LOCUS       NM_001330218            3813 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens cyclin Y like 1 (CCNYL1), transcript variant 3, mRNA.
ACCESSION   NM_001330218 XM_005246343
VERSION     NM_001330218.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3813)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3813)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   3  (bases 1 to 3813)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3813)
  AUTHORS   Zi,Z., Zhang,Z., Li,Q., An,W., Zeng,L., Gao,D., Yang,Y., Zhu,X.,
            Zeng,R., Shum,W.W. and Wu,J.
  TITLE     CCNYL1, but Not CCNY, Cooperates with CDK16 to Regulate
            Spermatogenesis in Mouse
  JOURNAL   PLoS Genet 11 (8), e1005485 (2015)
   PUBMED   26305884
  REMARK    Erratum:[PLoS Genet. 2019 Mar 4;15(3):e1008021. doi:
            10.1371/journal.pgen.1008021.. PMID: 30830908]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3813)
  AUTHORS   Mikolcevic,P., Sigl,R., Rauch,V., Hess,M.W., Pfaller,K.,
            Barisic,M., Pelliniemi,L.J., Boesl,M. and Geley,S.
  TITLE     Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin
            Y and is essential for spermatogenesis
  JOURNAL   Mol Cell Biol 32 (4), 868-879 (2012)
   PUBMED   22184064
REFERENCE   6  (bases 1 to 3813)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC096772.3.
            
            On Feb 27, 2020 this sequence version replaced NM_001330218.1.
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (3).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1538749.1,
                                           SRR14038194.427438.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295414.8/ ENSP00000295414.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-477               AC096772.3         32688-33164
            478-552             AC096772.3         45848-45922
            553-587             AC096772.3         47890-47924
            588-688             AC096772.3         54995-55095
            689-724             AC096772.3         58459-58494
            725-776             AC096772.3         61703-61754
            777-896             AC096772.3         63271-63390
            897-1063            AC096772.3         68095-68261
            1064-1226           AC096772.3         72005-72167
            1227-3813           AC096772.3         74636-77222
FEATURES             Location/Qualifiers
     source          1..3813
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.3"
     gene            1..3813
                     /gene="CCNYL1"
                     /note="cyclin Y like 1"
                     /db_xref="GeneID:151195"
                     /db_xref="HGNC:HGNC:26868"
                     /db_xref="MIM:620559"
     exon            1..477
                     /gene="CCNYL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..1337
                     /gene="CCNYL1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     cyclin-Y-like protein 1"
                     /codon_start=1
                     /product="cyclin-Y-like protein 1 isoform 3"
                     /protein_id="NP_001317147.1"
                     /db_xref="CCDS:CCDS82564.1"
                     /db_xref="GeneID:151195"
                     /db_xref="HGNC:HGNC:26868"
                     /db_xref="MIM:620559"
