LOCUS       NM_145012               5068 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens cyclin Y (CCNY), transcript variant 1, mRNA.
ACCESSION   NM_145012
VERSION     NM_145012.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5068)
  AUTHORS   Opacka,A., Zuryn,A., Krajewski,A. and Mikolajczyk,K.
  TITLE     The role of cyclin Y in normal and pathological cells
  JOURNAL   Cell Cycle 22 (8), 859-869 (2023)
   PUBMED   36576166
  REMARK    GeneRIF: The role of cyclin Y in normal and pathological cells.
            Review article
REFERENCE   2  (bases 1 to 5068)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5068)
  AUTHORS   Chen,L., Wang,X., Cheng,H., Zhang,W., Liu,Y., Zeng,W., Yu,L.,
            Huang,C. and Liu,G.
  TITLE     Cyclin Y binds and activates CDK4 to promote the G1/S phase
            transition in hepatocellular carcinoma cells via Rb signaling
  JOURNAL   Biochem Biophys Res Commun 533 (4), 1162-1169 (2020)
   PUBMED   33039146
  REMARK    GeneRIF: Cyclin Y binds and activates CDK4 to promote the G1/S
            phase transition in hepatocellular carcinoma cells via Rb
            signaling.
REFERENCE   4  (bases 1 to 5068)
  AUTHORS   Kyselova,A., Siragusa,M., Anthes,J., Solari,F.A., Loroch,S.,
            Zahedi,R.P., Walter,U., Fleming,I. and Randriamboavonjy,V.
  TITLE     Cyclin Y is expressed in Platelets and Modulates Integrin
            Outside-in Signaling
  JOURNAL   Int J Mol Sci 21 (21), 8239 (2020)
   PUBMED   33153214
  REMARK    GeneRIF: Cyclin Y is expressed in Platelets and Modulates Integrin
            Outside-in Signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5068)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   6  (bases 1 to 5068)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 5068)
  AUTHORS   Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
            Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
            Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
  TITLE     Proteomic, functional, and domain-based analysis of in vivo 14-3-3
            binding proteins involved in cytoskeletal regulation and cellular
            organization
  JOURNAL   Curr Biol 14 (16), 1436-1450 (2004)
   PUBMED   15324660
REFERENCE   8  (bases 1 to 5068)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   9  (bases 1 to 5068)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   10 (bases 1 to 5068)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL117336.22, AF413522.1, BC094815.2, AL121749.14 and AA476431.1.
            
            On Nov 22, 2018 this sequence version replaced NM_145012.5.
            
            Summary: Cyclins, such as CCNY, control cell division cycles and
            regulate cyclin-dependent kinases (e.g., CDC2; MIM 116940) (Li et
            al., 2009 [PubMed 18060517]).[supplied by OMIM, May 2009].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL834355.1, SRR1803614.55512.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374704.8/ ENSP00000363836.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-365               AL117336.22        129656-130020
            366-531             AF413522.1         1-166
            532-2129            BC094815.2         1-1598
            2130-4965           AL121749.14        59902-62737
            4966-5068           AA476431.1         9-111               c
FEATURES             Location/Qualifiers
     source          1..5068
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p11.21"
     gene            1..5068
                     /gene="CCNY"
                     /gene_synonym="C10orf9; CBCP1; CCNX; CFP1"
                     /note="cyclin Y"
