LOCUS       NM_001204451            2404 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens cell cycle progression 1 (CCPG1), transcript variant
            4, mRNA.
ACCESSION   NM_001204451
VERSION     NM_001204451.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2404)
  AUTHORS   Wang,G., Liu,Z., Wang,Q., Liu,B. and Li,J.
  TITLE     Clinical and prognostic significance of CCPG1 in hepatocellular
            carcinoma
  JOURNAL   Gen Physiol Biophys 42 (5), 431-442 (2023)
   PUBMED   37702448
  REMARK    GeneRIF: Clinical and prognostic significance of CCPG1 in
            hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 2404)
  AUTHORS   Smith,M.D., Harley,M.E., Kemp,A.J., Wills,J., Lee,M., Arends,M.,
            von Kriegsheim,A., Behrends,C. and Wilkinson,S.
  TITLE     CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for
            ER-Phagy and Pancreatic ER Proteostasis
  JOURNAL   Dev Cell 44 (2), 217-232 (2018)
   PUBMED   29290589
  REMARK    GeneRIF: identification of cell-cycle progression gene 1 (CCPG1),
            an ER-resident protein, as a non-canonical cargo receptor that
            directly binds to core autophagy proteins via an LIR motif to
            mammalian ATG8 proteins and, independently and via a discrete
            motif, to FIP200.
REFERENCE   3  (bases 1 to 2404)
  AUTHORS   Dunlop,E.A., Seifan,S., Claessens,T., Behrends,C., Kamps,M.A.,
            Rozycka,E., Kemp,A.J., Nookala,R.K., Blenis,J., Coull,B.J.,
            Murray,J.T., van Steensel,M.A., Wilkinson,S. and Tee,A.R.
  TITLE     FLCN, a novel autophagy component, interacts with GABARAP and is
            regulated by ULK1 phosphorylation
  JOURNAL   Autophagy 10 (10), 1749-1760 (2014)
   PUBMED   25126726
REFERENCE   4  (bases 1 to 2404)
  AUTHORS   Faghihi,M.A., Kocerha,J., Modarresi,F., Engstrom,P.G., Chalk,A.M.,
            Brothers,S.P., Koesema,E., St Laurent,G. and Wahlestedt,C.
  TITLE     RNAi screen indicates widespread biological function for human
            natural antisense transcripts
  JOURNAL   PLoS One 5 (10), e13177 (2010)
   PUBMED   20957177
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2404)
  AUTHORS   Myslinski,E., Gerard,M.A., Krol,A. and Carbon,P.
  TITLE     A genome scale location analysis of human Staf/ZNF143-binding sites
            suggests a widespread role for human Staf/ZNF143 in mammalian
            promoters
  JOURNAL   J Biol Chem 281 (52), 39953-39962 (2006)
   PUBMED   17092945
REFERENCE   6  (bases 1 to 2404)
  AUTHORS   Edwards,M.C., Liegeois,N., Horecka,J., DePinho,R.A., Sprague,G.F.
            Jr., Tyers,M. and Elledge,S.J.
  TITLE     Human CPR (cell cycle progression restoration) genes impart a Far-
            phenotype on yeast cells
  JOURNAL   Genetics 147 (3), 1063-1076 (1997)
   PUBMED   9383053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB084778.1, AK022459.1, AC018926.10 and AA740595.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001204451.1.
            
            Transcript Variant: This variant (4) lacks two segments in the 3'
            coding region, one of which causes a frameshift. The encoded
            isoform (3) has a distinct C-terminus and is shorter than isoform
            1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK022459.1, SRR14038197.1591508.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                DB084778.1         152-204
            54-956              AK022459.1         1-903
            957-957             AC018926.10        137253-137253       c
            958-1880            AK022459.1         905-1827
            1881-1975           AC018926.10        127714-127808       c
            1976-2404           AA740595.1         18-446              c
FEATURES             Location/Qualifiers
     source          1..2404
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.3"
     gene            1..2404
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /note="cell cycle progression 1"
                     /db_xref="GeneID:9236"
                     /db_xref="HGNC:HGNC:24227"
                     /db_xref="MIM:611326"
     exon            1..139
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /inference="alignment:Splign:2.1.0"
     exon            140..208
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1423
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /note="isoform 3 is encoded by transcript variant 4; cell
                     cycle progression restoration protein 8"
                     /codon_start=1
                     /product="cell cycle progression protein 1 isoform 3"
                     /protein_id="NP_001191380.1"
                     /db_xref="CCDS:CCDS55967.1"
                     /db_xref="GeneID:9236"
                     /db_xref="HGNC:HGNC:24227"
                     /db_xref="MIM:611326"
