LOCUS       NM_030937               3112 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens cyclin L2 (CCNL2), transcript variant 1, mRNA.
ACCESSION   NM_030937
VERSION     NM_030937.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3112)
  AUTHORS   Wu,C., Zhu,Q., Yao,Y., Shi,Z., Jin,C. and Chen,L.
  TITLE     Exosome miR-23a-3p from Osteoblast Alleviates Spinal Cord
            Ischemia/Reperfusion Injury by Down-Regulating KLF3-Activated CCNL2
            Transcription
  JOURNAL   Dev Neurosci 44 (3), 121-130 (2022)
   PUBMED   34937039
  REMARK    GeneRIF: Exosome miR-23a-3p from Osteoblast Alleviates Spinal Cord
            Ischemia/Reperfusion Injury by Down-Regulating KLF3-Activated CCNL2
            Transcription.
REFERENCE   2  (bases 1 to 3112)
  AUTHORS   Chen,S., Yang,C., Wang,Z.W., Hu,J.F., Pan,J.J., Liao,C.Y.,
            Zhang,J.Q., Chen,J.Z., Huang,Y., Huang,L., Zhan,Q., Tian,Y.F.,
            Shen,B.Y. and Wang,Y.D.
  TITLE     CLK1/SRSF5 pathway induces aberrant exon skipping of METTL14 and
            Cyclin L2 and promotes growth and metastasis of pancreatic cancer
  JOURNAL   J Hematol Oncol 14 (1), 60 (2021)
   PUBMED   33849617
  REMARK    GeneRIF: CLK1/SRSF5 pathway induces aberrant exon skipping of
            METTL14 and Cyclin L2 and promotes growth and metastasis of
            pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3112)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3112)
  AUTHORS   Kisaka,J.K., Ratner,L. and Kyei,G.B.
  TITLE     The Dual-Specificity Kinase DYRK1A Modulates the Levels of Cyclin
            L2 To Control HIV Replication in Macrophages
  JOURNAL   J Virol 94 (6), e01583-19 (2020)
   PUBMED   31852782
  REMARK    GeneRIF: The Dual-Specificity Kinase DYRK1A Modulates the Levels of
            Cyclin L2 To Control HIV Replication in Macrophages.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3112)
  AUTHORS   Kyei,G.B., Cheng,X., Ramani,R. and Ratner,L.
  TITLE     Cyclin L2 is a critical HIV dependency factor in macrophages that
            controls SAMHD1 abundance
  JOURNAL   Cell Host Microbe 17 (1), 98-106 (2015)
   PUBMED   25532805
  REMARK    GeneRIF: Therefore, cyclin L2-mediated control of SAMHD1 levels in
            macrophages supports HIV-1 replication.
REFERENCE   6  (bases 1 to 3112)
  AUTHORS   Loyer,P., Trembley,J.H., Grenet,J.A., Busson,A., Corlu,A., Zhao,W.,
            Kocak,M., Kidd,V.J. and Lahti,J.M.
  TITLE     Characterization of cyclin L1 and L2 interactions with CDK11 and
            splicing factors: influence of cyclin L isoforms on splice site
            selection
  JOURNAL   J Biol Chem 283 (12), 7721-7732 (2008)
   PUBMED   18216018
  REMARK    GeneRIF: CDK11(p110) interacts physically and functionally with
            cyclin Lalpha and -beta isoforms and SR proteins to regulate
            splicing.
REFERENCE   7  (bases 1 to 3112)
  AUTHORS   de Graaf,K., Hekerman,P., Spelten,O., Herrmann,A., Packman,L.C.,
            Bussow,K., Muller-Newen,G. and Becker,W.
  TITLE     Characterization of cyclin L2, a novel cyclin with an
            arginine/serine-rich domain: phosphorylation by DYRK1A and
            colocalization with splicing factors
  JOURNAL   J Biol Chem 279 (6), 4612-4624 (2004)
   PUBMED   14623875
  REMARK    GeneRIF: characterize cyclin L2 as a highly mobile component of
            nuclear speckles and suggest that DYRK1A may regulate splicing by
            phosphorylation of cyclin L2
REFERENCE   8  (bases 1 to 3112)
  AUTHORS   Edelheit,S. and Meiri,N.
  TITLE     Cyclin S: a new member of the cyclin family plays a role in
            long-term memory
  JOURNAL   Eur J Neurosci 19 (2), 365-375 (2004)
   PUBMED   14725631
REFERENCE   9  (bases 1 to 3112)
  AUTHORS   Cheng,H. and Bjerknes,M.
