LOCUS       NM_058241               6920 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens cyclin T2 (CCNT2), transcript variant b, mRNA.
ACCESSION   NM_058241
VERSION     NM_058241.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6920)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 6920)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 6920)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   4  (bases 1 to 6920)
  AUTHORS   Wang,F., Zhao,Q.H., Liu,J.Z. and Kong,D.L.
  TITLE     MiRNA-188-5p alleviates the progression of osteosarcoma via target
            degrading CCNT2
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (1), 29-35 (2020)
   PUBMED   31957815
  REMARK    GeneRIF: MiRNA-188-5p alleviates the progression of osteosarcoma
            via target degrading CCNT2.
REFERENCE   5  (bases 1 to 6920)
  AUTHORS   Ke,S., Li,R.C., Lu,J., Meng,F.K., Feng,Y.K. and Fang,M.H.
  TITLE     MicroRNA-192 regulates cell proliferation and cell cycle transition
            in acute myeloid leukemia via interaction with CCNT2
  JOURNAL   Int J Hematol 106 (2), 258-265 (2017)
   PUBMED   28409330
  REMARK    GeneRIF: miR-192 inhibits cell proliferation and induces G0/G1 cell
            cycle arrest in AML by regulating the expression of CCNT2.
REFERENCE   6  (bases 1 to 6920)
  AUTHORS   Napolitano,G., Licciardo,P., Gallo,P., Majello,B., Giordano,A. and
            Lania,L.
  TITLE     The CDK9-associated cyclins T1 and T2 exert opposite effects on
            HIV-1 Tat activity
  JOURNAL   AIDS 13 (12), 1453-1459 (1999)
   PUBMED   10465067
REFERENCE   7  (bases 1 to 6920)
  AUTHORS   Bieniasz,P.D., Grdina,T.A., Bogerd,H.P. and Cullen,B.R.
  TITLE     Analysis of the effect of natural sequence variation in Tat and in
            cyclin T on the formation and RNA binding properties of Tat-cyclin
            T complexes
  JOURNAL   J Virol 73 (7), 5777-5786 (1999)
   PUBMED   10364329
REFERENCE   8  (bases 1 to 6920)
  AUTHORS   Kwak,Y.T., Ivanov,D., Guo,J., Nee,E. and Gaynor,R.B.
  TITLE     Role of the human and murine cyclin T proteins in regulating HIV-1
            tat-activation
  JOURNAL   J Mol Biol 288 (1), 57-69 (1999)
   PUBMED   10329126
REFERENCE   9  (bases 1 to 6920)
  AUTHORS   Wimmer,J., Fujinaga,K., Taube,R., Cujec,T.P., Zhu,Y., Peng,J.,
            Price,D.H. and Peterlin,B.M.
  TITLE     Interactions between Tat and TAR and human immunodeficiency virus
            replication are facilitated by human cyclin T1 but not cyclins T2a
            or T2b
  JOURNAL   Virology 255 (1), 182-189 (1999)
   PUBMED   10049833
REFERENCE   10 (bases 1 to 6920)
  AUTHORS   Peng,J., Zhu,Y., Milton,J.T. and Price,D.H.
  TITLE     Identification of multiple cyclin subunits of human P-TEFb
  JOURNAL   Genes Dev 12 (5), 755-762 (1998)
   PUBMED   9499409
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK294889.1, AK292913.1 and
            AC016725.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_058241.2.
            
            Summary: The protein encoded by this gene belongs to the highly
            conserved cyclin family, whose members are characterized by a
            dramatic periodicity in protein abundance through the cell cycle.
            Cyclins function as regulators of CDK kinases. Different cyclins
            exhibit distinct expression and degradation patterns which
            contribute to the temporal coordination of each mitotic event. This
            cyclin and its kinase partner CDK9 were found to be subunits of the
            transcription elongation factor p-TEFb. The p-TEFb complex
            containing this cyclin was reported to interact with, and act as a
            negative regulator of human immunodeficiency virus type 1 (HIV-1)
            Tat protein. A pseudogene of this gene is found on chromosome 1.
            Alternate splicing results in multiple transcript
            variants.[provided by RefSeq, Dec 2010].
