LOCUS       NM_020739               6682 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens cell cycle progression 1 (CCPG1), transcript variant
            2, mRNA.
ACCESSION   NM_020739
VERSION     NM_020739.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6682)
  AUTHORS   Wang,G., Liu,Z., Wang,Q., Liu,B. and Li,J.
  TITLE     Clinical and prognostic significance of CCPG1 in hepatocellular
            carcinoma
  JOURNAL   Gen Physiol Biophys 42 (5), 431-442 (2023)
   PUBMED   37702448
  REMARK    GeneRIF: Clinical and prognostic significance of CCPG1 in
            hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 6682)
  AUTHORS   Smith,M.D., Harley,M.E., Kemp,A.J., Wills,J., Lee,M., Arends,M.,
            von Kriegsheim,A., Behrends,C. and Wilkinson,S.
  TITLE     CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for
            ER-Phagy and Pancreatic ER Proteostasis
  JOURNAL   Dev Cell 44 (2), 217-232 (2018)
   PUBMED   29290589
  REMARK    GeneRIF: identification of cell-cycle progression gene 1 (CCPG1),
            an ER-resident protein, as a non-canonical cargo receptor that
            directly binds to core autophagy proteins via an LIR motif to
            mammalian ATG8 proteins and, independently and via a discrete
            motif, to FIP200.
REFERENCE   3  (bases 1 to 6682)
  AUTHORS   Dunlop,E.A., Seifan,S., Claessens,T., Behrends,C., Kamps,M.A.,
            Rozycka,E., Kemp,A.J., Nookala,R.K., Blenis,J., Coull,B.J.,
            Murray,J.T., van Steensel,M.A., Wilkinson,S. and Tee,A.R.
  TITLE     FLCN, a novel autophagy component, interacts with GABARAP and is
            regulated by ULK1 phosphorylation
  JOURNAL   Autophagy 10 (10), 1749-1760 (2014)
   PUBMED   25126726
REFERENCE   4  (bases 1 to 6682)
  AUTHORS   Faghihi,M.A., Kocerha,J., Modarresi,F., Engstrom,P.G., Chalk,A.M.,
            Brothers,S.P., Koesema,E., St Laurent,G. and Wahlestedt,C.
  TITLE     RNAi screen indicates widespread biological function for human
            natural antisense transcripts
  JOURNAL   PLoS One 5 (10), e13177 (2010)
   PUBMED   20957177
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6682)
  AUTHORS   Myslinski,E., Gerard,M.A., Krol,A. and Carbon,P.
  TITLE     A genome scale location analysis of human Staf/ZNF143-binding sites
            suggests a widespread role for human Staf/ZNF143 in mammalian
            promoters
  JOURNAL   J Biol Chem 281 (52), 39953-39962 (2006)
   PUBMED   17092945
REFERENCE   6  (bases 1 to 6682)
  AUTHORS   Edwards,M.C., Liegeois,N., Horecka,J., DePinho,R.A., Sprague,G.F.
            Jr., Tyers,M. and Elledge,S.J.
  TITLE     Human CPR (cell cycle progression restoration) genes impart a Far-
            phenotype on yeast cells
  JOURNAL   Genetics 147 (3), 1063-1076 (1997)
   PUBMED   9383053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB084778.1, BC039871.1, AC018926.10 and AA740595.1.
            
            On Aug 13, 2020 this sequence version replaced NM_020739.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB033080.2, SRR11853567.10185.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                DB084778.1         152-246
            96-3079             BC039871.1         1-2984
            3080-6253           AC018926.10        127714-130887       c
            6254-6682           AA740595.1         18-446              c
FEATURES             Location/Qualifiers
     source          1..6682
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.3"
     gene            1..6682
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /note="cell cycle progression 1"
                     /db_xref="GeneID:9236"
                     /db_xref="HGNC:HGNC:24227"
                     /db_xref="MIM:611326"
     exon            1..139
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /inference="alignment:Splign:2.1.0"