  TITLE     Patterns of gene expression along the crypt-villus axis in mouse
            jejunal epithelium
  JOURNAL   Anat Rec 244 (1), 78-94 (1996)
   PUBMED   8838426
REFERENCE   10 (bases 1 to 3112)
  AUTHORS   Bunnell,B.A., Heath,L.S., Adams,D.E., Lahti,J.M. and Kidd,V.J.
  TITLE     Increased expression of a 58-kDa protein kinase leads to changes in
            the CHO cell cycle
  JOURNAL   Proc Natl Acad Sci U S A 87 (19), 7467-7471 (1990)
   PUBMED   2217177
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1991 Mar 15;88(6):2612]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY002650.1, AY037150.1,
            AL834432.1 and AK000685.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_030937.5.
            
            Summary: The protein encoded by this gene belongs to the cyclin
            family. Through its interaction with several proteins, such as RNA
            polymerase II, splicing factors, and cyclin-dependent kinases, this
            protein functions as a regulator of the pre-mRNA splicing process,
            as well as in inducing apoptosis by modulating the expression of
            apoptotic and antiapoptotic proteins. Alternatively spliced
            transcript variants encoding different isoforms have been described
            for this gene. [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1, also known as L2alpha or T2)
            encodes the longest isoform (A, also known as L2alpha) containing a
            cyclin box in the N-terminus and RS domain in the C-terminus.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.8616.1,
                                           SRR1803615.144952.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153932, SAMEA2154405
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000400809.8/ ENSP00000383611.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                HY002650.1         8-30
            24-1930             AY037150.1         1-1907
            1931-2561           AL834432.1         804-1434
            2562-2903           AK000685.1         2242-2583
            2904-3112           AK000685.1         2585-2793
FEATURES             Location/Qualifiers
     source          1..3112
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.33"
     gene            1..3112
                     /gene="CCNL2"
                     /gene_synonym="ANIA-6B; CCNM; CCNS; HCLA-ISO; HLA-ISO;
                     PCEE; SB138"
                     /note="cyclin L2"
                     /db_xref="GeneID:81669"
                     /db_xref="HGNC:HGNC:20570"
                     /db_xref="MIM:613482"
     exon            1..317
                     /gene="CCNL2"
                     /gene_synonym="ANIA-6B; CCNM; CCNS; HCLA-ISO; HLA-ISO;
                     PCEE; SB138"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1592
                     /gene="CCNL2"
                     /gene_synonym="ANIA-6B; CCNM; CCNS; HCLA-ISO; HLA-ISO;
                     PCEE; SB138"
                     /note="isoform A is encoded by transcript variant 1;
                     cyclin M; paneth cell-enhanced expression protein; cyclin
                     S"
                     /codon_start=1
                     /product="cyclin-L2 isoform A"
                     /protein_id="NP_112199.2"
                     /db_xref="CCDS:CCDS30557.1"
                     /db_xref="GeneID:81669"
                     /db_xref="HGNC:HGNC:20570"
                     /db_xref="MIM:613482"
                     /translation="MAAAAAAAGAAGSAAPAAAAGAPGSGGAPSGSQGVLIGDRLYSG
                     VLITLENCLLPDDKLRFTPSMSSGLDTDTETDLRVVGCELIQAAGILLRLPQVAMATG
                     QVLFQRFFYTKSFVKHSMEHVSMACVHLASKIEEAPRRIRDVINVFHRLRQLRDKKKP
                     VPLLLDQDYVNLKNQIIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECERNQHLVQT
                     SWNYMNDSLRTDVFVRFQPESIACACIYLAARTLEIPLPNRPHWFLLFGATEEEIQEI
