LOCUS       NM_001295               2646 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens C-C motif chemokine receptor 1 (CCR1), mRNA.
ACCESSION   NM_001295
VERSION     NM_001295.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2646)
  AUTHORS   Dai,Z., Wang,Y., Sun,N. and Zhang,C.
  TITLE     Characterizing ligand-receptor interactions and unveiling the
            pro-tumorigenic role of CCL16-CCR1 axis in the microenvironment of
            hepatocellular carcinoma
  JOURNAL   Front Immunol 14, 1299953 (2024)
   PUBMED   38274805
  REMARK    GeneRIF: Characterizing ligand-receptor interactions and unveiling
            the pro-tumorigenic role of CCL16-CCR1 axis in the microenvironment
            of hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2646)
  AUTHORS   Elbaz-Hayoun,S., Rinsky,B., Hagbi-Levi,S., Grunin,M. and Chowers,I.
  TITLE     CCR1 mediates Muller cell activation and photoreceptor cell death
            in macular and retinal degeneration
  JOURNAL   Elife 12, e81208 (2023)
   PUBMED   37903056
  REMARK    GeneRIF: CCR1 mediates Muller cell activation and photoreceptor
            cell death in macular and retinal degeneration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2646)
  AUTHORS   Li,J., Xue,L., Wang,J., Meng,A., Qiao,J., Li,M., Wang,X., Meng,L.,
            Ning,J., Gao,X., Li,W., Ma,C. and Wei,L.
  TITLE     Activation of the Chemokine Receptor CCR1 and Preferential
            Recruitment of Galphai Suppress RSV Replication: Implications for
            Developing Novel Respiratory Syncytial Virus Treatment Strategies
  JOURNAL   J Virol 96 (22), e0130922 (2022)
   PUBMED   36317881
  REMARK    GeneRIF: Activation of the Chemokine Receptor CCR1 and Preferential
            Recruitment of Galphai Suppress RSV Replication: Implications for
            Developing Novel Respiratory Syncytial Virus Treatment Strategies.
REFERENCE   4  (bases 1 to 2646)
  AUTHORS   Zvejniece,L., Kozireva,S., Rudevica,Z., Leonciks,A.,
            Ehlin-Henriksson,B., Kashuba,E. and Kholodnyuk,I.
  TITLE     Expression of the Chemokine Receptor CCR1 in Burkitt Lymphoma Cell
            Lines Is Linked to the CD10-Negative Cell Phenotype and
            Co-Expression of the EBV Latent Genes EBNA2, LMP1, and LMP2
  JOURNAL   Int J Mol Sci 23 (7), 3434 (2022)
   PUBMED   35408790
  REMARK    GeneRIF: Expression of the Chemokine Receptor CCR1 in Burkitt
            Lymphoma Cell Lines Is Linked to the CD10-Negative Cell Phenotype
            and Co-Expression of the EBV Latent Genes EBNA2, LMP1, and LMP2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2646)
  AUTHORS   Li,W., Li,N., Yang,G. and Li,Y.
  TITLE     The rs13075270 and rs13092160 polymorphisms of CCR1 and CCR3 genes
            on oral aphthous-like lesions in PFAPA syndrome
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 67 (4), 328-333 (2022)
   PUBMED   35809272
  REMARK    GeneRIF: The rs13075270 and rs13092160 polymorphisms of CCR1 and
            CCR3 genes on oral aphthous-like lesions in PFAPA syndrome.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2646)
  AUTHORS   Post,T.W., Bozic,C.R., Rothenberg,M.E., Luster,A.D., Gerard,N. and
            Gerard,C.
  TITLE     Molecular characterization of two murine eosinophil beta chemokine
            receptors
  JOURNAL   J Immunol 155 (11), 5299-5305 (1995)
   PUBMED   7594543
REFERENCE   7  (bases 1 to 2646)
  AUTHORS   Ben-Baruch,A., Xu,L., Young,P.R., Bengali,K., Oppenheim,J.J. and
            Wang,J.M.
