LOCUS       NM_001323572            5275 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens centriolar coiled-coil protein 110 (CCP110),
            transcript variant 6, mRNA.
ACCESSION   NM_001323572
VERSION     NM_001323572.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5275)
  AUTHORS   Xie,S., Naslavsky,N. and Caplan,S.
  TITLE     Emerging insights into CP110 removal during early steps of
            ciliogenesis
  JOURNAL   J Cell Sci 137 (4) (2024)
   PUBMED   38415788
  REMARK    GeneRIF: Emerging insights into CP110 removal during early steps of
            ciliogenesis.
            Review article
REFERENCE   2  (bases 1 to 5275)
  AUTHORS   Xie,S., Naslavsky,N. and Caplan,S.
  TITLE     EHD1 promotes CP110 ubiquitination by centriolar satellite delivery
            of HERC2 to the mother centriole
  JOURNAL   EMBO Rep 24 (6), e56317 (2023)
   PUBMED   37074924
  REMARK    GeneRIF: EHD1 promotes CP110 ubiquitination by centriolar satellite
            delivery of HERC2 to the mother centriole.
REFERENCE   3  (bases 1 to 5275)
  AUTHORS   Wang,Y., Zhang,Y., Guo,X., Zheng,Y., Zhang,X., Feng,S. and Wu,H.Y.
  TITLE     CCP5 and CCP6 retain CP110 and negatively regulate ciliogenesis
  JOURNAL   BMC Biol 21 (1), 124 (2023)
   PUBMED   37226238
  REMARK    GeneRIF: CCP5 and CCP6 retain CP110 and negatively regulate
            ciliogenesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5275)
  AUTHORS   O'Neill,A.C., Uzbas,F., Antognolli,G., Merino,F., Draganova,K.,
            Jack,A., Zhang,S., Pedini,G., Schessner,J.P., Cramer,K.,
            Schepers,A., Metzger,F., Esgleas,M., Smialowski,P., Guerrini,R.,
            Falk,S., Feederle,R., Freytag,S., Wang,Z., Bahlo,M., Jungmann,R.,
            Bagni,C., Borner,G.H.H., Robertson,S.P., Hauck,S.M. and Gotz,M.
  TITLE     Spatial centrosome proteome of human neural cells uncovers
            disease-relevant heterogeneity
  JOURNAL   Science 376 (6599), eabf9088 (2022)
   PUBMED   35709258
REFERENCE   5  (bases 1 to 5275)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 5275)
  AUTHORS   Casenghi,M., Meraldi,P., Weinhart,U., Duncan,P.I., Korner,R. and
            Nigg,E.A.
  TITLE     Polo-like kinase 1 regulates Nlp, a centrosome protein involved in
            microtubule nucleation
  JOURNAL   Dev Cell 5 (1), 113-125 (2003)
   PUBMED   12852856
REFERENCE   7  (bases 1 to 5275)
  AUTHORS   Chen,Z., Indjeian,V.B., McManus,M., Wang,L. and Dynlacht,B.D.
  TITLE     CP110, a cell cycle-dependent CDK substrate, regulates centrosome
            duplication in human cells
  JOURNAL   Dev Cell 3 (3), 339-350 (2002)
   PUBMED   12361598
  REMARK    GeneRIF: CP110, a cell cycle-dependent CDK substrate, regulates
            centrosome duplication (CP110)
REFERENCE   8  (bases 1 to 5275)
  AUTHORS   Takahashi,M., Yamagiwa,A., Nishimura,T., Mukai,H. and Ono,Y.
  TITLE     Centrosomal proteins CG-NAP and kendrin provide microtubule
            nucleation sites by anchoring gamma-tubulin ring complex
  JOURNAL   Mol Biol Cell 13 (9), 3235-3245 (2002)
   PUBMED   12221128
REFERENCE   9  (bases 1 to 5275)
  AUTHORS   Mayor,T., Stierhof,Y.D., Tanaka,K., Fry,A.M. and Nigg,E.A.
  TITLE     The centrosomal protein C-Nap1 is required for cell cycle-regulated
            centrosome cohesion
  JOURNAL   J Cell Biol 151 (4), 837-846 (2000)
   PUBMED   11076968
REFERENCE   10 (bases 1 to 5275)
  AUTHORS   Golsteyn,R.M., Mundt,K.E., Fry,A.M. and Nigg,E.A.