                     /db_xref="GeneID:219771"
                     /db_xref="HGNC:HGNC:23354"
                     /db_xref="MIM:612786"
     exon            1..699
                     /gene="CCNY"
                     /gene_synonym="C10orf9; CBCP1; CCNX; CFP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             546..1571
                     /gene="CCNY"
                     /gene_synonym="C10orf9; CBCP1; CCNX; CFP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cyclin fold protein 1; cyclin-box carrying protein 1;
                     cyc-Y; cyclin box protein 1; cyclin-X"
                     /codon_start=1
                     /product="cyclin-Y isoform 1"
                     /protein_id="NP_659449.3"
                     /db_xref="CCDS:CCDS7189.1"
                     /db_xref="GeneID:219771"
                     /db_xref="HGNC:HGNC:23354"
                     /db_xref="MIM:612786"
                     /translation="MGNTTSCCVSSSPKLRRNAHSRLESYRPDTDLSREDTGCNLQHI
                     SDRENIDDLNMEFNPSDHPRASTIFLSKSQTDVREKRKSLFINHHPPGQIARKYSSCS
                     TIFLDDSTVSQPNLKYTIKCVALAIYYHIKNRDPDGRMLLDIFDENLHPLSKSEVPPD
                     YDKHNPEQKQIYRFVRTLFSAAQLTAECAIVTLVYLERLLTYAEIDICPANWKRIVLG
                     AILLASKVWDDQAVWNVDYCQILKDITVEDMNELERQFLELLQFNINVPSSVYAKYYF
                     DLRSLAEANNLSFPLEPLSRERAHKLEAISRLCEDKYKDLRRSARKRSASADNLTLPR
                     WSPAIIS"
     exon            700..774
                     /gene="CCNY"
                     /gene_synonym="C10orf9; CBCP1; CCNX; CFP1"
                     /inference="alignment:Splign:2.1.0"
     exon            775..809
                     /gene="CCNY"
                     /gene_synonym="C10orf9; CBCP1; CCNX; CFP1"
                     /inference="alignment:Splign:2.1.0"
     exon            810..910
                     /gene="CCNY"
                     /gene_synonym="C10orf9; CBCP1; CCNX; CFP1"
                     /inference="alignment:Splign:2.1.0"
     exon            911..946
                     /gene="CCNY"
                     /gene_synonym="C10orf9; CBCP1; CCNX; CFP1"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1004
                     /gene="CCNY"
                     /gene_synonym="C10orf9; CBCP1; CCNX; CFP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1124
                     /gene="CCNY"
                     /gene_synonym="C10orf9; CBCP1; CCNX; CFP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1291
                     /gene="CCNY"
                     /gene_synonym="C10orf9; CBCP1; CCNX; CFP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1454
                     /gene="CCNY"
                     /gene_synonym="C10orf9; CBCP1; CCNX; CFP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..5068
                     /gene="CCNY"
                     /gene_synonym="C10orf9; CBCP1; CCNX; CFP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3707..3712
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNY"
                     /gene_synonym="C10orf9; CBCP1; CCNX; CFP1"
                     /note="hexamer: ATTAAA"
     polyA_site      3726
                     /gene="CCNY"
                     /gene_synonym="C10orf9; CBCP1; CCNX; CFP1"
                     /note="major polyA site"
     regulatory      4171..4176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNY"
                     /gene_synonym="C10orf9; CBCP1; CCNX; CFP1"
                     /note="hexamer: ATTAAA"
     polyA_site      4196
                     /gene="CCNY"
                     /gene_synonym="C10orf9; CBCP1; CCNX; CFP1"
                     /note="major polyA site"