     exon            140..208
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..2422
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /note="isoform 1 is encoded by transcript variant 2; cell
                     cycle progression restoration protein 8"
                     /codon_start=1
                     /product="cell cycle progression protein 1 isoform 1"
                     /protein_id="NP_065790.2"
                     /db_xref="CCDS:CCDS42039.1"
                     /db_xref="GeneID:9236"
                     /db_xref="HGNC:HGNC:24227"
                     /db_xref="MIM:611326"
                     /translation="MSENSSDSDSSCGWTVISHEGSDIEMLNSVTPTDSCEPAPECSS
                     LEQEELQALQIEQGESSQNGTVLMEETAYPALEETSSTIEAEEQKIPEDSIYIGTASD
                     DSDIVTLEPPKLEEIGNQEVVIVEEAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDD
                     ESSSDETSNQPSPAFRRRRARKKTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKC
                     VILALVIAISMGFGHFYGTIQIQKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYK
                     SLKENLARCWTLTEAEKMSFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQ
                     IRILEDKGTSTELVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKMLKRELERERLV
                     TTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWER
                     LYVEAKDQNGKQGTDGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTKEFVRHHK
                     EKIKQAKEAVKENLKKFSDSVKSTFRHFKDTTKNIFDEKGNKRFGATKEAAEKPRTVF
                     SDYLHPQYKAPTENHHNRGPTMQNDGRKEKPVHFKEFRKNTNSKKCSPGHDCRENSHS
                     FRKACSGVFDCAQQESMSLFNTVVNPIRMDEFRQIIQRYMLKELDTFCHWNELDQFIN
                     KFFLNGVFIHDQKLFTDFVNDVKDYLRNMKEYEVDNDGVFEKLDEYIYRHFFGHTFSP
                     PYGPRSVYIKPCHYSSL"
     exon            209..323
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /inference="alignment:Splign:2.1.0"
     exon            324..400
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /inference="alignment:Splign:2.1.0"
     exon            401..602
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /inference="alignment:Splign:2.1.0"
     exon            603..854
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /inference="alignment:Splign:2.1.0"
     exon            855..976
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /inference="alignment:Splign:2.1.0"
     exon            977..6682
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3060..3065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /note="hexamer: AATATA"
     polyA_site      3082
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /note="major polyA site"
     regulatory      6258..6263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /note="hexamer: AATAAA"
     polyA_site      6281
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /note="major polyA site"
     regulatory      6661..6666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /note="hexamer: AATAAA"
     polyA_site      6682
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
ORIGIN      
        1 gcccagccgg tcaccgcctg ccggctgcag acgcctgcga gcaggttgtt tttataagag
       61 gcgtcattgg cgcccgagct gtgaccgccg ccactggggc agccagcaca atcgggcgga
      121 ggtggcgctg ccccttcaga cctgaaagat gtctgaaaat tccagtgaca gtgattcatc
      181 ttgtggttgg actgtcatca gtcatgaggg gtcagatata gaaatgttga attctgtgac
      241 ccccactgac agctgtgagc ccgccccaga atgttcatct ttagagcaag aggagcttca
      301 agcattgcag atagagcaag gagaaagcag ccaaaatggc acagtgctta tggaagaaac
      361 tgcttatcca gctttggagg aaaccagctc aacaattgag gcagaggaac aaaagatacc
      421 cgaagacagt atctatattg gaactgccag tgatgattct gatattgtta cccttgagcc
      481 acctaagtta gaagaaattg gaaatcaaga agttgtcatt gttgaagaag cacagagttc
      541 agaagacttt aacatgggct cttcctctag cagccagtat actttctgtc agccagaaac