  TITLE     Cell cycle regulation of the activity and subcellular localization
            of Plk1, a human protein kinase implicated in mitotic spindle
            function
  JOURNAL   J Cell Biol 129 (6), 1617-1628 (1995)
   PUBMED   7790358
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC012621.8.
            
            On Jun 2, 2019 this sequence version replaced NM_001323572.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.206050.1,
                                           SRR1660805.187880.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000694978.1/ ENSP00000511625.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AC012621.8         6212-6358
            148-303             AC012621.8         10137-10292
            304-432             AC012621.8         14686-14814
            433-2080            AC012621.8         18210-19857
            2081-2211           AC012621.8         22927-23057
            2212-2389           AC012621.8         24157-24334
            2390-2529           AC012621.8         24891-25030
            2530-2646           AC012621.8         25148-25264
            2647-2748           AC012621.8         27067-27168
            2749-2865           AC012621.8         27364-27480
            2866-2939           AC012621.8         28087-28160
            2940-3002           AC012621.8         28682-28744
            3003-3062           AC012621.8         30225-30284
            3063-5275           AC012621.8         33466-35678
FEATURES             Location/Qualifiers
     source          1..5275
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.3"
     gene            1..5275
                     /gene="CCP110"
                     /gene_synonym="Cep110; CP110"
                     /note="centriolar coiled-coil protein 110"
                     /db_xref="GeneID:9738"
                     /db_xref="HGNC:HGNC:24342"
                     /db_xref="MIM:609544"
     exon            1..147
                     /gene="CCP110"
                     /gene_synonym="Cep110; CP110"
                     /inference="alignment:Splign:2.1.0"
     exon            148..303
                     /gene="CCP110"
                     /gene_synonym="Cep110; CP110"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..3138
                     /gene="CCP110"
                     /gene_synonym="Cep110; CP110"
                     /note="isoform 2 is encoded by transcript variant 6;
                     centrosomal protein CP110; centrosomal protein of 110 kDa;
                     centriolar coiled-coil protein of 110 kDa; centriolar
                     coiled-coil protein 110kDa"
                     /codon_start=1
                     /product="centriolar coiled-coil protein of 110 kDa
                     isoform 2"
                     /protein_id="NP_001310501.1"
                     /db_xref="CCDS:CCDS10579.1"
                     /db_xref="GeneID:9738"
                     /db_xref="HGNC:HGNC:24342"
                     /db_xref="MIM:609544"
                     /translation="MEEYEKFCEKSLARIQEASLSTESFLPAQSESISLIRFHGVAIL
                     SPLLNIEKRKEMQQEKQKALDVEARKQVNRKKALLTRVQEILDNVQVRKAPNASDFDQ
                     WEMETVYSNSEVRNLNVPATFPNSFPSHTEHSTAAKLDKIAGILPLDNEDQCKTDGID
                     LARDSEGFNSPKQCDSSNISHVENEAFPKTSSATPQETLISDGPFSVNEQQDLPLLAE