     regulatory      4299..4304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNY"
                     /gene_synonym="C10orf9; CBCP1; CCNX; CFP1"
                     /note="hexamer: AATAAA"
     regulatory      4320..4325
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNY"
                     /gene_synonym="C10orf9; CBCP1; CCNX; CFP1"
                     /note="hexamer: AATATA"
     polyA_site      4325
                     /gene="CCNY"
                     /gene_synonym="C10orf9; CBCP1; CCNX; CFP1"
     polyA_site      4337
                     /gene="CCNY"
                     /gene_synonym="C10orf9; CBCP1; CCNX; CFP1"
     regulatory      5050..5055
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNY"
                     /gene_synonym="C10orf9; CBCP1; CCNX; CFP1"
                     /note="hexamer: AATATA"
     polyA_site      5068
                     /gene="CCNY"
                     /gene_synonym="C10orf9; CBCP1; CCNX; CFP1"
ORIGIN      
        1 atcctccctg gccgcgccgc accgcgccgc gaggagtccg ggggctgcgc ccacgcccgc
       61 tgcccgcccg ctcgtcggct agtcccgccg tccggcgcgg acacgcgtgc ccccggcttg
      121 aaccggaacc tcttgccgag gcggccgccg tcgccgcagc cgccggggaa gcggacacca
      181 actggggaag cgcggggggg aggcggcctg cgcggcgccg cccgccatgg ccgcggcggg
      241 gtgaggtagg cgcggcggcc gcagtcgcgc ggacccgagc gctcctccgc cgcggatagg
      301 ccggccgagg gggagccggg gccgtcgccc gctcgtcgcc gccgccgccg ccgccgccca
      361 tggcgaggcc ccgccgccgc cgccgctgct gacccggcgg ccggccgccg ttccgccccc
      421 tcccgtggcg gcgagcgggc gggcctcccc acacgccccc gccgcccgcg ccccgcgtcc
      481 acccgcgccc cgctcccggg gactgggaga acaggatagc agcaggagtc ggggggccgc
      541 cgaagatggg gaacactacc tcgtgctgcg tgtcgtccag tcccaagctc cggaggaatg
      601 cccactcccg gctggagtcc taccggccag acacggacct gagccgcgag gacacgggct
      661 gcaacctgca gcacatcagc gaccgggaga acatagacga tttgaacatg gaattcaatc
      721 cttcagatca tcctcgggcc agcacaatat tcctcagtaa atctcagacg gacgtgagag
      781 aaaaacgcaa gagtctcttc attaaccatc atcctccagg acaaatagca aggaaataca
      841 gttcctgctc caccattttc ctagatgata gcacagtcag tcaaccaaac ctcaagtata
      901 caattaaatg tgtcgctctt gcaatatatt atcacatcaa aaacagggac ccagatggaa
      961 ggatgctctt agatattttt gatgaaaatc ttcaccctct ttcgaaatcc gaagtgccac
     1021 cagattatga caaacacaac ccagagcaga agcagattta ccggttcgtt cggacactgt
     1081 tcagtgctgc tcagctgacg gctgaatgtg ccatcgtcac cctggtgtac cttgaaagac
     1141 ttttaacata cgcagagata gatatctgtc cggccaactg gaagcggatt gttttagggg
     1201 cgatcctgct ggcctccaag gtgtgggatg accaggctgt atggaatgtg gattactgcc
     1261 agatcctgaa agacatcacg gtggaggaca tgaacgagct agagcgacag tttcttgaat
     1321 tgctgcagtt caacatcaat gttccttcca gtgtctatgc caagtattat tttgatcttc
     1381 gttctctggc agaagcgaac aacctgagct ttcccttgga gcccctgagc agggagaggg
     1441 ctcacaagct tgaggccatc tctcgcctct gcgaggacaa gtacaaggac ctaagaagat
     1501 ccgcgaggaa gcgctcagcc agtgcagaca acctgactct gccccggtgg tccccagcca
     1561 tcatctctta actacggagg cccgccggag gccacaccat cccttagttt ctcctttagt
     1621 ttgagaaaag acagacttgg ggtgggtttg tttttgtttt ttctttcctt ttcttttttt
     1681 acgcatagct ccgtcaagct gcctggatga gcgcccatgc agcaaggctt ggaggaagcg
     1741 tcagtgccct ggagatccca gctcgctctc cccactgtca gcaacagcac ttccttcgtg
     1801 gaggaagtgg actcgaatcc tggaggagga aataaaggga aagggaagtc gtggagaggc
     1861 agggaaaatg gttaagcagc ccggccctct ggagtcccca tgggggcggt agctgaagtt
     1921 ggcgagcgca gcggtggatg cagagctggc tgcacccagg gctgggccag tgtgtcctgt
     1981 aagacttctt gcattccttc tgctgctttt ttgggatggg ggtatttttg ttcatttgtt
     2041 tttgccctgt tttgattttg gtcccacaga gcaggggatg tagtttgtac ccaccatggc
     2101 gcagacttcc aaataaatag tactggtcat ttctctctgc actatttctg cgcgctgtct
