LOCUS       NM_001204450            3553 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens cell cycle progression 1 (CCPG1), transcript variant
            3, mRNA.
ACCESSION   NM_001204450
VERSION     NM_001204450.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3553)
  AUTHORS   Wang,G., Liu,Z., Wang,Q., Liu,B. and Li,J.
  TITLE     Clinical and prognostic significance of CCPG1 in hepatocellular
            carcinoma
  JOURNAL   Gen Physiol Biophys 42 (5), 431-442 (2023)
   PUBMED   37702448
  REMARK    GeneRIF: Clinical and prognostic significance of CCPG1 in
            hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 3553)
  AUTHORS   Smith,M.D., Harley,M.E., Kemp,A.J., Wills,J., Lee,M., Arends,M.,
            von Kriegsheim,A., Behrends,C. and Wilkinson,S.
  TITLE     CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for
            ER-Phagy and Pancreatic ER Proteostasis
  JOURNAL   Dev Cell 44 (2), 217-232 (2018)
   PUBMED   29290589
  REMARK    GeneRIF: identification of cell-cycle progression gene 1 (CCPG1),
            an ER-resident protein, as a non-canonical cargo receptor that
            directly binds to core autophagy proteins via an LIR motif to
            mammalian ATG8 proteins and, independently and via a discrete
            motif, to FIP200.
REFERENCE   3  (bases 1 to 3553)
  AUTHORS   Dunlop,E.A., Seifan,S., Claessens,T., Behrends,C., Kamps,M.A.,
            Rozycka,E., Kemp,A.J., Nookala,R.K., Blenis,J., Coull,B.J.,
            Murray,J.T., van Steensel,M.A., Wilkinson,S. and Tee,A.R.
  TITLE     FLCN, a novel autophagy component, interacts with GABARAP and is
            regulated by ULK1 phosphorylation
  JOURNAL   Autophagy 10 (10), 1749-1760 (2014)
   PUBMED   25126726
REFERENCE   4  (bases 1 to 3553)
  AUTHORS   Faghihi,M.A., Kocerha,J., Modarresi,F., Engstrom,P.G., Chalk,A.M.,
            Brothers,S.P., Koesema,E., St Laurent,G. and Wahlestedt,C.
  TITLE     RNAi screen indicates widespread biological function for human
            natural antisense transcripts
  JOURNAL   PLoS One 5 (10), e13177 (2010)
   PUBMED   20957177
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3553)
  AUTHORS   Myslinski,E., Gerard,M.A., Krol,A. and Carbon,P.
  TITLE     A genome scale location analysis of human Staf/ZNF143-binding sites
            suggests a widespread role for human Staf/ZNF143 in mammalian
            promoters
  JOURNAL   J Biol Chem 281 (52), 39953-39962 (2006)
   PUBMED   17092945
REFERENCE   6  (bases 1 to 3553)
  AUTHORS   Edwards,M.C., Liegeois,N., Horecka,J., DePinho,R.A., Sprague,G.F.
            Jr., Tyers,M. and Elledge,S.J.
  TITLE     Human CPR (cell cycle progression restoration) genes impart a Far-
            phenotype on yeast cells
  JOURNAL   Genetics 147 (3), 1063-1076 (1997)
   PUBMED   9383053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB084778.1, AK292795.1, AC018926.10 and AA740595.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001204450.1.
