 10"
                     /db_xref="GeneID:2826"
                     /db_xref="HGNC:HGNC:4474"
                     /db_xref="MIM:600240"
     exon            1..44
                     /gene="CCR10"
                     /gene_synonym="GPR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1109
                     /gene="CCR10"
                     /gene_synonym="GPR2"
                     /note="CC chemokine receptor 10; CCR-10; CC-CKR-10; C-C
                     CKR-10; G-protein coupled receptor 2; chemokine (C-C
                     motif) receptor 10"
                     /codon_start=1
                     /product="C-C chemokine receptor type 10"
                     /protein_id="NP_057686.2"
                     /db_xref="CCDS:CCDS11435.1"
                     /db_xref="GeneID:2826"
                     /db_xref="HGNC:HGNC:4474"
                     /db_xref="MIM:600240"
                     /translation="MGTEATEQVSWGHYSGDEEDAYSAEPLPELCYKADVQAFSRAFQ
                     PSVSLTVAALGLAGNGLVLATHLAARRAARSPTSAHLLQLALADLLLALTLPFAAAGA
                     LQGWSLGSATCRTISGLYSASFHAGFLFLACISADRYVAIARALPAGPRPSTPGRAHL
                     VSVIVWLLSLLLALPALLFSQDGQREGQRRCRLIFPEGLTQTVKGASAVAQVALGFAL
                     PLGVMVACYALLGRTLLAARGPERRRALRVVVALVAAFVVLQLPYSLALLLDTADLLA
                     ARERSCPASKRKDVALLVTSGLALARCGLNPVLYAFLGLRFRQDLRRLLRGGSCPSGP
                     QPRRGCPRRPRLSSCSAPTETHSLSWDN"
     exon            45..1773
                     /gene="CCR10"
                     /gene_synonym="GPR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1222..1227
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCR10"
                     /gene_synonym="GPR2"
                     /note="hexamer: ATTAAA"
     polyA_site      1257
                     /gene="CCR10"
                     /gene_synonym="GPR2"
                     /note="major polyA site"
     regulatory      1752..1757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCR10"
                     /gene_synonym="GPR2"
                     /note="hexamer: AATGAA"
     polyA_site      1773
                     /gene="CCR10"
                     /gene_synonym="GPR2"
ORIGIN      
        1 agaaacctgt gtagccagag atggggacgg aggccacaga gcaggtttcc tggggccatt
       61 actctgggga tgaagaggac gcatactcgg ctgagccact gccggagctt tgctacaagg
      121 ccgatgtcca ggccttcagc cgggccttcc aacccagtgt ctccctgacc gtggctgcgc
      181 tgggtctggc cggcaatggc ctggtcctgg ccacccacct ggcagcccga cgcgcagcgc
      241 gctcgcccac ctctgcccac ctgctccagc tggccctggc cgacctcttg ctggccctga
      301 ctctgccctt cgcggcagca ggggctcttc agggctggag tctgggaagt gccacctgcc
      361 gcaccatctc tggcctctac tcggcctcct tccacgccgg cttcctcttc ctggcctgta
      421 tcagcgccga ccgctacgtg gccatcgcgc gagcgctccc agccgggccg cggccctcca
      481 ctcccggccg cgcacacttg gtctccgtca tcgtgtggct gctgtcactg ctcctggcgc
      541 tgcctgcgct gctcttcagc caggatgggc agcgggaagg ccaacgacgc tgtcgcctca
      601 tcttccccga gggcctcacg cagacggtga agggggcgag cgccgtggcg caggtggccc
      661 tgggcttcgc gctgccgctg ggcgtcatgg tagcctgcta cgcgcttctg ggccgcacgc
      721 tgctggccgc cagggggccc gagcgccggc gtgcgctgcg cgtcgtggtg gctctggtgg
      781 cggccttcgt ggtgctgcag ctgccctaca gcctcgccct gctgctggat actgccgatc
      841 tactggctgc gcgcgagcgg agctgccctg ccagcaaacg caaggatgtc gcactgctgg
      901 tgaccagcgg cttggccctc gcccgctgtg gcctcaatcc cgttctctac gccttcctgg
      961 gcctgcgctt ccgccaggac ctgcggaggc tgctacgggg tgggagctgc ccctcagggc
     1021 ctcaaccccg ccgcggctgc ccccgccggc cccgcctttc ttcctgctca gctcccacgg
     1081 agacccacag tctctcctgg gacaactagg gctgcgaatc tagaggaggg ggcaggctga
     1141 gggtcgtggg aaaggggagt aggtggggga acactgagaa agaggcaggg acctaaaggg
     1201 actacctctg tgccttgcca cattaaattg ataacatgga aatgagatgc aacccaacaa
     1261 ctgttactat ttttgagtca ccgacttgga agtgatttgt ggcggggcag aaccggtggg
     1321 ttaacacccc gcccccgccc caccccccgc cctgccccgc gcttggctct ctgagtggaa
     1381 gacgctgagg gcctgggtgg gggtgggggg ctgctgagtc tgctaaagct ctagccactg
     1441 acaccccctc caccgtcacc tggcctcagc caacagaggt gaggtgggaa agctgccagg
     1501 caaggagggg cggtggttcc tcttgcaata ctgtaaggaa gagctttcta acaaccagag
     1561 cgctctccag taatggctgc cttagcaaat actgagttcc cgctattgga atgttcagac
     1621 tgtcggggac gctgtgggcc tttgcgtggt gtggggggag ggggaggggc aggggattcc
     1681 cgtttttggt gggcgtttgg atttcataac cactttacaa tcccttccta gtgtctgtga
     1741 tggaaagaaa aaatgaaaaa atgaattgta aaa
//