  TITLE     Monocyte chemotactic protein-3 (MCP3) interacts with multiple
            leukocyte receptors. C-C CKR1, a receptor for macrophage
            inflammatory protein-1 alpha/Rantes, is also a functional receptor
            for MCP3
  JOURNAL   J Biol Chem 270 (38), 22123-22128 (1995)
   PUBMED   7545673
REFERENCE   8  (bases 1 to 2646)
  AUTHORS   Nomura,H., Nielsen,B.W. and Matsushima,K.
  TITLE     Molecular cloning of cDNAs encoding a LD78 receptor and putative
            leukocyte chemotactic peptide receptors
  JOURNAL   Int Immunol 5 (10), 1239-1249 (1993)
   PUBMED   7505609
REFERENCE   9  (bases 1 to 2646)
  AUTHORS   Neote,K., DiGregorio,D., Mak,J.Y., Horuk,R. and Schall,T.J.
  TITLE     Molecular cloning, functional expression, and signaling
            characteristics of a C-C chemokine receptor
  JOURNAL   Cell 72 (3), 415-425 (1993)
   PUBMED   7679328
REFERENCE   10 (bases 1 to 2646)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX337412.2, BC064991.1,
            CK903574.1 and AI089760.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001295.2.
            
            Summary: This gene encodes a member of the beta chemokine receptor
            family, which is predicted to be a seven transmembrane protein
            similar to G protein-coupled receptors. The ligands of this
            receptor include macrophage inflammatory protein 1 alpha (MIP-1
            alpha), regulated on activation normal T expressed and secreted
            protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and
            myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and
            their receptors mediated signal transduction are critical for the
            recruitment of effector immune cells to the site of inflammation.
            Knockout studies of the mouse homolog suggested the roles of this
            gene in host protection from inflammatory response, and
            susceptibility to virus and parasite. This gene and other chemokine
            receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are
            found to form a gene cluster on chromosome 3p. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.272171.1,
                                           SRR1660803.95966.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296140.4/ ENSP00000296140.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BX337412.2         29-48
            21-2135             BC064991.1         5-2119
            2136-2639           CK903574.1         18-521
            2640-2646           AI089760.1         17-23               c
FEATURES             Location/Qualifiers
     source          1..2646
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..2646
                     /gene="CCR1"
                     /gene_synonym="CD191; CKR-1; CKR1; CMKBR1; HM145; MIP1aR;
                     SCYAR1"
                     /note="C-C motif chemokine receptor 1"
                     /db_xref="GeneID:1230"
                     /db_xref="HGNC:HGNC:1602"
                     /db_xref="MIM:601159"
     exon            1..32
                     /gene="CCR1"
                     /gene_synonym="CD191; CKR-1; CKR1; CMKBR1; HM145; MIP1aR;
                     SCYAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            33..2646
                     /gene="CCR1"
                     /gene_synonym="CD191; CKR-1; CKR1; CMKBR1; HM145; MIP1aR;
                     SCYAR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2628..2633
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCR1"
                     /gene_synonym="CD191; CKR-1; CKR1; CMKBR1; HM145; MIP1aR;