                     /translation="MSENSSDSDSSCGWTVISHEGSDIEMLNSVTPTDSCEPAPECSS
                     LEQEELQALQIEQGESSQNGTVLMEETAYPALEETSSTIEAEEQKIPEDSIYIGTASD
                     DSDIVTLEPPKLEEIGNQEVVIVEEAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDD
                     ESSSDETSNQPSPAFRRRRARKKTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKC
                     VILALVIAISMGFGHFYGTIQIQKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYK
                     SLKENLARCWTLTEAEKMSFETQKTNLATENQYLRKLFTDFVNDVKDYLRNMKEYEVD
                     NDGVFEKLDEYIYRHFFGHTFSPPYGPSRPDKKQRMVNIENSRHRKQEQKHLQPQPYK
                     REGKWHKYGRTNGRQMANLEIELGQLPFDPQY"
     exon            209..323
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /inference="alignment:Splign:2.1.0"
     exon            324..400
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /inference="alignment:Splign:2.1.0"
     exon            401..602
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /inference="alignment:Splign:2.1.0"
     exon            603..854
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /inference="alignment:Splign:2.1.0"
     exon            855..976
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1081
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1233
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..2404
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1980..1985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /note="hexamer: AATAAA"
     polyA_site      2003
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /note="major polyA site"
     regulatory      2383..2388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /note="hexamer: AATAAA"
     polyA_site      2404
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
ORIGIN      
        1 gcccagccgg tcaccgcctg ccggctgcag acgcctgcga gcaggttgtt tttataagag
       61 gcgtcattgg cgcccgagct gtgaccgccg ccactggggc agccagcaca atcgggcgga
      121 ggtggcgctg ccccttcaga cctgaaagat gtctgaaaat tccagtgaca gtgattcatc
      181 ttgtggttgg actgtcatca gtcatgaggg gtcagatata gaaatgttga attctgtgac
      241 ccccactgac agctgtgagc ccgccccaga atgttcatct ttagagcaag aggagcttca
      301 agcattgcag atagagcaag gagaaagcag ccaaaatggc acagtgctta tggaagaaac
      361 tgcttatcca gctttggagg aaaccagctc aacaattgag gcagaggaac aaaagatacc
      421 cgaagacagt atctatattg gaactgccag tgatgattct gatattgtta cccttgagcc
      481 acctaagtta gaagaaattg gaaatcaaga agttgtcatt gttgaagaag cacagagttc
      541 agaagacttt aacatgggct cttcctctag cagccagtat actttctgtc agccagaaac
      601 tgtattttca tctcagccta gtgacgatga atcaagtagt gatgaaacca gtaatcagcc
      661 cagtcctgcc tttagacgac gccgtgctag gaagaagacc gtttctgctt cagaatctga
      721 agaccggcta gttgctgaac aagaaactga accttctaag gagttgagta aacgtcagtt
      781 cagtagtggt ctcaataagt gtgttatact tgctttggtg attgcaatca gcatgggatt
      841 tggccatttc tatggcacaa ttcagattca gaagcgtcaa cagttagtca gaaagataca
      901 tgaagatgaa ttgaatgata tgaaggatta tctttcccag tgtcaacagg aacaagaatc
      961 ttttatagat tataagtcat tgaaagaaaa tcttgcaagg tgttggacac ttactgaagc
     1021 agagaagatg tcctttgaaa ctcagaaaac gaaccttgct acagaaaatc agtatttaag
     1081 aaagctcttc actgactttg ttaatgatgt taaagattat cttagaaaca tgaaggaata
     1141 tgaagtagat aatgatggag tatttgagaa gttggatgaa tatatatata gacacttctt
     1201 tggtcacact ttttcccctc catatggacc cagtcgacct gataaaaagc aacgtatggt
     1261 aaatattgaa aactccaggc atcgaaaaca agagcagaag caccttcagc cacagcctta
     1321 taaaagggaa ggtaaatggc ataaatatgg tcgcactaat ggaagacaaa tggcaaatct
     1381 tgaaatagaa ttggggcaat taccttttga tcctcaatac tgattcacaa ttgagttaaa
     1441 ttagacaact gtaagagaaa aatttatgct ttgtataatg tttggtattg aaactaatga
     1501 aattaccaag atgacaatgt cttttctttt gtttctaagt atcagtttga taactttata
     1561 ttattcctca gaagcattag ttaaaagtct actaacctgc attttcctgt agtttagctt
     1621 cgttgaattt tttttgacac tggaaatgtt caactgtagt tttattaagg aagccaggca
     1681 tgcaacagat tttgtgcatg aaatgagact tcctttcagt gtaagagctt aaagcaagct
     1741 cagtcataca tgacaaagtg taattaacac tgatgtttgt gttaaatttg cagcagagct
     1801 tgagaaaagt acattgttct ggaatttcat cattaacatt ttataatctt acactcactt
     1861 cttgtctttt tgtgggttca agagccctct gacttgtgaa gaatttgctg ccctcttaag
     1921 agcttgctga cttgttttct tgtgaaattt tttgcacatc tgaatatcgt ggaagaaaca
     1981 ataaaactac accatgagga aaactaaagg tctttattta aaatctggca ttgtattaac
     2041 atgtaatttt atactatgtg gtattttata catttcctca gtagtgatat ttggtaaagc
     2101 agttcataca gcttttttct aagttccatg aatcttaccc agtgtttacc gaagtattta
     2161 agcagcatct gaatatttcc acccagcaat gttaatttat ctaggaaagt tcagaatttc
     2221 atcttcatgt tgaatttccc ttttaacttc cgttcataga catatatgtg acttccaatt
     2281 cgaccctctg gcaagtgagt gtggaagaaa acagcagttc ttttataatt gcttgaaatt
     2341 aggaaagcgc ttatttccta gaagcaaata aatgtttaag taaataaagg ctacattttg
     2401 ctga
//