      601 tgtattttca tctcagccta gtgacgatga atcaagtagt gatgaaacca gtaatcagcc
      661 cagtcctgcc tttagacgac gccgtgctag gaagaagacc gtttctgctt cagaatctga
      721 agaccggcta gttgctgaac aagaaactga accttctaag gagttgagta aacgtcagtt
      781 cagtagtggt ctcaataagt gtgttatact tgctttggtg attgcaatca gcatgggatt
      841 tggccatttc tatggcacaa ttcagattca gaagcgtcaa cagttagtca gaaagataca
      901 tgaagatgaa ttgaatgata tgaaggatta tctttcccag tgtcaacagg aacaagaatc
      961 ttttatagat tataagtcat tgaaagaaaa tcttgcaagg tgttggacac ttactgaagc
     1021 agagaagatg tcctttgaaa ctcagaaaac gaaccttgct acagaaaatc agtatttaag
     1081 agtatccttg gagaaggaag aaaaagcctt atcctcatta caggaagagt taaacaaact
     1141 aagagaacag attagaatat tggaagataa agggacaagt actgaattag ttaaagaaaa
     1201 tcagaaactt aagcagcatt tggaagagga aaagcagaaa aaacacagct ttcttagtca
     1261 aagggagact ctgttgacag aagcaaagat gctaaagaga gaactggaga gagaacgact
     1321 agtaactacg gctttaaggg gggaactcca gcagttaagt ggtagtcagt tacatggcaa
     1381 gtcagattct cccaatgtat atactgaaaa aaaggaaata gcaatcttac gggaaagact
     1441 cactgagctg gaacggaagc taaccttcga acagcagcgt tctgatttgt gggaaagatt
     1501 gtatgttgag gcaaaagatc aaaatggaaa acaaggaaca gatggaaaaa agaaaggggg
     1561 cagaggaagc cacagggcta aaaataagtc aaaggaaaca tttttgggtt cagttaagga
     1621 aacatttgat gccatgaaga attctaccaa ggagtttgta aggcatcata aagagaaaat
     1681 taagcaggct aaagaagctg tgaaggaaaa tctgaaaaaa ttctcagatt cagttaaatc
     1741 cactttcaga cactttaaag ataccaccaa gaatatcttt gatgaaaagg gtaataaaag
     1801 atttggtgct acaaaagaag cagctgaaaa accaagaaca gtttttagtg actatttaca
     1861 tccacagtat aaggcaccta cagaaaacca tcataataga ggccctacta tgcaaaatga
     1921 tggaaggaaa gaaaagccag ttcactttaa agaattcaga aaaaatacaa attcaaagaa
     1981 atgcagtcct gggcatgatt gtagagaaaa ttctcattct ttcagaaagg cttgttctgg
     2041 tgtatttgat tgtgctcaac aagagtccat gagccttttt aacacagtgg tgaatcctat
     2101 aaggatggat gaatttagac agataattca aaggtacatg ttaaaagaac tggatacttt
     2161 ttgtcactgg aacgaacttg atcagttcat caataagttt ttcctaaacg gtgtctttat
     2221 acatgatcag aagctcttca ctgactttgt taatgatgtt aaagattatc ttagaaacat
     2281 gaaggaatat gaagtagata atgatggagt atttgagaag ttggatgaat atatatatag
     2341 acacttcttt ggtcacactt tttcccctcc atatggaccc aggtcggttt acataaaacc
     2401 gtgtcattac agtagtttgt aacatttgta gattggatag catttttatg atttgatgag
     2461 tttcttgtaa ggttaccgtt tctaagagtt gtgctttatg gccactgaga gaattcagaa
     2521 taaattgaaa gatggagtct aaaaattatt agctgttaca aatggaacat ttcattataa
     2581 cgtgatcact ttgacttgag caaatggttt aatttttatc ttaaaaatca gttaagaata
     2641 tataaaatcc tactttggcc aagtttgttt cttttcatta tagtttatat gaaaagatca
     2701 ccttaagtga aattattttc ctttaatctt ttatgtattt attcactttt ggaagctagg
     2761 aatgagcaac acaaatttta ctctgaagtc agaagagctc atatataata attctaatgt
     2821 cccacctatt ttcacttgtc cattccatgt accagcttag ttatgatact tagtcacata
     2881 attatctttg ataaaggtag aggcacaaag aggcaaacta agcaagtcaa attctaatgt
     2941 gtgtacttca taataatttt ttatccattt tcatctttat attctgtaac atgaaactta
     3001 cctaatcttc aaatgttagc ttcatttttt acctttgaaa tacttaatct ttctgaataa
     3061 atataatgtg tctataaaat aatgagactg attctggtgt ctttagtcat taagctggta
     3121 tctagtccta taatgaacaa aggtgaagct gccttgagga gacaagtgaa aaatttttgc
     3181 ttcaaaggag ctcacaagct aagtaaataa atgaaattaa ggtatggggc atggtggcct
     3241 caggctgtct ggaggtgttt ggaaaggctt cttgagtgag gtggcctttg aactgaactt
     3301 agtttttaaa gtagcttttg gaagagaaat gaggatttgc tatgcagaca gggaagggaa
     3361 tttcacttaa aaggaaggtc atttggagat gtgaagatac actgctttaa ggaagcaggg
     3421 tagagctgga ggataagaga tgcagaccat gaagggcccc attttatgct aaaggttttg
     3481 tcctgtagga catggagaac ttctgaagaa ttttcaaggc gggtgggata agattatatt
     3541 gtattttaga ttacagtagt ccccccttat cttcaggata tatgttccaa gacccccagt
     3601 ggatgctgga aaccagggat agaacataat tctatatata ctatgcatga atttcttttt