                     VIPDPYVMSLQNLMKKSKEYIEREQSRRSLRGSINRIVNESHLDKEHDAVEVADCVKE
                     KGQLTGKHCVSVIPDKPSLNKSNVLLQGASTQASSMSMPVLASFSKVDIPIRTGHPTV
                     LESNSDFKVIPTFVTENNVIKSLTGSYAKLPSPEPSMSPKMHRRRSRTSSACHILINN
                     PINACELSPKGKEQAMDLIIQDTDENTNVPEIMPKLPTDLAGVCSSKVYVGKNTSEVK
                     EDVVLGKSNQVCQSSGNHLENKVTHGLVTVEGQLTSDERGAHIMNSTCAAMPKLHEPY
                     ASSQCIASPNFGTVSGLKPASMLEKNCSLQTELNKSYDVKNPSPLLMQNQNTRQQMDT
                     PMVSCGNEQFLDNSFEKVKRRLDLDIDGLQKENCPYVITSGITEQERQHLPEKRYPKG
                     SGFVNKNKMLGTSSKESEELLKSKMLAFEEMRKRLEEQHAQQLSLLIAEQEREQERLQ
                     KEIEEQEKMLKEKKAMTAEASELDINNAVELEWRKISDSSLLETMLSQADSLHTSNSN
                     SSGFTNSAMQYSFVSANEAPFYLWGSSTSGLTKLSVTRPFGRAKTRWSQVFSLEIQAK
                     FNKITAVAKGFLTRRLMQTDKLKQLRQTVKDTMEFIRSFQSEAPLKRGIVSAQDASLQ
                     ERVLAQLRAALYGIHDIFFVMDAAERMSILHHDREVRKEKMLRQMDKMKSPRVALSAA
                     TQKSLDRKKYMKAAEMGMPNKKFLVKQNPSETRVLQPNQGQNAPVHRLLSRQGSICRK
                     NPKKAAKCCDNLRRQHSLG"
     exon            304..432
                     /gene="CCP110"
                     /gene_synonym="Cep110; CP110"
                     /inference="alignment:Splign:2.1.0"
     exon            433..2080
                     /gene="CCP110"
                     /gene_synonym="Cep110; CP110"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2211
                     /gene="CCP110"
                     /gene_synonym="Cep110; CP110"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2389
                     /gene="CCP110"
                     /gene_synonym="Cep110; CP110"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2529
                     /gene="CCP110"
                     /gene_synonym="Cep110; CP110"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2646
                     /gene="CCP110"
                     /gene_synonym="Cep110; CP110"
                     /inference="alignment:Splign:2.1.0"
     exon            2647..2748
                     /gene="CCP110"
                     /gene_synonym="Cep110; CP110"
                     /inference="alignment:Splign:2.1.0"
     exon            2749..2865
                     /gene="CCP110"
                     /gene_synonym="Cep110; CP110"
                     /inference="alignment:Splign:2.1.0"
     exon            2866..2939
                     /gene="CCP110"
                     /gene_synonym="Cep110; CP110"
                     /inference="alignment:Splign:2.1.0"
     exon            2940..3002
                     /gene="CCP110"
                     /gene_synonym="Cep110; CP110"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..3062
                     /gene="CCP110"
                     /gene_synonym="Cep110; CP110"
                     /inference="alignment:Splign:2.1.0"
     exon            3063..5275
                     /gene="CCP110"
                     /gene_synonym="Cep110; CP110"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5251..5256
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCP110"
                     /gene_synonym="Cep110; CP110"
                     /note="hexamer: AATAAA"
     polyA_site      5275
                     /gene="CCP110"
                     /gene_synonym="Cep110; CP110"
                     /note="major polyA site"