                     /translation="MGNTLTCCVSPNASPKLGRRAGSAELYCASDIYEAVSGDAVAVA
                     PAVVEPAELDFGEGEGHHLQHISDREMPEDLALESNPSDHPRASTIFLSKSQTDVREK
                     RKSNHLNHVSPGQLTKKYSSCSTIFLDDSTVSQPNLRTTVKCVTLAIYYHIKNRDANR
                     SLDIFDERSHPLTREKVPEEYFKHDPEHKFIYRFVRTLFSAAQLTAECAIVTLVYLER
                     LLTYAEIDICPTNWKRIVLGAILLASKVWDDQAVWNVDYCQILKDITVEDMNEMERHF
                     LELLQFNINVPASVYAKYYFDLRSLADDNNLNFLFAPLSKERAQNLEAISRLCEDKDL
                     CRAAMRRSFSADNFIGIQRSKAILS"
     exon            478..552
                     /gene="CCNYL1"
                     /inference="alignment:Splign:2.1.0"
     exon            553..587
                     /gene="CCNYL1"
                     /inference="alignment:Splign:2.1.0"
     exon            588..688
                     /gene="CCNYL1"
                     /inference="alignment:Splign:2.1.0"
     exon            689..724
                     /gene="CCNYL1"
                     /inference="alignment:Splign:2.1.0"
     exon            725..776
                     /gene="CCNYL1"
                     /inference="alignment:Splign:2.1.0"
     exon            777..896
                     /gene="CCNYL1"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1063
                     /gene="CCNYL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1226
                     /gene="CCNYL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..3813
                     /gene="CCNYL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3791..3796
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNYL1"
                     /note="hexamer: AATAAA"
     polyA_site      3813
                     /gene="CCNYL1"
                     /note="major polyA site"
ORIGIN      
        1 gcagacgagt cagcttaagg gaggcggcgg cagcgcggcg gtgggggtgc ggccgaggcc
       61 cgagccctgc ccggggccgg gccgcggggc gggcgggcga accgcgggcg aggcggcgtc
      121 tgcttgcgcg gtgcagcccc agcgtagccc ggggctgccg gtgccggccg cgccattgtt
      181 gggggagggg gcggctgttg agggcggcgg agtagggggc gagcgaaggc ggtggcagag
      241 aggagcggag gcttcccatg gggaacacgc tgacctgttg cgtgtccccc aatgccagcc
      301 ccaagctggg ccggcgcgcg gggtcggcgg agctgtactg cgcgtccgac atctacgagg
      361 cggtgtccgg ggacgcggtg gcggtagcgc ccgctgtggt ggagcctgcc gagttggatt
      421 tcggagaggg cgagggccac cacctgcagc acatcagcga ccgcgagatg cccgaagatt
      481 tagctttgga gtcaaaccct tctgaccatc caagggcaag cacaattttc ctgagcaaat
      541 ctcaaacgga tgtgcgagaa aagaggaaga gcaaccattt gaaccatgta tctccagggc
      601 agcttactaa aaagtatagc tcatgctcaa caatatttct agatgacagc acagtcagcc
      661 agcctaatct tagaaccaca gtaaaatgtg tgaccttagc aatatattac cacataaaga
      721 acagagatgc aaatagatcc ctggatattt ttgatgagag atcacatcca cttacacgag
      781 aaaaagttcc agaggaatac tttaagcatg atcctgagca caaatttatt tacagatttg
      841 ttcgtactct ttttagtgct gcacagctaa cagctgaatg tgcaatagta actttggttt
      901 acttagaaag gcttttaact tatgctgaaa tcgacatttg tcccaccaac tggaaaagga
      961 ttgttctggg agccattctt cttgcctcca aggtttggga cgatcaggct gtatggaatg
     1021 tggactactg ccagatcctc aaggacatta cagttgagga catgaatgaa atggaaaggc
     1081 attttctgga gcttcttcag tttaatatta atgttcctgc cagtgtttat gccaaatact
     1141 actttgacct tcgctcctta gcagatgaca acaacctgaa ttttctattt gctcctctta
