LOCUS       NM_020307               2322 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens cyclin L1 (CCNL1), transcript variant 1, mRNA.
ACCESSION   NM_020307
VERSION     NM_020307.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2322)
  AUTHORS   O'Brien,S., Kelso,S., Steinhart,Z., Orlicky,S., Mis,M., Kim,Y.,
            Lin,S., Sicheri,F. and Angers,S.
  TITLE     SCFFBXW7 regulates G2-M progression through control of CCNL1
            ubiquitination
  JOURNAL   EMBO Rep 23 (12), e55044 (2022)
   PUBMED   36278408
  REMARK    GeneRIF: SCF[FBXW7] regulates G2-M progression through control of
            CCNL1 ubiquitination.
REFERENCE   2  (bases 1 to 2322)
  AUTHORS   Zeng,X., Hu,Z., Shen,Y., Wei,X., Gan,J. and Liu,Z.
  TITLE     MiR-5195-3p functions as a tumor suppressor in prostate cancer via
            targeting CCNL1
  JOURNAL   Cell Mol Biol Lett 27 (1), 25 (2022)
   PUBMED   35260070
  REMARK    GeneRIF: MiR-5195-3p functions as a tumor suppressor in prostate
            cancer via targeting CCNL1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2322)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2322)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2322)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2322)
  AUTHORS   Hu,D., Mayeda,A., Trembley,J.H., Lahti,J.M. and Kidd,V.J.
  TITLE     CDK11 complexes promote pre-mRNA splicing
  JOURNAL   J Biol Chem 278 (10), 8623-8629 (2003)
   PUBMED   12501247
REFERENCE   7  (bases 1 to 2322)
  AUTHORS   Redon,R., Hussenet,T., Bour,G., Caulee,K., Jost,B., Muller,D.,
            Abecassis,J. and du Manoir,S.
  TITLE     Amplicon mapping and transcriptional analysis pinpoint cyclin L as
            a candidate oncogene in head and neck cancer
  JOURNAL   Cancer Res 62 (21), 6211-6217 (2002)
   PUBMED   12414649
REFERENCE   8  (bases 1 to 2322)
  AUTHORS   Dickinson,L.A., Edgar,A.J., Ehley,J. and Gottesfeld,J.M.
  TITLE     Cyclin L is an RS domain protein involved in pre-mRNA splicing
  JOURNAL   J Biol Chem 277 (28), 25465-25473 (2002)
   PUBMED   11980906
  REMARK    GeneRIF: role in pre-mRNA splicing
            GeneRIF: Cyclin L has been shown to associate with the PITSLRE
            kinase and is involved in pre-mRNA processing.
REFERENCE   9  (bases 1 to 2322)
  AUTHORS   Berke,J.D., Sgambato,V., Zhu,P.P., Lavoie,B., Vincent,M., Krause,M.
            and Hyman,S.E.
  TITLE     Dopamine and glutamate induce distinct striatal splice forms of
            Ania-6, an RNA polymerase II-associated cyclin
  JOURNAL   Neuron 32 (2), 277-287 (2001)
   PUBMED   11683997
REFERENCE   10 (bases 1 to 2322)
  AUTHORS   Bunnell,B.A., Heath,L.S., Adams,D.E., Lahti,J.M. and Kidd,V.J.
  TITLE     Increased expression of a 58-kDa protein kinase leads to changes in
            the CHO cell cycle
  JOURNAL   Proc Natl Acad Sci U S A 87 (19), 7467-7471 (1990)
   PUBMED   2217177
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1991 Mar 15;88(6):2612]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104411.5.