            
            Transcript Variant: This variant (b) contains an additional
            internal fragment in the 3' coding region, which results in a
            frameshift, compared to variant a. The resulting isoform (b) is
            longer and has a distinct C-terminus, compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.129851.1,
                                           SRR1660809.130149.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264157.10/ ENSP00000264157.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AK294889.1         1-8
            9-2654              AK292913.1         1-2646
            2655-6920           AC016725.5         117202-121467
FEATURES             Location/Qualifiers
     source          1..6920
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q21.3"
     gene            1..6920
                     /gene="CCNT2"
                     /gene_synonym="CYCT2"
                     /note="cyclin T2"
                     /db_xref="GeneID:905"
                     /db_xref="HGNC:HGNC:1600"
                     /db_xref="MIM:603862"
     exon            1..191
                     /gene="CCNT2"
                     /gene_synonym="CYCT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..2226
                     /gene="CCNT2"
                     /gene_synonym="CYCT2"
                     /note="isoform b is encoded by transcript variant b;
                     cyclin T2a; cyclin T2b; SDS-stable vimentin-bound DNA
                     fragment HEF42VIM22; subunit of positive elongation
                     transcription factor b"
                     /codon_start=1
                     /product="cyclin-T2 isoform b"
                     /protein_id="NP_490595.1"
                     /db_xref="CCDS:CCDS2174.1"
                     /db_xref="GeneID:905"
                     /db_xref="HGNC:HGNC:1600"
                     /db_xref="MIM:603862"
                     /translation="MASGRGASSRWFFTREQLENTPSRRCGVEADKELSCRQQAANLI
                     QEMGQRLNVSQLTINTAIVYMHRFYMHHSFTKFNKNIISSTALFLAAKVEEQARKLEH
                     VIKVAHACLHPLEPLLDTKCDAYLQQTQELVILETIMLQTLGFEITIEHPHTDVVKCT
                     QLVRASKDLAQTSYFMATNSLHLTTFCLQYKPTVIACVCIHLACKWSNWEIPVSTDGK
                     HWWEYVDPTVTLELLDELTHEFLQILEKTPNRLKKIRNWRANQAARKPKVDGQVSETP
                     LLGSSLVQNSILVDSVTGVPTNPSFQKPSTSAFPAPVPLNSGNISVQDSHTSDNLSML
                     ATGMPSTSYGLSSHQEWPQHQDSARTEQLYSQKQETSLSGSQYNINFQQGPSISLHSG
                     LHHRPDKISDHSSVKQEYTHKAGSSKHHGPISTTPGIIPQKMSLDKYREKRKLETLDL
                     DVRDHYIAAQVEQQHKQGQSQAASSSSVTSPIKMKIPIANTEKYMADKKEKSGSLKLR
                     IPIPPTDKSASKEELKMKIKVSSSERHSSSDEGSGKSKHSSPHISRDHKEKHKEHPSS
                     RHHTSSHKHSHSHSGSSSGGSKHSADGIPPTVLRSPVGLSSDGISSSSSSSRKRLHVN
                     DASHNHHSKMSKSSKSSGSSSSSSSSVKQYISSHNSVFNHPLPPPPPVTYQVGYGHLS
                     TLVKLDKKPVETNGPDANHEYSTSSQHMDYKDTFDMLDSLLSAQGMNM"
     exon            192..273
                     /gene="CCNT2"
                     /gene_synonym="CYCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            274..402
                     /gene="CCNT2"
                     /gene_synonym="CYCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            403..463
                     /gene="CCNT2"
                     /gene_synonym="CYCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            464..526
                     /gene="CCNT2"