                     CLKILQLYARKKVDLTHLEGEVEKRKHAIEEAKAQARGLLPGGTQVLDGTSGFSPAPK
                     LVESPKEGKGSKPSPLSVKNTKRRLEGAKKAKADSPVNGLPKGRESRSRSRSREQSYS
                     RSPSRSASPKRRKSDSGSTSGGSKSQSRSRSRSDSPPRQAPRSAPYKGSEIRGSRKSK
                     DCKYPQKPHKSRSRSSSRSRSRSRERADNPGKYKKKSHYYRDQRRERSRSYERTGRRY
                     ERDHPGHSRHRR"
     exon            318..392
                     /gene="CCNL2"
                     /gene_synonym="ANIA-6B; CCNM; CCNS; HCLA-ISO; HLA-ISO;
                     PCEE; SB138"
                     /inference="alignment:Splign:2.1.0"
     exon            393..502
                     /gene="CCNL2"
                     /gene_synonym="ANIA-6B; CCNM; CCNS; HCLA-ISO; HLA-ISO;
                     PCEE; SB138"
                     /inference="alignment:Splign:2.1.0"
     exon            503..623
                     /gene="CCNL2"
                     /gene_synonym="ANIA-6B; CCNM; CCNS; HCLA-ISO; HLA-ISO;
                     PCEE; SB138"
                     /inference="alignment:Splign:2.1.0"
     exon            624..688
                     /gene="CCNL2"
                     /gene_synonym="ANIA-6B; CCNM; CCNS; HCLA-ISO; HLA-ISO;
                     PCEE; SB138"
                     /inference="alignment:Splign:2.1.0"
     exon            689..788
                     /gene="CCNL2"
                     /gene_synonym="ANIA-6B; CCNM; CCNS; HCLA-ISO; HLA-ISO;
                     PCEE; SB138"
                     /inference="alignment:Splign:2.1.0"
     exon            789..893
                     /gene="CCNL2"
                     /gene_synonym="ANIA-6B; CCNM; CCNS; HCLA-ISO; HLA-ISO;
                     PCEE; SB138"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1035
                     /gene="CCNL2"
                     /gene_synonym="ANIA-6B; CCNM; CCNS; HCLA-ISO; HLA-ISO;
                     PCEE; SB138"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1147
                     /gene="CCNL2"
                     /gene_synonym="ANIA-6B; CCNM; CCNS; HCLA-ISO; HLA-ISO;
                     PCEE; SB138"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1240
                     /gene="CCNL2"
                     /gene_synonym="ANIA-6B; CCNM; CCNS; HCLA-ISO; HLA-ISO;
                     PCEE; SB138"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..3112
                     /gene="CCNL2"
                     /gene_synonym="ANIA-6B; CCNM; CCNS; HCLA-ISO; HLA-ISO;
                     PCEE; SB138"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2091..2096
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNL2"
                     /gene_synonym="ANIA-6B; CCNM; CCNS; HCLA-ISO; HLA-ISO;
                     PCEE; SB138"
                     /note="hexamer: AATAAA"
     polyA_site      2118
                     /gene="CCNL2"
                     /gene_synonym="ANIA-6B; CCNM; CCNS; HCLA-ISO; HLA-ISO;
                     PCEE; SB138"
                     /note="major polyA site"
     regulatory      2302..2307
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNL2"
                     /gene_synonym="ANIA-6B; CCNM; CCNS; HCLA-ISO; HLA-ISO;
                     PCEE; SB138"
                     /note="hexamer: AATAAA"
     polyA_site      2328
                     /gene="CCNL2"
                     /gene_synonym="ANIA-6B; CCNM; CCNS; HCLA-ISO; HLA-ISO;
                     PCEE; SB138"
                     /note="major polyA site"
     regulatory      3091..3096
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNL2"
                     /gene_synonym="ANIA-6B; CCNM; CCNS; HCLA-ISO; HLA-ISO;
                     PCEE; SB138"
                     /note="hexamer: CATAAA"
     polyA_site      3112
                     /gene="CCNL2"
                     /gene_synonym="ANIA-6B; CCNM; CCNS; HCLA-ISO; HLA-ISO;
                     PCEE; SB138"
                     /note="major polyA site"
ORIGIN      