                     SCYAR1"
                     /note="hexamer: AATAAA"
     polyA_site      2646
                     /gene="CCR1"
                     /gene_synonym="CD191; CKR-1; CKR1; CMKBR1; HM145; MIP1aR;
                     SCYAR1"
                     /note="major polyA site"
ORIGIN      
        1 agacttcacg gacaaagtcc cttggaacca gagagaagcc gggatggaaa ctccaaacac
       61 cacagaggac tatgacacga ccacagagtt tgactatggg gatgcaactc cgtgccagaa
      121 ggtgaacgag agggcctttg gggcccaact gctgccccct ctgtactcct tggtatttgt
      181 cattggcctg gttggaaaca tcctggtggt cctggtcctt gtgcaataca agaggctaaa
      241 aaacatgacc agcatctacc tcctgaacct ggccatttct gacctgctct tcctgttcac
      301 gcttcccttc tggatcgact acaagttgaa ggatgactgg gtttttggtg atgccatgtg
      361 taagatcctc tctgggtttt attacacagg cttgtacagc gagatctttt tcatcatcct
      421 gctgacgatt gacaggtacc tggccatcgt ccacgccgtg tttgccttgc gggcacggac
      481 cgtcactttt ggtgtcatca ccagcatcat catttgggcc ctggccatct tggcttccat
      541 gccaggctta tacttttcca agacccaatg ggaattcact caccacacct gcagccttca
      601 ctttcctcac gaaagcctac gagagtggaa gctgtttcag gctctgaaac tgaacctctt
      661 tgggctggta ttgcctttgt tggtcatgat catctgctac acagggatta taaagattct
      721 gctaagacga ccaaatgaga agaaatccaa agctgtccgt ttgatttttg tcatcatgat
      781 catctttttt ctcttttgga ccccctacaa tttgactata cttatttctg ttttccaaga
      841 cttcctgttc acccatgagt gtgagcagag cagacatttg gacctggctg tgcaagtgac
      901 ggaggtgatc gcctacacgc actgctgtgt caacccagtg atctacgcct tcgttggtga
      961 gaggttccgg aagtacctgc ggcagttgtt ccacaggcgt gtggctgtgc acctggttaa
     1021 atggctcccc ttcctctccg tggacaggct ggagagggtc agctccacat ctccctccac
     1081 aggggagcat gaactctctg ctgggttctg actcagacca taggaggcca acccaaaata
     1141 agcaggcgtg acctgccagg cacactgagc cagcagcctg gctctcccag ccaggttctg
     1201 actcttggca cagcatggag tcacagccac ttgggataga gagggaatgt aatggtggcc
     1261 tggggcttct gaggcttctg gggcttcagt cttttccatg aacttctccc ctggtagaaa
     1321 gaagatgaat gagcaaaacc aaatattcca gagactggga ctaagtgtac cagagaaggg
     1381 cttggactca agcaagattt cagatttgtg accattagca tttgtcaaca aagtcaccca
     1441 cttcccacta ttgcttgcac aaaccaatta aacccagtag tggtgactgt gggctccatt
     1501 caaagtgagc tcctaagcca tgggagacac tgatgtatga ggaatttctg ttcttccatc
     1561 acctcccccc ccccgccacc ctcccactgc caaagaactt ggaaatagtg atttccacag
     1621 tgactccact ctgagtccca gagccaatca gtagccagca tctgcctccc cttcactccc
     1681 accgcaggat ttgggctctt ggaatcctgg ggaacataga actcatgacg gaagagttga
     1741 gacctaacga gaaatagaaa tggggaacta ctgctggcag tggaactaag aaagccctta
     1801 ggaagaattt ttatatccac taaaatcaaa caattcaggg agtgggctaa gcacgggcca
     1861 tatgaataac atggtgtgct tcttaaaata gccataaagg ggagggactc atcatttcca
     1921 tttacccttc ttttctgact atttttcaga atctctcttc ttttcaagtt gggtgatatg
     1981 ttggtagatt ctaatggctt tattgcagcg attaataaca ggcaaaagga agcagggttg
     2041 gtttcccttc tttttgttct tcatctaagc cttctggttt tatgggtcag agttccgact
     2101 gccatcttgg acttgtcagc aaaaaaaaaa aataataata ataataaggc ctgctgtgta
     2161 agctgacagt atttgtagct gatagggggt tgggaggaaa gtgtctacta ggagggtggg
     2221 gtgagattct gtgttgatgt aggaggccga gaaggccctt aactcaaagt agcttattta
     2281 tccaaaatgt tctggatgca tcatctccaa ccaaggaccc cttatttatc atgcctttgt
     2341 tctcttttcc ctcagatgta tatttcttta aaaataattt tcctaataac aaaacttatt
     2401 tctaaaacag cttaaaaatt caaagaaaaa ccccaaacac tgacattacc tacacttcca
     2461 ctacccaaag acaaaatgtg cccactgtgt gcttttgagt gtattttctt ttagtttgtt
     2521 ttttgttggg tgcatattta tgataataac aatgatggac ttcaattgta ctcactgttc
     2581 tattgttggt tttaattagc agcaagttgt gatcactttc ccaggtgaat aaatcatttc
     2641 aaagca
//