     1201 gcaaagaaag agcacagaac ctagaggcta tttctagatt gtgtgaagac aaagacttgt
     1261 gtagagccgc tatgagaagg tctttcagtg ctgataactt cattggtatt cagcgctcta
     1321 aagccatcct ctcttaaaag gagaaatgag gggttataac gtcatgggac cttcatctac
     1381 aaagactgga gaaataccac ctttcctgct caaaaaccag caaaattagt gttttcatca
     1441 aaaggaaaga tctcaaattc aagagactca tggacaacaa ggattatact ccacaggaaa
     1501 gaatgggacc ttgtcaatgc aacaaaacac tcttctgtcc tttttaatgt aaacagagtt
     1561 acaaaaacca ctccaaagtg aaggctccca tcctacacac agatatttgc ttactgtgtg
     1621 ggccgatagc tgtgaactat gtaaggtttt ttaaacaata gtttaaattt ttagacttta
     1681 aagacactaa ccatataact tttatgtttc ttccagtttc tctccctccc cccgcatttt
     1741 gctgcatatg cctttaaaat caatgcagta ttaccattaa aacatgggac tctaactaaa
     1801 gccacttagg agcagacagc agcgttgtta ggtactgaag ggttcttcct ccctactgtt
     1861 accattgaag ctgctagtca ttggcaatca ttttaaacca aaaagctgct ggataacatt
     1921 tgtcattcat attctttgca agcattactt tagcatttta gcatgtttgg ggtcataaac
     1981 agaggaagta tcagttattg atatctactt ctattggagt ccatgttgca tttcttgtga
     2041 actataaatg gtgcttctca ttttctgata atttttctct tgctaaataa atgtattaaa
     2101 agatattttc ataatgccaa ccaacatggt ggttcagtga cgatgagaaa aagtgaagca
     2161 gttttaagct tgaatatagt ttgggccctc caaggcactg cagcatgagt ataaatgcta
     2221 taaaccttta aaaaacatga tttgaaagtt ttttgttttg ttttgtttgt ttttaaagag
     2281 atgggggtct tactgcgttg tccaggctgg agtgcagtgg cttttcacag gtgcaatcat
     2341 tgtgcactca ctgcagccta gaacttcctg gtctcaagcc atcctctagc ctcagccaca
     2401 caagtagctg ggactacaag tgcaactggc acctgtctcc tgaatattaa gcttttaatt
     2461 ttttgtttcg gtcactcttg atagcagaca ttgactgaaa caaaaaatta aaagctttat
     2521 attcaaaatt tgcaaaatga agctgggtgt ggtggtgcac gcctatagtc ccagctactt
     2581 gggaggctga ggctggagga ttgcttgagg tcaagtattg gaggctgcag tgtaccatga
     2641 tggtgcctat aggaatagct actacactcc aacctggaca acgttatcaa gaccccatct
     2701 cttagaaaaa tgcaaaatta aatgcaaaag aaatgggctg ggcatagtga ttcatgcctg
     2761 taatctcagt accctgggag gctgaggtgg aaggattgct tgagtgcagg agttcaagac
     2821 cagtctaggc aacatagtga gaccctgcct gtaaaaaaaa ataataaaaa tagttggata
     2881 tggtggcatg tgtctgtagt cccagccact ctggaggcta aggtgggagg atcagtagag
     2941 cccaggaggt caaggctgca gtgggccatg atcatgtcac tgctctccaa cctgggcgac
     3001 atccagaccc tgtctcaaag aaaaaagcag aagaaaaatg ttcagacaag gttttgtaaa
     3061 ggtttgtagc atttatattt ctacaagtat caaagcttaa aattacactg aacttttgga
     3121 ataccttgta tctccataaa atgccctctt tttaaaagta gttacccgca gagctgtgct
     3181 ctatatgctt tgattaccgc agtttcttta aaggaagatt ttgaagagca gtgttaatta
     3241 acatgtaata aaaggaattg gaccctaatt atagaaggtg atatgaacag ctgttttatc
     3301 atcctacatg ctaccaagct gtaggtgtcc cattaagtcc tgctatttaa gaaatactta
     3361 cataaccctt aggaactctt caggctttaa aaggcaagga gcaaataatt ttaggagacc
     3421 gataatgtca cctaaatttg aaatactaag aagaggttag tgttctcaac tatgtgaaat
     3481 ctgtttctcc tactttctca aatctaatcc taggaatctt gcttataaac aaagcatttc
     3541 tgggacagga gtacttcctc tattatagca atgcttcaca tcatattgtg ctgcagtttc
     3601 catcattttt aaaggacaga gacataaatg ataaataatg gtatacaaat attacaatct
     3661 accacctcaa aaaaacaaat attgtttatg gaattcagag tttggagatt caagtattga
     3721 ttgcagtttt attttgaaaa gaatgctaca atttatgtgg tttttatttc tcatgtttat
     3781 attaaaagct aataaactct attttaatta aaa
//