     2161 tctgagcttt cttcctcacc agtgggctgt gcttgttcca tttctgtaca cccttatttt
     2221 ataccgtttt tcttcaacaa tggcgaaatt gactgtagtg ctgaaccaaa agtatccctt
     2281 tccctcctta ttcctcaccc caagaacatt ctagatcaca tgggtgcttg tgccttccga
     2341 ttttcttgca tttgtttttt tcctgacctg aagttgttgt tacaaaatca gtcagacttt
     2401 gtgggctgaa ggacacggtg cagcagaggg tgtccctgtg agagttctgc agagtgctgg
     2461 gcatgtgcct ggaactaccg agtaggagcc atttctttgt acccctgcct aatccattcc
     2521 tctccttcca agtccattgt tgcaagcaat attcttctca atttttatat gtttacttta
     2581 aatcaaagtt agtctatttg tataaaattt ttaaaaaatc taaaagaaaa agaaaaaaaa
     2641 caagggtggg ttgggtattc cagtgggaag atcattgaag ggaaaaatgt tactatttac
     2701 tgaggtattt ttcacagaat gattgaatta aaaaaaactc aacttgcatt ttcattgtgg
     2761 gtgcttagag aagttctaca aaattcaaac tgtgaaggtt tatgcttcat taattatgac
     2821 catacttttt cattttctga cgatccctga tttccttatg gactcaataa gaatctttta
     2881 tatcaagtaa aatgaaagtt gatgatagaa tatcaaatag tgaatttgat atgaaatcta
     2941 agagtgtgag tcacttgcat atgtaatgct ttgggttttt gcatattttc ttaggtcaca
     3001 gtgacaggtt tctgagttgt ttcccttttc aagtctctgg gaggccagtg gcagcagcag
     3061 gtctgtgttt caccttcttc ccatgtgagc ttggaaaact ttggcatctt aattagtctt
     3121 gaatcataca cctgatcccc aaacattgcc tgctctcaat gaaacatgct ttggaaatgg
     3181 aagggactca gaaagtcgaa atcccaagaa ctccaagcca aaagtgttag gttttagtga
     3241 aatttgtgtc aggtataagc atacctgttt gggccagaat tattatcaca gcctttctga
     3301 cccaaacttt caaaagcaaa taaacagcat ataaaacgtt aattatcttt ccattgtaat
     3361 tgtgatgatc tactctgtat gggtaccaaa atcaccttct ctcttcaagt caaagttgaa
     3421 tttagaactt tgaatacagg tcaaaaaatg tagaaaatat cattttatat tccctaatct
     3481 atatagctga aaaagggttg tattttctta gctgaatatg aatacctctt aaacataaat
     3541 tagttcctct ccagtgaagt atcttatttt accaatccat ttcaggaaag aggttctgct
     3601 gccgtaaagg cagaaatttt atttttatcc cttttatttg aatgagagat ttgaaaatcg
     3661 aattatgtaa atatttcaat gcatctgcta ttattttgtg gagtttatta aactacttta
     3721 aaaaaattgt atagtctatt tattgtatgt atgtacatac agtctgatac ctaaaattta
     3781 aagtggattc cataaaacca gactcaagtc ttgtttagac tactgaatac tgttttagcc
     3841 tgtgccctgg attctacctc tgtataggaa aattttccat attcattaat tagtgttgat
     3901 ctgtattaat tggttatgtt tcttgcacta aggatgttta aaactccgct gtaagtgtag
     3961 attttagttt tactggcagg atgaatcact tgacacatag gtagatactt gaggttcatt
     4021 ttcttttctt tttctacatg atgatgaata gttatgtttt cttctctgat ttgttcaaag
     4081 tttgccaaaa gaaaacacaa aaccagtaca gtacttactg ataaatcgta gtgactgtaa
     4141 tttgtttgta aggcgaatta atgctctaca attaaagctg gattactatt gaggaacaca
     4201 ttgtcttagt gtagtttttg aatggaaagt ttttgtcatt aaggatgaag gaaacgacac
     4261 aatttgttac tttaatttta tatttgattt aaacaacaaa taaagtcatt gggacaataa
     4321 atatatatcc cgatgaatct ttttgatttg ttttactttt cttatttttt tttttttaac
     4381 tagaaaaagg gaaagaagaa gtcaggagtt taaaaccaaa ttggagggca gatgagaaat
     4441 cctgccaaga tcgggatgtg ccttcatgca tgaggtgagg ccagaggtgt gggcacctgt
     4501 acctgcctcc tcttctgggc tggctttcct gtctgcctgc tctcgggctt gggcagagcc
     4561 atctccatcc tggggtttcc tttaagctaa gctgaaagca aaatttgggg agtgaatgat
     4621 ttaaactttt cctgctgctt ttggtaactt ctcacctggg gccatatttt acagatttga
     4681 attttttttt ttcttttttt gagatggagt ctcgctcttg tcacccaggc tggtgtgcaa
     4741 tggtgcgatc tgggctcact gcaaccccca cttcccggat tcaagcaatt ctgcctcagc
     4801 ctcccgagta gctaggatca caggcaccca ccaccatgcc cagctgattt ttgtagtttt
     4861 agtagagaca gagtttcacc acgttggcca ggctggtctc aaactcctga cctcaagtga
     4921 tccacccccc tcagcctccc aaagtgctga gattacaggc gtgagccact gcccctggcc
     4981 cagatttgaa attttttaaa aataaaacat gattcttggt tattgtaggt atttaataaa
     5041 tgttaaataa atatatacat agaacaaa
//