        1 agaagccgaa ggggagtcgg cggcacaaaa tggcggcggc ggcggcggcg gctggtgctg
       61 cagggtcggc agctcccgcg gcagcggccg gcgccccggg atctgggggc gcaccctcag
      121 ggtcgcaggg ggtgctgatc ggggacaggc tgtactccgg ggtgctcatc accttggaga
      181 actgcctcct gcctgacgac aagctccgtt tcacgccgtc catgtcgagc ggcctcgaca
      241 ccgacacaga gaccgacctc cgcgtggtgg gctgcgagct catccaggcg gccggtatcc
      301 tgctccgcct gccgcaggtg gccatggcta ccgggcaggt gttgttccag cggttctttt
      361 ataccaagtc cttcgtgaag cactccatgg agcatgtgtc aatggcctgt gtccacctgg
      421 cttccaagat agaagaggcc ccaagacgca tacgggacgt catcaatgtg tttcaccgcc
      481 ttcgacagct gagagacaaa aagaagcccg tgcctctact actggatcaa gattatgtta
      541 atttaaagaa ccaaattata aaggcggaaa gacgagttct caaagagttg ggtttctgcg
      601 tccatgtgaa gcatcctcat aagataatcg ttatgtacct tcaggtgtta gagtgtgagc
      661 gtaaccaaca cctggtccag acctcatgga attacatgaa cgacagcctt cgcaccgacg
      721 tcttcgtgcg gttccagcca gagagcatcg cctgtgcctg catttatctt gctgcccgga
      781 cgctggagat ccctttgccc aatcgtcccc attggtttct tttgtttgga gcaactgaag
      841 aagaaattca ggaaatctgc ttaaagatct tgcagcttta tgctcggaaa aaggttgatc
      901 tcacacacct ggagggtgaa gtggaaaaaa gaaagcacgc tatcgaagag gcaaaggccc
      961 aagcccgggg cctgttgcct gggggcacac aggtgctgga tggtacctcg gggttctctc
     1021 ctgcccccaa gctggtggaa tcccccaaag aaggtaaagg gagcaagcct tccccactgt
     1081 ctgtgaagaa caccaagagg aggctggagg gcgccaagaa agccaaggcg gacagccccg
     1141 tgaacggctt gccaaagggg cgagagagtc ggagtcggag ccggagccgt gagcagagct
     1201 actcgaggtc cccatcccga tcagcgtctc ctaagaggag gaaaagtgac agcggctcca
     1261 catctggtgg gtccaagtcg cagagccgct cccggagcag gagtgactcc ccaccgagac
     1321 aggccccccg cagcgctccc tacaaaggct ctgagattcg gggctcccgg aagtccaagg
     1381 actgcaagta cccccagaag ccacacaagt ctcggagccg gagttcttcc cgttctcgaa
     1441 gcaggtcacg ggagcgggcg gataatccgg gaaaatacaa gaagaaaagt cattactaca
     1501 gagatcagcg acgagagcgc tcgaggtcgt atgaacgcac aggccgtcgc tatgagcggg
     1561 accaccctgg gcacagcagg catcggaggt gaggcggggt tgcagtgact ggtggccgca
     1621 agcccttccc tggggagtac ctgatggctg ccctttgacc cccggtggct gccctttgac
     1681 ccccgggtgt gctctcagcg caagtggtcc tagaacagga ttctttttgg aaatgtctgt
     1741 cgactggacc ttggtggatt tggaaatgga actgagggac cggtgacacg tgcttcagac
     1801 cggtctgggg tgcggcgcac acctgggccc gtgcagggct cagctcggca gcagctctga
     1861 gggcagctca atgaaaaagt gaatgcacac gcccttgttg gcgtggcctg gcatggcctg
     1921 gtgctatcgg cagccgctct ccactccccg actgatactc aattacgtga agccaagaaa
     1981 gatgattttt agaacctttg cctatattag gttgtactta tgtacatatt ttgcagtgtt
     2041 tcacaggaga aagtggcctt aactgcccct tattctctct ccacgttgta aataaacatg
     2101 tgtttaatac aagttaaagc tatgtatgaa aactcagaac ttgaatcccg tcagcttaaa
     2161 acttgtgtag ggaatcctga cttttaaaat gtgagggtat ttggatctgt gttgaaagtc
     2221 gtatattttt atctgtgcgg tgctgagtgc aggccaccag ctcctaaata gaggttccct
     2281 atatgcgcgt atgacatggt gaataaacac aactctctcc actcaggaca tccggagcgt
     2341 tatggacgtg gtaggtggtc gttctgtgtg cttgtgaaag tgtccaggcg tgtgcacagc
     2401 cagtgcgccc acttccgggc tccttgctcc ctgctgtact gaagttttgg attttgcatc
     2461 caatcctgtg tgcctgccct tctgccgaag gcttgtgagg ggcctgagtc ctctgcccat
     2521 caggatgaca ggctccttcc tgcagggcca taggagggaa gttttggaaa cacagaatga
     2581 ttccaaggtg ctctcgttcc tgagggggac tggtttgtaa cccatgacat ctgtgggcga
     2641 gagaggcagc tgggagcagg acacttggag ggtcacccca cgggggtggc acctgcactc
     2701 tgagtgcccc ccactgtcat cagctgcctc ttaccgtgga cacagttttg gttttgggga
     2761 ctagggggcc ccactcctgg tggtaccgtt tggacttact agggcagtgg gacatatagg
     2821 ccggggctag tgggataacg gggagttacg cctgatgact tttttgatgg aatcctgcat
     2881 tagatagctg gtgggacccc ccctcagaat tggggaactg aggagactcc agggagggtg
     2941 tccttccagg gagagcagct atgaggggcc ccctagcttc ctgtgcctgg aagtaagaga
     3001 accagtaaag ggccatacac acctgtaccc aagagaccgc tctccatttg ctttcttttt
     3061 ttactaaata attgtaaaat attattatga cataaagaac catttaaggc ca
//