            
            On Nov 30, 2019 this sequence version replaced NM_020307.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007081.1, AK022974.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295926.8/ ENSP00000295926.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-356               AC104411.5         31180-31535
            357-431             AC104411.5         31848-31922
            432-541             AC104411.5         32352-32461
            542-662             AC104411.5         38171-38291
            663-727             AC104411.5         39086-39150
            728-827             AC104411.5         40946-41045
            828-932             AC104411.5         41158-41262
            933-1074            AC104411.5         41350-41491
            1075-1186           AC104411.5         41731-41842
            1187-1285           AC104411.5         41942-42040
            1286-2322           AC104411.5         42738-43774
FEATURES             Location/Qualifiers
     source          1..2322
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.31"
     gene            1..2322
                     /gene="CCNL1"
                     /gene_synonym="ania-6a; ANIA6A; BM-001; PRO1073"
                     /note="cyclin L1"
                     /db_xref="GeneID:57018"
                     /db_xref="HGNC:HGNC:20569"
                     /db_xref="MIM:613384"
     exon            1..356
                     /gene="CCNL1"
                     /gene_synonym="ania-6a; ANIA6A; BM-001; PRO1073"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1634
                     /gene="CCNL1"
                     /gene_synonym="ania-6a; ANIA6A; BM-001; PRO1073"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cyclin L ania-6a; cyclin L gamma; cyclin-L"
                     /codon_start=1
                     /product="cyclin-L1 isoform 1"
                     /protein_id="NP_064703.1"
                     /db_xref="CCDS:CCDS3178.1"
                     /db_xref="GeneID:57018"
                     /db_xref="HGNC:HGNC:20569"
                     /db_xref="MIM:613384"
                     /translation="MASGPHSTATAAAAASSAAPSAGGSSSGTTTTTTTTTGGILIGD
                     RLYSEVSLTIDHSLIPEERLSPTPSMQDGLDLPSETDLRILGCELIQAAGILLRLPQV
                     AMATGQVLFHRFFYSKSFVKHSFEIVAMACINLASKIEEAPRRIRDVINVFHHLRQLR
                     GKRTPSPLILDQNYINTKNQVIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECERNQ
                     TLVQTAWNYMNDSLRTNVFVRFQPETIACACIYLAARALQIPLPTRPHWFLLFGTTEE
                     EIQEICIETLRLYTRKKPNYELLEKEVEKRKVALQEAKLKAKGLNPDGTPALSTLGGF
                     SPASKPSSPREVKAEEKSPISINVKTVKKEPEDRQQASKSPYNGVRKDSKRSRNSRSA
                     SRSRSRTRSRSRSHTPRRHYNNRRSRSGTYSSRSRSRSRSHSESPRRHHNHGSPHLKA
                     KHTRDDLKSSNRHGHKRKKSRSRSQSKSRDHSDAAKKHRHERGHHRDRRERSRSFERS
                     HKSKHHGGSRSGHGRHRR"
     exon            357..431
                     /gene="CCNL1"
                     /gene_synonym="ania-6a; ANIA6A; BM-001; PRO1073"
                     /inference="alignment:Splign:2.1.0"
     exon            432..541
                     /gene="CCNL1"
                     /gene_synonym="ania-6a; ANIA6A; BM-001; PRO1073"
                     /inference="alignment:Splign:2.1.0"
     exon            542..662
                     /gene="CCNL1"
                     /gene_synonym="ania-6a; ANIA6A; BM-001; PRO1073"
                     /inference="alignment:Splign:2.1.0"
     exon            663..727
                     /gene="CCNL1"
                     /gene_synonym="ania-6a; ANIA6A; BM-001; PRO1073"
                     /inference="alignment:Splign:2.1.0"
     exon            728..827
                     /gene="CCNL1"
                     /gene_synonym="ania-6a; ANIA6A; BM-001; PRO1073"
                     /inference="alignment:Splign:2.1.0"
     exon            828..932
                     /gene="CCNL1"
                     /gene_synonym="ania-6a; ANIA6A; BM-001; PRO1073"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1074
                     /gene="CCNL1"
                     /gene_synonym="ania-6a; ANIA6A; BM-001; PRO1073"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1186
                     /gene="CCNL1"
                     /gene_synonym="ania-6a; ANIA6A; BM-001; PRO1073"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1285