ORIGIN      
        1 gcagcctgag atccgtaata tggcggggag gaggaggaga aggcggcggc ggaccgagct
       61 gcgctctgtc agtaccattt gagccattcg cttcctgaca aggcccgtgg cgaggggaga
      121 ggagctgaag gggccgtggg ggatcagtgt gactgtggga agatggagga gtatgagaag
      181 ttctgtgaaa aaagtcttgc cagaatacaa gaagcatcac tatccacaga gagctttctc
      241 cctgctcagt ctgaaagtat ctcacttatt cgctttcatg gagtggctat cctttctcca
      301 ctgcttaaca ttgagaaaag aaaggaaatg caacaagaaa agcagaaagc acttgatgta
      361 gaagcaagaa agcaggttaa caggaagaaa gctttactga ctcgtgtcca ggagattctt
      421 gacaatgttc aggttagaaa agcacctaat gccagtgatt ttgatcagtg ggagatggaa
      481 acagtttact ctaattcaga agtcagaaac ttgaatgttc ctgctacatt tccaaatagc
      541 tttccaagcc atacggaaca ctctactgca gcaaagcttg ataagatagc tgggattttg
      601 ccattggata atgaggacca atgtaaaact gatggaatag acttagctag agattcagaa
      661 ggatttaatt ctccgaagca atgtgatagt tccaatatta gtcatgtaga aaatgaagct
      721 tttccaaaga cctcttcagc aaccccacaa gaaactctta tttctgatgg tcccttctca
      781 gtaaatgaac aacaggatct accacttttg gcagaagtca tcccagatcc ctatgtaatg
      841 agtcttcaga atctgatgaa aaagtcaaag gaatatatag aaagagaaca atctagacgc
      901 agtctgagag gtagtatcaa cagaattgtt aatgagagtc atttagacaa agaacatgat
      961 gctgttgaag tggctgactg tgtaaaagag aaaggccagt tgacaggcaa acactgtgtc
     1021 tcagttattc ctgacaaacc aagccttaat aaatcaaatg ttcttctcca aggtgcttcc
     1081 actcaagcaa gcagcatgag tatgccagtt ttagctagct tttcgaaagt ggacatacct
     1141 atacgaactg gccatcccac tgttctagag tctaattctg attttaaagt tattcccact
     1201 tttgttaccg aaaataatgt tatcaaaagt cttacaggtt catatgccaa attacctagt
     1261 ccagagccaa gtatgagtcc taaaatgcac cgaagacgtt ccaggacatc atcagcgtgt
     1321 catatactta taaataaccc aataaatgcc tgtgaattaa gccctaaagg aaaagaacag
     1381 gcaatggact taattattca agatactgat gaaaacacaa atgtgcccga aattatgcca
     1441 aagttaccaa ctgatttagc gggagtttgt tcaagcaagg tttatgtggg caaaaataca
     1501 tctgaagtca aagaagatgt ggttttaggt aaatcaaatc aggtatgtca atcttcagga
     1561 aatcatttag aaaataaagt tactcatgga cttgttactg tggaaggtca gttaacatcc
     1621 gatgagagag gcgcacacat aatgaacagt acctgtgctg cgatgccaaa gctgcatgaa
     1681 ccatatgcca gcagtcagtg tatagcaagt ccaaactttg gaactgtgag tggactcaag
     1741 ccagccagta tgttagagaa aaactgcagt ttgcaaacag aactgaataa gtcttatgat
     1801 gtaaaaaacc cttctccttt attgatgcaa aaccagaata cgagacagca gatggacaca
     1861 cctatggtgt cctgtggaaa tgaacaattt ttggataaca gttttgagaa agttaaacgg
     1921 agacttgatt tagatattga tggtttgcaa aaagaaaact gcccttatgt cataacaagt
     1981 ggaataactg aacaagaaag gcaacatttg ccagaaaaaa gataccctaa gggatctggc
     2041 ttcgttaaca agaataaaat gttaggaact agttccaaag aaagcgagga gttactaaaa
     2101 agcaagatgt tagcttttga agaaatgcgg aagagactag aagaacagca cgcccagcaa
     2161 ttatcactac tcatagctga gcaggaaagg gaacaagaaa gactgcaaaa ggaaatagaa
     2221 gagcaggaga aaatgttaaa agagaagaag gcaatgacag cggaagcctc tgagttggac
     2281 attaacaatg cagtggaatt agaatggaga aaaataagtg actctagttt gctggaaaca
     2341 atgctgtctc aagcggactc actccatact tcaaattcaa atagttctgg tttcacaaat
     2401 tctgccatgc aatatagctt tgtttctgca aacgaagcac cattctacct ctggggatca
     2461 tcaactagtg gcttgaccaa actctcagta acaaggcctt ttggaagagc caaaactaga
     2521 tggtctcaag tttttagtct ggaaatacaa gcaaaattta acaaaataac tgcagtggca
     2581 aaaggatttc ttactcgtag acttatgcag acagataagc tgaagcaact tcgacaaact