                     /gene_synonym="CYCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            527..572
                     /gene="CCNT2"
                     /gene_synonym="CYCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            573..736
                     /gene="CCNT2"
                     /gene_synonym="CYCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            737..807
                     /gene="CCNT2"
                     /gene_synonym="CYCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            808..6920
                     /gene="CCNT2"
                     /gene_synonym="CYCT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4568..4573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNT2"
                     /gene_synonym="CYCT2"
                     /note="hexamer: ATTAAA"
     polyA_site      4595
                     /gene="CCNT2"
                     /gene_synonym="CYCT2"
                     /note="major polyA site"
     regulatory      4955..4960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNT2"
                     /gene_synonym="CYCT2"
                     /note="hexamer: ATTAAA"
     polyA_site      4983
                     /gene="CCNT2"
                     /gene_synonym="CYCT2"
                     /note="major polyA site"
     regulatory      6895..6900
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNT2"
                     /gene_synonym="CYCT2"
                     /note="hexamer: AATAAA"
     polyA_site      6920
                     /gene="CCNT2"
                     /gene_synonym="CYCT2"
                     /note="major polyA site"
ORIGIN      
        1 gtgaatgaag gagcgggcgg aggaggaagt gtcatggcgt cgggccgtgg agcttcttct
       61 cgctggttct ttactcggga acagctggag aacacgccga gccgccgctg cggagtggag
      121 gcggataaag agctctcgtg ccgccagcag gcggccaacc tcatccagga gatgggacag
      181 cgtctcaatg tctctcagct tacaataaac actgcgattg tttatatgca caggttttat
      241 atgcaccatt ctttcaccaa attcaacaaa aatataatat cgtctactgc attatttttg
      301 gctgcaaaag tggaagaaca ggctcgaaaa cttgaacatg ttatcaaagt agcacatgct
      361 tgtcttcatc ctctagagcc actgctggat actaaatgtg atgcttacct tcaacagact
      421 caagaactgg ttatacttga aaccataatg ctacaaactc taggttttga gatcaccatt
      481 gaacacccac acacagatgt ggtgaaatgt acccagttag taagagcaag caaggatttg
      541 gcacagacat cctatttcat ggctaccaac agtctgcatc ttacaacctt ctgtcttcag
      601 tacaaaccaa cagtgatagc atgtgtatgc attcatttgg cttgcaaatg gtccaattgg
      661 gagatccctg tatcaactga tggaaagcat tggtgggaat atgtggatcc tacagttact
      721 ctagaattat tagatgagct aacacatgag tttctacaaa tattggagaa aacgcctaat
      781 aggttgaaga agattcgaaa ctggagggct aatcaggcag ctaggaaacc aaaagtagat
      841 ggacaggtat cagagacacc acttcttggt tcatctttgg tccagaattc cattttagta
      901 gatagtgtca ctggtgtgcc tacaaaccca agttttcaga aaccatctac atcagcattc
      961 cctgcgccag tacctctaaa ttcaggaaat atttctgttc aagacagcca tacatctgat
     1021 aatttgtcaa tgctagcaac aggaatgcca agtacttcat acggtttatc atcacaccag
     1081 gaatggcctc aacatcaaga ctcagcaagg acagaacagc tatattcaca gaaacaggag
     1141 acatctttgt ctggtagcca gtacaacatc aacttccagc agggaccttc tatatcactg
     1201 cattcaggat tacatcacag acctgacaaa atttcagatc attcttctgt taagcaagaa
     1261 tatactcata aagcagggag cagtaaacac catgggccaa tttccactac tccaggaata
     1321 attcctcaga aaatgtcttt agataaatat agagaaaagc gtaaactaga aactcttgat
     1381 ctcgatgtaa gggatcatta tatagctgcc caggtagaac agcagcacaa acaagggcag