                     /gene="CCNL1"
                     /gene_synonym="ania-6a; ANIA6A; BM-001; PRO1073"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..2322
                     /gene="CCNL1"
                     /gene_synonym="ania-6a; ANIA6A; BM-001; PRO1073"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2056..2061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNL1"
                     /gene_synonym="ania-6a; ANIA6A; BM-001; PRO1073"
                     /note="hexamer: AATACA"
     polyA_site      2079
                     /gene="CCNL1"
                     /gene_synonym="ania-6a; ANIA6A; BM-001; PRO1073"
                     /note="major polyA site"
     regulatory      2109..2114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNL1"
                     /gene_synonym="ania-6a; ANIA6A; BM-001; PRO1073"
                     /note="hexamer: ATTAAA"
     polyA_site      2136
                     /gene="CCNL1"
                     /gene_synonym="ania-6a; ANIA6A; BM-001; PRO1073"
     regulatory      2289..2294
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNL1"
                     /gene_synonym="ania-6a; ANIA6A; BM-001; PRO1073"
                     /note="hexamer: ATTAAA"
     polyA_site      2322
                     /gene="CCNL1"
                     /gene_synonym="ania-6a; ANIA6A; BM-001; PRO1073"
ORIGIN      
        1 agtcttgttt cgggttccgg ctgcgttggg cttgcgtgcg gctcgctaag actatggcgt
       61 ccgggcctca ttcgacagct actgctgccg cagccgcctc atcggccgcc ccaagcgcgg
      121 gcggctccag ctccgggacg acgaccacga cgacgaccac gacgggaggg atcctgatcg
      181 gcgatcgcct gtactcggaa gtttcactta ccatcgacca ctctctgatt ccggaggaga
      241 ggctctcgcc caccccatcc atgcaggatg ggctcgacct gcccagtgag acggacttac
      301 gcatcctggg ctgcgagctc atccaggccg ccggcattct cctccggctg ccgcaggtgg
      361 cgatggcaac ggggcaggtg ttgtttcatc gttttttcta ctccaaatct ttcgtcaaac
      421 acagtttcga gattgttgct atggcttgta ttaatcttgc atcaaaaatc gaagaagcac
      481 ctagaagaat aagagatgtg attaatgtat tccaccacct ccgccagtta agaggaaaaa
      541 ggactccaag ccccctgatc cttgatcaga actacattaa caccaaaaat caagttatca
      601 aagcagagag gagggtgcta aaggagttgg gattttgtgt tcatgtcaag catcctcata
      661 agatcattgt tatgtattta caagtcttag aatgtgaacg taatcaaacc ctggttcaaa
      721 ctgcctggaa ttacatgaat gacagtcttc gaaccaatgt gtttgttcga tttcaaccag
      781 agactatagc atgtgcttgc atctaccttg cagctagagc acttcagatt ccgttgccaa
      841 ctcgtcccca ttggtttctt ctttttggta ctacagaaga ggaaatccag gaaatctgca
      901 tagaaacact taggctttat accagaaaaa agccaaacta tgaattactg gaaaaagaag
      961 tagaaaaaag aaaagtagcc ttacaagaag ccaaattaaa agcaaaggga ttgaatccgg
     1021 atggaactcc agccctttca accctgggtg gattttctcc agcctccaag ccatcatcac
     1081 caagagaagt aaaagctgaa gagaaatcac caatctccat taatgtgaag acagtcaaaa
     1141 aagaacctga ggatagacaa caggcttcca aaagccctta caatggtgta agaaaagaca
     1201 gcaagagaag tagaaatagc agaagtgcaa gtcgatcgag gtcaagaaca cgatcacgtt
     1261 ctagatcaca tactccaaga agacactata ataataggcg gagtcgatct ggaacataca
     1321 gctcgagatc aagaagcagg tcccgcagtc acagtgaaag ccctcgaaga catcataatc
     1381 atggttctcc tcaccttaag gccaagcata ccagagatga tttaaaaagt tcaaacagac
     1441 atggtcataa aaggaaaaaa tctcgttctc gatctcagag caagtctcgg gatcactcag
     1501 atgcagccaa gaaacacagg catgaaaggg gacatcatag ggacaggcgt gaacgatctc
     1561 gctcctttga gaggtcccat aaaagcaagc accatggtgg cagtcgctca ggacatggca
     1621 ggcacaggcg ctgactttct cttcctttga gcctgcatca gttcttggtt ttgcctatct
     1681 acagtgtgat gtatggactc aatcaaaaac attaaacgca aactgattag gatttgattt
     1741 cttgaaaccc tctaggtctc tagaacactg aggacagttt cttttgaaaa gaactatgtt
     1801 aatttttttg cacattaaaa tgccctagca gtatctaatt aaaaaccatg gtcaggttca
     1861 attgtacttt attatagttg tgtattgttt attgctataa gaactggagc gtgaattctg
     1921 taaaaatgta tcttattttt atacagataa aattgcagac actgttctat ttaagtggtt
     1981 atttgtttaa atgatggtga atactttctt aacactggtt tgtctgcatg tgtaaagatt
     2041 tttacaagga aataaaatac aaatcttgtt ttttctaaac tgcttcaaat accttattta
     2101 aataaattat taaaaaggaa aattttaata gcaaaatggc tgtactggtt ttctgacaaa
     2161 cttattcttt cctccattag atggtagttt gagattatta aaatgcaatt cttaactgca
     2221 ttgtgagcta ttgtaagtct tcactgtata tatggaaaaa gtaaatggga gtcgcccaac
     2281 aatgtgacat taaatgttat attttagcac taaaccaaaa aa
//