     2641 gtaaaagata ctatggaatt cataagaagt tttcagtcag aagcaccatt aaagagaggc
     2701 attgtttcag ctcaagatgc ttcacttcag gaaagagtgt tagctcagtt gcgagctgcc
     2761 ttgtacggta ttcatgacat attctttgta atggatgcag ctgaaagaat gtctattcta
     2821 catcatgatc gagaagttcg caaagagaaa atgctcaggc aaatggataa aatgaaaagt
     2881 ccacgagtgg ctctttcagc tgcaacacag aagtctcttg ataggaagaa atacatgaaa
     2941 gctgctgaaa tgggaatgcc aaataagaaa tttctggtta aacaaaatcc ttctgaaaca
     3001 agagtccttc agccaaacca aggacagaat gcacctgttc ataggctact tagtagacaa
     3061 gggagtatat gcaggaaaaa tccaaagaaa gcggccaaat gttgcgacaa tttaagaaga
     3121 caacattcat taggataaaa tggggggaag gattattatt catgttattt tccctgccca
     3181 agactttatt taaccctgga ctccgtttac acagacaaag tgacatcaga aggctgagca
     3241 cttatctgga tcatttggtc agtttggtaa ttcctgctcc acacccctat tttcctctta
     3301 ataatacgtt tgggtgaaga caaattagtg tttagtaatt gcatcatctc tgtgcttacc
     3361 tatacaaaca taagtttatt ttatatgccc agatgtctac agagaccctt tttgtaaatg
     3421 tcaaggacat ttggatttac ttttacagaa tattgaaaag ataagacaaa ttataaataa
     3481 gttctaaaac ataaatttaa ttcatctctg catagtgatt tttgaatttg attcaaaggg
     3541 aaattattgc agaagaatgc ctttccctca ttttataact ttaaaaactt ggattaacca
     3601 ctcaatgtcc actttctttg acttacagta taaccatgta gccaattgtg gcccactaaa
     3661 atctacagaa gttaatgtgg gtcaccattt tggtcagaag catacattcc tgtcagacaa
     3721 ctagttgtct gacagaaatg ttaggcttca tgtatgttac cccagtactg ttagaaacat
     3781 ttgtactagg ttataagatc tttctgtgac aggtaacaaa tttggggaag acagcacaat
     3841 cttcttgaat gtagctcttg ggaatgcatt attacatcca tttctgtaac ataataatat
     3901 gttgcatgca gttatatttt ctatttagtc tgtatatttt gttcttcata gtctgttttt
     3961 tctagcatgc ttgatttagg agagaataaa gggctatata ataataaatc cagatttccg
     4021 gataagaata ttgcctggtt aaaattctgc attgcttaaa gacacccatg tttaagattt
     4081 ttcatcacta acatatccat taaaagtatc aactggccag gcagggtggc tcacgcctgt
     4141 actcccagca ttttgtgagg ccaaggtggg tggatcacct gaggtcagga gtttgagacc
     4201 agcctgacca aacatggcga aaccccatct gtactgaaaa tacaaaaatt aggcatggtg
     4261 gtgcatgcct gtagttccag ctacttggga ggctgagaca ggcgaattgc ttgaacctgg
     4321 gaggcagagg ttgcagtgag ctgagactgt gccattgcac tccagtcggg ttaacagagc
     4381 aagacactgt ctcaaaaaaa aaaaaaaaaa aaagtatcaa ccaacaaatg ttaccaagat
     4441 aacgtgactt catgagggag aatgtcacta ttaatttatc ataccatttc caaaaagggc
     4501 tttgtgcttt tcacataaaa ttgagacagt gtatatttaa tctaatttaa attttaaaga
     4561 gatactggta ttttgaaaat gcaacctata tatattctta atatcctttt aagaatatgg
     4621 agatgaagat tgttttctcc aattttctgt gccattttaa atttaacttt gacatccagc
     4681 tatagacaga aataataagc caccctgggt gtaaacttga ttttctttat tgagatgtat
     4741 catgtattga atgagtgaac cagaaaatta gaagatggtc aaaaaaagtc caagttacca
     4801 attttttaaa atttataggc aaagtatcaa attgtcttct taatatgata aactgtgctt
     4861 tatcattctg aaaactcagg atacagctta ttcatagcat tgtgggtctc tccagtaaga
     4921 aagatgctaa aagttttgtg cactttttgt gtgtgtaatg caaattagtt aaaacaaata
     4981 gttttggaga aagttaaaac tagctttaga gtaaggatga gaaacttgag tgtttttaat
     5041 ttaaagataa aagcctgtgt tttacacatt cttttttggt gttcatagct tcttctcata
     5101 caggtgccag acactgtttg tgcttttgat ggatttttat ttatatactt tttttgctta
     5161 tttttacttt gagtggaatg ttcattaatg taaattgtat ttatttttat acttttattt
     5221 tcactagttt tgcttctagg caaaaagcaa aataaacttt tcatcttaaa gaaaa
//