            
            Transcript Variant: This variant (3) lacks a segment in the 3'
            coding region that results in a frameshift. The encoded isoform (2)
            has a distinct and longer C-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292795.1, SRR18074967.741057.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000442196.8/ ENSP00000403400.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               DB084778.1         152-251
            101-2680            AK292795.1         1-2580
            2681-3124           AC018926.10        127714-128157       c
            3125-3553           AA740595.1         18-446              c
FEATURES             Location/Qualifiers
     source          1..3553
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.3"
     gene            1..3553
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /note="cell cycle progression 1"
                     /db_xref="GeneID:9236"
                     /db_xref="HGNC:HGNC:24227"
                     /db_xref="MIM:611326"
     exon            1..139
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /inference="alignment:Splign:2.1.0"
     exon            140..208
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..2572
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /note="isoform 2 is encoded by transcript variant 3; cell
                     cycle progression restoration protein 8"
                     /codon_start=1
                     /product="cell cycle progression protein 1 isoform 2"
                     /protein_id="NP_001191379.1"
                     /db_xref="CCDS:CCDS55966.1"
                     /db_xref="GeneID:9236"
                     /db_xref="HGNC:HGNC:24227"
                     /db_xref="MIM:611326"
                     /translation="MSENSSDSDSSCGWTVISHEGSDIEMLNSVTPTDSCEPAPECSS
                     LEQEELQALQIEQGESSQNGTVLMEETAYPALEETSSTIEAEEQKIPEDSIYIGTASD
                     DSDIVTLEPPKLEEIGNQEVVIVEEAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDD
                     ESSSDETSNQPSPAFRRRRARKKTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKC
                     VILALVIAISMGFGHFYGTIQIQKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYK
                     SLKENLARCWTLTEAEKMSFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQ
                     IRILEDKGTSTELVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKMLKRELERERLV
                     TTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWER
                     LYVEAKDQNGKQGTDGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTKEFVRHHK
                     EKIKQAKEAVKENLKKFSDSVKSTFRHFKDTTKNIFDEKGNKRFGATKEAAEKPRTVF
                     SDYLHPQYKAPTENHHNRGPTMQNDGRKEKPVHFKEFRKNTNSKKCSPGHDCRENSHS
                     FRKACSGVFDCAQQESMSLFNTVVNPIRMDEFRQIIQRYMLKELDTFCHWNELDQFIN
                     KFFLNGVFIHDQKLFTDFVNDVKDYLRNMKEYEVDNDGVFEKLDEYIYRHFFGHTFSP
                     PYGPSRPDKKQRMVNIENSRHRKQEQKHLQPQPYKREGKWHKYGRTNGRQMANLEIEL
                     GQLPFDPQY"
     exon            209..323
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /inference="alignment:Splign:2.1.0"
     exon            324..400
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /inference="alignment:Splign:2.1.0"
     exon            401..602
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /inference="alignment:Splign:2.1.0"
     exon            603..854
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /inference="alignment:Splign:2.1.0"
     exon            855..976
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /inference="alignment:Splign:2.1.0"
     exon            977..2382
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..3553
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3129..3134
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /note="hexamer: AATAAA"
     polyA_site      3152
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /note="major polyA site"
     regulatory      3532..3537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
                     /note="hexamer: AATAAA"
     polyA_site      3553
                     /gene="CCPG1"
                     /gene_synonym="CPR8"
ORIGIN      
        1 gcccagccgg tcaccgcctg ccggctgcag acgcctgcga gcaggttgtt tttataagag
       61 gcgtcattgg cgcccgagct gtgaccgccg ccactggggc agccagcaca atcgggcgga