     1441 tcacaggcag ccagcagcag ttctgttact tctcccatta aaatgaaaat acctatcgca
     1501 aatactgaaa aatacatggc agacaaaaag gaaaagagtg ggtcactgaa attacggatt
     1561 ccaataccac ccactgataa aagcgccagt aaagaagaac tgaaaatgaa aataaaagtt
     1621 tcttcttcag aaagacacag ctcttctgat gaaggcagtg ggaagagcaa acattcaagc
     1681 ccacatatta gcagagacca taaggagaag cacaaggagc atccttcaag ccgccaccac
     1741 accagcagcc acaagcattc ccactcgcat agtggcagca gcagcggtgg cagtaaacac
     1801 agtgccgacg gaataccacc cactgttctg aggagtcctg ttggcctgag cagtgatggc
     1861 atttcctcta gctccagctc ttcaaggaag aggctgcatg tcaatgatgc atctcacaac
     1921 caccactcca aaatgagcaa aagttccaaa agttcaggta gttcatctag ttcttcctcc
     1981 tctgttaagc agtatatatc ctctcacaac tctgttttta accatccctt accccctcct
     2041 ccccctgtca cataccaggt gggctacgga catctcagca ccctcgtgaa actggacaag
     2101 aagccagtgg agaccaacgg tcctgatgcc aatcacgagt acagtacaag cagccagcat
     2161 atggactaca aagacacatt cgacatgctg gactcactgt taagtgccca aggaatgaac
     2221 atgtaataat ttgtttaggt caatttttcc tttacttttt taatttaaaa attgttagaa
     2281 tggaaaaatt ccttctgatc tagcagtggt aacccctgct gttgctgcca ctgcttcaat
     2341 atttgtaagt gctgctttat tcttcattct gaaaagaaga gattatagta aacaagtctt
     2401 tatctccaca tatgatagtg ttataaatac tgtaaaagca tggaaggtgc aaaactcagt
     2461 atttctacaa ttgcagctaa gaacattagg atgaatggct ggctgcttct aggaatataa
     2521 gatgcctcaa gcattcatta tttatgattt gaatactgta gctatttttt gttgcttggc
     2581 ttttgaatga gtgtaaattg ttttcttttg tgtatttata cttgtatgta tgatttgcat
     2641 gtttcaatga taaagggata aaacagtata ctgacaactg tttacaagaa agtggagaaa
     2701 aatgtacata catttttgta tgtttagata ttaccgtaaa tactcaggat tggagctgct
     2761 tgtaagtata acaatataca gaataacttt attttatctt gtcagagtcc atcactaatc
     2821 taaaacaaag gtggcacttt tttatgttaa ccttaaactc taggccttac tggaagccac
     2881 tgatagggga cacttcacta ccagatgtgt gcagtgcaac agatggtcat atacactgtg
     2941 aggcactgaa attttgcctt cagaggttct gaccagattg gctgctgaaa tagcccctaa
     3001 ctttctgaag gcttgaagag gaaaaaataa agtttacata ctcttgatgt gaagtgcatt
     3061 taaatgtttg ttggcttgtt gcagttctat gaaacagagc tgttaataat ggttatgtgg
     3121 attactgtga tttgaaaact aaattcacaa taacttacct agtagagatt tagtgagttg
     3181 tttcctttaa agaattttac actacatatt ttaatagtaa acagggatca cttttccttt
     3241 agcattcaga atgacaccat attcttaaat atactccttc cctgaagcgt gtttgtgtgt
     3301 gatgccatat ttctttttca ggtaaatgta gtcttcctta taaaaatgaa attaaaccta
     3361 tgctctcaat tcttttatat tctaacaata aataaaaaag aaaagattac tgactgtgca
     3421 ttgtacctgt atttatagtt tatggttatc aggaagctct gtaagaaaga aaaggtcagc
     3481 ctcccaggca aaccagtagt ggaggtttta catttgtttg cacatctcag tatatttctg
     3541 ttgaggtaaa gtttgcacag tcatctgact tctgatcaag cattagattt taacttgttt
     3601 agattttgtc ttaaacacca gtaatatggc tcttgtttat cagctaatct tgaatttatt
     3661 ctgtggtaaa tcttttgagt tgttgagtat atttgagatt gattggattc gacctcttgt
     3721 tgaactgaaa acttaatttt ttctctgtat ttttgttaca aagccactga tacgtgcaca
     3781 attgtaatta agtatgttgc agttgtaaat attagagttt aatctcatgc tctaccttta
     3841 tttagcaatt acctaatttg ccagtagctt tataattttt aaagataatt gttcattatt
     3901 ttgtcaatgt tatttgaact tggggtactt aggagcctct ttgtagggac tgtgcctagg
     3961 tagcatgtcc taacatttgt tctggtcttg cataacttca gtaatctttg tcattatatg
     4021 taactttgtt gctctgtatg gcataatatt gtatccataa acatggtaat tttgatacag
     4081 ttatactttt acagtggtac ataatccaag gactagtata gaattaagct gagtgcaaga
     4141 tgagggaggg aagggctttc ttggtaattt agatgtgaaa cctctacaga gctatcatgt