     3661 ccttctttac aatctcacac ataggtttgt tcttactata gatcttacca atctcagcat
     3721 acttttattt ctcttgagaa ccttcaccct ttcacttaaa ggaggcgctt tatagcttct
     3781 ctttggcata tccaaatgcc agcatcactg ttgtattttg gggtcattat taagttactt
     3841 aatcatcctt aatccttatc ttagggatac ttgaacacaa acactgtggt aggataacag
     3901 tatatctgat taacagactg ctactaggtg attaatgggt gggtagtgta aatacacaag
     3961 aaaaggatga ttcacatccc atgtgggatg gagcagaact gcattatttc attacattac
     4021 tcagaacagg catataattg aaaacttatg aattattttt ttttaattat ttgagatgga
     4081 atcttgcttt gtcagccagg ctggagtgca gtgacacgat ctcagctcac tgcaacctct
     4141 gtctcctggg ttcaggtgat tctcctccct agtctcccaa gtagctggga ctataggcac
     4201 gtgccaccac acccggctaa ttttcatatt tttagtagag atggggtttc accatgttgg
     4261 ccaggctgtt cttgaaatcc tgacctcaag tgatccacac atgtctacct cccaaagtgc
     4321 tgggattaca gtcgtgagcc actgtacccc gcctaaaact gatgaattat ttctgaaatt
     4381 ttctatttaa cattttcaga ccacagttga ccacaggtaa cggaaacctc aatcacagaa
     4441 agtaaagccg tggatacggt gggactaatg tattggtagc agcctagagg attgatggga
     4501 aaggtatgaa gctagaaggt ggtcaatata atacagacat gagctgatga acatctaaac
     4561 tgggactata ctagtaggag aggaaaggaa aaaacatttg gaaaatagta acattgatat
     4621 ttcttgtgaa ggagaagtag aaagtaacag tgacttctag atttctgggt tgggtcatct
     4681 tgttggatag tagtaccact gagataggga attcaaggtt tggggcaagg gtaattggag
     4741 atgagaattg tgtttggagg taactactga cattcaagtg gagagggtta gttggcagtt
     4801 agttctatgg tcatctcttt tgccgagact gtatatttat cagactcctg ggagaacacc
     4861 aacatccatg gggttgtagg gaaggctaag gacaggagtg gggagtggta ccttgaaaat
     4921 ccaaaagcca tctcaagtaa aaggaataaa tgtgtcatgc tttttaaaaa gttgatgtgc
     4981 ggaaaatgtt ttcttggctt ggaaactggg cggccagggg atgacagtat ggacttccag
     5041 tgaagtagtg acggaagcct gatcatagac attaaggaaa gcggtgtagg tgttgtgagc
     5101 ttttgctgta agaaaaagtt gagacttttg ttttgctttg tttgtgagag atgtgtatgt
     5161 atttctgctg agtgataaag ccagcgggga gggactgatt tttataggaa aggaggaaaa
     5221 ataatggaaa cacatctcat tattttattg tcacatttct tttctttgtt atcttttgag
     5281 tgtttccctt ttttgccagt agagttattg tctatttttt ctttctatag gacaaaaaaa
     5341 ctaatacaga ctcctttatt tttatatgga tatactagga ttgtaattca gatatttaat
     5401 atcttttatc agtgttcaga tcatagatta atggagaaaa catttaaaat tgttttaaat
     5461 ttaaatacat tgaactctaa catagatgaa aaatgtgttt actgctttca gtcgacctga
     5521 taaaaagcaa cgtatggtaa atattgaaaa ctccaggcat cgaaaacaag agcagaagca
     5581 ccttcagcca cagccttata aaagggaagg taaatggcat aaatatggtc gcactaatgg
     5641 aagacaaatg gcaaatcttg aaatagaatt ggggcaatta ccttttgatc ctcaatactg
     5701 attcacaatt gagttaaatt agacaactgt aagagaaaaa tttatgcttt gtataatgtt
     5761 tggtattgaa actaatgaaa ttaccaagat gacaatgtct tttcttttgt ttctaagtat
     5821 cagtttgata actttatatt attcctcaga agcattagtt aaaagtctac taacctgcat
     5881 tttcctgtag tttagcttcg ttgaattttt tttgacactg gaaatgttca actgtagttt
     5941 tattaaggaa gccaggcatg caacagattt tgtgcatgaa atgagacttc ctttcagtgt
     6001 aagagcttaa agcaagctca gtcatacatg acaaagtgta attaacactg atgtttgtgt
     6061 taaatttgca gcagagcttg agaaaagtac attgttctgg aatttcatca ttaacatttt
     6121 ataatcttac actcacttct tgtctttttg tgggttcaag agccctctga cttgtgaaga
     6181 atttgctgcc ctcttaagag cttgctgact tgttttcttg tgaaattttt tgcacatctg
     6241 aatatcgtgg aagaaacaat aaaactacac catgaggaaa actaaaggtc tttatttaaa
     6301 atctggcatt gtattaacat gtaattttat actatgtggt attttataca tttcctcagt
     6361 agtgatattt ggtaaagcag ttcatacagc ttttttctaa gttccatgaa tcttacccag
     6421 tgtttaccga agtatttaag cagcatctga atatttccac ccagcaatgt taatttatct
     6481 aggaaagttc agaatttcat cttcatgttg aatttccctt ttaacttccg ttcatagaca
     6541 tatatgtgac ttccaattcg accctctggc aagtgagtgt ggaagaaaac agcagttctt
     6601 ttataattgc ttgaaattag gaaagcgctt atttcctaga agcaaataaa tgtttaagta
     6661 aataaaggct acattttgct ga
//