      121 ggtggcgctg ccccttcaga cctgaaagat gtctgaaaat tccagtgaca gtgattcatc
      181 ttgtggttgg actgtcatca gtcatgaggg gtcagatata gaaatgttga attctgtgac
      241 ccccactgac agctgtgagc ccgccccaga atgttcatct ttagagcaag aggagcttca
      301 agcattgcag atagagcaag gagaaagcag ccaaaatggc acagtgctta tggaagaaac
      361 tgcttatcca gctttggagg aaaccagctc aacaattgag gcagaggaac aaaagatacc
      421 cgaagacagt atctatattg gaactgccag tgatgattct gatattgtta cccttgagcc
      481 acctaagtta gaagaaattg gaaatcaaga agttgtcatt gttgaagaag cacagagttc
      541 agaagacttt aacatgggct cttcctctag cagccagtat actttctgtc agccagaaac
      601 tgtattttca tctcagccta gtgacgatga atcaagtagt gatgaaacca gtaatcagcc
      661 cagtcctgcc tttagacgac gccgtgctag gaagaagacc gtttctgctt cagaatctga
      721 agaccggcta gttgctgaac aagaaactga accttctaag gagttgagta aacgtcagtt
      781 cagtagtggt ctcaataagt gtgttatact tgctttggtg attgcaatca gcatgggatt
      841 tggccatttc tatggcacaa ttcagattca gaagcgtcaa cagttagtca gaaagataca
      901 tgaagatgaa ttgaatgata tgaaggatta tctttcccag tgtcaacagg aacaagaatc
      961 ttttatagat tataagtcat tgaaagaaaa tcttgcaagg tgttggacac ttactgaagc
     1021 agagaagatg tcctttgaaa ctcagaaaac gaaccttgct acagaaaatc agtatttaag
     1081 agtatccttg gagaaggaag aaaaagcctt atcctcatta caggaagagt taaacaaact
     1141 aagagaacag attagaatat tggaagataa agggacaagt actgaattag ttaaagaaaa
     1201 tcagaaactt aagcagcatt tggaagagga aaagcagaaa aaacacagct ttcttagtca
     1261 aagggagact ctgttgacag aagcaaagat gctaaagaga gaactggaga gagaacgact
     1321 agtaactacg gctttaaggg gggaactcca gcagttaagt ggtagtcagt tacatggcaa
     1381 gtcagattct cccaatgtat atactgaaaa aaaggaaata gcaatcttac gggaaagact
     1441 cactgagctg gaacggaagc taaccttcga acagcagcgt tctgatttgt gggaaagatt
     1501 gtatgttgag gcaaaagatc aaaatggaaa acaaggaaca gatggaaaaa agaaaggggg
     1561 cagaggaagc cacagggcta aaaataagtc aaaggaaaca tttttgggtt cagttaagga
     1621 aacatttgat gccatgaaga attctaccaa ggagtttgta aggcatcata aagagaaaat
     1681 taagcaggct aaagaagctg tgaaggaaaa tctgaaaaaa ttctcagatt cagttaaatc
     1741 cactttcaga cactttaaag ataccaccaa gaatatcttt gatgaaaagg gtaataaaag
     1801 atttggtgct acaaaagaag cagctgaaaa accaagaaca gtttttagtg actatttaca
     1861 tccacagtat aaggcaccta cagaaaacca tcataataga ggccctacta tgcaaaatga
     1921 tggaaggaaa gaaaagccag ttcactttaa agaattcaga aaaaatacaa attcaaagaa
     1981 atgcagtcct gggcatgatt gtagagaaaa ttctcattct ttcagaaagg cttgttctgg
     2041 tgtatttgat tgtgctcaac aagagtccat gagccttttt aacacagtgg tgaatcctat
     2101 aaggatggat gaatttagac agataattca aaggtacatg ttaaaagaac tggatacttt
     2161 ttgtcactgg aacgaacttg atcagttcat caataagttt ttcctaaacg gtgtctttat
     2221 acatgatcag aagctcttca ctgactttgt taatgatgtt aaagattatc ttagaaacat
     2281 gaaggaatat gaagtagata atgatggagt atttgagaag ttggatgaat atatatatag
     2341 acacttcttt ggtcacactt tttcccctcc atatggaccc agtcgacctg ataaaaagca
     2401 acgtatggta aatattgaaa actccaggca tcgaaaacaa gagcagaagc accttcagcc
     2461 acagccttat aaaagggaag gtaaatggca taaatatggt cgcactaatg gaagacaaat
     2521 ggcaaatctt gaaatagaat tggggcaatt accttttgat cctcaatact gattcacaat
     2581 tgagttaaat tagacaactg taagagaaaa atttatgctt tgtataatgt ttggtattga
     2641 aactaatgaa attaccaaga tgacaatgtc ttttcttttg tttctaagta tcagtttgat
     2701 aactttatat tattcctcag aagcattagt taaaagtcta ctaacctgca ttttcctgta
     2761 gtttagcttc gttgaatttt ttttgacact ggaaatgttc aactgtagtt ttattaagga
     2821 agccaggcat gcaacagatt ttgtgcatga aatgagactt cctttcagtg taagagctta
     2881 aagcaagctc agtcatacat gacaaagtgt aattaacact gatgtttgtg ttaaatttgc
     2941 agcagagctt gagaaaagta cattgttctg gaatttcatc attaacattt tataatctta
     3001 cactcacttc ttgtcttttt gtgggttcaa gagccctctg acttgtgaag aatttgctgc
     3061 cctcttaaga gcttgctgac ttgttttctt gtgaaatttt ttgcacatct gaatatcgtg
     3121 gaagaaacaa taaaactaca ccatgaggaa aactaaaggt ctttatttaa aatctggcat
     3181 tgtattaaca tgtaatttta tactatgtgg tattttatac atttcctcag tagtgatatt
     3241 tggtaaagca gttcatacag cttttttcta agttccatga atcttaccca gtgtttaccg
     3301 aagtatttaa gcagcatctg aatatttcca cccagcaatg ttaatttatc taggaaagtt
     3361 cagaatttca tcttcatgtt gaatttccct tttaacttcc gttcatagac atatatgtga
     3421 cttccaattc gaccctctgg caagtgagtg tggaagaaaa cagcagttct tttataattg
     3481 cttgaaatta ggaaagcgct tatttcctag aagcaaataa atgtttaagt aaataaaggc
     3541 tacattttgc tga
//