     4201 aaaaactaca taaggtggtt gtgctactgt ataattgggg gtgataatac caggaatttt
     4261 aataagattt tgtaaagaat atccagaaaa gtagtgaact tattttcagt agacatagaa
     4321 aacaatgtga atatttaagg tctgtgacta tagttaaact tcactaagaa tttgcagaat
     4381 tgttttgaga tgtgtgaata aaggtaattt tattgaatct tcattggtgc taatgatgga
     4441 cagttaaaaa gatagctagt gtatattgtt atgggtcagt acttattagt acttccaaaa
     4501 ttgaatttga aatgctatgt attcactttt cactctgtaa atgtaattct ttacaatgac
     4561 tttatttatt aaagggcagc cagttgtcat ttttacagga ttgtgtgagc tattcaaact
     4621 cttcaacccc tgaacagggt attaagcttc caaaataatg atggggataa atatggaaat
     4681 cctttttaag ttgtatttcc attaaacaaa aacccttata attcatacta tcatgaattt
     4741 gctttatcca tctcatttgc ataacagttc atctgtctgg tcccattagg ctctaccaaa
     4801 gaaagactct gatgagtgga cattattact gtgactcttg taagtagcca taaataaacc
     4861 aaaatagtat caaatttagg tatgaaattc cacatgtgca aagtactgtt aaggtgataa
     4921 catttttgat gagatttaaa aaaatatttg aaatattaaa aagcattatc tttaaacatc
     4981 ctataaaaga gtgagtcatt tttaagttgt gttttcccta gatcactgat ttgttacctt
     5041 tacacagaag cacattgcaa agaaaggctt tatttctacc tcttccattc agttttccaa
     5101 tattgagctg tgtccctctg aatatttgcc ttagctattt caaaataggt attttcagaa
     5161 ccaaagcaaa gggtggtttg ttcactgaaa cattcttaga ggcctactta acgggcggca
     5221 gtatccggta gtggtaaaac ctcacagttt cctaattgca ggtatgtaaa taccaaaaaa
     5281 gtcctgttgt cagccctagg tttatctttg aaagcagtta aatgtgcacc ttggtcttcc
     5341 tccgtgtgtt cagattcctt ctggttaaag ttcttattca gagtcatcta aaagaaattt
     5401 ctaacatgat gtatggtttc ttgaatgtca tgagtggctg cgtatattgc tttgtagcaa
     5461 cagattgtat taataattaa tagaatacct aatttttttg gcctatcctc tttgaactag
     5521 aaatgactac ttgagggcta tttcagagaa ccaatatgaa atgtttttgt tagtacaaaa
     5581 taccattgcc ttaaaaggtt tcaagcacat tttcttttct atttgagaac ttaaattgct
     5641 gacttgtatt cgttaagcaa ccttagaaat aaaccactgc ttatatctgc atgaatatta
     5701 tgcatttcat gagtacagtt agttgattag atatttcagg gttttgcatt ttctatagac
     5761 atggggactt ttttaacatg gtaacgtctt aggaaaacca ttctctcaag gtattacacc
     5821 atttccaatt ttatccaaat gaaaagcata tctgcttaaa tttaggatgt ctttgctgag
     5881 aatatttgga ggctcttgtt aggaagaatc atggattcag tatttctaac ctgattactg
     5941 cctcagaggc tgtcttgaag ggagacagta ggattcactg actaccttta cccagatgag
     6001 ggatcaacaa atctcacact taaactaaat gagttgacag gacaataggt gctaatctca
     6061 tgtgccctaa gatggactta tttagatagg gatttttgca ttggaaaagc agcacattct
     6121 ctgaccttgg gtaccaagct atgatactaa tttgagaatc acattctgat acgttaatat
     6181 cagaaatcag tgagcaacct aattgctgta agctgacata catggaagcc gaaatcaaaa
     6241 ggttgctttt gttagtttcc ctggagcatc tatttttgta atacattttg ccagtgggac
     6301 tgaaaagctc aaaatgtttt agacctaata tcatacatta attttctgct ctgcagtgtc
     6361 aatttgggca cagccagttt ttacctctgt ggcaccttct ttataattta ctgttaccta
     6421 ttctgcctga cagattgatt aagtaggttg ataagatcca tcgaagattg aatggctagg
     6481 agtaattctg ttctcgtata ggcaacttaa cttcactgtg gaatccattt atctcaaagt
     6541 ttgagggctg tctactttat tttcaagttt ggggcggaaa ctcaaaatcc cgagcattgc
     6601 cactttagta gtttgtttga tttgcctatt gtttaataat gagtacattc ttattaagtg
     6661 atgagtacat tcttaatttt aaggtatgtt tttttcaagc agcttcattt tattaggaaa
     6721 aatacatact catttgttgt aaacagtgat tgtggggttt cattttctga atgtactcaa
     6781 aactcccaac aacaattgaa caggatgttt gctaatagaa aatctaaaac aggaatatgt
     6841 gtatatggca tgaattagtc attgacttta agcttcttat ccatacaagg aactaataaa
     6901 atgtttattg acaacataaa
//
